| Project/Area Number |
08041184
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Field Research |
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| Research Institution | Aichi Medical University |
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Principal Investigator |
KIMURA Eisaku Aichi Medical Univ., School of Medicine, Professor, 医学部, 教授 (70153187)
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| Co-Investigator(Kenkyū-buntansha) |
GNAWARDENA Nk Univ.of Ruhuna, Faculty of Medicine, 医学部, 講師
WEERASOORIYA Mv Univ.of Ruhuna, Faculty of Medicine, 医学部, 助教授
FUJIMAKI Yasunori Nagasaki Univ., Institute of Tropical Medicine, 熱帯医学研究所, 講師 (10209083)
ITOH Makoto Aichi Medical Univ., School of Medicine, 医学部, 助教授 (90137117)
GUNAWARDENA エヌ・ケイ Ruhuna大学, 医学部, 講師
WEERASOORIYA エム・ヴイ Ruhuna大学, 医学部, 助教授
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| Project Period (FY) |
1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Wuchereria bancrofti / diethylcarbamazine / Culex quinquefasciatus / permethrin / circulating antigen / elephantiasis / PCR / Sri Lanka |
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| Research Abstract |
1.The situation of Wuchereria bancrofti infection in Matara
(1) A total of 3384 people were examined. The microfilaria (mf) rate was 5.1%. There were 123 cases (5.1% of those examined) with filarial fever and 78 cases (3.3%) with elephantiasis/edema.
(2) The positive rate of filarial circulating antigen was 20.7%, which was much higher than those obtained using conventional methods. The level of antigenemia was closely related to mf densities in the blood. Many 'antigen (+) and mf (-)' people were found. They constitute a new entity unknown to us before the antigenemia survey.
2.The effect of annual single-dose diethylcarbamazine (DEC) treatment at 6 mg/kg
The single dose of DEC reduced mf count from the original 100% to 20% at 6 months, and to 27% at 12 months. If repeated yearly, the annual doses would reduce filarial transmission potential sharply.
3.Studies on mosquito vectors in Matara
(1) Mosquito (Culex quinquefasciatus) infection rate was 4.9%. Infected mosquitoes were collected through a year, indicating that tha filarial transmission occurs year-round.
(2) Permethrin impregnated curtain was effective to reduce mosquito biting densities for the period of 22 weeks.
4.Other activities
Simple methods to determine serum concentration of anti-filarial drugs, and to measure circulating antigen level have been developed. PCR was successfully applied for the diagnosis of 2 species of lymphatic filariasis.
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