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DEVELOPMENT OF GENE THERAPY FOR CARDIOVASCULAR DISEASES

Research Project

Project/Area Number 08044273
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research Field Circulatory organs internal medicine
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SASAYAMA Shigetake  KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE PROFESSOR, 医学研究科, 教授 (70109007)

Co-Investigator(Kenkyū-buntansha) ゴールドシュタイン ジョ  テキサス大学, 医学部, 教授
ジェラルド ロバート  カソリード大学, 遺伝子導入治療センター, 教授
HASEGAWA Kouji  KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE ASSISTANT PROFESSOR, 医学研究科, 助手 (50283594)
MATSUMORI Akira  KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE ASSOCIATE PROFESSOR, 医学研究科, 講師 (70135573)
GOLDSTEIN Joseph L.  Univ.of Texas, Southwestern Medical Center at Dallas Professor
GERARD Robert D.  Catholide Univ., Gene Transfer and Gene Therapy Center Professor
GERARD Rober  テキサス大学, 医学部, 教授
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥15,800,000 (Direct Cost: ¥15,800,000)
Fiscal Year 1997: ¥7,900,000 (Direct Cost: ¥7,900,000)
Fiscal Year 1996: ¥7,900,000 (Direct Cost: ¥7,900,000)
Keywordsadenoviridae / gene transfer / polylysin modified adenovirus / cardiovascular system / cytokines / growth factor / ion channel / gene therapy / 循環器 / 心筋炎 / 心筋症
Research Abstract

Adenoviral vectors for gene transfer to cardiovascular systems were investigated.
The role of domestic institute was to establish the in vitro and in vivo model of cardiovascular diseases. In vitro system includes cardiac myocytes from adult rats or new born rats, human umbilical venous endothelial cells, and vascular smooth muscle cells. All were successfully prepared in primary culture for gene transfer target cells. In vivo system includes myocardial infarction model by coronary ligation, mouse heart transplant model, viras induced myocarditis and cardiomyopathy model, and have established. Further establishment of long QT syndrome model are on going.
For the candidate genes, cytokines, growth factors, ion channels, transcription factors are prepared. To test the functions of these factors, molecular and biochemical analysis including northern blottings, western blottings, gel shift assays, and others are performed in various myocaridal disease models. Adenovirus vectors including mod … More ified form with polylysin or other chemicals were constructed and tested in the oversea collaborators. Adenovirus containing reporter genes, beta-galactosidase were used as a reference. Target cells were 293 cells, COS cells or CHO cells. Control viruses works fine and recombinant adenovirus containing cDNAs of interest were tested in these cells and in mice. Tissue plasminogen activator, tissue plasminogen activator inhibitor, endothelial nitric oxide synthase, preproendothelin are tested as candidate genes for in vivo gene transfers. Polylysin conjugated adenovirus were also tested in cultured cells to transfer reporter genes. In all cell types listed above are prone to successful transfer by modified adenovirus. Considering that this system has vertually no limit in cDNA size while recombinant adenovirus limits its insert size less than 7kb, larger genes which could not be integrated in recombinant virus may have opportunity of gene transfer. Also, adenovirus is inactivated with during conjugation with polylysin, the risk of biaohazard is minimized in this system. Gene transfer with conventional non viral vectors are on going for growth factors, cytokines, and ion channels including thier native forms and mutant forms.
