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Bio-chemoprevention of recurrenceof superficial bladder cancer-Mechanisms of inhibition by Lactobacillus casei preparation (BLP) on bladder carcinogenesis-

Research Project

Project/Area Number 07807148
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionUniversity of Tsukuba

Principal Investigator

AKAZA Hideyuki  University of Tsukuba, Institute of Clinical Medicine, Professor, 臨床医学系, 教授 (70010486)

Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
KeywordsBladder cancer / Promotor / Lactobacillus Casei / Smoking / chemo-prevention / Cancer recurrence / Prevention of Cancer / 乳酸捍菌 / 膀胱癌 / 予防 / 発癌 / 再発予防
Research Abstract

It is reported that BLP (p.o.administration) prevents recurrence of superficial bladder cancer after TUR-Bt. In this study, we have investigated mechanisms of the preventive effects of BLP.Seven kinds of lacto-bacilli were tested for its inhibitory ability on carcinogenic promotion using concanavalin-A agglutinating method. Half of bacilli tested including BLP showed the inhibitory effect on bladder carcinogenesis. It is important to investigate the viability in the intestine and other biological characteristics of the lacto-bacilli tested.
Tabaco smoking is a major risk factor for bladder carcinogenesis in human, which is known to excrete mutagens in urine. In our preliminary investigation, BLP clearly decreased the mutagenic products in the urine (TA98, S9+) in some volunteers but not in all. BLP which grow in the intestine might contribute to inhibit metabolization of mutagenic (carcinogenic) substances as a result of alternating microflora in intestine. (ex : reducing nitroso-urea producing bacterias).
We have hypothesized two mechanisms of recurrence of superficial bladder cancer ; one is true recurrence and the other second primary cancer. The second primary cancer may arise from initiated cells, which persist for long time in the bladder epithelium of the patients with bladder cancer and grow to cancer by some promoting influences. From our investigations, BLP is promising to inhibit the second primary cancer by reducing the promoting influences.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Tsu Tsami M., Akaya H et al.: "Correlation of alleic loss of the P53 gene and tumor grade stage, and malignant progression in bladder cancer" LNT.J.Urol. 4(1). 74-78 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Imada.S., Akaya H. et al.: "Promoting effects and mechanisms of action of androgen in bladder carcinogenesis in mak rats." Eur.Urol.31(3). 360-364 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akaya.H.et al.: "Evaluation of uninary NMP-22 as a diagnostic marker for urothelial cancer" Jap.T.Cancer and Chemother. 24(7). 837-842 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akaya H.: "New strategy of bio-chemoprevention on recurrence of superficial bladder cancer based on a hypothesis of the mechanism of recurrence." Jap.T.Cancer and Chemother. 24(supl). 253-256 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] shimazaki T, Akaya H et al.: "Prognostic value of cadherin herin-associated mole cules in bladder tumors" Cancer Res. 56. 4154-4158 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Lamm DL, Akaza H et al.: "Intraiesical chemotherapy and immunotheropy : how do we assess their effectiveness and what are their limitations and uses" Int.J.Urol. 2(suppl). suppl 2 23-35 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tsutsumi M., Akaza H.et.al.: "Correlation of alleic loss of the P53 gene and tumor.grade stage, and malignant progression in bladder cancer." Int.J.Urol.4 (1). 74-78 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Imada S., Akaza H.et.al.: "Promoting effects and mechanisms of action of androgen in bladder carcinogenesis in male rats." Eur.Urol.31 (1). 360-364 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akaza H.et.al.: "Evaluation of urinary NMP-22 as a diagnostic marker for urothelial cancer." Jap.J.Cancer and Chemother. 24 (7). 837-842 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akaza H.: "New strategy of bio-chemoprevention on recurrence of superficial bladder cancer based on a hypothesis of the mechanism of recurrence." Jap.J.Cancer and Chemoth. 24 (supl). 253-256 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimazui.T., Agaza H.et.al.: "Prognostic value of cadherin-associated molecules in bladder tumors" Cancer Res.56. 4154-4158 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Lamm DL,Akaza H.et.al.: "Intravesical chemotherapy and immunotherapy : how do we assess their effectiveness and what are their limitation and uses?" Int.J.Urol.2 (supl2). 23-35 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tsutsumi M., Akaza H.et al.: "Correlation of atleic loss of the p53 gene and tumor grade stage,and malignant progression in bladder cancer." Int.J.Urol.4(1). 74-78 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Imada S., Akaza H.et al.: "Promoting effects and mechanisms of action of androgen in bladder carcinogeresis in male rats." Eur.Urol.31(3). 360-364 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akaza H.et al.: "Evaluation of urinary NMP-22 as a diagnostic mark for urothelial cancer." Jap.J.Cancer and Chemother.24(7). 837-842 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akaza H.: "New strategy of bio-chemoprevention on recurrence of superficial bladder cancer based on a hypothesis of the mechanism of recurrence." Jap.J.Cancer and Chemoth.24(supl). 253-256 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shimazui T.Akaza.H et al.: "Prognostic value of cadherin-associated molecules in bladder tumors" Cancer Res. 56. 4154-4158 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 赤座英之: "表在性膀胱癌再発予防の現状と今後" 腎泌予防医誌. 14. 54 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 赤座 英之: "BCGと膀胱癌;その後の展開" BCG・BRM療法誌. 19. 1-10 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 赤座英之: "表在性膀胱癌の治療" 日本医事新報. NO.3730. 30-34 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 今田世紀,赤座英之,他: "雄性マウスのN-butyl-N-(4-hydroxybutyl)nitrosamine膀胱発癌に対するAndrogen regulation systemの影響" 日泌尿会誌. 86. 1666-1672 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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