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Cyclic ADP-ribose signal transduction : Molecular mechanism and pathophsiological significance

Research Project

Project/Area Number 08102003
Research Category

Grant-in-Aid for Specially Promoted Research

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

OKAMOTO Hiroshi  Tohoku University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (60025632)

Co-Investigator(Kenkyū-buntansha) TAKASAWA Shin  Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (50187944)
Project Period (FY) 1996 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥288,000,000 (Direct Cost: ¥288,000,000)
Fiscal Year 2000: ¥40,000,000 (Direct Cost: ¥40,000,000)
Fiscal Year 1999: ¥40,000,000 (Direct Cost: ¥40,000,000)
Fiscal Year 1998: ¥63,000,000 (Direct Cost: ¥63,000,000)
Fiscal Year 1997: ¥61,000,000 (Direct Cost: ¥61,000,000)
Fiscal Year 1996: ¥84,000,000 (Direct Cost: ¥84,000,000)
KeywordsCD38 / cyclic ADP-ribose / ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase / second messenger / Ca^<2+> release channel / insulin secretion / molecular cloning / Ca^<2+>放出チャンネル
Research Abstract

Calcium mobilization plays a central role in a variety of cellular responses such as insulin secretion by glucose in pancreatic β-cells. We have recently found that cyclic ADP-ribose (cADPR), a metabolite of NAD^+, is a novel second messenger for Ca^<2+> mobilization for insulin secretion. In the project, we have elucidated the molecular mechanism of cADPR signal transduction in mammalian cells.
1. We identified the binding sites for NAD^+ (substrate), cADPR (product) and ATP (regulator) for CD38 (mammalian ADP-ribosyl cyclase/cADPR hydrolase) by site-directed mutagenesis.
2. We isolated the human CD38 gene and determined its primary structure. The gene consists of 8 exons that extend -100 kbp on band p15 of chromosome 4 as a single copy gene. We found an Arg140→Trp mutation in Japanese NIDDM patients and the mutated protein exhibited a decrease in the enzymic activity of CD38 to form cADPR.
3. We found autoantibodies against CD38 that impair glucose-induced insulin secretion in Japanese … More and Caucasian subjects with diabetes.
4. We demonstrated that cADPR binds to FK506-binding protein 12.6 (FKBP12.6) on rat islet ryanodine receptor (RyR) and that the binding of cADPR to FKBP12.6 frees the RyR from FKBP12.6, releasing Ca^<2+>. In addition, in heart failure, the stoichiometry of FK506-binding protein per the ryanodine receptor was decreased. We isolated the human FKBP12.6 gene and determined the primary structure. The gene spans about 16 kbp on chromosome 2p21-23.
5. We found that the Ca^<2+> release from microsomes was greatly enhanced by the activation of CaM kinase II and A-kinase.
6. We produced knockout mice carrying a null mutation in the CD38 gene by homologous recombination and found that CD38 disruption impairs glucose-induced increases in cADPR, intracellular Ca^<2+> concentration, and insulin secretion.
7. Using CD38 knockout mice, we found that muscarinic Ca^<2+> signaling in pancreatic acinar cells involves a CD38-dependent pathway responsible for two cADPR-dependent Ca^<2+> release mechanisms in which the one sensitive to ryanodine plays a crucial role for the generation of repetitive Ca^<2+> spikes.
8. We determined the primary structure of streptococcal ADP-ribosyl cyclase/cADPR hydrolase. Using sitedirected mutagenesis, we found that Lys-162 and/or Lys-163 of the streptococcal enzyme, which correspond to Lys-129 of human CD38, participate in the cADPR binding and that Glu-307 of the streptococcal enzyme and Glu-226 of human CD38 are essential for the NAD^+ binding.
9. We found type 2 and type 3 ryanodine receptor Ca^<2+> channel (RyR) is expressed in normal pancreatic β-cells and the expression is markedly reduced in diabetic β-cells. We have made mutant mice lacking the both types of RyR gene in insulin producing β-cells. Less

Report

(6 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (323 results)

All Other

All Publications (323 results)

  • [Publications] Baeza,N.J.: "Pancreatic regenerating gene overexpression in the nonobese diabetic mouse during active diabetogenesis."Diabetes. 45. 67-70 (1996)

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  • [Publications] Asahara,M.: "Reg gene expression is increased in rat gastric enterochromaffin-like cells following water immersion stress."Gastroenterology. 111. 45-55 (1996)

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  • [Publications] Kawase,M.: "Inducible nitric oxide synthase following hypoxia in rat cultured glial cells."Brain Res.. 738. 319-322 (1996)

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  • [Publications] Kato,I.: "Enhancement of glucose-induced insulin secretion in transgenic mice overexpressing human VIP gene in pancreatic B cells."Ann.NY Acad.Sci.. 805. 232-243 (1996)

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  • [Publications] Yonekura,H.: "Identification of the five essential histidine residues for peptidy lgly cine monooxy gease."Biochem.Biophys.Res.Commun.. 218. 495-499 (1996)

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  • [Publications] Kimura,N.: "Deficiency of phenylethanolamine N-methyltransferase in norepinephine-producing pheochromocy toma."Endocrine Pathol.. 7. 131-136 (1996)

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  • [Publications] Okamoto,H.: "Anovel mechanism of insulin secretion : the cy clic ADP-ribose-CD38 signaling sy stem in normal and transgenic islets."Exp.Clin.Endocrinol.Diabetes. 104. A36-A36 (1996)

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  • [Publications] Okamoto,H.: "Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 : Inhibition of hydrolysis by ATP and the physiological significance."Methods Enzymol.. 280. 306-318 (1997)

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  • [Publications] Narushima,Y.: "Structure, chromosomal localization and expression of mouse genes encoding type III Reg, Reg IIIα, Reg IIIβ, Reg IIIγ."Gene. 185. 159-168 (1997)

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  • [Publications] Nata,K.: "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) : Organizatson, nucleotide sequence and altemative splicing."Gene. 186. 285-292 (1997)

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  • [Publications] Noguchi,N.: "Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca^<2+> from islet microsomes."J.Biol.Chem.(Communication). 272. 3133-3136 (1997)

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  • [Publications] Tohgo,A.: "Lysine 129 of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) participates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase."J.Biol.Chem.(Communication). 272. 3879-3882 (1997)

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  • [Publications] Ebihara,S.: "Role of cyclic ADP-ribose in ATP-activ ated potassium currents in alv eolar macrophages."J.Biol.Chem.. 272. 16023-16029 (1997)

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  • [Publications] Okamoto,H.: "The cyclic ADP-ribose-CD38 signaling system."Jpn.J.Pharmacol.. 73. 30P-30P (1997)

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  • [Publications] Yagui,K.: "CD38 gene Arg 140T rp mutation in Japanese subjects with NIDDM."Diabetes. 46. 74A-74A (1997)

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  • [Publications] Okamoto,H.: "Identification of cyclic ADP-ribose-binding protein in ry anodine receptor of islet microsomes."Diabetes. 46. 214A-214A (1997)

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  • [Publications] Gross,D.J.: "Treatment of adv anced disease in NOD mice by immunomodulation and expansion of B-cell mass : a combined approach."Exp.Clin.Endocrinol.Diabetes. 105. 72-73 (1997)

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  • [Publications] Okamoto,H.: "The role of Reg genes : Genetic introduction of human REG I and/or administration of REG I product may be effective in the prevention and cure of diabetes in man."Exp.Clin.Endocrinol.Diabetes. 105. A12-A13 (1997)

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  • [Publications] Fujimura,M.: "Attenuation of nitric oxide synthase induction in IRF-1-deficient glial cells."Brain Res.. 759. 247-250 (1997)

