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Dynamics of chromosome partition apparatus

Research Project

Project/Area Number 08277104
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionInstitute of Molecular Embryology and Genetics, Kumamoto University

Principal Investigator

HIRAGA Sota  Institute of Molecular Embryology and Genetics, Kumamoto University Professor, 発生医学研究センター, 教授 (40027321)

Co-Investigator(Kenkyū-buntansha) WACHI Masaaki  Department of Bioengineeing, Tokyo Institute of Technology, Associate Professor, 生命理工学部, 助教授 (90192822)
OHYA Yoshikazu  Graduate School of Science, University of Tokyo, Professor, 大学院・新領域創成科学研究科, 教授 (20183767)
OGURA Teru  Institute of Molecular Embryology and Genetics, Kumamoto University Associate Professor, 発生医学研究センター, 助教授 (00158825)
NISHIMURA Akiko  Genetic Strains Research Center, National Institute of Genetics, Associate Professor, 助教授 (20142002)
HORIUCHI Takashi  National Institute for Basic Biology, Professor, 教授 (60108644)
加藤 潤一  東京大学, 医科学研究所, 助手 (10194820)
岡崎 恒子  藤田保健衛生大学, 医学部, 教授 (10022584)
松澤 洋  東京大学, 大学院・農学生命科学研究科, 教授 (00011966)
永井 和夫  東京工業大学, 生命理工学部, 教授 (00011974)
Project Period (FY) 1996 – 1999
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥253,400,000 (Direct Cost: ¥253,400,000)
Fiscal Year 1999: ¥61,100,000 (Direct Cost: ¥61,100,000)
Fiscal Year 1998: ¥63,200,000 (Direct Cost: ¥63,200,000)
Fiscal Year 1997: ¥66,000,000 (Direct Cost: ¥66,000,000)
Fiscal Year 1996: ¥63,100,000 (Direct Cost: ¥63,100,000)
Keywordschromosome segregation / chromosome partitioning / control of replication initiation / cohesion of sister chromosomes / replication origin / DNA methylation / centromere / plasmid partitioning / 細胞周期 / 複製開始 / SeqA / DnaA / 大腸菌染色体 / 免疫蛍光顕微鏡法 / oriCDNA / ミニFプラスミドDNA / 枯草菌 / 人工ミニ染色体 / ヒトセントロメア / 細胞分裂 / トポイソメラーゼ / プロテアーゼ / モーター蛋白 / 修飾環 / ヒストン様蛋白
Research Abstract

The ultimate goal of this research proposal is to understand molecular mechanisms of segregation of sister chromosomes in both prokaryotes and eukaryotes. During this research period, we have developed new cytological microscopy techniques to visualize specific proteins and DNA segments in small prokaryotic cells. Using these techniques, we have found as follows. The plasmid partition system, which is controlled by two plasmid gene products and the cis-acting site, determines subcellular locations of plasmid DNA molecules at the 1/4 and 3/4 cell positions prior to cell division. The replication origin oriC is replicated at the middle cell position and the sister chromosomes are cohesive with each other for an appropriate period of the generation time in E.coli. After releasing from the cohesion in the late period of replication, the oriC sister copies migrate to pole proximal ends of the nucleoid. Terminal DNA segments are located at division site before the cell divides. The subcellular localization of SeqA, which binds hemimethylated nascent DNA, supports the model 'translocating replication factories' in E.coli. The MukF-MukE-MukB protein complex of E.coli and the Smc protein of B.subtilis participate in segregation of sister chromosomes and maintenance of the folded chromosome structure. Three different regulatory mechanisms of replication initiation have been found in the E.coli ; hydrolysis of DnaA-binding ATP by DNA polymerase III, competitive inhibition of the binding of DnaA and the hemimethylated oriC region by SeqA, and trapping a large amount of DnaA in datA sister copies. In human chromosome, the centromere region and its DNA-protein complex were precisely analyzed. Specific proteins involved chromosome segregation and protein kinases involved in the M period were found in eukaryotes.