In conclusion, this collaborative research was fruitful and successful. Modified and nonmodified adenovirus gene transefer for cardiovascular system was successfully performed for establishing disease models, identifying candidate genes, constructing vectors, and testing gene transfers. Further applications of more genes in in vivo system are to be continued. Less

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (124 results)

All Other

All Publications (124 results)

  • [Publications] Furukawa Y,et al.: "Angiotensin II receptor antagonist TCV-116 reduces graft coronary artery disease and preserves graft status in a murine model." Circulation. 93. 333-339 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sasayama S,et al.: "Role of cytokines in the syndrome of heart failure." Int Med. 35. 60-63 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,et al.: "Increased circulating hepatocyte growth factor in the early stage of acute myocardial infarction." Biochem Biophys Res Commun. 221. 391-395 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Furukawa Y,et al.: "Immunomodulation by an adenylate cyclase activator,NKH477,in vivo and in vitro." Clin Immunol Immunopathol. 79. 25-35 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hasegawa K,et al.: "Endothelin-1 and its receptor in hypertrophic cardiomyopathy." Hypertension. 27. 254-264 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,et al.: "Detection of hepatitis C virus RNA from the heart of patients with hypertrophic cardiomyopathy." Biochem Biophys Res Commun. 222. 678-682 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A.: "Cytokines in myocarditis and cardiomyopathies." Curr Opin Cardiol. 11. 302-309 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,et al.: "Antimyosin antibody imaging in clinical myocarditis and cardiomyopathy:principle and application." Int J Cardiol. 54. 183-190 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,et al.: "Inotropic agents differntially inhibit the induction of nitric oxide synthase by endotoxin in cultured macrophages." Life Sci. 59. PL121-PL125 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Li L-X,et al.: "Comparative study of 201TI-scintigraphic image and myocardial pathologic findings in parients with dilated cardiomyopathy." Nucl Med. 10. 307-314 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakamura H,et al.: "A Pathogenic mechanisms of chronic ongoing myocarditis." Jpn Circ J. 60. 609-617 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,et al.: "Differential modulation of cytokine production by drugs:Implication for therapy in heart failure." J Mol Cell Cardiol. 28. 2491-2499 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sasayama S,et al.: "Vesnarinone:A Potential Cytokine Inhibitor." J Cardiac Failure. 2. 251-258 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shioi T,et al.: "Persistent expression of cytokine in the chronic stage of viral myocarditis in mice." Circulation. 94. 2930-2937 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,et al.: "Newer aspects of pathogenesis of heart failure:Hepatitis C vires infection in myocarditis and cardiomyopathy." J Cardiac Failure. 2. S187-S194 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sasayama S,et al.: "Immunomodulation:A new horizon for medical treatment of heart failure." J Cardiac Failure. 2. S287-S294 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tadamura E,et al.: "Myocardial metabolic changes in hypertrophic cardiomyopathy." J Nucl Med. 37. 572-577 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakamura H,et al.: "Autoimmune response in chronic ongoing myocarditis demonstrated by heterotopic cardiac transplantation in mice." Circulation. 94. 3348-3354 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A.: "Molecular and immune mechanisms in the pathogenesis of cardiomyopathy." Jpn Circ J. 61. 275-291 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ono K,et al.: "Enhanced expression of hepatocyte growth factor/c-met by myocardial ischemia and reperfusion in a rat model." Circulation. 95. 2552-2558 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamada T,et al.: "Indium-111 antimyosin antibody imaging and thallium-201 imaging:A comparative myocardial scintigraphic study using SPECT in patients with myocarditis and dilated cardiomyopathy." Jpn Circ J. 61. 827-835 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,et al.: "Modulation of cytokine production and protection against lethal endotoxemia by the cardiac glycoside ouabain." Circulation. 