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  • [Publications] Okamoto,H.: "Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hy drolase) in diabetic patients."Diabetologia. 40. A108-A108 (1997)

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  • [Publications] Higashida,H.: "Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell mambranes analyzed by thin layer chromatography."J.Biol.Chem.. 272. 31272-31277 (1997)

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  • [Publications] Okamoto,H.: "The CD38-cyclic ADP-ribose signaling system in insulin secretion : molecular basis and clinical implications."Diabetologia. 40. 1485-1491 (1997)

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  • [Publications] Takamura,T.: "Transgenic mice overexpressing type 2 nitric oxide synthase in pancreatic β cells develop insulin-dependent diabetes without insulitis"J.Biol.Chem.(Communication). 273. 2493-2496 (1998)

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  • [Publications] Takasawa,S.: "Cyclic ADP-ribose and inositol 1, 4, 5-trisphosphate as alternate second messengers for intracellular Ca^<2+> mobilization in normal and diabetic β-cells."J.Biol.Chem.(Communication). 273. 2497-2500 (1998)

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  • [Publications] Yagui,K.: "A missense mutation in the CD38 gene, a novel factor for insulin secretion : Association with Type I diabetes mellitus in Japanese subjects and evidence of abnormal furction when expressed in vitro."Diabetologia. 41. 1024-1028 (1998)

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  • [Publications] Gross,D.J.: "Amelioration of diabetes in NOD mice with advanced disease by Linomide-induced immunoregulation combined with Reg protein treatment."Endocrinology. 139. 2369-2374 (1998)

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  • [Publications] Ikehata,F.: "Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) which impair glucose-induced insulin secretion in non-insulin dependent diabetes patients."J.Clin.Invest.. 102. 395-401 (1998)

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  • [Publications] Isoyama,S.: "Dev elopment of myocardial hy pertrop hy in CD38 knockout mice."Circulation. 98. l-626-l-626 (1998)

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  • [Publications] Anastasi,E.: "Reg and cy tocheratin 20 expression during ductal cell differentiation and proliferation in a mouse model of autoimmune diabetes."Diabetologia. 41. A67-A67 (1998)

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  • [Publications] Fukui,H.: "Regenerating gene protein may mediate gastric mucosal proliferation induced by hy pergastrinemia in rats."Gastroenterology. 115. 1483-1493 (1998)

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  • [Publications] Pupilli,C.: "A new autoimmune marker (anti-CD38-Ab) in NIDDM : Possible role in insulin secretion."Diabetes. 47. A83-A83 (1998)

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  • [Publications] Nakazawa,T.: "IRF-1-deficient nonobese diab etic mice do not develop autoimmune diab etes."Diabetes. 47. A208-A208 (1998)

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  • [Publications] Anastasi,E.: "Beta cells do differentiate and proliferate in autoimmune diab etes."Diabetes. 47. A234-A234 (1998)

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  • [Publications] Okamoto,H.: "Cy clic ADP-ribose-mediated insulin secretion and Reg, regenerating gene."J.Mol.Med.. 77. 74-79 (1999)

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  • [Publications] Kato,I.: "CD38 disruption impairs glucose-induced increases in cy clic ADP-ribose, [Ca^<2+>] i and insulin secretion."J.Biol.Chem.(Communication). 274. 1869-1872 (1999)

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  • [Publications] Bemard-Penone,F.R.: "Expression of REG protein during cell growth and differentiation of two human carcinoma cells."J.Histochem.Cytochem.. 47. 863-870 (1999)

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  • [Publications] Anastasi,E.: "Reg and cytokeratin 20 expression during ductal cell differentiatior and proliferation in a mouse model of autoimmune diab etes."Eur.J.Endocrinol.. 141. 644-652 (1999)

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  • [Publications] Okamoto,H.: "The Reg gene family and Reg proteins : With special attention to the regeneration of pancreatic β-cells."J.Hepatobiliary Pancreat.Surg.. 6. 254-262 (1999)

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  • [Publications] Okamoto,H.: "Autoantibody against REG I protein in NIDDM patients."Diabetes. 48. 1965-1965 (1999)

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  • [Publications] Pupilli,C.: "Autoanitibodies to CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in Caucasian patients with diabetes : Effects on insulin release from human islets."Diabetes. 48. 2309-2315 (1999)

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  • [Publications] Okamoto,H.: "The CD38-cy clic ADP-ribose signaling system in insulin secretion."Mol.Cell.Biochem.. 193. 115-118 (1999)

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  • [Publications] Kamii,H.: "Amelioration of vasospasm after subarachnoid hemorrhage in trans genic mice overexp ressing CuZn-superoxide dismutase."Stroke. 30. 867-872 (1999)

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  • [Publications] Okamoto,H.: "A novel mechanism of insulin secretion, the CD38-cy clic ADP-ribose signal system-Molecular basis and clinical implications."Update in Clinical Endocrinology. 35-37 (1999)

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  • [Publications] Yamamoto,Y.: "Roles of the AGE-RAGE system in vascular injury in diabetes."Ann.N Y Acad.Sci.. 902. 163-170 (2000)

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  • [Publications] Abe,M.: "Identification of a novel Reg family gene, Reg IIIδ, and mapping of all three types of Regfamiiy gene in a 75 kilobase mouse genomic region."Gene. 246. 111-122 (2000)

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  • [Publications] Kobayashi,S.: "Identification of a receptor for Reg (Regenerating Gene) protein, a pancreatic beta-cell regeneration factor."J.Biol.Chem.(Accelerated Publication). 275. 10723-10726 (2000)

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  • [Publications] Yano,M.: "Altered stoichiomrtory of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca^<2+> leak through ryanodine receptor in heart failure."Circulation. 102. 2131-2136 (2000)

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  • [Publications] Kazumori,H.: "Neutrophil chemoattractant 2β regulates expression of the Reg gene in injured gastric mucosa in rats."Gastroenterology. 119. 1610-1622 (2000)

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  • [Publications] Kimura,N.: "Immunohistochemical expression of chromogranins A and B, prohormone convertase 2 and 3, and amidating enzyme in carcinoid tumors and pancreatic endocrine tumors."Modern Pathology. 13. 140-146 (2000)

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  • [Publications] Okamoto,H.: "Transcriptional activ ation of Reg (Hegenerating gene) by nicotinamide."Diabetes. 49・Suppl.1. A256-A256 (2000)

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  • [Publications] Okamoto,H.: "Isolation and functional expression of a receptor for Reg protein."Diabetes. 49・Suppl.1. A44-A44 (2000)

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  • [Publications] Akiyama,T.: "Activation of Reg gene, a gene for insulin-producing -cell regeneration : Poly (ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly (ADP-ribosyl) ation."Proc.Natl.Acad.Sci.U.S.A.. 98. 48-53 (2001)

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  • [Publications] Fukushi,Y.: "Identification of cyclic ADP-ribose-dependent mechanisms in pancreatic muscarinic Ca^<2+> signaling using CD38 knockout mice."J.Biol.Chem.. 276. 649-655 (2001)

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  • [Publications] Okamoto,H.: "Enhancement of Reg-induced β-cell regeneration by hepatocyte growth factor."Diabetes. 50(in press). (2001)

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  • [Publications] 岡本宏: "新しいインスリン分泌機構とその病態"DMB. 18. 1821-1831 (1996)

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  • [Publications] 成島陽一: "ヒトREGファミリーの4つの遺伝子は第2染色体短腕12上の95kbp内の領域に隣接して存在する"糖尿病. 39. 491-491 (1996)

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  • [Publications] 高沢伸: "膵β細胞小胞体からのcyclic ADP-riboseによるCa^<2+>放出のCaM kinase IIによる増強"糖尿病. 39. 182-182 (1996)