Report

(5 results)
  • 2000 Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (153 results)

All Other

All Publications (153 results)

  • [Publications] Inoue,Y.H., M.do Carmo Avides, et al.: "Orbit, a novel microtubule-associated protein essential for mitosis in Drosophila melanogaster."J Cell Biol. 149. 153-166 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Imai,Y., N.Ogasawara, et al.: "Subcellular localization of Dna-initiation proteins of Bacillus subtilis : evidence that chromosome replication begins at either edge of the nucleoids."Mol Microbiol. 36. 1037-1048 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohashi,K., K.Nagata, et al.: "Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop."J Biol Chem. 275. 3577-3582 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Niki,H., Y.Yamaichi, et al.: "Dynamic organization of chromosomal DNA in Escherichia coli."Genes Dev. 14. 212-223 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoda,K., S.Ando, et al.: "Human centromere protein A (CENP-A)can replace histone H3 in nucleosome reconstitution in vitro."Proc Natl Acad Sci USA. 97. 7266-7271 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hiraga,S., C.Ichinose, et al.: "Bidirectional migration of SeqA-bound hemimethylated DNA clusters and pairing of oriC copies in Escherichia coli."Genes Cells. 5. 327-341 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Masumoto,H., A.Sugino, et al.: "Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast."Mol Cell Biol. 20. 2809-2817 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ashizawa,Y., T.Yokochi, et al.: "Mechanism of DNA gyrase-mediated illegitimate recombination : characterization of Escherichia coli gyrA mutations that confer hyper-recombination phenotype."J Mol Biol. 289. 447-458 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamada,T., R.Fukuda, et al.: "Functioonal domain structure of human heterochromatin protein HPI (Hsalpha) : involvement of internal DNA-binding and C-terminal self-association domains in the formation of discrete dots in inte hase nuclei."J Biochem (Tokyo). 125. 832-837 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Karata,K., T.Inagawa, et al.: "Dissecting the role of conserved motif (the second region of homology) in the AAA family of ATPases. Site-directed mutagenesis of the ATP-dependent protease FtsH."J Biol Chem. 274. 26225-26232 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kanemaki,M., Y.Kurokawa, et al.: "TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a."J Biol Chem. 274. 22437-22444 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamazoe,M., T.Onogi, et al.: "Complex formation of MukB, MukE and MukF proteins involved in chromosome partitioning in Escherichia coli."EMBO J. 18. 5873-5884 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] McEwen,R.K., S.K.Dove, et al.: "Complementation analysis in PtdlnsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fablp homologues are phosphatidylinositol 3-phosphate 5-kinases."J Biol Chem. 274. 33905-33912 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Wachi,M., G.Umitsuki, et al.: "Escherichia coli cafA gene encodes a novel RNase, designated as RNase G, involved in processing of the 5'end of 165 rRNA."Biochem Biophys Res Commun. 259. 483-488 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Inoue,S.B., H.Qadota, et al.: "Prenylation of Rho 1p is required for activation of yeast 1, 3-beta-glucan synthase."J Biol Chem. 274. 38119-38124 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sugata,N., E.Munekata, et al.: "Characterization of a novel kinetochore protein, CENP-H."J Biol Chem. 274. 27343-27346 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nishito,Y., H.Usui, et al.: "Interconversion of Mn(2+)-dependent and-independent protein phosphatase 2A from human erythrocytes : role of Zn(2+) and Fe(2+) in protein phosphatase 2A."J Biochem (Tokyo). 126. 632-638 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kobayashi,T., D.J.Heck, et al.: "Expansion and contraction of ribosomal DNA repeats in Saccharctmyces cerevisiae : requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I."Genes Dev. 12. 3821-3830 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ukai,H., H.Matsuzawa, et al.: "ftsE (Ts) affects translocation of K+-pump proteins into the cytoplasmic membrane of Escherichia coli."J Bacteriol. 180. 3663-3670 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kitagawa,R., T.Ozaki, et al.: "Negative control of replication initiation by a novel chromosomal locus exhibiting exceptional affinity for Escherichia coli DnaA protein."Genes Dev. 12. 3032-3043 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Homma,K., S.Terui, et al.: "Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis."J Biol Chem. 273. 