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Genetic Effects of Low Dose Radiations in Man and Animals

Research Project

Project/Area Number 08041174
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionField Research
Research Field 環境影響評価(含放射線生物学)
Research InstitutionOsaka University

Principal Investigator

NOMURA Taisei  Osaka University Faculty of Medicine, Professor, 医学部, 教授 (90089871)

Co-Investigator(Kenkyū-buntansha) KRUPNOVA Evelina V.  Belarus Academy of Sciences, Institute of Genetics and Cytology, Senior Research, 遺伝学・細胞学研究所, 主任研究員
ELISSEEVA Kl  ベラルーシ科学アカデミー, 遺伝学・細胞学研究所, 部長
HONGYO Tadashi  Osaka University Faculty of Medicine, Assistant Professor, 医学部, 助手 (90271569)
NAKAJIMA Hiroo  Osaka University Faculty of Medicine, Assistant Professor, 医学部, 助手 (20237275)
SUGIYAMA Haruo  Osaka University Faculty of Medicine, Professor, 医学部, 教授 (70162906)
ELISSEEVA Klavdiya G.  Belarus Academy of Sciences, Institute of Genetics and Cytology, Chief
EVELINA V.Kr  ベラルーシ科学アカデミー, 遺伝学・細胞学研究所, 主任研究員
KLAVDIYA G.E  ベラルーシ科学アカデミー, 遺伝学・細胞学研究所, 部長
MATSKO Vladi  ベラルーシ科学アカデミー, 放射線生物学研究所, 副所長
藤堂 剛  京都大学, 放射線生物研究センター, 助教授 (90163948)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥18,600,000 (Direct Cost: ¥18,600,000)
Fiscal Year 1998: ¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1997: ¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1996: ¥5,900,000 (Direct Cost: ¥5,900,000)
KeywordsLow dose radiations / Chernobyl catastrophe / Genetic effects / Ecological effects / Wild animals and plants / Biological concentration / Leukemia / WTl gene / 遺伝的影響 / 野生動植物 / 白血病
Research Abstract

1. Contamination of Radionuclides after Chernobyl Catastrophe : Radionuclides were measured and identified in the contaminated area (Gomel, Khoiniki, Bragin) and uncontaminated area (Minsk). Radionuclides, mostly ^<137>, are concentrated in the glasshopper < dragonfly <mole <mouse, although those in the soil are decreasing. High concentration was also observed in carp and frog.
2. Ecological and Transgenerational Effects : Chromosomal aberrations still remain in Drosophila, frog, and mouse as high as those just after the accident, although ten years have passed. It may be caused by highly concentrated radionuclides in these animals, rather than transgenerational (genetic) effects.
3. Experimental Studies : Significantly high incidence of somatic mutations (spot test) was ditected in Drosophila by feeding contaminated red berry.
4. Genetic Effects in Human : Lymphocytes in the peripheral blood were collected from liquidators and people living in the contaminated area, and expression level of WT1 tumor gene, a maker of leukemia, was quantitated. 16 of 28 liquidators with hematological abnormality showed significantly high expression of WT1 gene, indicating a higher risk of leumekia. Some of the liquidators without hematological change and control Belarusian in the uncontaminated area (Minsk) showed moderately high expression of WT1, but all of 49 Japanese and 26 Cocasians living in Osaka showed undectable level of WT1.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (51 results)

All Other

All Publications (51 results)

