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Roles of Cytokines in Stress-induced Immune Responses

Research Project

Project/Area Number 08044300
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

HORI Tetsuro  KYUSHU UNIV., DEPT.OF PHYSIOL., PROFESSOR, 医学部, 教授 (00022814)

Co-Investigator(Kenkyū-buntansha) ARIMURA Akira  TULANE UNIV., US-JAPAN BIOMEDICAL RES.LABS., PROFESSOR, 日生物医学研究所, 教授
SIMON Eckhar  マックスプランク生理学臨床研究所, 教授
TAKAKI Atsushi  KYUSHU UNIV., DEPT.OF PHYSIOL.ASSISTANT, 医学部, 助手 (30243934)
KATAFUCHI Toshihiro  KYUSHU UNIV., DEPT.OF PHYSIOL.ASSISTANT, 医学部, 講師 (80177401)
AOU Shuji  KYUSHU UNIV., DEPT.OF PHYSIOL.ASSOCIATE, 医学部, 助教授 (40150908)
ECKHART Simon  MAX-PLANCK INSTITUTE,PROFESSOR
ECKHART Simo  マックスブランク生理学臨床研究所, 教授
武 幸子  九州大学, 医学部, 助手 (80253425)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1996: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsantisense / thermoregulation / quantitative RT-PCR / hypothalamus / stress / the brain-gut-liver-immune axis / enteric flora / cytokines / 定量化RT-PCR / 海馬 / 記憶 / プロスタグランディン / インターフェロンα / インターロイキン6 / 肝門脈 / CRF類縁ペプタイド
Research Abstract

In this project, we are going to clarify the mechanisms how the neuroimmuno-endocrine network funcations as the host-defense system against the environmental stress. What we found in this project is as follows ; 1) Interleukin-6 inhibits long-term potentiotion in rat hippocampal neurons. 2) Tumor necrosis factor alpha not beta suppressed neuronal activity in the ventromedial hypothalamic neurons in vitro. 3) The mRNA of interferon alpha in the brain increased during immobilization stress. The medial preoptic area (MPO), which is the most potent acting site of IFN alpha, is involved in the central regulation of immunity by its suppressive influence on the splenic sympathetic nervous activity. 4) The c-fos protein expressed in the POA during hyper and hypothermic condition. Microinjection of antisense oligonucreotide for c-fos into the POA decreased body temperature. 5) Both IL-1 beta mRNA tissue content in the hypothalamus, the pituitary, and the liver but not in the hippocampus and the spleen increased by immobilization stress for 30 min. 6) Delayd cell death in the CAI neurons induced by brain ischemia was protected by continuous infusion of PACAP either intothe brain or in to the jugular vein. Since IL-6 concentration in the CSF increased by continuous infusion of PACAP,the tropic effect of PACAP on neurons might be, at least partly, mediated by brain cytokines. 7) The IM-induced IL-6 increase is completely abolished by in vivo neutralization of LPS.8) The concentration of LPS in the hepatoportal vein increases during IM.9) A fluorescent dye (FITC)-labeled LPS injected into the intestinal lumen is detected in Kupffer cells and sinusoidal endothelial cells after IM,78% of which are also stained with an anti-IL-6 antibody. The results suggest the presence of a brain-gut-liver immune axis, which is activated during pschophysical stresses.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (92 results)

All Other

All Publications (92 results)

