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Studies on the control of hantavirus infection and rodent

Research Project

Project/Area Number 08044227
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research Field Public health/Health science
Research InstitutionHokkaido University

Principal Investigator

ARIKAWA Jiro  Hokkaido University School of Medicine Professor, 医学部, 教授 (10142704)

Co-Investigator(Kenkyū-buntansha) SUGIYAMA Kazuyosi  National Institute of Infectious Disease Section of Biosafety chief, バイオセーフティー管理室, 室長 (90150185)
TAKASHIMA Ikuo  Hokkaido University Graduate School of Veterinary Medicine Professor, 大学院・獣医学研究科, 教授 (30002083)
MORIMATSU Kumiko  Hokkaido University School of Medicine Instructor, 医学部, 助手 (90220722)
王 華  中国予防医学科学院, 伝染病疫学研究所, 助手
CLARENCE Peters  Centers for Disease Control and Prevention Special Pathogen Branch Chief, Special Pathogen Branch, 主任
WANG Hua  Chinese Acad. Of Preventive Med. Inst.of Infect. Dis.and Epidemiology Instructor
CLARENCE Pet  Centers for Disease Control and Preventi, 主任
宋 干  中国予防医学科学院, 病毒学研究所, 教授
李 徳新  中国予防医学科学院, 病毒学研究所, 助教授
ANTTI Vaheri  University of Helsinki, Department of Vir, 教授
BO Niklasson  Swedish Institute for Infectious Dieseas, 教授
網 康至  国立予防衛生研究所, 動物管理室, 研究員
伊勢川 裕二  大阪大学, 微生物病研究所, 助手 (20184583)
五十嵐 章  長崎大学, 熱帯医学研究所, 教授 (40029773)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥12,300,000 (Direct Cost: ¥12,300,000)
Fiscal Year 1997: ¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1996: ¥6,500,000 (Direct Cost: ¥6,500,000)
KeywordsHemorrhagic fever with renal syndrome / HFRS / hantavirus / vaccine / zoonosis / epidemiology / rodent / virus infection / ウイルス感染
Research Abstract

Japanese investigator, Dr. Sugiyama carried out a epizootiologicstudy of wild rodents at Beijing and Xian city. A total of 100 rodents were captured from the two regions and were examined for their antibody and antigen distribution.
Chinese investigator, Dr. Li, stayed at Japanese research institution for examining genetic comparison among Chinese hantaviruses obtained from above materials. He examined partial nucleotide sequence of two Chinese isolates and showed the higher relationship to Korean isolates than to Japanese one.
Finish investigator, Dr. Vaheri, visited at Japanese investigator's institutions for information exchange regarding the epidemiologicand epizootiologicsituations of hantavirus infection in northern part of Europe.
Head investigator (Dr. Arikawa) and Japanese investigator (Dr. Morimatsu) visited at Centers for Disease Control and Prevention for information exchange regarding the prevalence of hantavirus infection over the world with American investigator Dr. Peters.
… More Head investigator, Dr. Arikawa and Japanese investigator, Dr. Takashima, visited institutions in Austria and Slovakia to obtain information about epidemiologicsituation of hantavirus infection in Eastern Europe.
Japanese investigators, Drs. Kariwa and Morimatsu visited Glasgow university to obtain technical information regarding the genetic reassortant virus and reverse genetic.
Japanese head investigator, Dr. Arikawa and investigators, Drs. Takashima, Kariwa, Morimatsu visited Korean investigator, Dr. Lee at Asan Life Science Institute at Seoul Korea for information exchange regarding the comparison of variabilities of Japanese and Korean isolates.
Chinese investigator, Dr. Wang stayed at head investigator's institute (Hokkaido University School of Medicine) for 6 months and accomplished antigenic and genetic comparison among 50 isolates.
Chinese investigator, Dr. Chen, visited institutions of Japanese investigators at Sapporo and Tokyo information exchange about relation between ecology of wild rodents and prevalence of hantavirus infection. Less

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Kariwa, H: "Modes of Seoul virus infections : persistency in newborn rats nd transiency in abult rats"Archives of Virology. 141. 2327-2338 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshimatsu, K: "Western blotting using recombinant Hantaan virus nucleocapsid protein expressed in silkworm as a serological confirmation of hantavirus infection in human sera"Journal of Veterinary Medical Science. 58. 71-74 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshimatsu, K: "Characterization of the nucleocapsid protein of Hantaan virus strain 76-118 using monoclonal antibodies"Journal of General Virology. 77. 695-704 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshimatsu, K: "Hantavirus infection in SCID mice"Journal of Veterinary Medical Science. 59. 863-868 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kikuchi, M: "Characterization of neutralizing monoclonal antibody escape mutants of Hantaan virus 76118"Archives of Virology. 143. 73-83 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kariwa, H: "Urine-associated transmission of Seoul virus among rats"Archives of Virology. 143. 15-24 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kariwa,H: "Modes of Seoul virus infections : persistency in newborn rats nd transiency in abult rats"Archives of Virology. 141. 2327-2338 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshimatsu,K: "Western blotting using recombinant Hantaan virus nucleocapsid protein expressed in silkworm as a serological confirmation of hantavirus infection in human sera"Journal of Veterinary Medical Science. 58. 71-74 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshimatsu,K: "Characterization of the nucleocapsid protein of Hantaan virus strain 76-118 using monoclonal antibodies"Journal of General Virology. 77. 695-704 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshimatsu,K: "Hantavirus infection in SCID mice"Journal of Veterinary Medical Science. 59. 863-868 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kikuchi,M: "Characterization of neutralizing monoclonal antibody escape mutants of Hantaan virus 76118"Archives of Virology. 143. 73-83 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kariwa,H: "Urine-associated transmission of Seoul virus among rats"Archives of Virology. 143. 15-24 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshimatsu, K: "Hantavirus infection in SCID mice" Journal of Veterinary Medical Scince. 59. 863-868 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kikuchi, M: "Characterization of neutralizing monoclonal antibody escape mutants of Hantaan virus 76118" Archives of Virology. 143. 73-83 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kariwa, H: "Urine-associated transmission of Seoul virus among rats" Archives of Virology. 143. 15-24 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kariwa,H.: "Modes of Seoul virus infections : persistency in newborn rats and transiency in adult rats." Archives of Virology. 141. 2327-2338 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoshimatsu,K.: "Western blotting using recombinant Hantaan virus nucleocapsid protein expressed in silkworm as a serological confirmation of hantavirus infection in human sera." Journal of Veterinary Medical Science. 58. 71-74 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoshimatsu,K.: "Characterization of the nucleoapsid protein of Hantaan virus strain 76-118 using monoclonal antibodies" Journal of General Virology. 77. 695-704 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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