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Study on hepatitis C virus new genotypes in Southeast Asia

Research Project

Project/Area Number 08041176
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionField Research
Research InstitutionKobe University School of Medicine

Principal Investigator

HOTTA Hak  Kobe Univ, Sch Med, Professor, 医学部, 教授 (40116249)

Co-Investigator(Kenkyū-buntansha) BARZAGA Nina G  University of the Philippines Manila, College of Public Health, Assistant Profes, 公衆衛生学部, 助教授
APICHARTPIYAKU C  Chiang Mai Univ, Sch Med, Lecturer, 医学部, 講師
SOETJIPTO  Airlangga Univ, Sch Med, Assistant Professor, 医学部, 助教授
KATAYAMA Yuko  Kobe Univ, Sch Med, Assistant, 医学部, 助手 (10224461)
SOETJIPTO  アイルランガ大学, 医学部, 講師
Project Period (FY) 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordshepatitis C virus / genotype / seroepidemiology / molecular epidemiology / Southeast Asia / lndonesia / Thailand / Philippines
Research Abstract

Sero- and molecular epidemiological analyzes of hepatitis C virus (HCV) in Surabaya, lndonesia, were performed. Prevalence of anti-HCV antibodies was 2.3% in healthy blood donors. The prevalence was 5-times higher in those with liver dysfunction than in those without. HCV subtype 2a (HCV-2a) was most common (52%) among HCV isolates from blood donors. On the other hand, HCV-1a, -1b and -1d were associated with elevation of serum ALT levels in blood donors, suggesting a possibly more pathogenic feature of those subtypes than HCV-2a. These results would be beneficial to control posttransfusion hepatitis. In patients on maintenance hemodialysis, the prevalence of anti-HCV antibodies was 62.3%. HCV-1a and -1b (each 31%) were among the most common subtypes in this group. These results suggest an increased risk of HCV infection in hemodialysis, where preventive measures should be taken. In contrast to the case with blood donors, there was no significant difference in subtype prevalence between hemodialyzed patients with liver dysfunction and those without. Impaired immune responses of hemodialyzed patients might be responsible for the apparently decreased hepatocytic injury caused by HCV infection. In patients with HCC,the prevalence of anti-HCV antibodies was 64.7%. HCV-1b (57%) was the most common subtype, followed by HCV-1d (19%) and -2a (5%). Subtype prevalence was not different between HCC patients with advanced liver cirrhosis and those without. A novel subtype (HCV-3g) was identified, although its prevalence was rather low.
Hepatitis G virus (HGV) infection in Chiang Mai, Thailand, was also studied. The prevalence of HGV RNA was 32%, 25%, 10% and 1% in intravenous drug users, hemodialyzed patients, chronic liver disease patients and blood donors, respectively. The prevalence was significantly higher in individuals with HCV infection (24%) than in those without (5%).

Report

(2 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] 本間,守男、堀田,博: "C型肝炎のアジアにおける疫学的研究調査" 神緑会学術誌. 12. 17-23 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Doi,H.: "Hepatitis C virus (HCV) subtype prevalence in Chiang Mai,Thailand,and identification of novel subtypes of HCV major type 6." Journal of Clinical Microbiology. 34(3). 569-574 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Soetjipto: "Differential prevalence of hepatitis C virus subtypesin healthy blood donors,patients on maintenancehemodialysis and patients with hepatocellular carcinoma in Surabaya,Indonesia." Journal of Clinical Microbiology. 34(12). 2875-2880 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katayama,Y.: "Genotype analysis of hepatitis C virus among blood donors and inmates in Metro Manila,the Philippines." Microbiology and Immunology. 40(7). 525-529 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Darmadi,S.: "Hepatitis C virus infection-associated markers in sera from blood donors in Surabaya,Indonesia." Microbiology and Immunology. 40(5). 401-405 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hotta,H.: "Differential distribution of hepatitis C virus subtypes in Asia:Comparative study among Thailand,Indonesia,the Philippines and Japan." Southeast Asian Journal of Tropical Medicine and Public Health. 28 (Suppl 2) (印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Homma, M., Hotta, H.: "Epidemiological Study of hepatitis C virus infection in Asia." Shinryokukai-zasshi. 12. 17-23 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Doi, H.: "Hepatitis C virus (HCV) subtype prevalence in Chiang Mai, Thailand, and identification of novel subtypes of HCV major type 6." J.Clin.Microbiol.34 (3). 569-574 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Soetjipto: "Differential prevalence of hepatitis C virus subtypesin healthy blood donors, patients on maintenancehemodialysis and patients with hepatocellular carcinoma in Surabaya, Indonesia" J.Clin.Microbiol.34 (12). 2875-2880 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katayama, Y.: "Genotype analysis of hepatitis C virus among blood donors and inmates in Metro Manila, the Philippines." Microbiol. Immunol.40 (7). 525-529 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Darmadi, S.: "Hepatitis C virus infection-associated markers in sear from blood donors in Surabaya, Indonesia." Microbiol. Immunol.40 (5). 401-405 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hotta, H.: "Differential distribution of hepatitis C virus subtypes in Asia : Comparative study among Thailand, Indonesia, the Philippines and Japan" Southeast Asian J.Trop.Med.Pul.Hlth.28 (Suppl.2) (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 本間,守男、堀田,博: "G型肝炎のアジアにおける疫学的研究調査" 神緑会学術誌. 12. 17-23 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Doi,H.: "Hepatitis C virus (HCV) subtype prevalence in Chiang Mai,Thailand,and identification of novel subtypes of Hcv major type 6." Journal of Clinical Microbiology. 34(3). 569-574 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Soetjipto: "Differential prevalence of hepatitis C virus subtypes in healthy blood donors.patients on maintenance hemodialysis and patients with hepatocellular carcinoma in Surabaya,Indonesia." Journal of Clinical Microbiology. 34(12). 2875-2880 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Katayama,Y.: "Genotype analysis of hepatitis C virus among blood donors and inmates in Metro Manila,the Philippines." Microbiology and Immunology. 40(7). 525-529 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Darmadi,S.: "Hepatitis C virus infection-associated markers in sera from blood donors in Surabaya,Indonesia." Microbiology and Immunology. 40(5). 401-405 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hotta,H.: "Differential distribution of hepatitis C virus subtypes in Asia : Comparative study among Thailand,Indonesia,the Philippines and Japan." Southeast Asian Journal of Tropical Medicine and Public Health. 28(Suppl 2)(印刷中). (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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