  • [Publications] Ota,K.: "The AV3V neurons which send axons to hypothalamic nuclei respond to the systemic injection of IL-1β." Am.J.Physiol.272. R532-R540 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Li,A.J.: "Interleukin-6 inhibits long-term potentiation in rat hippocampal slices." Brain Res.748. 30-38 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oka,T.: "Biphasic alteration in the trigeminal nociceptive neuronal responses after intracercbroventricular injection of prostaglandin E2 in rats." Brain Res.749. 354-357 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Katafuchi,T.: "Differential effects of tumor necrosis factor-α and -β on the rat ventromedlal hypothalamic neurons in vitro." Am.J.Physiol.272. R1966-R1971 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hosoi,M.: "Prostaglandin E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca in rats." Pain. 71. 303-311 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oka,K.: "Prostaglandin E2 may induce hyperthermia through EPl-receptors in the anterior wall of the third ventricle and neighboring preoptic regions." Brain Res.767. (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 堀 哲郎: "脳・免疫系連関における伝達物質" Clinical Neuroscience. 16(in press). 92-99 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Huang,Q.: "Central noradrenergic system modulates plasma interleukin-6 production by peripheral interleukin-1b" Am.J.Physio1.273. R731-R738 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 高木 厚司: "ストレス時に腸内細菌が果たす免疫賦活作用" ストレス科学. 12(2). 90 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shioda,S.: "PACAP protects hipocampal neurons against apotosis:involvement of JNK/SAPK signaling pathway." Ann NY Acad Sci. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ortega,H.: "Neuroimmunological effects of exposure to methylmercury forms in the spargue-dawley rats.Activation of the hypothamic-pituitary-adrenal axis and lymphocyte responsness" Toxicology and Industrial Health. 13(1). 57-66 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Uchimura,D.: " Facilitatory effects of pituitary adenylate cyclase activating polypeptide(PACAP)on nel in the magnocellular portion of the rat hypothalamic paraventricular nucleus(PVN)in vit" J.Neuroendocrinol.8. 137-143 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Li,A-J.: "Fibroblast growth factor receptor-1 in the lateral hypothalamic area regulates food intake." Exptl.Neurol.137. 318-323 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimizu,N.: "Immobilization increases noradrenaline release and reduces NK cytotoxicity in spleen of conscious rat." Am.J.Physiol.271. R537-R544 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mo,Z.L.: "The effects of IL-1 β on neuronal activities in the dorsal motor nucleus of the vagus in rat brain slices." Brain Res.Bull.41. 249-255 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oka,T.: "Intracerebroventricular injection of tumor necrosis factor α induces thermal hyperalgesia in rats." Neuroimmunomodulation. 3. 135-140 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oka,T.: "Inhibition of peripheral interleukirβ l induced hyperalgesia by the intracerebroventricular administration of diclofenac and α-melanocyte-stimulating hormone." Brain Res.736. 237-242 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 岡 考和: "痛みと情動" Clinical Neuroscience. 14. 1025-1027 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hori,T.: "Cell biology and the functions of thermosensitive neurons in the brain." Prog.Brain Res.115. 9-23 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shiramine,K.: "Lateral hypothalamic injection of GABAA antagonist induces gastric vagus-mediated hypocalcemia in the rat." Am.J.Physiol.273. R1492-R1500 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oka,T.: "Biphasic modulation in the trigeminal nociceptive neuronal responses by the intracerebroventricular prostaglandin E2 may be mediated through different EP receptors subtype in rats." Brain Res.77l. 278-284 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Katafuchi,T.: "Sequential relationship between actions of CRF and PGE2 in the brain on splenic sympathetic nerve activity in rats." J.Auton.Nerv.Syst.67. 200-206 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hori,T.: "Pain modulatory actions of cytokines and PGE2 in the brain." Ann.New York Acad.Sci.840. 319-334 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 堀 哲郎: "ストレスとNeuroimmunomodulation" 日本集中治療医学会雑誌. 4. 3-9 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 堀 哲郎: "自律神経系による免疫系制御" Clinical Neuroscience. 15. 394一396 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 堀 哲郎: "発熱の科学" 救急医学. 21. 1000-1015 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 堀 哲郎: "怒りはどこから湧き、どのように発散されるか" COMMUNlCATlON. 68. 12-15 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Li,A-J.: "A singie pre-training glucose injection induces memory facilitation in rodents performing various tasks:contribution of acidic fibroblast growth factor." Neuroscience. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hori,T.: "Neuroimmunomodulatory actions of hypothalamic interferon-α." Neuroimmunomodulation. 5(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 堀 哲郎: "サイトカインと脳・免疫連関" Clinical Neuroscience. 16(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 片渕 俊彦: "交感神経による脾臓ナチュラルキラー細胞活性制御の視床下部機序" 自律神経. 33. 267-272 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 堀 哲郎: "発熱の病態生理" Today's Therapy. 20. 115-118 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 堀 哲郎: "最新内科学大系プログレスシリーズ2「内分泌・代謝疾患」" 中山書店, 419 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oka,T.: "Brain cytokines and pain." Birkhaeuser Publishing Ltd(in press), (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takaki,A.: "Is immobilization-induced plasma IL-6 elevation regulated by hepatic innervatron?in Liver Innervation" John Libbey & Company Ltd., 484 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 堀 哲郎: "最新内科学大系、PartI.内科総論部門、第2巻「科学としての内科学」" 中山書店, 372 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 堀 哲郎: "脳機能の解明-21世紀に向けて" 九州大学出版会, 615 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hori,T.: "Discussion on Future Directions in Psycnoneurolmmunology and Cancer." Nishimura Co.,Ltd.and Smith-Gordon Co.,Ltd., 166 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hori,T.: "Pnysiological Basis of Occupational Health:Stressful" SPB Academic Publishing bv, 278 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 堀 哲郎: "現代の神経内分泌学" メディカル・サイエンス・インターナショナル, 506 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shioda, S.: "PACAP proteacts hipocampal neurons against apotosis : involvement of JNK/SAPK signaling pathway." Ann NY Acad Sci.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Li, A-J.: "A single pre-training glucose injection induces memory facilitation in rodents performing various tasks : contribution of acidic fibroblast growth factor" Neuroscience. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hori, T.: "Neuroimmunomodulatory actions of hypothalamic interferon alpha" Neuroimmunomodulation. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ota, K.: "The AV3V neurons which send axons to hypothalamic nuclei respond to athe systemic injection of IL-1b" Am.J.Physiol.272. R532-R540 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Li, A.J.: "Interleukin-6 inhibits long-term potentiation in rat hippocampal slices." Brain Res.748. 30-38 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oka, T.: "Biphasic alteration in the trigeminal nociceptive neuronal responeses after intracerebroventricular injection of prostaglandin E2 in rats." Brain Res.749. 354-357 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Katafuchi, T.: "Differential effects of tumor necrosis factor-Eo and -Ei on the rat ventromedial hypothalamic neurons in vitro." Am.J.Physiol.272. R1966-R1971 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hosoi, M.: "Prostaglandin E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca in rats." Pain. 71. 303-311 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oka, K.: "Prostaglandin E2 may induce hyperthermia through E-P1receptors in the anterior wall of the third ventricle and neighboring preoptic regions." Brain Res.767. 92-99 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hori, T.: "Cell biology and the functions of thermosensitive neurons in the brain." Prog.Brain Res.115. 9-23 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shiramine, K.: "Lateral hypothalamic injection of GABAA antagonist induces gastric vagus-mediated hypocalcemis in the rat." Am.J.Physiol.273. R1492-R1500 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oka, T.: "Biphasic modulation in the trigeminal nociceptive neuronal responses by the intracerebroventricular prostaglandin E2 may be mediated through differnt EP receptors subtype in rats." Brain Res.771. 278-284 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Katafuchi, T.: "Sequential relationship between actions of CRF and PGE2 in the brain on splenic sympathetic nerve activity in rats." J.Auton.Nerv.Syst.67. 200-206 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hori, t.: "Pain modulatory actions of cytokines and PGE2 in the brain." Ann.New York Acad.Sci.840. 319-334 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Huang.Q.: "Central noradrenergic system modulates plasma intrerleukin-6 production by peripheral interleukin-1b" Am.J.Physiol.273. R731-R738 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ortega, H.: "Neuroimmunological effects of exposure to methylmercury forms in the spargue-dawley rats. Activation of thehypothamic-pituitary-adrenal axis and lymphocyte responsness" Toxicology and Industrial Heakth. 13 (1). 57-66 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Uchimura, D.: "Facilitatory effects of pituitary adenylate cyclase activating polypeptide (PACAP) on neurons in the magnocellular portion of the rat hypothalamic paraventricular nucleus (PVN) in vitro" J.Neuroendocrinol.8. 137-143 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Li, A-J.: "Fibroblast growth factor receptor-1 in the lateral hypothalamic area regulates food intake" Exptl.Neurol.137. 318-323 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimizu, N.: "Immobilization increases noradrenaline release and reduces NK cytotoxicity in spleen of conscious rat." Am.J.Physiol.271. R537-R544 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mo, Z.L.: "The effects of IL-1 beat on neuronal activities in the dorsal motor nucleus of the vagus in rat brain slices." Brain Res.Bull.41. 249-255 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oka, T.: "Intracerebroventricula injection of tumor necrosis factor alpha induces thermal hyperalgesia in rats." Neuroimmunomodulation. 3. 135-140 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oka, T.: "Inhibition of peripheral interleukin-1 beta induced hyperalgesia by the intracerebroventricular administration of diclofenac and Eo-melanocyte-stimulating hormone." Brain Res.736. 237-242 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oka, T.: Brain cytokines and pain. Birkhaeuser Publishing Ltd.(in press), 19

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 堀 哲郎: "自律神経系による免疫系制御" Clinical Neuroscience. 15. 394-396 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 堀 哲郎: "発熱の科学" 救急医学. 21. 1000-1015 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 堀 哲郎: "怒りはどこから湧き、どのように発散されるか" COMMUNICATION. 68. 12-15 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Li, A-J.: "A single pre-training glucose injection induces memory facilitation in rodents performing various tasks : contribution of acidic fibroblast growth factor." Neuroscience. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hori, T.: "Neuroimmunomodulatory actions of hypothalamic interferon-α." Neuroimmunomodulation. 5(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 堀 哲郎: "サイトカインと脳・免疫連関" Clinical Neuroscience. 16(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 堀 哲郎: "脳・免疫系連関における伝達物質" Clinical Neuroscience. 16(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Huang, Q.: "Central noradrenergic system modulates plasma interleukin-6 production by peripheral interleukin-1b" Am.J.Physiol.273. R731-R738 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 高木 厚司: "ストレス時に腸内細菌が果たす免疫賦活作用" ストレス科学. 12(2). 90 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shioda, S.: "PACAP protects hipocampal neurons against apotosis : involvement of JNK/SAPK signaling pathway." Ann NY Acad Sci. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Uchimura,D.: "Facilitatory effects of pituitary adenylate cyclase activating polypeptide (PACAP) on neurons in the magnocellular portion of the rat hypothalamic paraventricular nucleus (PVN) in vitro." J.Neuroendocrinol.8. 137-143 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Li,A-J.: "Fibroblast growth factor receptor-1 in the lateral hypothalamic area regulates food intake." Exptl.Neurol.137. 318-323 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimizu,N.: "Immobilization increases noradrenaline release and reduces NK cytotoxicity in spleen of conscious rat." Am.J.Physiol.271. R537-R544 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mo,Z.L.: "The effects of IL-1β on neuronal activities in the dorsal motor nucleus of the vagus in rat brain slices." Brain Res.Bull.41. 249-255 (1996)

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      1996 Annual Research Report
  • [Publications] Oka,T.: "Intracerebroventricular injection of tumor necrosis factor α induces thermal hyperalgesia in rats." Neuroimmunomodulation. 3. 135-140 (1996)

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      1996 Annual Research Report
  • [Publications] Oka,T.: "Inhibition of peripheral interleukin-1-β-induced hyperalgesia by the intracerebroventricular administration of diclofenac and α-melanocyte-stimulating hormone." Brain Res.736. 237-242 (1996)

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      1996 Annual Research Report
  • [Publications] Ota,K.: "The AV3V neurons which send axons to hypothalamic nuclei respond to the systemic injection of IL-1β." Am.J.Physiol.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] Oka,T.: "Biphasic alteration in the trigeminal nociceptive neuronal responses after intracerebroventricular injection of prostaglandin E2 in rats." Brain Res.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] Li,A.J.: "Interleukin-6 inhibits long-term potentiation in rat hippocampal slices." Brain Res.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] Katafuchi,T.: "Differential effects of tumor necrosis factor-α and-β on the rat ventromedial hypothalamic neurons in vitro." Am.J.Physiol.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] 片渕俊彦: "交感神経による脾臓ナチュラルキラー細胞活性制御の視床下部機序" 自律神経. 33. 267-272 (1996)

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      1996 Annual Research Report
  • [Publications] 岡孝和: "痛みと情動" Clinical Neuroscience. 14. 1025-1027 (1996)

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      1996 Annual Research Report
  • [Publications] 堀 哲郎: "発熱の病態生理" Today's Therapy. 20. 115-118 (1996)

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      1996 Annual Research Report
  • [Publications] 堀 哲郎: "ストレスとNeuroimmunomodulation" 日本集中治療医学界雑誌. 4(1). 3-10 (1997)

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      1996 Annual Research Report
  • [Publications] Hori,T.: "Discussion on Future Directions in Psychoneuroimmunology and Cancer." Nishimura Co.,Ltd.and Smith-Gordon Co.,Ltd., 166 (1996)

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      1996 Annual Research Report
  • [Publications] Hori,T.: "Physiological Basis of Occupational Health : Stressful Environments." SPB Academic Publishing bv, 278 (1997)

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      1996 Annual Research Report
  • [Publications] 堀 哲郎: "最新内科学大系、PartI.内科総論部門、第2巻「科学としての内科学」" 中山書店, 372 (1996)

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      1996 Annual Research Report
  • [Publications] 堀 哲郎: "現代の神経内分泌学" メディカル・サイエンス・インターナショナル, 506 (1996)

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      1996 Annual Research Report
  • [Publications] Tkaki,A.: "Is immobilization-induced plasma IL-6 elevation regulated by hepatic innervation? in Liver Innervation" John Libbey & Company Ltd., 484 (1997)

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      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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