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Mechanisms of absorption, transport, and storge of vitamin A-by using rats and polar animals-

Research Project

Project/Area Number 08044237
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionAkita university School of Medicine

Principal Investigator

SENOO Haruki  Akita University, School of Medicine, Professor, 医学部, 教授 (90171355)

Co-Investigator(Kenkyū-buntansha) TROND Berg  University of Oslo, Institute of Biology, 医学部, 教授
RUNE Blomhoff  University of Oslo, Institute for Nutrition Research, 医学部, 教授
KAARE R Norum  University of Oslo, Institute for Nutrition Research, 医学部, 教授
IMAI Katsuyuki  Akita University, School of Medicine, Research Associate, 医学部, 助手 (80006741)
SATO Mitsuru  Akita University, School of Medicine, Research Associate, 医学部, 助手 (60226008)
BERG Trond  オスロ大学, 理学部, 教授
BLOMHOFF Run  オスロ大学, 医学部, 教授
NORUM Kaare  オスロ大学, 医学部, 教授
Project Period (FY) 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsSvalbard archipelago / Arctic animal / vitamin A / hepatic stellate cell / hypervitaminosis A / leukemin / cancer therapy / retionid-binding proteins
Research Abstract

Seven Svalbard reindeers, 3 ringed seals, 2 bearded seals, 4 glaucous gulls, 3 Brunnich's guillemots, and 1 puffin were caught in the Svalbard archipelago from August through September, 1996. Fresh each organs, namely, the liver, kidneys, lungs, jejunum, spleen, and skin were investigated with gold chloride staining, fluorescence microscopy for autofluorescence of vitamin A,Sudan 3 lipid staining, hematoxylin and eosin staining, Azan staining, Ishii and Ishii's silver impregnation method, and transmission electron microscopy.
The Arctic animals and birds store a large amount of vitamin A in hepatic stellate cells. Only a small amount of vitamin A existed in other organs : kidneys, jejunum, spleen, lungs, and skin. On the other hand, extrahepatic stellate cells in normal rats were demonstrated to store vitamin A in the kidneys, lungs, spleen, and intestine.
These results indicated that the Arctic animals and birds can store a huge amount of vitamin A in hepatic stellate cells in physiological conditions. These data also indicated that the molecular mechanisms such as retinoid-binding proteins in the Arctic animals and birds play pivotal roles in their vitamin A storage. Applying these molecular mechanisms the prevention methods will be developed for hypervitaminosis A as a side effect of vitamin A treatment to malignant diseases such as leukemia.

Report

(2 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Nagy N.: "Extrahepatic stellate cells play an important role in vitaminA storage" J.Liqid Res.38(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Senoo H.: "Hepatic stellate cells-from the viewpoint of vitaminA handling and functions of extracellular matrix-" Acta Anat. Nippon.72(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 妹尾春樹: "スバルバ-ル群島動物におけるビタミンA貯蔵系" ビタミン. 71(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 俣野吉計: "小腸のビタミンA吸収・貯蔵細胞系" ビタミン. 72(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 妹尾春樹: "北極圏動物のビタミンA貯蔵システム" Acta Anat. Nippon.72(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 俣野吉計: "腸管におけるビタミンAの吸収と貯蔵" Acta Anat. Nippon.72(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 妹尾春樹: "ビジュアル臨床栄養百科1,臨床栄養の基礎" 小学館, 210 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 妹尾春樹: "細胞外マトリックス〜臨床医学への応用〜" メディカルレビュー社, 519 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nagy N.: "Extrahepatic stellate cells play an important role in vitaminA storage" J.Liqid Res.38 (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Senoo H.: "Hepatic stellate cells-from the viewpoint of vitaminA handling and functions of extracellular matrix-" Acta Anat.Nippon.72 (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Senoo H.: "VitaminA-storing system in animals of Svalbard archipelago" Vitamins. 71 (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Matano Y.: "VitaminA-absorption and storing system in the intestine" Vitamins. 71 (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Senoo H.: "VitaminA-storing system in Arctic animals" Acta Anat.Nippon.72 (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Matano Y.: "Absorption and storage of VitaminA in the digestive tract" Acta Anat.Nippon.72 (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Senoo H.: Clinical Nutrition Encyclopedia. Shogakukan, 210 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Senoo H.: Producing cells. Medical Review Sha, 519 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nagy N.: "Storage of vitamin A in extrahepatic stellate cells in normal rats" J. Lipid Res.38(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Senoo H: "Hepatic stellate cells-From the viewpoint of vitamin A handling and functions of extracellular matrix-" Acta Anat. Nippon.72・2(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 妹尾春樹: "スバルバ-ル群島動物におけるビタミンA貯蔵系" ビタミン. 71(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 俣野吉計: "小腸のビタミンA吸収・貯蔵細胞系" ビタミン. 71(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 妹尾春樹: "北極圏動物のビタミンA貯蔵システム" Acta Anat. Nippon.72(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 俣野吉計: "腸管におけるビタミンAの吸収と貯蔵" Acta Anat. Nippon.72(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 妹尾春樹: "ビジュアル臨床栄養百科1、臨床栄養の基礎" 小学館, 210 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 妹尾春樹: "「細胞外マトリックス」-臨床医学への応用" メディカルレビュー社, 519 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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