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Statistical analyses of allergy-related polymorphisms

Research Project

Project/Area Number 07F07462
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section外国
Research Field Immunology
Research InstitutionJuntendo University

Principal Investigator

OKUMURA Ko  順天堂大学, 医学部, 特任教授 (50009700)

Co-Investigator(Kenkyū-buntansha) POTACZEK Daniel  順天堂大学, 医学部, 外国人特別研究員
DANIEL Potaczek  順天堂大学, 医学部, 外国人特別研究員
POTACZEK Daniel  順天堂大学, 大学院・医学研究科, 外国人特別研究員
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2008: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsアレルギー学 / 遺伝子 / IgE / 一塩基置換多型 / アレルギー / FCER1A / FCER2 / FcεRI
Outline of Final Research Achievements

アレルギー疾患原因遺伝子研究を混沌とさせている要因の一つに、個人間で遺伝子塩基配列の異なる多型の存在やその比率が民族間で異なっていることが挙げられる。本研究では、日本とポーランドの共同研究により、IgE受容体遺伝子を中心に、この問題点を考慮した解析を行い、相違点・一致点を明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (12 results)

All 2008 2007 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (2 results)

  • [Journal Article] FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians2008

    • Author(s)
      Danile Potaczek
    • Journal Title

      Int. J. Immunogenetics 35

      Pages: 339-340

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FCER1A gene exon 1A polymorphisms in Japanese and Polish subjects-a comparative analysis of haplotypes2008

    • Author(s)
      Daniel Potaczek
    • Journal Title

      Allergy 63

      Pages: 626-627

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two different transcription factors discriminate the-315C>T-polymorphism of the FcεRIα gene2008

    • Author(s)
      Shunsuke Kanada
    • Journal Title

      J. Immunol. 180

      Pages: 8204-10

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between inflammatory markers and the interleukin-6-174 G/C polymorphism is abolished in peripheral arterial occlusive disease2007

    • Author(s)
      Potaczek DP
    • Journal Title

      Int Angiol. 26

      Pages: 318-23

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variability of the high-affinity IgE receptor alpha subunit(FcepsilonRIalpha)is related to total serun IgE levels in allergic subiects2007

    • Author(s)
      Sanak M
    • Journal Title

      Allergol Int. 56

      Pages: 397-401

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coding region for the high affinity receptor of immunoglobulin E is highly conservative in allergic patients2007

    • Author(s)
      Potaczek DP
    • Journal Title

      Clin Exp Allergy 37

      Pages: 1574-5

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Additive association between FCERIA and FCERIB genetic polymorphisms and total serum IgE levels2007

    • Author(s)
      Potaczek DP
    • Journal Title

      Allergy 62

      Pages: 1095-6

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms of the novel FCERIA gene region: relation to total serum IgE levels2007

    • Author(s)
      Potaczek DP
    • Journal Title

      Ann Allergy Asthma Immunol 98

      Pages: 500-1

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FCERIA gene promoter polymorphisms: lack of association with aspirin hypersensitivity in whites2007

    • Author(s)
      Sanak M
    • Journal Title

      J Allergy Clin Immunol 119

      Pages: 1280-1

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FCERIA gene exon IA polymorphisms in Japanese and Polish subjects-a comparative analysis of haplotypes

    • Author(s)
      Potaczek DP
    • Journal Title

      Allergy (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Analysis of linkage, haplotypes and function of FCER2 genetic polymorphisms and its possible implications2008

    • Author(s)
      Daniel Potaczek
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      京都(国立京都国際会館)
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Functional analysis of FCER1A-18483A>C polymorphism2008

    • Author(s)
      Daniel Potaczek
    • Organizer
      日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Year and Date
      2008-11-27
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2024-03-26  

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