  • [Publications] Nakajima, H., et al.: "Radionuclides carved on the annual rings of a tree near Chernobyl." Health Physics. 74. 265-267 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hongyo, T., et al.: "Frequent p53 Mutations at Dipyrimidine Sites in Patients with Pyothorax associated Lymphoma (PAL)" Cancer Res.58. 1105-1107 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukuda, K., et al.: "Morphology and function of human benign tumors and normal thyroid tissues maintained in severe combined immunodeficient mice." Cancer Letters. 132. 153-158 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Inoue, K., et al.: "Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells." Blood. 91. 2969-2976 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sako, M., et al.: "Abnormal expression of the Wilms' tumor gene WT1 in juvenile chronic myeloid leukemia and infantile monosomy 7 syndrome." Leukemia Research. 22. 965-967 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamaki, H., et al.: "The Wilms' tumor gene WT1 is a good maker for diagnosis of disease progression of myelodysplastic syndromes." Leukemia. in press. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Nomura: "Trens in Radiation and Cancer Biology" Forschungzentrum Julich, Germany, 7 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 野村大成: "適塾" 適塾記念会, 8 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakajima, H., et al.: "Radionuclides carved on the annual rings of a tree near Chernobyl." Health Physics. 74. 265-267 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hongyo, T., et al.: "Frequent p53 Mutations at Dipyrimidine Sites in Patients with Pyothorax-associated Lymphoma (PAL)" Cancer Res.58. 1105-1107 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukuda, K., et al.: "Morphology and function of human benign tumors and normal thyroid tissues maintained in severe combined immunodeficient mice." Cancer Letters. 132. 153-158 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Inoue, K., et al.: "Wilms'tumor gene (WTl) competes with differentiation-inducing signal in hematopoietic progenitor cells." Blood. 91. 2969-2976 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sako, M., et al.: "Abnormal expression of the Wilms' tumor gene WTl in juvenile chronic myeloid leukemia and infantile monosomy 7 syndrome." Leukemia Research. 22. 965-967 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Nomura: "Dose rate effectiveness and repair in radiation-induced mutagenesis, teratogenesis, and carcinogenesis in mice." Trens in Radiation and Cancer Biology (R.N.Sharan, Ed.). Forschungzentrum Julich, Germany. 149-155 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamaki, H.: "The Wilms' tumor gene WTl is a good marker for diagnosis of disease progression of myelodysplastic syndromes." Leukemia. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakajima,H., et al.: "Radionuclides carved on the annual rings of a tree near Chernobyl." Health Physics. 74. 265-267 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hongyo,T., et al.: "Frequent p53 Mutations at Dipyrimidine Sites in Patients with Pyothorax associated Lymphoma(PAL)" Cancer Res.58. 1105-1107 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fukuda,K., et al.: "Morphology and function of human benign tumors and normal thyroid tissues maintained in severe combined immunodeficient mice." Cancer Letters. 132. 153-158 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Inoue,K., et al.: "Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematoietic progenitor cells." Blood. 91. 2969-2976 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sako,M., et al.: "Abnormal expression of the Wilms' tumor gene WT1 in juvenile chronic myeloid leukemia and infantile monosomy 7 syndrome." Leukemia Research. 22. 965-967 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tamaki,H., et al.: "The Wilms' tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndrom." Leukemia. (in press). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Nomura: "Trens in Radiation and Cancer Biology" Forschungzentrum Julich, Germany, 7 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 野村大成: "適塾" 適塾記念会, 8 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nomura, T., et al.: "Comparative study on germ cell mutation induced by urethane (ethyl carbamate) gas and X-rays in Drosophila melanogaster." Jpn.J.Cancer Res.88. 461-467 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Li, L.Y., et al.: "Dose rate effectiveness and potentially lethal damage repair in normal and double-strand break repair deficient murine cells by γ-rays and 5 fluorouracil." Cancer Letters. 123. 227-232 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakajima, H., et al.: "Radionuclides carved on the annual rings of a tree near Chernobyl." Health Physics. 74. 