| Co-Investigator(Kenkyū-buntansha) |
KUZUYAMA Tomohisa University of Tokyo, Institute of Molecular and Cellular Biosciences, Assist. (30280952)
YOKOYAMA Kenji Japan Advanced Institute of Science and Technology, Hokuriku, School of Material (80242121)
YASUDA Kunio Nara Institute of Science and Technology, Graduate School of Biological Sciences (30025473)
KOSEKI Haruhiko Chiba University, School of Medicine, Assist. (40225446)
WATANABE Takeshi Kyusyu University, Medical Institute of Bioregulation, Prof. (40028684)
本庶 佑 京都大学, 医学部, 教授 (80090504)
坂口 志文 東京都老人総合研究所, 部長 (30280770)
奥村 康 順天堂大学, 医学部, 教授 (50009700)
菊谷 仁 大阪大学, 微生物病研究所, 教授 (80161412)
笹月 健彦 九州大学, 生体防御医学研究所, 教授 (50014121)
岸本 忠三 大阪大学, 医学部, 教授 (10093402)
阪口 薫雄 熊本大学, 医学部, 教授 (70192086)
清野 宏 大阪大学, 微生物病研究所, 教授 (10271032)
嶋田 一夫 東京大学, 薬学部, 教授 (70196476)
堀之内 末治 東京大学, 農業生命科学研究所, 教授 (80143410)
志村 令郎 京都大学, 理学部, 教授 (60025426)
鎌田 博 筑波大学, 生物科学系, 教授 (00169608)
山田 康之 京都大学, 農学部, 教授 (50026415)
軽部 征夫 東京大学, 先端科学技術研究センター, 教授 (50089827)
別府 輝彦 日本大学, 獣医学部, 教授 (80011873)
MATHIS D. CNRS免疫研究所, 室長
BENOIST C CNRS免疫研究所, 室長
PIATIGORSKY ジェイ 米国国立眼研究所, 室長
MARTY J.L. ペルピニャン大学, 教授
THOMPSON C. バーゼル大学, 教授
GOSSLER A ジャクション研究所, 主任研究員
斉藤 隆 千葉大学, 医学部, 教授 (50205655)
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| Budget Amount *help |
¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 1996: ¥9,800,000 (Direct Cost: ¥9,800,000)
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| Research Abstract |
(1) Immunology
Upon the agreement with CNRS,France in 1989, a joint research program in the field of immunology was first undertaken in 1994. In this fiscal year 1996 the research was focused on the following 4 points : a) Molecular basis for T cell differentiation, T cell tolerance, and pathogenesis of autoimmune disease ; b) Regulation of signal transducing cascade and gene expression during B cell development ; c) Molecular basis underlying signal transduction via antigen receptor complexes ; and d) Development and pathogenesis of immune system. Several remarkable achievements were established by using mouse transgenic techniques and they greatly contributed the establishment of new region of transgenics.
(2) Embryology
a) Functions of mammalian Polycomb group gene products were investigated. Genetic analysis using mel-18 and bmi-1 deficient mice revealed that these gene products were synergically required for the establishment of anterior-posterior axis. b) Enhancer elements required for the tissue specific expression of BETAB1-crystallin were identified by using cell culture and transgenic system.
(3) Molecvlar Recognition
The chemical compound, Thiosrepton, activated transcriptional activity of Thiosrepton-binding protein. Derivatives of Thiosrepton also possessed the same biological activity which was strongly correlated with the length of Deala-side chain.
(4) Biosensor
The highly sensitive biosensor to detect the trace of an insecticide containing organic phosphorus was developed by using Acetylcholine esterace (AChE).
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