96. 1501-1506 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,et al.: "Amiodarone inhibits production of tumor necrosis factor-α by human mononuclear cells.A possible mechanism for its effect in heart failure." Circulation. 96. 1386-1389 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shioi T,et al.: "Increased expression of interleukin-1 β and monocyte chemotactic and activating factor(MCAF)/monocyte chemoattractant protein-1(MCP-1)in the hypertrophied and failing heart with pressure overload." Circ Res. 81. 664-671 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sasayama s,et al.: "Immunomodulatory therapy and survival with cardiac disease." Heart Failure Reviews. 1. 221-227 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato Y,et al.: "Elevated circulating levels of tumor necrosis factor in patients with mitral valve disease and ventricular septum defect." Heart Vessels. 11. 218-220 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Wang W-Z,et al.: "Beneficial effects of amlodipine in a murine model of congestive heart failure induced by viral myocarditis:A possible mechanism through inhibition of nitric oxide production." Circulation. 95. 245-251 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A.: "Implications of cytokine inhibition for the drug therapy of heart failure." Bio Drugs. 7. 107-118 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hirozane T,et al.: "Prolongation of murine cardiac allograft survival with vesnarinone." J Mol Cell Cardiol. 29. 67-76 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,et al.: "Plasma levels of the monocyte chemotactic and activating factor/monocyte chemotactic protein-1 are elevated in patients with acute myocardial infarction." J Mol Cell Cardiol. 29. 419-423 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato Y,et al.: "Measuring serum aminoterminal type III procollagen peptide,7S domain of type IV collagen,and cardiac troponin T in patients with idiopathic dilated cardiomyopathy and secondary cardiomyopathy." HEART. 78. 505-508 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shioi T,et al.: "Protective role of Interleukin-12 in viral myocarditis." J Mol Cell Cardiol. 29. 2327-2334 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A.: "Calcium channel blocker-induced protection against cardiovascular damage." Int.J.Cardiol.62. S39-S46 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A.: "The use of cytokine inhibitors A new therapeutic insight into heart failure." Int.J.Cardiol.62. S3-S12 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,et al.: "Edited by Sasayama S,Springer-Verlag,Tokyo" Cytokines and heart failure:Immunomodulating agents for the management of heart failure.In New Horizons for Failing Heart Syndrome,14 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sasayama S,et al.: "Edited by Endoh M,Morad M,Scholz H,Iijima T,Springer-Verlag,Tokyo" Immunomodulating effects as new aspects of a positive inotropic agent.In Molecular and Cellular Mechanism of Cardiovascular Regulation,11 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Furukawa Y,Matsumori A,Hirozane T,Sasayama S: "Angiotensin II receptor antagonist TCV-116 reduces graft coronary artery disease and preserves graft status in a murine model" Circulation. 93. 333-339 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sasayama S,Matsumori A: "Role of cytokines in the syndrome of heart failure" Int Med. 35. 60-63 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,Furukawa Y,Hashimoto T,Ono K,Shioi T,Okada M,Iwasaki A,Nishio R,Sasayama S: "Increased circulating hepatocyte growth factor in the early stage of acute myocardial infarction" Biochem Biophys Res Commun. 221. 391-395 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Furukawa Y,Matsumori A,Hirozane T,Matsui S,Sato Y,Ono K,Sasayama S: "Immunomodulation by an adenylate cyclase activator, NKH477, in vivo and in vitro" Clin Immunol Immunopathol. 79. 25-35 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hasegawa K,Fujiwara H,Koshiji M,Inada T,Ohtani S,Doyama K,Tanaka M,Matsumori A,Fujiwara T,Shirakami G,Hosoda K,Nakao K,Sasayama S: "Endothelin-1 and its receptor in hypertrophic cardiomyopathy" Hypertension. 27. 259-264 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,Matoba Y,Nishio R,Shioi T,Ono K,Sasayama S: "Detection of hepatitis C virus RNA from the heart of patients with hypertrophic cardiomyopathy" Biochem Biophys Res Commun. 