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Diet, genetic factor and cancer in Japanese Brazilian

Research Project

Project/Area Number 08042014
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionNational Cancer Center

Principal Investigator

TSUGANE Shoichiro  National Cancer Center Research Institute East, Epidemiology and Biostatistics Division, Chief, 支所・臨床疫学研究部, 部長 (40179982)

Co-Investigator(Kenkyū-buntansha) BRENTANI Ricardo  Sao Paulo University Medical School, Department of Biochemistry, Professor, 医学部・生化学教室, 教授
HAMADA Gerson  Sao Paulo University Public Health School, Department of Epidemiology, Associate, 公衆衛生学部・疫学教室, 助教授
LAURENTI Ruy  Sao Paulo University Public Health School, Department of Epidemiology, Professor, 公衆衛生学部・疫学教室, 教授
SUGIMURA Haruhiko  Hamamatsu University of Medicine, First department of Pathology, Professor, 第一病理, 教授 (00196742)
WAKABAYASHI Keiji  National Cancer Center Research Institute, Cancer Prevention Division, Chief, 生化学部, 部長 (60158582)
Project Period (FY) 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 1996: ¥4,600,000 (Direct Cost: ¥4,600,000)
KeywordsJapanese immigrants / Brazil / Carcinogenic factor / Dietary habit / Genetic factor / Cross-sectional study / Case-control study / Stomach cancer
Research Abstract

(1)Cross-sectional study
We obtained a 3 day dietary record form 166 randomly sampled Japanese Brazilians aged 47 to 75 years in Sao Paulo and compared these data with five Japanese populations in Japan. Japanese Brazilians consumed more sugar and sweats, beans, fruits, chickes and red meats, while less soybean products, vegetables and pickled vegetables. We tried to detect heterocyclic amine-DNA adducts such as dG-C8-MeIQx and dG-C8-PhIP in liver, kidney and colon tissues from autopsy cases and in colon tissues from colon cancer patients, however all samples were less than our detection limit of measurement method.
(2)Case-control study of stomach cancer
Cases were 101 Japanese Brazilians and 245 non-Japanese Brazilian with stomach cancer and controls were 202 and 245 patients without cancer, respectively. Beef consumption was associated with increased risk of stomach cancer in Japanese, while this association was not found in non-Japanese. Vegetable intake was associated with reduced risk in non-Japanese, while not in Japanese. These discordance of dietary risk factors may be cause by different intake level of these foods between two groups. The distributions of RsaI polymorphism of CYPIIE1 were similar between cases and controls in both groups, however these were significantly different between Japanese and non-Japanese.

Report

(2 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Tsubono Y.,et al.: "A data-based approach for designing semiquantitative food frequency questionnaire for a population-based prospective study in Japan" J.Epidemiol.6. 45-53 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsubono Y.,et al.: "Differential effects of cigarette smoking and alcohol consumption on the plasma levels of carotenoids in middle-aged Japanese men." Jpn.J.Cancer Res.87. 563-569 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsubono Y.,et al.: "Food consumption and gastric cancer mortality in five regions of Japan." Nutr.Cancer. 27. 60-64 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsubono Y.,et al.: "Nutrient consumption and gastric cancer mortality in five regions of Japan." Nutr.Cancer. 27. 310-315 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsugane S.: "Cancer pattern and lifestyle in the city of Sao Paulo,Brazil" J.Epidemiol.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsubono Y.,et al.: "Green tea intake in relation to serum lipid levels in middle-aged japanese men and women" Ann.Epidemiol.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsugane S.,et al.: "Cancer patterns and lifestyle among Japanese immigrants and their descendants in the city of Sao Paulo,Brazil.In : Gann Monograph on Cancer Research 44" Japan Scientific Societies Press,Tokyo, 8 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsubono Y,Takamori S,Kobayashi M,Takahashi T,Iwase Y,Iitoi Y,Akabane M,Yamaguchi M,Tsugane S.: "A data-based approach for designing a semiquantitative food frequency questionnaire for a population-based prospective study in Japan." J.Epidemiol. 6. 45-53 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsubono Y,Tsugane S,Gey K.F.: "Differential effects of cigarette smoking and alcohol consumption on the plasma levels of carotenoids in middle-aged Japanese men." Jpn.J.Cancer Res.87. 563-569 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsubono Y,Kobayashi M,Tsugane S.: "Food consumption and gastric cancer mortality in five regions of Japan." Nutr.Cancer.27. 60-64 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsubono Y,Takahashi T,Iwase Y,Iitoi Y,Akabane M,Tsugane S.: "Nutrient consumption and gastric cancer mortality in five regions of Japan." Nutr.Cancer.27. 310-315 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsugane S.: "Cancer pattern and lifestyle among Japanese Brazilian in Sao Paulo." J.Epidemiol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsubono Y,Tsugane S.: "Green tea intake in relation to serum lipid levels in middle-aged Japanese men and women." Annals of Epidemiology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsugane S,Hamada GS,Karita K,Tsubono Y,Laurenti R.: Cancer patterns and lifestyle among Japanese immigrants and their descendants in the city of Sao Paulo, Brazil. In : Tajima K,Sonda S,eds. Ethnoepidemiology of cancer. Gann Monograph on Cancer Research.Japan Scientific Societies Press, Tokyo, 44 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsubono Y.,et al.: "A data-based approach for desigining semiquantitative food frequency questionnaire for a population-based prospective study in Japan" J.Epidemiol.6. 45-53 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsubono Y.,et al.: "Differential effects of cigarette smoking and alcohol consumption on the plasma levels of carotenoids in middle-aged Japanese men." Jpn.J.Cancer Res.87. 563-569 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsugane S.,et al.: "A pilot study for a randomized controlled trial to prevent gastric cancer in high-risk Japanese population : study design and feasibility evaluation." Jpn.J.Cancer Res.87. 676-379 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsubono Y.,et al.: "Food consumption and gastric cancer mortality in five regions of Japan." Nutr.Cancer. 27. 60-64 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsubono Y.,et al.: "Nutrient consumption and gastric cancer mortality in five regions of Japan." Nutr.Cancer. 27. 310-315 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsugane S.,et al.: "Cancer patterns and lifestyle among Japanese immigrants and their descendants in the city of Sao Poulo,Brazil. In : Gann Monograph on Cancer Research 44" Japan Scientific Societies Press,Tokyo, 8 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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