• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Collaborative study for the best treatment of acute leukemia.

Research Project

Project/Area Number 08044265
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research Field Hematology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

OHNO Ryuzo  Hamamatsu University School of Medicine, Professor, 医学部, 教授 (70093002)

Co-Investigator(Kenkyū-buntansha) NAOE Tomoki  Nagoya University School of Medicine, Assoc.Prof., 医学部, 助教授 (50217634)
DEGOS Laurent  University of Paris, School of Medicine, Professor, 医学部, 教授
REES John K  University of Cambridge, School of Medicine, Lecturer, 医学部, 講師
BURNETT Alan  University of Wales, School of Medicine, Professor, 医学部, 教授
HOROWITZ Mary  Medical College of Wisconsin, Professor, 教授
REES John K  ケンブリッジ大学, 医学部, 講師
王 伯銘  千葉大学, 医学部, 助手 (60223707)
栗山 一孝  長崎大学, 医学部, 講師 (90128174)
朝長 万左男  長崎大学, 医学部, 教授 (40100854)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1997: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1996: ¥3,200,000 (Direct Cost: ¥3,200,000)
Keywordsacute leukemia / chemotherapy / bone marrow transplantation / differentiation therapy / matched-pair analysis / meta-analysis / JALSG / acute promyelocytic leukemia / 急性リンパ性白血病 / 急性骨髄性白血病 / matched-pair analysis / メタアナリス / IBMTR / MRC
Research Abstract

