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Molecular Mechanism of Insect Metamorphosis and Diapause

Research Project

Project/Area Number 08276103
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionNAGOYA UNIVERSITY

Principal Investigator

YAMASHITA Okitsugu  Nagoya University, Graduate School of Bioagricultural Sciences, Professor, 大学院・生命農学研究科, 教授 (50023411)

Co-Investigator(Kenkyū-buntansha) SUZUKI Akinori  Akita Prefectural University, President, 学長 (90011907)
KUBO Takeo  University of Tokyo, Graduate School of Pharmaceutical Sciences, Associate Professor, 大学院・薬学系研究科, 助教授 (10201469)
KATAOKA Hiroshi  University of Tokyo, Graduate School of Frontier Sciences, Professor, 大学院・新領域創成科学研究科, 教授 (60202008)
NATORI Syunji  RIKEN, Natori Industry-Sponsored Laboratory, Invited Chief Scientist, 特別研究員 (50012662)
NAGASAWA Hiromichi  University of Tokyo, Graduate School of Agricultural and Life Sciences, Professor, 大学院・薬学生命科学研究科, 教授 (60134508)
藤田 恒夫  日本歯科大学, 新潟歯学部, 教授 (00032863)
日高 敏隆  滋賀県立大学, 学長 (70014892)
堀田 凱樹  国立遺伝研究所, 所長 (30010036)
竹市 雅俊  京都大学, 大学院・理学研究科, 教授 (00025454)
桜井 勝  金沢大学, 理学部, 教授 (80143874)
Project Period (FY) 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥82,600,000 (Direct Cost: ¥82,600,000)
Fiscal Year 2000: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 1998: ¥19,600,000 (Direct Cost: ¥19,600,000)
Fiscal Year 1997: ¥19,700,000 (Direct Cost: ¥19,700,000)
Fiscal Year 1996: ¥25,900,000 (Direct Cost: ¥25,900,000)
Keywordsinsect / metamorphosis / diapause / hormone / neurosecretion / non-self recognition / gene expression / environmental response / 神経ペプチドホルモン / ホルモン受容体 / ペプチドホルモン / プロテアーゼ / 生体防御 / 分子認識 / 再生 / 幼若ホルモン / 受容体
Research Abstract

The research project "Molecular Mechanism of Insect Metamorphosis and Diapause" (abbreviated as metamorphosis and diapause mechanism) was conducted for 4 years from 1996 to 1999 by 62 scientists in various fields. This project took aim at the molecular analysis of metamorphosis and diapause of insects that are the essential events supporting the prosperity of insects in this planet. Toward this goal research proposals employing molecular genetics, biochemical analysis, cellular biology and environmental physiology were encouraged, and large members of new genes and components responsible for synthesis of neuropeptide hormone, for its action, for non-self recognition of larval tissues, for social differentiation of honey bees and for environmental response. Part of research achievements was made public in an open symposium ; "University and Sciences" organized by the Ministry of Education, Science, Sports and Culture. Core members of this project have examined and summarized the results obtained by research members. Thc outline of the results has been presented to the authority for the final evaluation of research activity. Finally, the research activity of this project was collectively compiled to the booklet to distribute to a large number of scientists, specialists and offices in the related field.