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  • [Publications] 東郷暁: "ATPは直接CD38に作用してcyclic ADP-ribose分解活性を抑制する"糖尿病. 39. 183-183 (1996)

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  • [Publications] 池端史子: "糖尿病患者における抗CD38(cyclic ADP-ribose合成・分解酵素)自己抗体の存在"糖尿病. 39. 183-183 (1996)

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  • [Publications] 岡本宏: "新しい情報伝達系The CD38-Cyclic ADP-ribose Signalling System"毒素シンポジウム予稿集. 12-13 (1996)

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  • [Publications] 成島陽一: "Reg遺伝子ファミリーは染色体上、極めて隣接した領域に存在する"生化学. 68. 1268-1268 (1996)

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  • [Publications] 那谷耕司: "cyclic ADP-ribose依存性Ca^<2+>放出のCaM kinase IIによる増強"生化学. 68. 837-837 (1996)

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  • [Publications] 東郷暁: "CD38(ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase)の基質(NAD,cyclic ADP-ribose)と調節因子(ATP)の結合部位"生化学. 68. 837-837 (1996)

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  • [Publications] 唐澤忠宏: "A型レンサ球菌NAD分解酵素のcyclic ADP-ribose代謝活性"生化学. 68. 838-838 (1996)

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  • [Publications] 篁俊成: "誘導型NO合成酵素をインスリン産生細胞で過剰発現するトランスジェニックマウスの作成とその解析"生化学. 68. 1015-1015 (1996)

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  • [Publications] 成島陽一: "ヒトREGファミリー遺伝子の構造と染色体座位:ヒトREGファミリーの4つの遺伝子は全て第2染色体短腕12の95kbpの範囲に局在する"生化学. 68. 1740-1740 (1996)

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  • [Publications] 野口直哉: "cyclic ADP-ribose介する情報伝達のCaM kinase IIによる活性化"生化学. 68. 1740-1740 (1996)

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  • [Publications] 金塚東: "NIDDMにおけるCD38遺伝子ミスセンス変異"糖尿病. 40. 120-120 (1997)

    • Description
      「研究成果報告書概要(和文)」より
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      2000 Final Research Report Summary
  • [Publications] 那谷耕司: "マウスReg I遺伝子を過剰発現する膵β細胞の増殖能:トランスジェニックマウスを用いた解析"糖尿病. 40. 209-209 (1997)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 東郷暁: "ATPによる膵β細胞内cyclic ADP-ribose生成の調節機構の解明"糖尿病. 40. 211-211 (1997)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 野口直哉: "膵β細胞のcyclic ADP-ribose感受性Ca^<2+>チャンネルからのCa^<2+>放出機構:FK506結合タンパク質の関与"糖尿病. 40. 211-211 (1997)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 八木一夫: "NIDDMにおけるCD38遺伝子異常の検索と変異Arg140Trp-CD38の検討"糖尿病. 40. 333-333 (1997)

    • Description
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  • [Publications] 岡本宏: "新しい細胞内情報伝達系"The CD38-cyclic ADP-ribose signal system""生化学. 69. 519-519 (1997)

    • Description
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  • [Publications] 高沢伸: "サイクリックADPリボースをセカンドメッセンジャーとするインスリン分泌"生化学. 69. 525-525 (1997)

    • Description
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  • [Publications] 東郷暁: "CD38(ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase)のATPによる活性調節機構の解明"生化学. 69. 638-638 (1997)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 野口直哉: "FK506結合蛋白質12.6を介するcyclic ADP-ribose感受性Ca^<2+>チャンネルからのCa^<2+>放出"生化学. 69. 638-638 (1997)

    • Description
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  • [Publications] 中沢哲也: "ヒトFK506-binding protein12遺伝子の構造と染色体座位"生化学. 69. 638-638 (1997)

    • Description
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  • [Publications] 佐々木司: "ラッ肺胞マクロファージのATP惹起K^+電流におけるサイクリックADPリボース(cADPR)の関与"生化学. 69. 638-638 (1997)

    • Description
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  • [Publications] 唐沢忠宏: "A群レンサ球菌NAD分解酵素遺伝子のクローニング"生化学. 69. 638-638 (1997)

    • Description
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  • [Publications] 野口直哉: "FK506結合蛋白質のcyclic ADP-ribose結合活性とその生理的意義"生化学. 69. 1319-1319 (1997)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 東郷暁: "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (CD38)のATPによる調節とその分子機構"生化学. 69. 1319-1319 (1997)

    • Description
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  • [Publications] 岡本宏: "膵B細胞は疲弊するのか"糖尿病学の進歩 '97. 34-40 (1997)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 海野倫明: "Reg遺伝子とその産物Reg蛋白質の構造と機能-新しい糖尿病治療への展望を求めて-"日本臨床. 55. 817-821 (1997)

    • Description
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  • [Publications] 岡本宏: "インスリン分泌の分子機構Insulin secretion in physiological and pathophysiological conditions : A new balanced view."糖尿病学の進歩 '98. 25-28 (1998)

    • Description
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  • [Publications] 高沢伸: "サイクリックADPリボースをセカンドメッセンジャーとするインスリン分泌"生化学. 70. 425-433 (1998)

    • Description
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  • [Publications] 岡本宏: "Reg遺伝子と膵再生"第111回日本医学会シンポジウム記録集. 83-91 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Gross,D.J.: "Treatment of diabetes in NOD mice by Beg peptide."糖尿病. 41. 126-126 (1998)

    • Description
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  • [Publications] 加藤一郎: "CD38ノックアウトマウスの作製とその膵β細胞のグルコース刺激インスリン分泌の低下"糖尿病. 41. 136-136 (1998)

    • Description
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  • [Publications] 中沢哲也: "IRF-1欠損NODマウスにおける膵島炎及び糖尿病発症の抑制"糖尿病. 41. 147-147 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 秋山貴子: "IL-6とDexamethasoneによる膵β細胞のReg I遺伝子の発現誘導"糖尿病. 41. 389-389 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 黒木実智雄: "膵ランゲルハンス島のリアノジン受容体型Ca^<2+>チャンネルcDNAの単離と構造決定"糖尿病. 41. 391-391 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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      2000 Final Research Report Summary
  • [Publications] 中沢哲也: "cyclic ADP-ribose結合蛋白質(FK506-binding protein) 遺伝子の構造と染色体座位"糖尿病. 41. 434-434 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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      2000 Final Research Report Summary
  • [Publications] 黒木実智雄: "膵ランゲルハンス島で発現している新しいリアノジン受容体型Ca^<2+>チャンネルcDNAの単離と構造決定"生化学. 70. 778-778 (1998)

    • Description
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  • [Publications] 阿部倫明: "新しいマウスReg遺伝子の単離とReg遺伝子ファミリーの遺伝子地図の作製"生化学. 70. 811-811 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 熊谷智子: "膵β細胞の再生増殖因子:Reg Iトランスジェニック、ノックアウトマウスを用いた解析"生化学. 70. 900-900 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 秋山貴子: "膵ランゲルハンス島β細胞増殖因子Reg Iの発現誘導機構"生化学. 70. 900-900 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 加藤一郎: "CD38/サイクリックADPリボース情報伝達系:CD38ノックアウトマウスを用いたインスリン分泌の解析"生化学. 70. 931-931 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 高沢伸: "Cyclic ADP-riboseとinsulin分泌におけるCa^<2+>シグナルの分子機構"第27回日本分子生物学会年会プログラム講演要旨集. 199-199 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 岡本宏: ""The CD38-cyclic ADP-ribose signal system":その分子機構と医学・生物学上の意義"日本薬理学会雑誌(Folia Pharmacol.Jpn.). 114. 131-139 (1999)

