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Comparative Study of ATL and HTLV-I Related Diseases

Research Project

Project/Area Number 08042008
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionKumamoto University School of Medicine

Principal Investigator

YAMAGUCHI Kazunari  Kumamoto University School of Medicine Associate Professor, 医学部・附属病院, 講師 (20128325)

Co-Investigator(Kenkyū-buntansha) YANTO Lunard  メリーランド大学, ヒトウイルス研究所, 助教授
MOCHIZUKI Manabu  Kurume University School of Medicine Professor, 医学部, 教授 (10010464)
HATA Hiroyuki  Kumamoto University School of Medicine Assistant Professor, 医学部, 助手 (70271129)
MATSUZAKI Hiromitsu  Kumamoto University School of Medicine Associate Professor, 医学部・附属病院, 講師 (30136725)
MATSUOKA Masao  Kumamoto University School of Medicine Assistant Professor, 医学部・附属病院, 助手 (10244138)
LUNARDI-ISKANDAR Yanto  Institute of Human Retrovirology, University of Maryland Associate Professor
ABRAHAM Blan  カリ, バジェ大学, 講師
Project Period (FY) 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1996: ¥3,500,000 (Direct Cost: ¥3,500,000)
KeywordsHTLV-I / Costa Rica / Indonesia / Florida / Egypt / ATL / HAM
Research Abstract

HTLV-I is a retrovirus associated with adult T-cell leukemia (ATL), spastic paraplegia (HAM/TSP), HTLV-I uveitis and possibly other diseases.
Seroepidimiological studies have been shown distinct geographic endemic clusters of HTLV-I infection and its associated diseases in Southwestern Japan, the Caribbean Basin, South and Central America and Central Africa.
Although the actual incidence of HTLV-I carriers in Asia and Central America is difficult to assess, and values of 0% to 37% have been reported.
Results : (1) Costa Rica : The subjects were 86 patients with various diseases and 25 blood donors in National Children's Hospital in San Jose and 64 psychiatric patients. Three out of 86 patients in hospital were positive for HTLV-I.All of them are female and black from Caribbean Coast. This area is highly endemic for HTLV-I.(Dr.Jose Bonilla)
(2) Indonesia : The subjects were 500 patients with various diseases and 100 blood donors and 100 healthy volunteers at Kristen Indonesia University Hospital. The only one case in this study was indeterminate for HTLV-I.It should be concluded that HTLV-I is not endemic in Jakarta. (Dr.Yunus Tanggo)
(3) Miami (Florida) : The subjects were 40 patients with uveitis. All samples were negative for HTLV-I.(Dr.Janet Davis)
(4) Egypt : We found two patients with HAM/TSP in the Neurology Department of Cairo University. Both patients were males (24,26 years old). (Dr.Ahmed Gohary)

Report

(2 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Takemoto S.: "Primary adult T-cell leukemia of bone : two patients with primary bone tumor showing monoclonal integration of HTLV-I." Leukemia. 10. 333-337 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tamiya S.: "Two types of defective human T-lymphotropic virus type I (HTLV-I) provirus in adult T cell leukemia." Blood. 88. 3065-3073 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takatsuki K.: "Adult T cell leukemia in Japan." J.AIDS and Human Retro.13. 15-19 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mochizuki M.: "HTLV-I uveitis" J.AIDS and Human Retro.13. 50-56 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Henderson ES: "Leukemia" Saunders, 821 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hoellsberg P: "Human T-cell lymphotropic virus type I." John Wiley & Sons Ltd., 325 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takemoto S.: "Primary adult T-cell leukemia of bone : two patients with primary bone tumor showing monoclonal integration of HTLV-I proviral DNA" Leukemia. 10. 333-337 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tamiya S.: "Two types of defective human T-lymphotropic virus type I (HTLV-I) provirus in adult T cell leukemia." Blood. 88. 3065-3073 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takatsuki K.: "Adult T cell leukemia in Japan." J.AIDS & Human Retro.13. 15-19 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mochizuki M.: "HTLV-I uveitis." J.AIDS & Human Retro.13. 50-56 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takemoto S.: "Primary adult T-cell leukemia of bone: two patients with primary bone tumor showing monoclonal integration of HTLV-I proviral DNA." Leukemia. 10. 333-337 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tamiya S.: "Two types of defective human Tlymphotropic virus type I (HTLV-I) provirus in adult T cell leukemia." Blood. 88. 3065-3073 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takatsuki K.: "Adult T cell leukemia in Japan." J. AIDS and Human Retro.13. 15-19 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mochizuki M.: "HTLV-I uveitis" J. AIDS and Human Retro.13. 50-56 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Henderson ES: "Leukemia" Saunders, 821 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hoellsberg P: "Human T-cell lymphotropic virus type I" John Wiley & Sons Ltd., 325 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Pepose JS: "Ocular Infection and Immunity" Mosby, 1552 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2019-02-28  

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