222. 678-682 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A: "Cytokines in myocarditis and cardiomyopathies" Curr Opin Cardiol. 11. 302-309 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,Yamada T,Sasayama S: "Antimyosin antibody imaging in clinical myocarditis and cardiomyopathy : principle and application" Int J Cardiol. 54. 183-190 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,Okada I,Shioi T,Furukawa Y,Nakamura T,Ono K,Iwasaki A,Sasayama S: "Inotropic agents differentially inhibit the induction of nitric oxide synthase by endotoxin in cultured macrophages" Life Sci. 59. PL121-PL125 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Li L-X,Nohara R,Okuda K,Hosokawa R,Hata T,Tanaka M,Matsumori A,Fujita M,Tamaki N,Konishi J,Sasayama S: "Comparative study of 201TI-scintigraphic image and myocardial pathologic findings in patients with dilated cardiomyopathy" Nucl Med. 10. 307-314 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakamura H,Yamamura T,Fukuta S,Matsumori A,Matsuzaki M: "A pathogenic mechanisms of chronic ongoing myocarditis" Jpn Circ J. 60. 609-617 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,Ono K,Sato Y,Shioi T,Nose Y,Sasayama S: "Differential modulation of cytokine production by drugs : Implication for therapy in heart failure" J Mol Cell Cardiol. 28. 2491-2499 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sasayama S,Matsumori A.Vesnarinone: "A Potential Cytokine Inhibitor" J Cardiac Failure. 2. 251-258 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shioi T,Matsumori A,Sasayama S: "Persistent expression of cytokine in the chronic stage of viral myocarditis in mice" Circulation. 94. 2930-2937 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,Sasayama S: "Newer aspects of pathogenesis of heart failure : Hepatitis C virus infection in myocarditis and cardiomyopathy" J Cardiac Failure. 2 (Suppl.). S187-S194 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sasayama S,Matsumori A,Matoba Y,Matsui S,Yamada T,Shioi T,Sato Y,Doyama K,Kishimoto C: "Immunomodulation : A new horizon for medical treatment of heart failure" J Cardiac Failure. 2 (Suppl.). S287-S294 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tadamura E,Tamaki N,Matsumori A,Magata Y,Yonekura Y,Nohara R,Sasayama S,Yoshibayashi M,Kamiya T,Konishi J: "Myocardial metabolic changes in hypertrophic cardiomyopathy" J Nucl Med. 37. 572-577 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakamura H,Yamamura T,Umemoto S,Fukuta S,Matsumori A,Matsuzaki M: "Autoimmune response in chronic ongoing myocarditis demonstrated by heterotopic cardiac transplantation in mice" Circulation. 94. 3348-3354 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sasayama S,Matsumori A,Matsui S,Hirozane T,Yamada T,Kishimoto C: "Immunomodulatory therapy and survival with cardiac disease" Heart Failure Reviews. 1. 221-227 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato Y,Takatsu Y,Ito H,Kataoka K,Takeuchi Y,Matsumori A: "Elevated circulating levels of tumor necrosis factor in patients with mitral valve disease and ventricular septum defect" Heart Vessels. 11. 218-220 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Wang W-Z,Matsumori A,Yamada T,Shioi T,Okada I,Matsui S,Sato Y,Suzuki H,Shiota K,Sasayama S: "Beneficial effects of amlodipine in a murine model of congestive heart failure induced by viral myocarditis : A possible mechanism through inhibition of nitric oxide production" Circulation. 95. 245-251 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A: "Implications of cytokine inhibition for the drug therapy of heart failure" BioDrugs. 7. 107-118 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hirozane T,Matsumori A,Furukawa Y,Matsui S,Matoba Y,Sasayama S: "Prolongation of murine cardiac allograft survival with vesnarinone" J Mol Cell Cardiol. 29. 67-76 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,Furukawa Y,Hashimoto T,Yoshida A,Ono K,Shioi T,Okada M,Iwasaki A,Nishio R,Matsushima K,Sasayama S: "Plasma levels of the monocyte chemotactic and activating factor/monocyte chemotactic protein-1 are elevated in patients with acute myocardial infarction" J Mol Cell Cardiol. 29. 419-423 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A: "Molecular and immune mechanisms in the pathogenesis of cardiomyopathy" Jpn Circ J. 61. 