15779-15786 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoda,K., S.Ando, et al.: "In vitro assembly of the CENP-B/alpha-satellite DNA/core histone complex : CENP-B causes nucleosome positioning."Genes Cells. 3. 533-548 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Niki,H. and S.Hiraga: "Polar localization of the replication origin and terminus in Escherichia coli nucleoids during chromosome partitioning."Genes Dev. 12. 1036-1045 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Moriya,S., E.Tsujikawa, et al.: "A Bacillus subtilis gene-encoding protein homologous to eukaryotic SMC motor protein is necessary for chromosome partition."Mol Microbiol. 29. 179-187 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Masumoto,H., M,Ikeno, et al.: "Assay of cenatromere function using a human artificial chromosome."Chromosoma. 107. 406-416 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hiraga,S., C.Ichinose, et al.: "Cell cycle-dependent duplication and bidirectional migration of SeqA- associated DNA-protein complexes in E.coli."Mol Cell. 1. 381-387 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Eguchi,S., K.Numaguchi, et al.: "Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells."J Biol Chem. 273. 8890-8896 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamashino,T., M.Isomura, et al.: "The yhhP gene encoding a small ubiquitous protein is fundamental for normal cell growth of Escherichia coli."J Bacteriol. 180. 2257-2261 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Oishi,I., S.Sugiyama, et al.: "A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling."J Biol Chem. 272. 11916-11923 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Niki,H. and S.Hiraga: "Subcellular distribution of actively partitioning F plasmid during the cell division cycle in E.coli."Cell. 90. 951-957 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoda,K. and T.Okazaki: "Site-specific base deletions in human alpha-satellite monomer DNAs are associated with regularly distributed CENP-B boxes."Chromosome Res. 5. 207-211 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Makino,S., J.N.Qu, et al.: "A silent mutation in the fisH gene of Escherichia coli that affects FtsH protein production and colicin tolerance."Mol Gen Genet. 254. 578-583 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kitagawa,R., H.Mitsuki, et al.: "A novel DnaA protein-binding site at 94.7 min on the Escherichia coli chromosome."Mol Microbiol. 19. 1137-1147 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kataoka,K., T.Mizushima, et al.: "Heat shock-induced DNA relaxation in vitro by DNA gyrase of Escherichia coli in the presence of ATP."J Biol Chem. 271. 24806-24810 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukagawa,T., Y.Nakamura, et al.: "Human pseudoautosomal boundary-like sequences : expression and involvement in evolutionary formation of the present-day pseudoautosomal boundary of human sex chromosomes."Hum Mol Genet. 5. 23-32 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Inoue, Y.H., M.do Carmo Avides, M.Shiraki, P.Deak, M.Yamaguchi, Y.Nishimoto, A.Matsukage and D.M.Glover: "Orbit, a novel microtubule-associated protein essential for mitosis in Drosophila melanogaster."J Cell Biol. 149. 153-166 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Imai, Y., N.Ogasawara, D.Ishigo-Oka, R.Kadoya, T.Daito and S.Moriya: "Subcellular localization of Dna-initiation proteins of Bacillus subtilis : evidence that chromosome replication begins at either edge of the nucleoids."Mol Microbiol. 36. 1037-1048 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohashi, K., K.Nagata, M.Maekawa, T.Ishizaki, S.Narumiya and K.Mizuno: "Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop."J Biol Chem. 275. 3577-3582 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Niki, H., Y.Yamaichi and S.Hiraga: "Dynamic organization of chromosomal DNA in Escherichia coli."Genes Dev. 14. 212-223 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoda, K., S.Ando, S.Morishita, K.Houmura, K.Hashimoto, K.Takeyasu and T.Okazaki: "Human centromere protein A (CENP-A) can replace histone H3 in nucleosome reconstitution in vitro."Proc Natl Acad Sci USA. 97. 726-7271 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hiraga, S., C.Ichinose, T.Onogi, H.Niki and M.Yamazoe: "Bidirectional migration of SeqA-bound hemimethylated DNA clusters and pairing of oriC copies in Escherichia coli."Genes Cells. 5. 327-341 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Masumoto, H., A.Sugino and H.Araki: "Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast."Mol Cell Biol. 20. 