265-267 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kurooka, M., et al.: "High incidence of esophageal cancer in esophageal achalasia by the oral administration of N-amyl-N-methylnitrosamine and its prevention by nicardipine hydrochloride in mice." Cancer Letters. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hongyo, T., et al.: "Frequent p53 Mutations at Dipyrimidine Sites in Patients with Pyothorax-associated Lymphoma." Cancer Res.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Inoue, K., et al.: "Aberrant overexpression of the Wilms tumor gene (WT1) in human leukemia." Blood. 89. 1405-1412 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Murata, Y., et al.: "The Wilms tumor suppressor gene WT1 induces G1 arrest and apoptosis in myeloblastic leukemia M1 cells." FEBS Letters. 409. 41-45 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ogawa, H.,: "A high incidence of chemotherapy-induced acral erythema (CAE) in female patients with non-Hodgkin's lymphoma who were treated with VACOP-B regimen." Leukemia and Lymphoma. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ogawa, H., et al.: "Successful donor leukocyte transfusion at molecular relapse for a patient with acute myeloid leukemia who was treated with allogeneic bone marrow transplantation : Importance of the monitoring of minimal residual disease by WT1 assay." Bone Marrow Transplantation. (in press.). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Inoue, K., et al.: "Wilms'tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells." Blood. (in press.). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sugiyama, H., et al.: "Wilms tumor gene (WT1) mRNA is equally expressed in blast cells from acute myeloid leukemia and normal CD34 progenitors (Response)." Blood. (in press.). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamagami, T., et al.: "Suppression of Wilms'tumor gene (WT1) expression induces G_2/M arrest in leukemic cells." Leukemia Research. (in press.). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 野村大成: "新人為起源有害物質の継世代的人体影響" 環境科学会誌. 9. 83-95 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 野村大成: "放射線および人為起源化合物の継世代影響について" 環境科学会誌. 9. 317-326 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nomura,T.,et al.: "Cytogenotoxicities of sublimed urethane gas to the mouse embryo." Mutat.Res.368. 59-64 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamaguchi,Y.,et al.: "Standardization of an irradiation field using ^<60>C_o and ^<137>C_s sources" International Congress on Radiation Protection,Proceeding. 4. 212-214 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kawaguchi,T.,et al.: "Consecutive maintenance of human solitary and hereditary colorectal polyps in SCID mice." Cancer Detection and Prevention. (印刷中). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nomura,T.,et al.: "Comparative study on germ cell mumtation induced by urethane(ethyl carbamate)gas and X-rays in Drosophila melanogaster." Japanese J.Cancer Res.88(印刷中). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tamaki,H,et al.: "Increased expression of the Wilmas tumor gene(WT1)at relapse in acute leukemia." Blood. 88. 4396-4398 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamagami,T.,et al.: "Growth inhibition of human leukemic cells by WT1(Wilms tumor gene)antisense oligodeoxynucleotides:Implications for the involvement of WT1 in leukemia." Blood. 88. 2878-2278 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Inoue,K.,et al.: "Long-term follow-up of minimal residual disease in leukemia patients by moitoring WT1(Wilms tumor gene)expression levels." Blood. 88. 2267-2278 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Inoue,K.,et al.: "Aberrant overexpression of the Wilms tumor gene(WT1)in human leukemia." Blood. 89. 印刷中 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Todo,T.,et al.: "Similarity between the Drosophila(6-4)photolyase,a Human Homolog,and the DNA Photolyase/Blue Light Photoreceptor Family." Science. 272. 109-112 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kim,S-T.,et al.: "Purification and characterization of Drosophila melanogaster photolyase." Mutat.Res.363. 97-104 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hsu,D.S.,et al.: "Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins." Biochemistry. 35. 13871-13877 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimoi,K.,et al.: "3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole(Trp-P-1)inhibits the binding activity of T4 endonuclease V to UV-damaged DNA." Carcinogenesis. 17. 1279-1283 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Todo,T.,et al.: "Flavin adenine dinucleotideas a chromophore of the Xenopus(6-4)photolyase." Nucleic Acids Res.25(印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Naka,N.,et al.: "Mutation of p53 tumor suppressor gene in angiosarcoma." Intl.J.Cancer. (印刷中). (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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