Report

(6 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] H.Kataoka et al.: "Cloning and sequence analysis of cDNA for diuretic hormone receptor from the Bombyx mori."Mol.Cells. 10. 13-17 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kataoka et al.: "Molecular characterization of a cDNA from the true army worm pseudaletia unipuncta encoding manduca sexta allatotropin peptide."Insect Biochem.Mol.Biol.. 30. 691-702 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Arai et al.: "Identification, characterization and cDNA cloning of two novel proteins secreted into the external space of the regenerating leg of Periplaneta americana."Insect Biochem.Molec.Biol.. 30. 287-295 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Kamikouchi et al.: "Concentrated expression of Ca2+/calmodulin-dependent protein kinase II and protein kinase C in the mushroom bodies of the brain of the honeybee Apis mellifera L."J.Comp.Neurol.. 417. 501-510 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Shiomi et al.: "Structure of the VAP-peptide (BmACP-6.7) gene in the silkworm, Bombyx mori and a possible regulation of its expression by BmFTZ-F1."Insect Biochem.Molec.Biol.. 30. 119-125 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Ishida et al.: "The cis-regulatory region responsible for the BomDH-PBAN gene expression in FXPRLamide peptide producing neurosecretory cells of the transformed Drosophila."J.Seric.Sci.Jpn.. 69. 111-119 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kataoka et al.: "Cloning and sequence analysis of cDNA for diuretic hormone receptor from the Bombyx mori."Mol. Cells. 10. 13-17 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kataoka et al.: "Molecular characterization of a cDNA from the true army worm pseudaletia unipuncta encoding manduca sexta allatotropin peptide."Insect Biochem.Mol.Biol.. 30. 691-702 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Arai et al.: "Identification, characterization and cDNA cloning of two novel proteins secreted into the external space of the regenerating leg of Peripaneta americana."Insect Biochem.Molec.Biol.. 30. 287-295 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Kamikouchi et al.: "Concentrated expression of Ca^<2+> calmodulin-dependent protein kinase II and protein kinase C in the mushroom bodies of the brain of the honeybee Apis mellifera L."J.Comp.Neurol.. 417. 501-510 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Shiomi et al.: "Structure of the VAP-peptide (BmACP-6.7) gene in the silkworm, Bombyx mori and a possible regulation of its expression by BmFTZ-F1."Insect Biochem.Molec.Biol.. 30. 119-125 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Ishida et al.: "The cis-regulatory region responsible for the BomDH-PBAN gene expression in FXPRLamide peptide producing neurosecretory cells of the transformed Drosophila."J.Seric.Sci.Jpn.. 69. 111-119 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kataoka et al.: "Cloning and sequence analysis of cDNA for diuretic hormone receptor from the Bombyx mori"Mol.Cells. 10. 13-17 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Kataoka et al.: "Molecular characterization of a cDNA from the true army worm pseudaletia unipuncta encoding manduca sexta allatotropin peptide."Insect Biochem.Mol.Biol.. 30. 691-702 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Arai et al.: "Identification, characterization and cDNA cloning of two novel proteins secreted into the external space of the regenerating leg of Periplaneta americana"Insect Biochem.Molec.Biol.. 30. 287-295 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] A.Kamikouchi et al.: "Concentrated expression of Ca2+/ calmodulin-dependent protein kinase II and protein kinase C in the mushroom bodies of the brain of the honeybee Apis mellifera L."J.Comp.Neurol.. 417. 501-510 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Shiomi et al.: "Structure of the VAP-peptide (BmACP-6.7) gene in the silkworm, Bombyx mori and a possible regulation of its expression by BmFTZ-F1."Insect Biochem.Molec.Biol.. 30. 119-125 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.Ishida et al.: "The cis-regulatory region responsible for the BomDH-PBAN gene expression in FXPRLamide peptide producing neurosecretory cells of the transformed Drosophila"J.Seric.Sci.Jpn.. 69. 111-119 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] S. G. Dedos: "Differences between recombinant PTTH and crude brain extracts in cAMP-mediated ecdysteroid secreation from the prothoracic glands of the silkworm, Bomyx mori"J. Insect Physiol.. 45. 415-422 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y. Fujimoto: "Two subunits of 26/29-dDa proteinase are probably derived from a common precursor protein"J. Biochem.. 125. 566-573 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] S. D. Ha: "Isolation and structure determination of a paralytic peptide from the hemolymph of Bombyx mori"Peptides. 20. 561 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y. Ishida: "The stage- and cell-specific expression of the Bombyx mori diapause hormone-pheromone biosynthesis activating neuropeptide (BomDH-PBAN)gene in the transformed Drosophila"J. Seric. Sci. Jpn.. 68(5). 