    • Description
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  • [Publications] Okamoto,H.: "Lessons from Animal Diabetes VI"Shafrir, E.(Birkhauser). 15 (1996)

    • Description
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  • [Publications] Okamoto,H.: "Physiology and Pat hophysiology of the Islets of Langerhans"Soria, B.(Plenum Press). 12 (1997)

    • Description
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  • [Publications] Okamoto,H.: "Human CD38 and related molecules"Kapil Mehta and Fabio Malavasi (KARGER). 25 (2000)

    • Description
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  • [Publications] Okamoto,H.: "Encyclopedia of Molecular Medicine"Creighton,T.E.(John Wiley & Sons)(in press). (2001)

    • Description
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  • [Publications] Baeza, N.J.: "Pancreatic regenerating gene overexpression in the nonobese diabetic mouse during active diabetogenesis."Diabetes. 45. 67-70 (1996)

    • Description
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  • [Publications] Asahara, M.: "Reg gene expression is increased in rat gastric enterochromaffin-like cells following water immersion stress."Gastroenterology. 111. 45-55 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Kawase, M.: "Inducible nitric oxide synthase following hypoxia in rat cultured glial cells."Brain Res.. 738. 319-322 (1996)

    • Description
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  • [Publications] Kato, I.: "Enhancement of glucose-induced insulin secretion in transgenic mice overexpressing human VIP gene in pancreatic_cells."Ann.NY Acad.Sci.. 805. 232-243 (1996)

    • Description
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  • [Publications] Yonekura, H.: "Identification of the five essential histidine residues for peptidylglycine monooxygease."Biochem.Biophys.Res.Commun.. 218. 495-499 (1996)

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  • [Publications] Kimura, N.: "Deficiency of phenylethanolamine N-methyltransferase norepinephrine-producing pheochromocytoma."Endocrine Pathol.. 7. 131-136 (1996)

    • Description
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  • [Publications] Okamoto, H.: "A novel mechanism of insulin secretion : the cyclic ADP-ribose-CD38 signaling system in normal and transgenic islets."Exp.Clin.Endocrinol.Diabetes. 104. A36 (1996)

    • Description
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  • [Publications] Okamoto, H.: "Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 : Inhibition of hydrolysis by ATP and the physiological significance."Methods Enzymol.. 280. 306-318 (1997)

    • Description
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  • [Publications] Narushima, Y.: "Structure, chromosomal localization and expression of mouse genes encoding type III Reg, Reg IIIα, Reg IIIβ, Reg IIIγ."Gene. 185. 159-168 (1997)

    • Description
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  • [Publications] Nata, K.: "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) : Organization, nucleotide sequence and alternative splicing."Gene. 186. 285-292 (1997)

    • Description
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  • [Publications] Noguchi, N.: "Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca^<2+> from islet microsomes."J.Biol.Chem.(Communication). 272. 3133-3136 (1997)

    • Description
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  • [Publications] Tohgo, A.: "Lysine 129 of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) participates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase."J.Biol.Chem.(Communication). 272. 3879-3882 (1997)

    • Description
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  • [Publications] Ebihara, S.: "Role of cyclic ADP-ribose in ATP-activated potassium currents in alveolar macrophages."J.Biol.Chem.. 272. 16023-16029 (1997)

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  • [Publications] Okamoto, H.: "The cyclic ADP-ribose-CD38 signaling system."Jpn.J.Pharmacol.. 73. 30P (1997)

    • Description
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  • [Publications] Yagui, K.: "CD38 gene Arg 140Trp mutation in Japanese subjects with NIDDM."Diabetes. 46. 174A (1997)

    • Description
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  • [Publications] Okamoto, H.: "Identification of cyclic ADP-ribose-binding protein in ryanodine receptor of islet microsomes."Diabetes. 46. 214A (1997)

    • Description
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  • [Publications] Gross, D.J.: "Treatment of advanced disease in NOD mice by immunomodulation and expansion of B-cell mass : a combined approach."Exp.Clin.Endocrinol.Diabetes. 105. 72-73 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Okamoto, H.: "The role of Reg genes : Genetic introduction of human REG I and/or administration of REG I product may be effective in the prevention and cure of diabetes in man."Exp.Clin.Endocrinol.Diabetes. 105. A12-A13 (1997)

    • Description
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  • [Publications] Fujimura, M.: "Attenuation of nitric oxide synthase induction in IRF-1-deficient glial cells."Brain Res.. 759. 247-250 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Okamoto, H.: "Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in diabetic patients."Diabetologia. 40. A108 (1997)

    • Description
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  • [Publications] Higashida, H.: "Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell membranes analyzed by thin layer chromatography."J.Biol.Chem.. 272. 31272-31277 (1997)

    • Description
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  • [Publications] Okamoto, H.: "The CD38-cyclic ADP-ribose signaling system in insulin secretion : molecular basis and clinical implications."Diabetologia. 40. 1485-1491 (1997)

    • Description
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  • [Publications] Takasawa, S.: "Cyclic ADP-ribose and inositol 1,4,5-trisphosphate as alternate second messengers for intracellular Ca^<2+> mobilization in normal and diabetic β-cells."J.Biol.Chem.(Communication). 273. 2497-2500 (1998)

    • Description
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  • [Publications] Takamura, T.: "Transgenic mice overexpressing type 2 nitric oxide synthase in pancreatic β cells develop insulin-dependent diabetes without insulitis."J.Biol.Chem.(Communication). 273. 2493-2496 (1998)

    • Description
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  • [Publications] Yagui, K.: "A missense mutation in the CD38 gene, a novel factor for insulin secretion : Association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro."Diabetologia. 41. 1024-1028 (1998)

    • Description
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  • [Publications] Guross, D.J.: "Amelioration of diabetes in NOD mice with advanced disease by Linomide-induced immunoregulation combined with Reg protein treatment."Endocrinology. 139. 2369-2374 (1998)

    • Description
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  • [Publications] Ikehata, F.: "Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) which impair glucose-induced insulin secretion in non-insulin dependent diabetes patients."J.Clin.Invest.. 102. 395-401 (1998)

    • Description
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  • [Publications] Isoyama, S.: "Development of myocardial hypertrophy in CD38 knockout mice."Circulation. 98. I-626 (1998)

    • Description
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  • [Publications] Anastasi, E.: "Reg and cytocheratin 20 expression during ductal cell differentiation and proliferation in a mouse model of autoimmune diabetes."Diabetologia. 41. A67 (1998)

    • Description
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  • [Publications] Fukui, H.: "Regenerating gene protein may mediate gastric mucosal proliferation induced by hypergastrinemia in rats."Gastroenterology. 115. 1483-1493 (1998)

    • Description
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  • [Publications] Pupilli, C.: "A new autoimmune marker (anti-CD38-Ab) in NIDDM : Possible role in insulin secretion."Diabetes. 47. A83 (1998)

    • Description
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  • [Publications] Nakazawa, T.: "IRF-1-deficient nonobese diabetic mice do not develop autoimmune diabetes."Diabetes. 47. A208 (1998)

    • Description
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  • [Publications] Anastasi, E.: "Beta cells do differentiate and proliferate in autoimmune diabetes."Diabetes. 47. A234 (1998)

    • Description
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  • [Publications] Okamoto, H.: "Cyclic ADP-ribose-mediated insulin secretion and Reg, regenerating gene."J.Mol.Med.. 77. 74-79 (1999)

    • Description
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  • [Publications] Kato, I.: "CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca^<2+>]i and insulin secretion."J.Biol.Chem.(Communication). 274. 1869-1872 (1999)