2809-2817 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ashizawa, Y., T.Yokochi, Y.Ogata, Y.Shobuike, J.Kato and H.Ikeda: "Mechanism of DNA gyrase-mediated illegitimate recombination : characterization of Escherichia coli gyrA mutations that confer hyper-recombination phenotype."J Mol Biol. 289. 447-458 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamada, T., R.Fukuda, M.Himeno and K.Sugimoto: "Functional domain structure of human heterochromatin protein HP1 (Hsalpha) : involvement of internal DNA-binding and C-terminal self-association domains in the formation of discrete dots in interphase nuclei."J Biochem (Tokyo). 125. 832-837 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Karata, K., T.Inagawa, A.J.Wilkinson, T.Tatsuta and T.Ogura: "Dissecting the role of a conserved motif (the second region of homology) in the AAA family of ATPases. Site-directed mutagenesis of the ATP-dependent protease FtsH."J Biol Chem. 274. 26225-26232 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kanemaki, M., Y.Kurokawa, T.Matsu-ura, Y.Makino, A.Masani, K.Okazaki, T.Morishita and T.A.Tamura: "TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a."J Biol Chem. 274. 22437-22444 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamazoe, M., T.Onogi, Y.Sunako, H.Niki, K.Yamanaka, T.Ichimura and S.Huraga: "Complex formation of MukB, MukE and MukF proteins involved in chromosome partitioning in Escherichia coli."EMBO J. 18. 5873-5884 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] McEwen, R.K., S.K.Dove, F.T.Cooke, G.F.Painter, A.B.Holmes, A.Shisheva, Y.Ohya, P.J.Parker and R.H.Michell: "Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fablp homologues are phosphatidylinositol 3-phosphate 5-kinases."J Biol Chem. 274. 33905-33912 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Wachi, M., G.Umitsuki, M.Shimizu, A.Takada and K.Nagai: "Escherichia coli cafA gene encodes a novel RNase, designated as RNase G, involved in processing of the 5' end of 16S rRNA."Biochem Biophys Res Commun. 259. 483-488 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Inoue, S.B., H.Qadota, M.Arisawa, T.Watanabe and Y.Ohya: "Prenylation of Rholp is required for activation of yeast 1, 3-beta-glucan synthase."J Biol Chem. 274. 38119-38124 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sugata, N., E.Munekata and K.Todokoro: "Characterization of a novel kinetochore protein, CENP-H."J Biol Chem. 274. 27343-27346 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nishito, Y., H.Usui, O.Tanabe, M.Shimizu and M.Takeda: "Interconversion of Mn (2+)-dependent and -independent protein phosphatase 2A from human erythrocytes : role of Zn (2+) and Fe (2+) in protein phosphatase 2A."J Biochem (Tokyo). 126. 632-638 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kobayashi, T., D.J.Heck, M.Nomura and T.Horiuchi: "Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae : requirement of replication fork blocking (Fobl) protein and the role of RNA polymerase I."Genes Dev. 12. 3821-3830 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ukai, H., H.Matsuzawa, K.Ito, M.Yamada and A.Nishimura: "ftsE (Ts) affects translocation of K+-pump proteins into the cytoplasmic membrane of Escherichia coli."J Bacteriol. 180. 3663-3670 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kitagawa, R., T.Ozaki, S.Moriya and T.Ogawa: "Negative control of replication initiation by a novel chromosomal locus exhibiting exceptional affinity for Escherichia coli DnaA protein."Genes Dev. 12. 3032-3043 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Homma, K., S.Terui, M.Minemura, H.Qadota, Y.Anraku, Y.Kanaho and Y.Ohya: "Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis."J Biol Chem. 273. 15779-15786 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoda, K., S.Ando, A.Okuda, A.Kikuchi and T.Okazaki: "In vitro assembly of the CENP-B/alpha-satellite DNA/core histone complex : CENP-B causes nucleosome positioning."Genes Cells. 3. 533-548 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Niki, H.and S.Hiraga: "Polar localization of the replication origin and terminus in Escherichia coli nucleoids during chromosome partitioning."Genes Dev. 12. 1036-1045 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Moriya, S., E.Tsujikawa, A.K.Hassan, K.Asai, T.Kodama and N.Ogasawara: "A Bacillus subtilis gene-encoding protein homologous to eukaryotic SMC motor protein is necessary for chromosome partition."Mol Microbiol. 29. 179-187 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Masumoto, H., M.Ikeno, M.Nakano, T.Okazaki, B.Grimes, H.Cooke and N.Suzuki: "Assay of centromere function using a haman artificial chromosome."Chromosoma. 107. 406-416 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hiraga, S., C.Ichinose, H.Niki and M.Yamazoe: "Cell cycle-dependent duplication and bidirectional migration of SeqA-associated DNA-protein complexes in E.coli."Mol Cell. 1. 