275-291 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ono K,Matsumori A,Shioi T,Furukawa Y,Sasayama S: "Enhanced expression of hepatocyte growth factor/c-met by myocardial ischemia and reperfusion in a rat model" Circulation. 95. 2552-2558 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sasayama S,Matsumori A,Matoba Y,Yamada T,Matsui S,Shioi T: "Recent advances in our understanding of dilated cardiomyopathy. ISFC Special Lecture at the 11th Asian-Pacific Congress of Cardiology. Denpasar" Bali-Indonesia. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamada T,Matsumori A,Tamaki N,Nohara R,Konishi J,Sasayama S: "Indium-111 antimyosin antibody imaging and thallium-201 imaging : A comparative myocardial scintigraphic study using SPECT in patients with myocarditis and dilated cardiomyopathy" Jpn Circ J. 61. 827-835 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,Ono K,Nishio R,Igata H,Shioi T,Mats : ui S,Furukawa Y,Iwasaki A,Nose Y,Sasayama S: "Modulation of cytokine production and protection against lethal endotoxemia by the cardiac glycoside ouabain" Circulation. 96. 1501-1506 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,Ono K,Nishio R,Nose Y,Sasayama S: "Amiodarone inhibits production of tumor necrosis factor-a by human mononuclear cells. A possible mechanism for its effect in heart failure" Circulation. 96. 1386-1389 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shioi T,Matsumori A,Kihara Y,Inoko M,Ono K,Iwanaga Y,Yamada T,Iwasaki A,Matsushima K,Sasayama S: "Increased expression of interleukin-1b and monocyte chemotactic and activating factor (MCAF)/monocyte chemoattractant protein-1 (MCP-1) in the hypertrophied and failing heart with pressure overload" Circ Res. 81. 664-671 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato Y,Kataoka K,Matsumori A,Sasayama S,Yamada T,Ito H,Takasu Y: "Measuring serum aminoterminal type III procollagen peptide, 7S domain of type IV collagen, and cardiac troponin T in patients with idiopathic dilated cardiomyopathy and secondary cardiomyopathy" HEART. 78. 505-508 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shioi T,Matsumori A,Ono K,Nishio R,Kakio T,Sasayama S: "Protective role of Interleukin-12 in viral myocarditis" J Mol Cell Cardiol. 29. 2327-2334 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A: "Calcium channel blocker-induced protection against cardiovascular damage" Int.J.Cardiol. 62 (suppl.2). S39-S46 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A: "The use of cytokine inhibitors A new therapeutic insight into heart failure" Int.J.Cardiol. 62 (suppl.1). S3-S12 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumori A,Yamada T,Matsui S,Shioi T,Sasayama S: Cytokines and heart failure : Immunomodulating agents for the management of heart failure. In New Horizons for Failing Heart Syndrome. Edited by Sasayama S,Springer-Verlag, Tokyo, 219-232 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sasayama S,Matsumori A,Matsui S,Shioi T,Yamada T: Immunomodulating effects as new aspects of a positive inotropic agent. In Molecular and Cellular Mechanism of Cardiovascular Regulation. Edited by Endoh M,Morad M,Scholz H,Iijima T,Springer-Verlag, Tokyo, 433-443 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Furukawa Y, et al.: "Angiotensin II receptor antagonist TCV-116 reduces gerft coronary artery disease and preserves graft status in a murine model." Circulation. 93. 333-339 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sasayama S, et al.: "Role of cytokines in the syndrome of heart failure." Int Med. 35. 60-63 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A, et al.: "Increased circulating hepatocyte growth factor in the early stage of acute myocardial infarction" Biochem Biophys Res Commun. 221. 391-395 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Furukawa Y, et al.: "Immunomodulation by an adenylate cyclase activator,NKH477,in vivo and in vitro." Clin Immunol Immunopathol. 79. 25-35 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hasegawa K, et al.: "Endothelin-1 and its receptor in hypertrophic cardiomyopathy." Hypertension. 27. 254-264 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A, et al.: "Detection of hepatitis C virus RNA from the heart of patients with hypertrophic cardiomyopathy." Biochem Biophys Res Commun. 222. 678-682 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A.: "Cytokines in myocarditis and cardiomyopathies." Curr Opin Cardiol. 11. 