    • Description
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  • [Publications] Bernard-Perrone, F.R.: "Expression of REG protein during cell growth and differentiation of two human carcinoma cells."J.Histochem.Cytochem.. 47. 863-870 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Anastasi, E.: "Reg and cytokeratin 20 expression during ductal cell differentiation and proliferation in a mouse model of autoimmune diabetes."Eur.J.Endocrinol.. 141. 644-652 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Okamoto, H.: "The Reg gene family and Reg proteins : With special attention to the regeneration of pancreatic β-cells."J.Hepatobiliary Pancreat.Surg.. 6. 254-262 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Okamoto, H.: "Autoantibody against REG I protein in NIDDM patients."Diabetes. 48. 1965 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Pupilli, C.: "Autoanitibodies to CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in Caucasian patients with diabetes : Effects on insulin release from human islets."Diabetes. 48. 2309-2315 (1999)

    • Description
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  • [Publications] Okamoto, H.: "The CD38-cyclic ADP-ribose signaling system in insulin secretion."Mol.Cell.Biochem.. 193. 115-118 (1999)

    • Description
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  • [Publications] Kamii, H.: "Amelioration of vasospasm after subarachnoid hemorrhage in transgenic mice overexpressing CuZn-superoxide dismutase."Stroke. 30. 867-872 (1999)

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      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okamoto, H.: "A novel mechanism of insulin secretion, the CD38-cyclic ADP-ribose signal system-Molecular basis and clinical implications."Update in Clinical Endocrinology. 35-37 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamamoto, Y.: "Roles of the AGE-RAGE system in vascular injury in diabetes."Ann.NY Acad.Sci.. 902. 163-172 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Abe, M.: "Identification of a novel Reg family gene, Reg IIIδ, and mapping of all three types of Reg family genes in a 75-kilobase mouse genomic region."Gene. 246. 111-112 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kobayashi, S.: "Identification of a receptor for Reg (Regenerating Gene) protein, a pancreatic β-cell regeneration factor."J.Biol.Chem.(Accelerated Publication). 275. 10723-10726 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okamoto, H.: "Isolation and functional expression of a receptor for Reg protein."Diabetes. 49. A44 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okamoto, H.: "Transcriptional activation of Reg (Regenerating gene) by nicotinamide."Diabetes. 49. A256 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yano, M.: "Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca^<2+> leak through ryanodine receptor in heart failure."Circulation. 102. 2131-2136 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kazumori, H.: "Neutrophil chemoattractant-2β regulates the expression of the Reg gene in injured gastric mucosa in rats."Gastroenterology. 119. 1610-1622 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okamoto, H.: "Molecular mechanisms of functioning, degeneration and regeneration of mammalian cells : Lessons from insulin-producing pancreatic β-cells."2000 Fall Symposium on Molecular Aspects of Human Diseases at the Post-Genomic Era. 45-46 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukushi, Y.: "Identification of cyclic ADP-ribose-dependent mechanisms in pancreatic muscarinic Ca^<2+> signaling using CD38 knockout mice."J.Biol.Chem.. 276. 649-655 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akiyama, T.: "Activation of Reg gene, a gene for insulin-producing β-cell regeneration : Poly (ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly (ADP-ribosyl) ation."Proc.Natl.Acad.Sci.USA. 98. 48-53 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okamoto, H.: "The OKAMOTO model for B-cell damage : recent advances."Lessons from Animal Diabetes VI (Shafrir, E.ed.), Birkhauser, Boston. 97-111 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okamoto, H.: "New aspects to the functioning and regeneration of pancreatic β-cells : Cyclic ADP-ribose and Reg gene."Physiology and Pathophysiology of the Islets of Langerhans (Soria, B.ed), Plenum Press, New York. 301-311 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okamoto, H.: "Physiological and pathological significance of the CD38-cyclic ADP-ribose signaling system."Human CD38 and Related Molecules (Mehta, K.and Malavasi, F.eds.), Karger, Basel. 121-145 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okamoto, H.: "CD38."Encyclopedia of Molecular Medicine (Creighton, T.E.ed.) John Wiley & Sons, Inc., New York (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Seiichi Kobayashi: "Identification of a receptor for Reg (Regenerating Gene) protein, a pancreatic beta-cell regeneration factor."Journal of Biological Chemistry. 275. 10723-10726 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yasue Fukushi: "Identification of cyclic ADP-ribose-dependent mechanisms in pancreatic muscarinic Ca^<2+> signaling using CD38 knockout mice."Journal of Biological Chemistry. 276. 649-655 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takako Akiyama: "Activation of Reg gene, a gene for insulin-producing _-cell regeneration : Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly (ADP-ribosyl) ation."Proc.Natl.Acad.Sci.U.S.A.. 98. 48-53 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Michiaki Abe: "Identification of a novel Reg family gene, Reg IIIδ, and mapping of all three types of Reg family gene in a 75 kilobase mouse genomic region."Gene. 246. 111-122 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Masafumi Yano: "Altered stoichiomrtory of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca^<2+> leak through ryanodine receptor in heart failure."Circulation. 102. 2131-2136 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hideaki Kazumori: "Neutrophil chemoattractant 2β regulates expression of the Reg gene in injured gastric mucosa in rats."Gastroenterology. 119. 1610-1622 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yasuhiko Yamamoto: "Roles of the AGE-RAGE system in vascular injury in diabetes."Annals of New York Academy of Sciences. 902. 163-170 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Noriko Kimura: "Immunohistochemical expression of chromogranins A and B, prohormone convertase 2 and 3, and amidating enzyme in carcinoid tumors and pancreatic endocrine tumors."Modern Pathology. 13. 140-146 (2000)

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      2000 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Isolation and functional expression of a receptor for Reg protein."Diabetes. 49・Suppl.1. A44-A44 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Transcriptional activation of Reg (Regenerating gene) by nicotinamide."Diabetes. 49・Suppl.1. A256-A256 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Enhancement of Reg-induced β-cell regeneration by hepatocyte growth factor."Diabetes. 50(in press). (2001)

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      2000 Annual Research Report
  • [Publications] 劉一: "新規ヒトREGファミリー遺伝子(REG III)の発見:その構造、発現、染色体座位"糖尿病. 43・Suppl.1. S191-S191 (2000)

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      2000 Annual Research Report
  • [Publications] 秋山貴子: "ニコチン酸アミドのReg遺伝子発現増強効果"糖尿病. 43・Suppl.1. S191-S191 (2000)

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      2000 Annual Research Report
  • [Publications] 那谷耕司: "新しいヒトREG遺伝子(REG III)の単離と構造、発現、染色体座位の解明"生化学. 72・8. 908-909 (2000)

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      2000 Annual Research Report
  • [Publications] 小林誠一: "Reg蛋白質受容体の構造と機能"生化学. 72・8. 908-908 (2000)

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      2000 Annual Research Report
  • [Publications] 秋山貴子: "ポリADPリボシル化によるReg遺伝子の転写調節機構"生化学. 72・8. 908-908 (2000)

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      2000 Annual Research Report
  • [Publications] 小林誠一: "Reg蛋白質受容体の単離:その構造と機能発現"糖尿病. 43・Suppl.1. S192-S192 (2000)

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      2000 Annual Research Report
  • [Publications] 岡本宏: "膵臓:インスリン分泌"生体の科学. 51・5. 460-461 (2000)

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      2000 Annual Research Report
  • [Publications] 秋山貴子: "Reg遺伝子の転写誘導とポリADPリボシル化による転写調節機構"生化学. 73・2. 132-132 (2001)

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      2000 Annual Research Report
  • [Publications] 小林誠一: "インスリン産生細胞増殖因子Reg受容体の構造・発現・機能"生化学. 73・2. 132-132 (2001)

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  • [Publications] 中川圭: "Regによる膵β細胞massの調節におけるHGFの役割"糖尿病. 44・Suppl.1(印刷中). (2001)