381-387 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Eguchi, S., K.Numaguchi, H.Iwasaki, T.Matsumoto, T.Yamakawa, H.Utsunomiya, E.D.Motley, H.Kawakatsu, K.M.Owada, Y.Hirata, F.Marumo and T.Inagami: "Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells."J Biol Chem. 273. 8890-8896 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamashino, T., M.Isomura, C.Ueguchi and T.Mizuno: "The yhhP gene encoding a small ubiquitous protein is fundamental for normal cell growth of Escherichia coli."J Bacteriol. 180. 2257-2261 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Oishi, I., S.Sugiyama, Z.J.Liu, H.Yamamura, Y.Nishida and Y.Minami: "A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling."J Biol Chem. 272. 11916-11923 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Niki, H.and S.Hiraga: "Subcellular distribution of actively partitioning F plasmid during the cell division cycle in E.coli."Cell. 90. 951-957 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoda, K.and T.Okazaki: "Site-specific base deletions in human alpha-satellite monomer DNAs are associated with regularly distributed CENP-B boxes."Chromosome Res. 5. 207-211 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Makino, S., J.N.Qu, K.Uemori, H.Ichikawa, T.Ogura and H.Matsuzawa: "A silent mutation in the ftsH gene of Escherichia coli that affects FtsH protein production and colicin tolerance."Mol Gen Genet. 254. 578-583 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kitagawa, R., H.Mitsuki, T.Okazaki and T.Ogawa: "A novel DnaA protein-binding site at 94.7 min on the Escherichia coli chromosome."Mol Microbiol. 19. 1137-1147 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kataoka, K., T.Mizushima, Y.Ogata, T.Miki and K.Sekimizu: "Heat shock-induced DNA relaxation in vitro by DNA gyrase of Escherichia coli in the presence of ATP."J Biol Chem. 271. 24806-24810 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukagawa, T., Y.Nakamura, K.Okumura, M.Nogami, A.Ando, H.Inoko, N.Saitou and T.Ikemura: "Human pseudoautosomal boundary-like sequences : expression and involvement in evolutionary formation of the present-day pseudoautosomal boundary of human sex chromosomes."Hum Mol Genet. 5. 23-32 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] .Hiraga S.: "Bidirectional migration of SeqA-bound hemimethylated DNA clusters and pairing of oriC copies in Escherichia coli"Genes Cdlls. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Niki H.: "Dynamic organization of chromosomal DNA in Escherichia coli"Genes Dev. 14. 212-223 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Niki H.: "細菌における分子細胞生物学の新展開-染色体分配と細胞分裂"蛋白質核酸酵素. 45. 153-163 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kotani S.: "Regulation of APC activity by phosphorylation and regulatory factors"J.Cell Biol.. 146. 791-800 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ashizawa Y.: "Mechanism of DNA gyrase-mediatedillegitimate recombination:Characterization of Escherichia coli gyrA mutations that confer hyperrecombination phenotype"J.Mol.Biol. 289. 447-458 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Wachi M.: "A murC gene from coryneform bacteria"Appl.Microbiol.Biotechnol.. 51. 223-228 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Wachi M.: "Escherichia coli cafA gene encodes a novel RNase,designated as RNaseG,involved in processing of the 5'end of 16SrRNA"Biochem.Biophys.Res.Commun.. 259. 483-488 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nagano K.: "fcsA29 mutation in an allele of polA gene of Escherichia coli"Biosci.Biotechnol.Biochem.. 63. 427-429 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sugimoto K.: "Visualization of prekinetochorelocus on the centromeric region of highly extended chromatin fibers:does kinetochore autoantigen CENP-C constitute a kinetochore organizing center?"Chromosome Res.. 7. 9-19 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamazoe,M.: "Complex formation of MukB,MukE and MukF proteins involved in chromosome partitioning in Escherichia coli"EMBO J.. 18. 5873-5884 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nishito Y.: "Direct metal analyses of Mn^<2+>-dependent and-independent protein phosphatase 2A from human erythrocytes detect zinc and iron only in the Mn^<2+>-independent one."FEBS Lett. 447. 29-33 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Guo L.: "Isolation adn characterization of nevel cold-sensitive dnaA mutants of Escherichia coli"FEBS Micribiol.Lett.. 176. 357-366 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Malatihi K.C.: "Isolation of the murI gene from Brevibacterium lactofermentum ATCC13869 encoding D-glutamate racemase."FEBS Microbiol.Lett.. 175. 