302-309 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A, et al.: "Antimyosin antibody imaging in clinical myocarditis and cardiomyopathy:principle and application." Int J Cardiol. 54. 183-190 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A, et al.: "Inotropic agents differentially inhibit the induction of nitric oxide synthase by endotoxin in cultured macrophages." Life Sci. 59. PL121-PL125 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] LiL-X, et al.: "Comparative study of 201TI-scintigraphic image and myocardial pathologic findings in patients with dilated cardiomyopathy." Nucl Med. 10. 307-314 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakamura H, et al.: "A pathogenic mechanisms of chronic ongoing myocarditis." Jpn Circ J. 60. 609-617 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A, et al.: "Differential modulation of cytokine production by drugs:Implication for therapy in heart failure." J Mol Cell Cardiol. 28. 2491-2499 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sasayama S, et al.: "Vesnarinone:A Potential Cytokine Inhibitor." J Cardiac Failure. 2. 251-258 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shioi T, et al.: "Persistent expression of cytokine in the chronic stage of viral myocarditis in mice." Circulation. 94. 2930-2937 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A, et al.: "Newer aspects of pathogenesis of heart failure:Hepatitis C virus infection in myocarditis and cardiomyopathy." J Cardiac Failure. 2. S187-S194 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sasayama S, et al.: "Immunomodulation:A new horizon for medical treatment of heart failure." J Cardiac Failure. 2. S287-S294 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tadamura E, et al.: "Myocardial metabolic changes in hypertrophic cardiomyopathy." J Nucl Med. 37. 572-577 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakamura H, et al.: "Autoimmune respones in chronic ongoing myocarditis demonstrated by heterotopic cardiac transplantation in mice." Circulation. 94. 3348-3354 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A.: "Molecular and immune mechanisms in the pathogenesis of cardiomyopathy." Jpn Circ J. 61. 275-291 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ono K, et al.: "Enhanced expression of hepatocyte growth factor/c-met by myocardial ischemia and reperfusion in a rat model." Circulation. 95. 2552-2558 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamada T, et al.: "Indium-111 antimyosin antibody imaging and thallium-201 imaging:A comparative myocardial scintigraphic study using SPECT in patients with myocarditis and dilated cardiomyopathy." Jpn Circ J. 61. 827-835 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A, et al.: "Modulation of cytokine production and protection against lethal endotoxemia by the cardiac glycoside ouabain." Circulation. 96. 1501-1506 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A, et al.: "Amiodarone inhibits production of tumor necrosis factor-α by human mononuclear cells.A possible mechanism for its effect in heart failure." Circulation. 96. 1386-1389 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shioi T, et al.: "Increased expression of interleukin-1 β and monocyle chemotactic and activating factor(MCAF)/monocyte chemoattractant protein-1(MCP-1)in the hypertrophied and failing heart with pressure overload." Circ Res. 81. 664-671 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sasayama S, et al.: "Immunomodulatory therapy and survival with cardiac disease." Heart Failure Reviews. 1. 221-227 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sato Y, et al.: "Elevated circulating levels of tumor necrosis factor in patients with mitral valve disease and ventricular septum defect." Heart Vessels. 11. 218-220 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Wang W-Z, et al.: "Beneficial cffects of amlodipine in a murine model of congestive heart failure induced by viral myocarditis:A possible mechanism through inhibition of nitric oxide production." Circulation. 95. 245-251 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A.: "Implications of cytokine inhibition for the drug therapy of heart failure." Bio Drugs. 7. 107-118 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hirozane T, et al.: "Prolongation of murine cardiac allograft survival with vesnarinone." J Mol Cell Cardiol. 29. 67-76 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A, et al.: "Plasma levels of the monocyte chemotactic and activating factor/monocyte chemotactic protein-1 are elevated in patients with acute myocardial infarction." J Mol Cell Cardiol. 