| Project/Area Number |
07838048
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 時限 |
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| Research Field |
咀嚼
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| Research Institution | Tokyo Metropolitan Institute for Neuroscience |
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Principal Investigator |
TERASHIMA Toshio Tokyo Metro. Inst. Neurosci. Senior Researcher, 解剖発生学研究部門, 副参事研究員 (20101892)
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| Co-Investigator(Kenkyū-buntansha) |
KISHIMOTO Yasuko Tokyo Metro. Inst. Neurosci. Research Associate, 解剖発生学研究部門, 主事研究員
IKEDA Yayoi Tokyo Metro. Inst. Neurosci. Research Associate, 解剖発生学研究部門, 研究員
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1995: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | reeler mouse / trigeminal motor nucleus / trigeminal mesencephalic nucleu / reelin / gill arch / facial nucleus / 細胞移動 / ハンマーツ-マウス / 神経奇形マウス / 神経堤 / カルボンアニン蛍光色素 |
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| Research Abstract |
Reeler (gene symbol, rl) is an autosomal recessive mutation occurring in mice and characterized by the abnormal positioning of neurons in the central nervous system. In this mutant, however, the cytoarchitecture of the peripheral nervous system is normal, implying that the reeler genetic locus does not affect migration of neurons in the periperal system. Mesencephalic trigeminal nucleus (Me5) neurons are unique in that they are derived from the neural crest like other neurons in the peripheral nervous system, but enter secondarily the central nervous system. We labeled Me5 neurons by injecting horseradish peroxidase or Fast Blue into the temporal muscle of normal and reeler mice to determine whether the migration of these neurons is affected by the reeler genetic locus. Labeled Me5 neurons of the reeler mouse were more widely scattered in comparison with their normal counterparts, suggesting that the reeler genetic locus affects migration of neurons which originate in the neural crest and then migrate into the central nervous system.
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