193-196 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Lim Y.M.: "Genetic analysis of rolled,which encodes a Drosophila mitogen-activated protein kinase"Genetics. 153. 763-771 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ali Azam T.: "Growth phase-dependent variation in protein composition of the Escherichia coli nucleoid"J Bacteriol. 181. 6361-6370 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nihito Y.: "Interconversion of Mn^<2+>-dependent and-independent protein phosphatase 2A from human erythrocytes:role of Zn^<2+> and Fe^<2+> in protein phosphatase 2A"J Biochem(Tokyo). 126. 632-638 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Inoue R.: "Studies on functions of the 63-kDaA-and 74-kDaB'(delta)-regulatory subunits in human erythrocyte protein phosphatase 2A:dissociation and reassociation of the subunits"J Biochem(Tokyo). 126. 1127-1135 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] McEwen R.K.: "Complementation analysis in PtdlnsP kinase-deticient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases"J Biol Chem. 274. 33905-33912 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] InoueS.B.: "Prenylation of Rho1p is required for activation of yeast1,3-beta-glucan synthase."J Biol Chem. 274. 38119-38124 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kato J.: "The E.coli homologue of yeast Rer2,a key enzyme of dolichol synthesis,is essential for carrier lipid formation in bacterial cell wall synthesis"J Bacteriol. 181. 2733-2738 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamada T.: "Functional domain structure of human heterochromatin protein HP1(Hsalpha):involvement of internal DNA-binding and C-terminal self-association domains in the formation of discrete dots in interphase nuclei"J.Biochem.(Tokyo). 125. 832-837 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Karata K.: "Dissecting the role of a conserved motif(the second region of homology)in the AAA family of ATPases"J.Biol.Chem. 274. 26225-26232 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sugata N.: "Characterization of a novel kinetochore protein CENP-H"J.Biol.Chem. 274. 27343-27346 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Taki K.: "The SOS response is induced by replication fork blockage at a Ter site located on a pUC-derived plasmid:dependence on the deistance between ori and Ter sites"Mol Gen Genet. 262. 302-309 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Niki H.: "Subcellular localization of plasmids containing the oriC region of the Escherichia coli chromosome,with or without the sopABC partitioning sytem"Mol Microbiol. 34. 498-503 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sato M.: "The yeast RER2 gene,identified by ER protein localization mutations,encodes cis-prenyltransferase,a key enzyme in the dolichol synthesis"Mol.Cell.Biol.. 19. 471-483 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ogura T.: "alanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH(HfIB) in Escherichia coli"Mol.Microbiol. 31. 833-844 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Onogi T.: "The assembly and migration of SeqA-Gfp fusion in living cells of Escherichia coli"Mol.Microbiol. 31. 1775-1782 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kurasawa Y.: "Identification of human APC10/Doc 1 as a subunit of anaphase promoting complex"Oncogene. 18. 5131-5137 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamaguchi M.: "Ectopic expression of human p53 inhibits entry into S phase and induces apoptosis in the Drosophila eye imaginal disc"Oncogene. 18. 6767-6775 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kikyo M.: "An FH domain-containing Bnr1p is a multifunctional protein interacting with a variety of cytoskeletal proteins in Saccharomyces cerevisiae"Oncogene. 18. 7046-7054 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Moriya S.: "Regulation of initiation of Bacillus subtilis chromosome replication"Plasmid. 41. 17-29 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ohno M.: "間期核の染色体DNA中に存在する三重鎖構造とその機能"蛋白質核酸酵素. 44. 1757-1763 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Araki H.: "間期核の染色体DNA中に存在する三重鎖構造とその機能"蛋白質核酸酵素. 44. 1822-1829 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Niki,H.: "Polar of the replication origin and terminus in Escherichia coli nucleoids during chromosome partitioning." Genus&Development. 12. 1036-1045 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hirano,M.: "Autoregulation of the partition genus of mini-F plasmid and the intracellilar localization of their products in Escherichia coli." Mol.Gen.Genet.257. 392-403 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiraga,S.: "Cell cycle-dependent duplication and bidirectional migration of SeqA-associated DNA-protein comlexes in E.coli." Mol.Cell.1. 