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Clinical Trial of Natriuretic Peptides in Heart Failure

Research Project

Project/Area Number 08044277
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SAITO Yoshihiko  Kyoto Univ., Grad.Sc.of Med., Assistant Professor, 医学研究科, 助手 (30250260)

Co-Investigator(Kenkyū-buntansha) MASUDA Izuru  kyoto Univ., Grad.Sc.of Med., Assistant Professor, 医学研究科, 助手 (10229370)
NAKAO Kazuwa  Kyoto Univ., Grad.Sc.of Mcd., Professor, 医学研究科, 教授 (00172263)
THOMAS Hedner  Schlgenska Univ.Hospital.Dept.of Pharmacology, Professor and Chairman, Depertme, Professor
CHIーMING Wei  Depertment of Surgery, School of Medicine, Associate
JOHN.C Burne  Mayo Clinic, Cardorenal Res. Labo., Director a
JOHN C Burnett Jr  Mayo Clinic, Cardiorenal Res.Lab., Director and Professor
WEI Chi-Min  Univ.of Maryland sc.of Med., Dept.of Surgery, Associate Professor
城ヶ崎 倫久  Mayo Clilic, Cardiorenal Research Laborat, Research F
HEDNER Thoma  Schlgrenska University Hospital, Depertme, Professor
WEI ChiーMing  University of MarylandSchool of Medicine, Associate
BURNETT John  Mayo Clinic, Cardiorenal Res. Labo., Director a
Project Period (FY) 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1996: ¥6,000,000 (Direct Cost: ¥6,000,000)
KeywordsANP / BNP / Congestive heart failure / hypertrophy / cohort
Research Abstract

Heart failure is the pathological state in which the heart is unable to pump blood to vaital organs and thereby sometimes causes the death.
Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are cardiac hormones, posessing natriuretic, diuretic and vasodilating activities. Accumulating evidence indicates that the natriuretic peptide system especially, ANP and BNP,is clinically useful for not only the diagnosis of heart diseases but also treatment of congestive heart failure.
To further evaluate clinical usefulness of natriuretic peptides in cardiac diseases, we organize three kinds of large scale cooperative studies in Japan, United States of America and Sweden.
The first study was designed to prospectively determine whether one of the natriuretic peptides-ANP or BNP-is superior to another for ditection of left ventricular dysfunction in 94 consecutive patients referred for cardiac catheterization. The elevated plasma BNP concentration was a more powerful marker of left … More ventricular systolic, diastolic dysfunction and left ventricular hypertrophy evaluated by echocardiography than the elevated plasma ANP level.
in the second study, to evaluate whether the plasma BNP level predicts mortality in old population, we3 measured the plasma BNP level in 541 subjects from the 85-year old population in Gothenburg, Sweden. We found that the incr ased BNP level significantly predicted 5-years mortality in the total population. In subjects witl a known cardiovascular disorder, 5-yeare mortality was significantly correlated with the ele ated plasma BNP level.
In the third study, we examined the effect of a long-term infusion of ANP on hemodynamics and renal functions in patients with congestive heart failure. Although the short-term infusion of ANP was reported to improve congestive heart failure, the long-term infusion of ANP decreased preload and increased urine volume. In spite of the diuretic action, the long-term infusion of ANP did not deteriorate serum electrolyte balance. Any side effects were observed during the infusion.
We concluded that natriuretic peptides are clinically useful for diagnosis and treatment of cardiovascular diseases. Less

Report

(2 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] T.Nishikimi et.al: "Relationship between left Ventricular geometry and natriuretic peptides levels in essential hypertension." Hypertension. 28(1). 22-30 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Yamamoto et.al.: "Superiority of brain natriuretic peptide as a hormonal marker of ventricular systolic and diastolic dysfunction and ventricular hypertrophy." Hypertension. Vol.28. 988-994 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Tamura et.al: "Two cardiac natriuretic peptide genes(atrial natriuretic peptide and brain natriuretic peptide)are organized in tandem in the mouse and human genomes." Journal of Molecular Cellular Cardiology. Vol.28. 1811-1815 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Ishikawa et.al.: "cDNA cloning of rat cardiotrophin-1(CT-1) : augmented expression of CT-1 gene in ventricle of genetically hypertesive rats." Biochemical and Biophysical Research Communication. 219(2). 377-381 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Wallen et.al: "Brain natriuretic peptide predicts mortality i the elderly." Heart. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Yoshibayashi et.al.: "Brain ntriuretic peptide versus atrial ntriuretic peptide : Physiological and pathophysiological significance in children and adults." European Journal of Endocrinology. Vol.135. 265-268 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishikimi T,Yoshihara F,Morimoto A,Ishikawa K,Ishimitsu T saito Y,Kangawa K,Matsuo H,Omac T,Matsuoka H: "Relationship between left ventricular geometry and natriuretic peptides levels in cssential hypertension." Hypertension. 28. 22-30 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamamoto K,Burnett J.C.Jr., Jougasaki M,Nishimura R,Bailey K,Saito Y,Nakao K,Redfield M.M: "Superiority of brain natriuretic peptide as a hormonal marker of ventricular systolic and diastolic dysfunction and ventricular hypertrophy." Hypertension. 28. 988-994 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tamura N,Ogawa Y,Yasoda A,Itoh H,Saito Y,Nakao K: "Two cardiac natriuretic peptide genes (atrial natriuretic peptide and brain natriuretic peptide) are organized in tandem in the mouse and human genomes." J.ofMol.Cell.Cardiol. 28. 1811-1815 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ishikawa M,Saito Y,Miyamoto Y,Kuwahara K,Ogawa E,Nakagawa O,Harada M,Hori Y,Masuda, Nakao K: "cDNA cloning of rat cardiotrophin-1 (CT-1) : augmented expression of CT-1 gene in ventricle of genetically hypertesive rats." Biochem.Biophys.Rcs.Commun 219. 377-381 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Wallen T,Landahl S,Hedner T,Nakao K,Saito Y: "Brain natriuretic peptide prediets mortality i the elderly." Heart 1997. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshibayashi M,Saito Y,Nakao K: "Brain ntriuretic peptide versus atrial ntriuretic peptide : Physiological and pathophysiological significance in children and adults." Eur.J.Endocrinol.135. 265-268 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Nishikimi et.al.: "Relationship between left ventricular geometry and natriuretic peptides levels in essential hypertension." Hypertension. 28(1). 22-30 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Yamamoto et al.: "Superiority of brain natriuretic peptide as a hormonal marker of ventricular systolic and diastolic dysfunction and ventricular hypertrophy." Hypertension. Vol.28. 988-994 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.Tamura et al.: "Two cardiac natriuretic peptide genes(atrial natriuretic peptide and brain natriuretic peptide)are organized in tandem in the mouse and human genomes." Journal of Molecular Cellular Cardiology. Vol.28. 1811-1815 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Ishikawa et al.: "cDNA cloning of rat cardiotrophin-1(CT-1):augmented expression of CT-1 gene in ventricle of genetically hypertesive rats." Biochemical and Biophysical Research Communication. 219(2). 377-381 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.wallen.et al.: "Brain natriuretic peptide predicts mortality in the elderly." Heart. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Yoshibayashi et al.: "Brain ntriuretic peptide versus atrial ntriuretic peptide:Physiological and pathophysiological significance in children and adults." European Journal of Endocrinology. Vol.135. 265-268 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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