417-427 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K. Ohashi: "Expression of amylase and glucose oxidase in the hypopharyngeal gland of the worker honeybee (Apis mellifera L.)"Eur. J. Biochem.. 265. 127-133 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K. Matsumoto: "Phosphocarrier protein in an intracellular symbiotic bacterium of aphids"J. Biochem.. 126. 578-583 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y.Sato: "Phe-X-Pro-Arg-Leu-NH_2 peptide producing cells in the central nervous system of the silkworm,Bombyx mori." J.Insect Physiol.44. 333-342 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.Nakabachi: "Provision of riboflavin by endosymbionts to the host aphid,Acyrthosiphon pisum." J.Insect Physiol.45. 1-6 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Y.Choi: "Isolation and identification of the cDNA encoding the pheromone biosynthesis activating neuropeptide and additional neuropeptides in the oriental tobacco budworm,Helicoverpa assulta(Lepidoptera:Noctuidae)." Insect Biochem.Molec.Biol.28. 759-766 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.Kamikouchi: "Preferential expression of the gene for a putative inositol 1,4,5-triphosphate receptor homologue in the mushroom bodies of the brain of the worker honeybee Apis mellifera L." Biochem.Biophys.Res.Commun.242. 181-186 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] I.Yoshida: "A novel member of bombyxin gene family:structure and expression of bombyxin G1 gene,an insulin-related peptide gene of the silkmoth Bombyx mori." Dev.Genes Evol.208・7. 407-410 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Fujita: "A novel lectin from Sarcophaga." J.Biol.Chem.273. 9697-9672 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Kunieda et al.: "Regeneration of Sarcophaga imaginaldiscs in vitro: Implication of 20‐hydroxy‐ecdyson." Dev.Biol.183. 86-93 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] N.Makiet al.: "Purification and characterization of a protease degrading 30kDa yolk proteins of the silkworm,Bombyx mori." Insect Biochem.Molec.Biol.27. 721-728 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y.Nakajima et al.: "A novel protease in the pupal yellow body of Sarcophaga peragrina(flesh fly)." J.Biol.Chem.272. 23805-23810 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Ohashi et al.: "Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L." Eur.J.Biochem.249. 797-802 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Satake et al.: "Bombyxin,an Insulin‐Related Peptide of Insects,Reduces the Major Strage Carbohydrates in the Silkworm Bombyx mori." Comp.Biochem.Physiol.118B・2. 349-357 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Tsuzuki et al.: "Structure and expression of bombyxin El gene,a novel family gene that encodes bombyxin‐IV,an insect insulin‐related neurosecretory peptide." Comp.Biochem.Physiol.117B・3. 409-416 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Rybczynski,R.et al.: "Bombyx and Manduca prothoracico tropic hormone : an immunologic test for relatedness." Gen.Comp.Endocri.102. 247-354 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Akai,H.et al.: "Development and secretary functiono f neurosecretory A cell in brain of Bombyx mori." Arch.Insect Biochem.Physiol.32. 333-340 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kubo,T.: "Insect lectins and epimorphosis." Trends in Glycosci.Glycotech.8. 357-364 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 久保健雄: "ミツバチの分子社会生物学" 化学と生物. 34. 793-798 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Homma,K.et al.: "Identification of substrate proteins for cathepsin L that are selectively hydrolyzed during the differentiation of imaginal discs of Sarcophaga peregrina." Eur.J.Biochem.240. 443-447 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Iwami,M.et al.: "Bombyxin gene expression in tissues other thatn brain detected by reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridzation." Experimentia. 52. 882-887 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sasaki,T.et al.: "Nitrogen recycling in the brown planthopper,Nilaparvata lugens : involvement of yeastlike endosymbionts in uric acid metabolism." J.Insect Physiol.42. 125-129 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Harada,H.et al.: "A consideration about the origion of aphid intra-symbiont in connection with gut bacteria flora." J.Gen.Appl.Microbiol.42. 17-42 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Komaki,K.et al.: "A characteristic defference among GroEL homologues from intracellular symbionts of closely-intrarelated species of aphid." Zool.Sci.13. 320-323 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Imai,K.et al.: "Isolation and partial structure of a unique lipophilic peptide,VAP peptide,from the heads of male silkworm moth." Biosci.Biotechnol.Biochem.60. 355-357 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Niimi,T.et al.: "Structure of the Bombyx sorbitol dehydrogenease gene : a possible alternative use of the promoter." Insect Molec.Biol.5. 269-280 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yanashita,O.: "Diapause hormone of the silkworm,Bombyx mori : structure,gene expression and function." J.Insect Physiol.42. 669-679 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2019-02-15  

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