381-387 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Okano,H.: "Importance of Phenylalanine Residues of yeast Calmodulin for Target Binding and Activation." J.Biol.Chem.273. 26375-26382 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sekiya,-K.M.: "Identification of Functional Connections between Calmodulin and the yeast Actin Cytoskeleton." Genetics. 150. 43-58 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Homma,K.: "Phosphatidylinositol-4-Phosphate 5-Kinase Localized on the plasma Membrane Is Essential for Yeast Cell Morphogenesis." J.Biol.Chem.273. 15779-15786 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ukai,H.: "ftsE(Ts)affect translocation of K^+ -pump proteins into the membrane of Escherichia coli." J.Bacteriol.180. 3663-3670 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishimura,A: "Timing of cell division:Ap4A as the signal." TiBS. 23. 157-159 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Heo,S-j.: "The RHC21 gene of budding yeast,a homologue of the fission yeast rad21^+ gene,is essential for chromosome segregation." Mol.Gen.Genet.257. 149-156 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tatebayashi,K: "Isolation of a Schizosaccharomyces pombe rad21st mutant that is aberrant in chromosome segregation,microtubule function,DNA repair and sensetive to hydroxyurea:possible involvement of Rad21 in ubiquitinmediated proteolysis." Genetics. 148. 49-57 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamagata,K.: "Bloom's and Werner's syndrime genes suppress hyperrecombination in yeast sgs1 mutant:implication for genomic instability in human diseases." Proc.Natl.Acad.Sci.USA. 95. 8733-8738 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shanado,Y.: "Escherichia coli HU protein suppresses DNA gyrase-mediated illegitimate recombination and SOS induction." Genes to Cells. 3. 511-250 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Caplin B.E.: "Amino Acid Residues That Define Both the Isoprenoid and CAAX Preferences of the Saccharomyces cerevisiae Protein Farnesyltransferase.Creating the perfect farnesyltransferase." J.Biol.Chem.273. 9472-9479 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Helliwell,S.B.: "The RH01 effector PKC1,but not BNL1,mediates signalling from TOR2 to the actin cytoskeleton." Curr.Biol.22. 1211-1214 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kijima,N.: "Induction of only limited elongation instead of filamentation by inhibition of cell division in Corynebacterium glutamicum." Appl.Microbiol.Biotechnol.50. 227-232 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 和地正明: "コリネ型細菌の細胞複製機構の解析" バイオサイエンスとインダストリー. 56. 101-103 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 和地正明: "大腸菌の細胞周期と核様体タンパク質" バイオサイエンスとインダストリー. 56. 229-232 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kobayashi,T.: "Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae:requirement of replication fork blocking(Fobl)protein and the role of RNA polymerase I." Gene&Development. 12. 3821-3830 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kitagawa,R.: "Negative control of replication initiation by a novel chromosomal locus exhibiting exceptional affinity for Escherichia coli DnaA protein." Genes&Development. 12. 3032-3043 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mizushima,T.: "Site-directed mutational analysis for the ATP binding of DnaA prtein.Functions of two conserved amino acids(Lys-178 and Asp-235)located in the ATP-binding domain of DnaA protein in vitro and in vivo." J.Biol.Chem.273. 20847-20851 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hashimoto,Y.: "Construction of a yeast expression system with positive-selection in the absence of a specific phenotype." Gen. 207. 167-170 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoda,K.: "In vitro assembly of CENP-B/alpha-satellite DNA/core histon comlex:CENP-B causes nucleosome positioning." Genes to Cells. 3. 533-548 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Moriya,S.: "A Bacilus subtilis gene-encoding protein homologous to eukaryotic SMC motor protein is necessary for chromosome partition." Mol.Microbiol.29. 179-187 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nanamiya,H.: "ClpC regulates the fate of a sporulation initiation sigma factor,s H protein,in Bacillus subtilis at elevated temperatures." Mol.Microbiol.29. 505-513 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sugimoto,K: "Nucleotide specificity at the boundary and size requirement of the target sites recognized by human centromere protein B(CENP-B)in vitro." Chromosome Res.6. 