29. 419-423 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sato Y, et al.: "Measuring serum aminoterminal type III procollagen peptide,7S domain of type IV collagen,and cardiac troponin T in patients with idiopathic dilated cardiomyopathy and secondary cardiomyopathy." HEART. 78. 505-508 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shioi T, et al.: "Protective role of Interleukin-12 in viral myocarditis." J Mol Cell Cardiol. 29. 2327-2334 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A.: "Calcium channel blocker-induced protection against cardiovascular damage." Int.J.Cardiol.62. S39-S46 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A.: "The use of cytokine inhibitors A new therapeutic insight into heart failure." Int.J.Cardiol.62. S3-S12 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumori A, et al.: "Edited by Sasayama S,Springer-Verlag,Tokyo" Cytokines and heart failure:Immunomodulating agents for the management of heart failure.In New Horizons for Failing Heart Syndrome,14 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sasayama S, et al.: "Edited by Endoh M,Morad M,Scholz H,Iijima T,Springer-Verlag,Tokyo" Immunomodulating effects as new aspects of a positive inotropic agent.In Molecular and Cellular Mechanism of Cardiovascular Regulation,11 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Furukawa Y,et al.: "Augiotensin II receptor antagonist TCV-116 reduces graft coronary artery disease and preserves graft status in a murine model" Circulation. 93. 333-339 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sasayama S,et al.: "Role of cytokines in the syndrome of heart failure" Int Med. 35. 60-63 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsumori A,et al.: "Increased circulating hepatocyte growth factor in the early stage of acute myocardial infarction" Biochem Biophys Res Commun. 221. 391-395 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Furukawa Y,et al.: "Immunomodulation by an adenylate cyclase activator, NKH477,in vivo and in vitro" Clin Immunol Immunopathol. 79. 25-35 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hasegawa K,et al.: "Endothelin-1 and its receptor in hypertrophic cardiomyopathy" Hypertension. 27. 259-264 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsumori A,et al.: "Detection of hepatitis C virus RNA from the heart of patients with hypertrophic cardiomyopathy" Biochem Biophys Res Commun. 222. 678-682 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsumori A,et al.: "Autimyosin antibody imaging in clinical myocarditis and cardiomyopathy:principle and application" Int J Cardiol. 54. 183-190 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsumori A,et al.: "Inotropic agents differentially inhibit the induction of nitric oxide synthase by endotoxin in cultured macrophages" Life Sci. 59. PL121-PL125 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Li L-X,et al.: "Comparative study of ^<201>TI-scintigraphic image and myocardial pathologic findings in patients with dilated cardiomyopathy" Nucl Med. 10. 307-314 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsumori A,et al.: "Differential modulation of cytokine production by drugs: Implication for therapy in heart failure" J Mol Cell Cardiol. 28. 2491-2499 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sasayama S,et al.: "Vesnarinone:A Potential Cytokine Inhibitor" J Cardiac Failure. 2. 251-258 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shioi T,et al.: "Persistent expression of cytokine in the chronic stage of viral myocarditis in mice" Circulation. 94. 2930-2937 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsumori A,et al.: "Newer aspects of pathogenesis of heart failure:patitis C virus infection in myocarditis and cardiomyopathy" J Cardiac Failure. 2(Suppl). S187-S194 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sasayama S,et al.: "Immunomodulation:A new horizon for medical treatment of heart failure" J Cardiac Failure. 2(Suppl). S287-S294 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Wang W-Z,et al.: "Beneficial effects of amlodipine in a murine model of congestive heart failure induced by viral myocarditis:A possible mechanism through inhibition of nitric oxide production" Circulation. 95. 245-251 (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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