| Project/Area Number |
08044266
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Field |
Pathological medical chemistry
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| Research Institution | NAGOYA UNIVERSITY |
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Principal Investigator |
HAMAGUCHI Michinari NAGOYA UNIVERSITY Medical Professor, 医学部, 教授 (90135351)
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| Co-Investigator(Kenkyū-buntansha) |
IWATA Hiroyuki NAGOYA UNIVERSITY Medical Assistant, 医学部, 助手 (30273197)
MAYER Bruce J. Howard University Medical Assistant Professor, 医学部, 講師
HANAFUSA Hidesaburo The Rockefeller University Medical Professor, 医学部, 教授
小池 晃彦 名古屋大学, 医学部, 助手 (90262906)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1997: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1996: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | src / ras / signal transduction / cell adhesion / cytoskeleton |
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| Research Abstract |
This project is aimed to clarify the critical signaling pathway for the regulation of cell morphology and adhesion that depends on protein-protein interactions regulated by SH2-phosphotyrosine binding or SH3-proline bindings, under the international collaborative study. Advance of recent study revealed that signaling pathway that regulates cell morphology and adhesion plays a critical role in cell growth, differentiation, organ formation and others essential for life.
Collaborators of this project, Mayr and Hanafusa have revealed that protein-protein interactions regulated by SH2-phosphotyrosine binding or SH3-proline bindings play a key role in this signaling pathway. The director of this project, Hamaguchi showed that cadherin-dependent cell adhesion was regulated by tyrosine phosphorylation. Based on these studies, Hamaguchi studied, in collaboration with Mayr and Hanafusa, the signaling pathway that regulate cadherin function, and found that c-ras playd an important role in cell-cell adhesion in v-src and v-fps transformed cells. In addition, Hamaguchi found that c-ras also playd an important role in cell-cell adhesion in v-crk transformed cells. Further studies of tyrosine phosphorylated proteins critical for cell adhesion are currently underwent by use of GST-SH2 fusion protein that offered by Mayr.
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