133-140 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikeno,M.: "Construction of YAC-based mammalianatificial chromosomes." Nature Biotechnolozy. 16. 431-439 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tomoyasu,T.: "Levels of DnaK and DnaJ provide tight control of heat shock gene expression and protein repair in Escherichia coli." Mol.Microbiol.30. 567-581 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ogura,T.: "Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FisH(HfIB)in Escherichia coli." Mol.Microbiol.31. 833-844 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Akiyama,Y.: "Roles of the periplamic domain of Escherichia coli FtsH(HfIB),in protein interactions and activity modulation." J.Biol.Chem.28. 22326-22333 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tatsuta,T.: "Heat shock regulation in the FtsH null mutant of Escherichia coli:dissection of stability and activity control mechanisms of σ^<32> in vivo." Mol.Microbiol.30. 583-593 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Cutting, S.: "SpoVM, a small protein essential to development in Bacillus subtilis, interacts with the ATP-dependent protease, FtsH." J. Bacteriol.179. 5534-5542 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Makino, S.: "A silent mutation in the ftsH gene of Escherichia coli that affects FtsH production and colicin tolerance." Mol. Gen. Genet.254. 578-583 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hirano, M.: "Autoregulation of the partition genes of mini-F plasmid and intracellilar localization of their products in Escherichia coli." Mol. Gen. Genet.257. 392-403 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Wachi, M.: "Functional relationship between Escherichia coli RNase E and the CafA protein." Mol. Gen. Genet.253. 515-519 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kim, D. -W.: "A silent mutation in the ftsH gene of Escherichia coli that affects FtsH protein production and colicin tolerance." Mol. Gen. Genet.254. 578-583 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nishimura, A.: "Diadenosine 5', 5'''-P1, P4-tetraphosphate(Ap4A)controls the timing of cell division in Escherichia coli." Genes to Cells. 2. 401-413 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kawasaki, M.: "Identification of three core regions essential for protein splicing of the yeast Vma1 protozyme." J. Biol. Chem.272. 15668-15674 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamamoto, Y.: "Construction of a contiguous 874 kb sequence of the Escherichia coli K-12 genome corresponding to 50.0-68.8 min region on the linkage map and analysis of its sequence features." DNA Research. 4. 91-113 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yoda, K.: "Site specific base deletions in human a-satellite monomer DNAs are associated with regularly distributed CENP-B boxes." Chromosome Res.5. 207-211 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hanada, K.: "A suppressive role of RecQ DNA helicase on illegitimate recombination in Escherichia coli." Proc. Natl. Acad. Sci. USA. 94. 3860-3865 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Imamura,R.: "Identification of the cpdA gene encoding cyclic 3',5'-adenosine monophosphate phosphodiesterase in Escherichia coli." J.Biol.Chem.271. 25423-25429 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kido,M.: "RNase E polypeptides lacking a carboxyl-terminal half suppress a mukB mutation in Escherichia coli." J.Bacteriol.178. 3917-3925 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Saleh,A.Z.M.: "Carboxyl terminal region of the MukB protein in Escherichia coli is essential for DNA binding activity." FEMS Microbiol.Lett.143. 211-216 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamanaka,K.: "Identification of two new genes,mukE and mukF,involved in chromosome partitioning in Escherichia coli." Mol.Gen.Genet.259. 241-251 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Lysenko,E.: "Characterization of the ftsH gene of Bacillus subtilis." Microbioolgy. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hanada,K.: "A suppressive role of RecQ DNA helicase on illegitimate recombination in Escherichia coli." Proc.Natl.Acad.Sci.USA. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Goyal,D.: "A cryptic pBL1 from Brevibacterium lactofermentum causes growth inhibition and filamentation in Escherichia coli." Plasmid. 36. 62-66 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Itoh,T.: "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Research. 3. 379-392 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Qu,J.-N.: "The tolZ gene of Escherichia coli is identified as the ftsH gene." J.Bacteriol.178. 3457-3461 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2019-02-15  

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