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  • [Publications] 那谷耕司: "Reg遺伝子の過剰発現によるNODマウスの糖尿病発症抑制"糖尿病. 44・Suppl.1(印刷中). (2001)

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      2000 Annual Research Report
  • [Publications] 海野倫明: "Reg蛋白レセプター"分子糖尿病学の進歩. (印刷中). (2001)

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      2000 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Human CD38 and related molecules"Kapil Mehta and Fabio Malavasi (KARGER). 25 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Encyclopedia of Molecular Medicine"Creighton, T.E.(John Wiley & Sons)(in press). (2001)

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      2000 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Cyclic ADP-ribose-mediated insulin secretion and Reg, regenerating gene"Journal of Molecular Medicine. 77. 74-79 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ichiro Kato: "CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca^<2+>]I and insulin secretion"Journal of Biological Chemistry. 274. 1869-1872 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroshi Okamoto: "The Reg gene family and Reg proteins : With special attention to the regeneration of pancreatic β-cells"Journal of Hepatobiliary Pancreatic Surgery. 6. 254-262 (1999)

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      1999 Annual Research Report
  • [Publications] Emanuela Anastasi: "Reg and Cytokeratin 20 expression during ductal cell differentiation and proliferation in a mouse model of autoimmune diabetes"European Journal of Endocrinology. 141. 644-652 (1999)

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      1999 Annual Research Report
  • [Publications] F. R. Bernard-Perrone: "Expression of Reg protein during cell growth and differentiation of two human carcinoma cells"Journal of Histochemistry Cytochemistry. 47. 863-870 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroshi Okamoto: "The CD38-cyclic ADP-ribose signaling system in insulin secretion"Molecular Cellular Biochemistry. 193. 115-118 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Autoantibody against REG I protein in NIDDM patients"Diabetes. 48. 1965-1965 (1999)

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      1999 Annual Research Report
  • [Publications] Cinzia Pupilli: "Autoanitibodies to CD38(ADP-ribosyl cyclase/cyclic ADP-ribosehydrolase)in Caucasian patients with diabetes : Effects on insulin releases from human islets"Diabetes. 48. 2309-2315 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H. Kamii: "Amelioration of vasospasm after subarachnoid hemorrhage in transgenic mice overexpressing CuZn-superoxide dismutase"Stroke. 30. 867-872 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroshi Okamoto: ""The CD38-cyclic ADP-ribose signal system " : molecular mechanism and biological significance"Nippon Yakurigaku Zasshi. 114. 131-139 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yasuhiko Yamamoto: "Roles of the AGE-RAGE system in vascular injury in diabetes"Annals of New York Academy of Sciences. ( in press ). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Michiaki Abe: "Identification of anovel Reg family gene, Reg IIIδ, and mapping of all three types of Reg family genes in a 75-kilobase mouse genomic region"Gene. ( in press ). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Seiichi Kobayashi: "Identification of areceptor for Reg(Regenerating Gene) protein, apancreatic β-cell regeneration factor"Journal of Biological Chemistry. 275 ( in press ). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Isolation and function expression of a receptor for Reg Protein"Diabetes. 49 ( in ppress ). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 高沢 伸: "糖尿病患者における抗REGI自己抗体の存在"糖尿病. 42. S111-S111 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松井加奈: "PCR-RFLP法によるCD38遺伝子変異の検出"糖尿病. 42. S157-S157 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 山本晴彦: "ヒトRAGEをトランスジーンとしたマウスの糖尿病性腎病変"糖尿病. 42. S194-S194 (1999)

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      1999 Annual Research Report
  • [Publications] 唐沢忠宏: "連鎖球菌cyclic ADP-ribose(cADPR)合成・分解酵素の構造決定と酵素活性に必須のアミノ酸残基"生化学. 71. 899-899 (1999)

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      1999 Annual Research Report
  • [Publications] 福士靖江: "CD38欠損マウス膵腺腺房細胞でのムスカリン性カルシウム応答"生化学. 71. 900-900 (1999)

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      1999 Annual Research Report
  • [Publications] 黒木実智雄: "膵ランゲルハンス島で発現している新しいリアノジン型受容体の構造、発現、機能"生化学. 71. 900-900 (1999)

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      1999 Annual Research Report
  • [Publications] 山本靖彦: "糖尿病性腎症発症進展に関わる分子の解明-トランスジェニックマウスを用いた検討-"生化学. 71. 982-982 (1999)

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      1999 Annual Research Report
  • [Publications] 加藤一郎: "遺伝子改変マウスを用いた糖尿病の病態解析"生化学. 71. 1357-1357 (1999)

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      1999 Annual Research Report
  • [Publications] 黒木実智雄: "新規リアノジン型受容体の構造、発現と機能"生化学. 71. 1360-1360 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小林誠一: "Reg蛋白質受容体の単離 : その構造と機能発現"糖尿病. 43 ( 印刷中 ). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 秋山貴子: "ニコチン酸アミドのReg遺伝子発現増強効果"糖尿病. 43 ( 印刷中 ). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 劉 一: "新規ヒトREGファミリー遺伝子(REG III)の発見 : その構造、発現、染色体座位"糖尿病. 43 ( 印刷中 ). (2000)

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      1999 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Human CD38 and Related Molecules"Karger (K. Mehta & F. Malavasi, eds. ). 24 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 森泉茂樹: "別冊医学の歩み 消化器疾患 II. 肝・胆・膵"医歯薬出版 (玉熊正悦、石井浩正、編). 5 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ichiro Kato: "CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose,[Ca^<2+>],and insulin secretion." Journal of Biological Chemistry. 274. 1869-1872 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Cyclin ADP-ribose-mediated insulin secretion and Reg,regenerating gene." Journal of Molecular Medicine. 77. 74-79 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Toshinari Takamura: "Transgenic mice overexpressing type 2 nitric oxide synthase in pancrealic β cells develop insulin-dependent diabetes without insulitis." Journal of Biological Chemistry. 273. 2493-2496 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shin Takasawa: "Cyclic ADP-ribose and inositol 1,4,5-trisphosphate as altemate second messengers for intracellular Ca2+ mobilization in normal and diabetic β-cells." Journal of Biological Chemistry. 273. 2497-2500 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fumiko Ikehata: "Autoaotbodies agaimst CD38(ADP-nbosyl cyclaselcyclic ADP-ribose hydrolase)which impair glucose-induced insulin secretion in non-insulin dependent diabetes patients." Journal of Clinical Investigation. 102. 395-401 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kazuo Yagui: "A missense mutation in the CD38 gene, a novel factor for insulin: secretion: Association with Type II diabetes mellitus in Japanease subjects and evidence of abnormal function when expressed in vitro." Diabetologia. 41. 1024-1028 (1998)