In this study, we compared the treatment results of the Japan Adult Leukemia Study Group (JALSG) with those of the International Bone Marrow Transplantation Registry (IBMTR) and of several international leukemia study groups by a matched-pair analysis or a meta-analysis for the best treatment of acute leukemia.
(1) Data on leukemia patients who had been treated with several protocols of JALSG were sent to the IBMTR statistical center in USA and the MRC statistical center in UK through E-mail, FAX and floppy discs.
(2) Japanese investigators visited IBMTR・and participated in the matched-pair analysis of JALSG's adult acute lymphoblastic leukemia patients with IBMTR's patients who received BMT.The results were accepted for publication in Bone Marrow Transplantation.
(3) Japanese investigators visited the MRC statistical center in UK and participated in the meta-analysis of leukemia patients from leading leukemia study groups in the world including JALSG,and the results on G-CSF is in preparation for publication. However, the results on chemotherapy need more discussion including item definition proposed by WHO,which will continue further.
(4) Japanese investigators visited University of Paris and had a discussion on the differentiation therapy of acute promyelocytic leukemia including the basic mechanism why the differentiationtherapy is effective only for this leukemia.
(5) The result of a study concomitantly done for chronic myeloid leukemia was published in the Journal of National Cancer Institute.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Kobayashi T., Ohno R. et al.: "Randomized trials between behenoyl cytarabine and cytarabine in combination induction and consolidation therapy,and with or without ubenimex aftr maintenance/intensification therapy in adult acute myeloid leukemia." J.Clin.Oncol.14(1). 204-213 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tobita T., Ohno R. et al.: "Treatment with a new synthetic retinoid,Am80,of acute promyelocytic leukemia relapsed from complete remission induced by all-trans retinoic acid" Blood. 90(3). 967-973 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohno R., Miyawaki S. et al.: "Human urinary macrophage colony-stimulating factor reduces the incidence and duration of febrile neutropenia and shortens the period required to finish three courses of intensive consolidation therapy in acute myeloid leukemia:a double-blind controlled study" J.Clin.Oncol.15(8). 2954-2965 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Chronic Myeloid Leukemia Trialists Collaborative Group: "Interferon alfa versus chemotherapy for chronic myeloid leukemia:a meta-analysis of seven randomized trials" J.Natl.Cancer Inst.89(21). 1616-1620 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asou N., Ohno R. et al.: "Analysis of prognostic factors in newly diagnosed acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy." J.Clin.Oncol.16(1). 78-85 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oh H,,Ohno R. et al.: "Chemotherapy versus HLA-identical sibling transplants for adults with acute lymphoblastic leukemia in first remission" Bone Marrow Transplantation. 21(印刷中). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kobayashi, T., Ohno, R.et al.: "Randomized trials between behenoyl cytarabine and cytarabine in combination induction and consolidation therapy, and with or without ubenimex after maintenance/intensification therapy in adult acute myeloid leukemia." J.Clin.Oncol.14(1). 204-213 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tobita, T., Ohno, R.et al.: "Treatment with a new synthetic retinoid, Am80, of acute promyelocyticleukemia relapsed from complete remission induced by all-trans retinoic acid." Blood. 90(3). 967-973 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohno, R., Miyawaki, S.et al: "Human urinary macrophage colony-stimulating factor reduces the incidence and duration of febrile neutropenia and shortens the period required to finish three courses of intensive consolidation therapy in acute myeloid leukemia : a double-blind controlled study." J.Clin.Oncol.15(8). 2954-2965 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Chronic Myeloid Leukemia Trialists' Collaborative Group: "Interferon alfa versus chemotherapy for chronic myeloid leukemia : a meta-analysis of seven randomized trials." J.Natl.Cancer Inst.89(21). 1616-1620 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asou, N., Ohno, R.et al: "Analysis of prognostic factors in newly diagnosed acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy." J.Clin.Oncol.16(1). 78-85 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oh, H,Ohno, R.et al.: "Chemotherapy versus HLA-identical sibling rtansplants for adults with acute lymphoblastic leukemia in first remission." Bone Marrow Transplantaion. 21 : (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tobita, T.Ohno, R.et al.: "Treatment with a new synthetic retinoid,Am80,of acute promyelocytic leukemia relapsed from complete remission induced by all-trans retnoic acid" Blood. 90(3). 967-973 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohno, R.Miyawaki, S.et al.: "Human urinary macrophage colony-stimulating factor reduces the incidence and duration of febrile neutropenia and shortens the period required to finish three courses of intensive consolidation therapy in acute myeloid leukemia." J.Clin.Oncol.15(8). 2954-2965 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kiyoi, H, Ohno, R.et al.: "Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia." Leukemia. 11(9). 1447-1452 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Chronic Myeloid Leukemia trialists′ Collaborative Group: "Interferon alfa versus chemotherapy for chronic myeloid leukemia:a meta-analysis of seven randomized trials" J.Natl Cancer Inst. 89(21). 1616-1620 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Asou, N.Ohno, R.et al.: "Analysis of prognostic factors in newly diagnosed acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy." J.Clin.Oncol.16(1). 78-85 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Oh, H.Ohno, R.et al.: "Chemotherapy versus hla-identical slbing transplants for adults with acute lymphoblastic leukemia in first remission" Bone Marrow Transplantation. 21(印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kanamaru,A.,Ohno,R.et al.: "All-trans retinoic acid for the treatment of newly diagnosed acute promyelocytic leukemia." Blood. 85. 1202-1206 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ohnishi,K.,Ohno,R.et al.: "A randomized trial comparing interferon-α with busulfan for newly diagnosedchronic myelogenous leukemia in chronic phase." Blood. 86. 906-916 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shinjo,K.,Ohno,R.et al.: "Expression of granulocyte colony-stimulating factor receptor increases with differentiation in myeloid cells by a newly-devised puantitative flow- cytometric assay." Br.J.Haematol.91. 783-794 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kobayashi,T.,Ohno,R.et al.: "Randomized trials between behenoyl cytarabine and bytarabine in combination induction and consolidation therapy,and with or without ubenimex after maintenance/intensification therapy in adult acute myeloid leukemia." J.Clin.Oncol.14. 204-213 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takeshita,A.,Ohno,R.et al.: "Successful treatment of relapse of acute promyelocytic leukemia with a new synthetic retinoid, Am80." Ann.Intern.Med. 124. 893-896 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kubo,K.,Ohno,R.et al.: "Different T-cell receptor repertories between lesions and peripheral blood in acute graft-versus-host disease after allogeneic bone marrow transplantation." Blood. 87. 3019-3026 (1996)

    • Related Report
      1996 Annual Research Report

URL: 

Published: 1996-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi