| Project/Area Number |
08042014
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | National Cancer Center |
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Principal Investigator |
TSUGANE Shoichiro National Cancer Center Research Institute East, Epidemiology and Biostatistics Division, Chief, 支所・臨床疫学研究部, 部長 (40179982)
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| Co-Investigator(Kenkyū-buntansha) |
BRENTANI Ricardo Sao Paulo University Medical School, Department of Biochemistry, Professor, 医学部・生化学教室, 教授
HAMADA Gerson Sao Paulo University Public Health School, Department of Epidemiology, Associate, 公衆衛生学部・疫学教室, 助教授
LAURENTI Ruy Sao Paulo University Public Health School, Department of Epidemiology, Professor, 公衆衛生学部・疫学教室, 教授
SUGIMURA Haruhiko Hamamatsu University of Medicine, First department of Pathology, Professor, 第一病理, 教授 (00196742)
WAKABAYASHI Keiji National Cancer Center Research Institute, Cancer Prevention Division, Chief, 生化学部, 部長 (60158582)
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| Project Period (FY) |
1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 1996: ¥4,600,000 (Direct Cost: ¥4,600,000)
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| Keywords | Japanese immigrants / Brazil / Carcinogenic factor / Dietary habit / Genetic factor / Cross-sectional study / Case-control study / Stomach cancer |
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| Research Abstract |
(1)Cross-sectional study
We obtained a 3 day dietary record form 166 randomly sampled Japanese Brazilians aged 47 to 75 years in Sao Paulo and compared these data with five Japanese populations in Japan. Japanese Brazilians consumed more sugar and sweats, beans, fruits, chickes and red meats, while less soybean products, vegetables and pickled vegetables. We tried to detect heterocyclic amine-DNA adducts such as dG-C8-MeIQx and dG-C8-PhIP in liver, kidney and colon tissues from autopsy cases and in colon tissues from colon cancer patients, however all samples were less than our detection limit of measurement method.
(2)Case-control study of stomach cancer
Cases were 101 Japanese Brazilians and 245 non-Japanese Brazilian with stomach cancer and controls were 202 and 245 patients without cancer, respectively. Beef consumption was associated with increased risk of stomach cancer in Japanese, while this association was not found in non-Japanese. Vegetable intake was associated with reduced risk in non-Japanese, while not in Japanese. These discordance of dietary risk factors may be cause by different intake level of these foods between two groups. The distributions of RsaI polymorphism of CYPIIE1 were similar between cases and controls in both groups, however these were significantly different between Japanese and non-Japanese.
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