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      1998 Annual Research Report
  • [Publications] David J.Gross: "Amelioration of diabetes in NOD mice with advanced disease by Linomide-induced immunoregulation combined with Reg protein treatment." Endocr-inology. 139. 2369-2374 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Fukui: "Regenerating gene protein may mediate gastric mucosal proliferation induced by hypergastrinemia in rats." Gastroenterology. 115. 1483-1493 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shogen Isoyama: "Development of myocardial hypertrophy in CD38 Knockout mice." Circulation. 98. I-626-I-626 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Emanuela Anastasi: "Reg and cytocheratin 20 expression during ductal cell differentiation and proliferation in a mouse model of autoimmune diabetes." Diabetologia. 41. A67-A67 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Cinzia Pupilli: "A new autoimmune marker(anti-CD38-Ab)in NIDDM:Possible role in insulin secretion." Diabetes. 47. A83-A83 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tetsuya Nakazawa: "IRF-1-deficient nonobese diabetic mice do not develop autoimmune diabetes." Diabetes. 47. A208-A208 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Emanuela Anastasi: "Beta cells do differentiate and proliferate in autoimmune diabetes." Diabetes. 47. A234-A234 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] F.R.Bernard-Perrone: "Expression of REG protein during cell growth and differentiation of two human carcinoma cells." Journal of Histochemistry and Cytochemistry. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Recent advances in Reg gene research:The role of Reg genes in the prevention and cure of diabetes mellitus." Journal of Hepato-Pancreatic Surgery. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiroshi Okamoto: "The CD38-Cyclic ADP-Ribose Signaling System in Insulin Secretion." Molecular and Cellular Biochemistry. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 海野倫明: "Reg遺伝子とその産物Reg蛋白質の機能-新しい糖尿病治療への展望を求めて-" 日本臨床. 55. 817-821 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 高沢 伸: "サイクリックADPリボースをセカンドメッセンジャーとするインスリン分泌" 生化学. 70. 425-425 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 黒木実智雄: "膵ランゲルハンス島で発現している新しいリアノジン受容体型Ca2+チャンネルcDNAの単離と構造決定" 生化学. 70. 778-778 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 阿部倫明: "新しいマウスReg遺伝子の単離とReg遺伝子ファミリーの遺伝子地図の作製" 生化学. 70. 811-811 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 熊谷智子: "膵β細胞の再生増殖因子:RegIトランスジェニック、ノックアウトマウスを用いた解析" 生化学. 70. 901-901 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 秋山貴子: "膵ランゲルハンス島β細胞増殖因子RegIの発現誘導機構" 生化学. 70. 901-901 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 加藤一郎: "CD38/サイクリックADPリボース情報伝達系:CD38ノックアウトマウスを用いたインスリン分泌の解析" 生化学. 70. 931-931 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 加藤一郎: "CD38ノックアウトマウスの作製とその膵β細胞のグルコース刺激インスリン分泌の低下" 糖尿病. 41. 136-136 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中沢哲也: "IRF-1欠損NODマウスにおける膵島炎及び糖尿病発症の抑制" 糖尿病. 41. 147-147 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 秋山貴子: "IL-6とDexamethasoneによる膵β細胞のRegI遺伝子の発現誘導" 糖尿病. 41. 389-389 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 黒木実智雄: "膵ランゲルハンス島のリアノジン受容体型Ca^<2+>チャンネルcDNAの単離と構造決定" 糖尿病. 41. 391-391 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中沢哲也: "cyclin ADP-ribose結合蛋白質(FK506-binding protein)遺伝子の構造と染色体座位" 糖尿病. 41. 434-434 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] David J.Gross: "Treatment of diabetes in NOD mice by Reg peptide." 糖尿病. 41. 126-126 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 岡本 宏: "Reg遺伝子と膵再生" 第111回日本医学会シンポジウム記録集. 42. 83-91 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 高沢 伸: "糖尿病患者における抗REGI自己抗体の存在" 糖尿病. 42(印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 山本靖彦: "ヒトRAGEをトランスジーンとしたマウスの糖尿病性腎病変" 糖尿病. 42(印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松井加奈: "PCR-RFLP方によるCD38遺伝子変異の検出" 糖尿病. 42(印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 阿部倫明: "新しいReg遺伝子(Reg IIIδ)の発見:その構造決定とマウスRegファミリーの遺伝子地図の作製" 糖尿病. 42(印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Naoya Noguchi: "Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca^2 from islet microsomes." Journal of Biological Chemistry. 272. 3133-3136 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akira Tohgo: "Lysine 129 of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose) participates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase." Journal of Biological Chemistry. 272. 3879-3882 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Satoru Ebihara: "Role of cyclic ADP-ribose in ATP-activated potassium currents in alveolar macrophage." Journal of Biological Chemistry. 272. 16023-16029 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Haruhiro Higashida: "Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell membranes." Journal of Biological Chemistry. 272. 31272-31277 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Toshinari Takamura: "Transgenic mice overexpressing type 2 nitric oxide synthase in pancreatic β cells develop insulin-dependent diabetes without insulits." Journal of Biological Chemistry. 273. 2493-2496 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shin Takasawa: "Cyclic ADP-ribose and inositol 1,4,5-trisphosphate as alternate second messengers for intracellular Ca2_+mobilization in normal and diabetic β-cells." Journal of Biological Chemistry. 273. 2497-2500 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiroshi Okamoto: "The CD38-cyclic ADP-ribose signalling system in insulin secretion : molecular basis and clinincal implications." Diabetologia. 40. (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yoichi Narushima: "Structure,chromosomal localization and expression of mouse genes encoding type III Reg,Reg,IIIα,Reg IIIβ,Reg IIIγ." Gene. 185. 159-168 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Koji Nata: "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase):organization,nucleotide sequence and altemative splicing" Gene. 186. 285-292 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiroshi Okamoto: "The CD38-Cyclic ADP-Ribose Signaling System in Insulin Secretion" Molecular and Cellular Biochemistry. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Claus J.Fimmel: "Differential expression of the ribosomal S15/rig protein by rat hepatic stellate cells" Hepatology. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Cyclic ADP-ribose-mediated insulin secretion and Reg,regenerating gene." Jornal of Molecular Medicine. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiroshi Okamoto: "The cyclic ADP-ribose-CD38 signaling system." Japanese Journal Pharmacology. 73. 30P-30P (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kazuo Yagui: "CD38 gene Arg140Trp mutation in Japanese subjects with NIDDM." Diabetes. 46. 174A-174A (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Identification of cyclic ADP-ribose-binding protein in ryanodine receptor of islet microsomes." Diabetes. 46. 214A-214A (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] David J.Gross: "Treatment of advanced diabetes in NOD mice by immunomodulation and expansion of B-cell mass : a combined approach." Experimental and Clinical Endoclinology and Diabetes. 105. 72-73 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiroshi Okamoto: "The role of Reg genes : Geneic introduction of human REGI and/or administration of REGI product may be effective in the prevention and cure of diabetes in man." Experimental and Clinical Endoclinology and Diabetes. 105. A12-A13 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in diabetic patients." Diabetologia. 40. A108-A108 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] David J.Gross: "Amelioration of diabetes in NOD mice with advanced disease by Linomide induced immunomodulation combined with reg protein treatment." Endocrinology. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kazuo Yagui: "A missense mutayion in the CD38 gene,a novel factor for insulin secretion Association with Japanese NIDDM subjects and evidence of abnormal function when expressed in vitro." Diabetologia. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 海野倫明: "Reg遺伝子とその産物Reg蛋白質の構造と機能-新しい糖尿病治療への展望を求めて-" 日本臨床. 55. 817-821 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 那谷耕司: "マウスRegI遺伝子を過剰発現する膵β細胞の増殖能:トランスジェニックマウスを用いた解析" 糖尿病. 40. 209-209 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 東郷 暁: "ATPによる膵β細胞内cyclic ADP-ribose生成の調節機構の解明" 糖尿病. 40. 211-211 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 野口 直哉: "膵β細胞のyclic ADP-ribose感受性Ca2_+チャンネルからのCa2_+放出機構:FK506結合タンパク質の関与" 糖尿病. 40. 211-211 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 八木一夫: "NIDDMにおけるCD38遺伝子異常の検索と変異Arg140Tro-CD38の検討" 糖尿病. 40. 333-333 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 金塚 東: "NIDDMにおけるCD38遺伝子ミスセンス変異" 糖尿病. 40. 120-120 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 岡本 宏: "新しい細胞内情報伝達系 "The CD38-cyclic ADP‐ribose signal system"" 生化学. 69. 519-519 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 高沢 伸: "サイクリックADPリボースをセカンドメッセンジャーとするインスリン分泌" 生化学. 69. 525-525 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 東郷 暁: "CD38(ADP‐ribosyl cyclase/cyclic ADP-ribose hydrolase)のATPによる活性調節機構の解明" 生化学. 69. 638-638 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 野口直哉: "FK506結合蛋白質12.6を介するcyclic ADP-ribose感受性Ca^<2+>+チャンネルからのCa^<1+>+放出" 生化学. 69. 638-638 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 中沢哲也: "ヒトFK506-binding protein 12遺伝子の構造と染色体座位" 生化学. 69. 638-638 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 佐々木 司: "ラット肺胞マクロファージのATP惹起K_+電流におけるサイクリックADPリポ-ズ(cADPR)の関与" 生化学. 69. 638-638 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 唐沢忠宏: "A群連鎖球菌NAD分解酵素遺伝子のクローニング" 生化学. 69. 638-638 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 野口直哉: "Fk506結合蛋白質のcyclic ADP-ribose結合活性とその生理作用" 生化学. 69. 1319-1319 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 東郷 暁: "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase(CD38)のATPによる調節とその分子機構" 生化学. 69. 1319-1319 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 篁 俊成: "NO合成酵素(iNOS)を膵β細胞で常時発現するトランスジェニックマウス" 分子糖尿病学. 8(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 秋山貴子: "RegI遺伝子の膵ランゲルハンス島β細胞における発現機構" 分子糖尿病学. 8(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 秋山貴子: "IL-6とDexamethasoneによる膵β細胞のRegI遺伝子の発現誘導" 糖尿病. 41(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 黒木実智雄: "膵ランゲルハンス島のリアノジン受容体型Ca^<1+>チャンネルcDNAの単離と構造決定" 糖尿病. 41(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 中沢哲也: "cyclic ADP-ribose結合蛋白質(FK506-binding protein)遺伝子の構造と染色体座位" 糖尿病. 41(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 加藤一郎: "CD38ノックアウトマウスの作製と膵β細胞のグルコース刺激インスリン分泌の低下" 糖尿病. 41(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Methods in Enzymology (Vitamins and Coenzymes,Part J)" D.B.McCormic,J.W.Suttie and C.Wagner (Academic Press), 306-318 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Naoya Noguchi: "Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca^<2+> from islet microsomes." Journal of Biological Chemistry. 272. 3133-3136 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Akira Tohgo: "Lysine 129 of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose) paricipates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase." Journal of Biological Chemistry. 272. 3879-3882 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nathalie J. Beaza: "Pancreatic regenerating gene overexpression in the nonobese diabetic mouse during active diabetogenesis." Diabetes. 45. 67-70 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hideto Yonekura: "Identification of the five essential histidine residues for peptidylglycine monooxygenase." Biochemical and Biophysical Research Communications. 218. 495-499 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Noriko Kimura: "Deficiency of phenylethanolamine N-methyltransferase in norepinephrine-producing pheochromocytoma." Endocrine Pathology. 7. 131-136 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Masakyo Asahara: "Reg gene expression is increased in rat gastric enterochromaffin-like cells following water immersion stress." Gastroenterology. 111. 45-55 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ichiro Kato: "Enhancement of glucose-induced insulin secretion in transgenic mice overexpressing human VIP gene-in pancreatic β cells." Annals of New York Academy of Sciences. 805. 232-243 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Makoto Kawase: "Inducible nitric oxide synthase following hypoxia in rat cultured glial cells." Brain Research. 738. 319-322 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoichi Narushima: "Structure, chromosomal localization and expression of mouse genes encoding type III Reg, Reg IIIα, Reg IIIβ, Reg IIIγ." Gene. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koji Nata: "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) : organization, nucleotide sequnece and alternative splicing." Gene. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Satoru Ebihara: "Role of cyclic ADP-ribose in ATP-activated potassium currents in alveolar macrophages." Journal of Biological Chemistry. 272 (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Claus J. Fimmel: "Differential expression of the ribosomal S15/rig protein by rat hepatic stellate cells." Hepatology. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hiroshi Okamoto: "Cyclic ADP-ribose-mediated insulin secretion and Reg, regenerating gene." Jornal of Molecular Medicine. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Miki Fujimura: "Attenuation of nitric oxide synthase induction in IRF-1-deficient glial cells." Brain Research. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 高沢 伸: "膵β細胞小胞体からのcyclic ADP-riboseによるCa^<2+>放出のCaM kinase IIによる増強" 糖尿病. 39. 182-182 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 東郷 暁: "ATPは直接CD38に作用してcyclic ADP-ribose分解活性を抑制する" 糖尿病. 39. 183-183 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 池端史子: "糖尿病患者における抗CD38 (cyclic ADP-ribose合成・分解酵素)自己抗体の存在" 糖尿病. 39. 183-183 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 成島陽一: "ヒトREGファミリーの4つの遺伝子は第2染色体短腕12上の95kbp内に隣接して存在する" 糖尿病. 39. 491-491 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 那谷耕司: "cyclic ADP-ribose 依存性 Ca^<2+> 放出のCaM kinase IIによる増強" 生化学. 68. 837-837 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 東郷 暁: "CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase)の基質(NAD, cyclic ADP-ribose)と調節物質(ATP)の結合部位" 生化学. 68. 837-837 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 唐沢忠宏: "A群レンサ球菌NAD分解酵素のcyclic ADP-ribose代謝活性" 生化学. 68. 838-838 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 篁 俊成: "誘導型NO合成酵素をインスリン産生細胞で過剰発現するトランスジェニックマウスの作成とその解析" 生化学. 68. 1015-1015 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 成島陽一: "Reg遺伝子ファミリーは染色体上、極めて隣接した領域に存在する" 生化学. 68. 1268-1268 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 野口直哉: "cyclic ADP-riboseを介する情報伝達のCaM kinase IIによる活性化" 生化学. 68. 1740-1740 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 成島陽一: "ヒトREGファミリー遺伝子の構造と染色体座位:ヒトREGファミリーの4つの遺伝子は全て第2染色体短腕12の95kbpの範囲に存在する" 生化学. 68. 1740-1740 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 篁 俊成: "NO合成酵素(iNOS)を膵β細胞で常時発現するトランスジェニックマウス" 分子糖尿病学. 7 (印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 東郷 暁: "インスリン分泌のセカンドメッセンジャーcyclic ADP-riboseの合成・分離酵素(CD38)のATPによる調節の分子機構" 分子糖尿病学. 7 (印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 那谷耕司: "マウスReg遺伝子を過剰発現する膵β細胞の増殖能:トランスジェニックマウスを用いた解析" 糖尿病. 40 (印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 野口直哉: "膵β細胞のcyclic ADP-ribose感受性Ca^<2+>チャンネルからのCa^<2+>放出機構:FK506結合蛋白質の関与" 糖尿病. 40 (印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 東郷 暁: "ATPによる膵β細胞内cyclic ADP-ribose生成の調節機構の解明" 糖尿病. 40 (印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 金塚 東: "NIDDMにおけるCD38遺伝子ミスセンス変異" 糖尿病. 40 (印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 八木一夫: "NIDDMにおけるCD38遺伝子変異と変異CD38の機能異常" 糖尿病. 40 (印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hiroshi-Okamoto: "The OKAMOTO model for B-cell damafe :recent advances. in Lessons from Animal Diabetes VI" Eleazar Shafrir (Birkhauser), 97-111 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hiroshi-Okamoto: "Methods in Enzymology (Vitamins and Coenzymes, Part J)" D. B. McCormic, J. W. Suttie and C. Wagner (Academic Press) (in press), (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2018-03-28  

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