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免疫識別と応答の多様性の分子機構

Research Project

Project/Area Number 08282104
Research Category

Grant-in-Aid for Scientific Research on Priority Areas (A)

Allocation TypeSingle-year Grants
Research InstitutionKumamoto University (1998-1999)
Kyushu University (1996-1997)

Principal Investigator

西村 泰治 (1998-1999)  熊本大学, 大学院・医学研究科, 教授 (10156119)

笹月 健彦 (1996-1997)  九州大学, 生体防御医学研究所, 教授 (50014121)

Co-Investigator(Kenkyū-buntansha) 吉開 泰信  名古屋大学, 医学部, 教授 (90158402)
武田 俊一  京都大学, 医学研究科, 教授 (60188191)
稲葉 カヨ  京都大学, 医学研究科, 教授 (00115792)
猪子 英俊  東海大学, 医学部, 教授 (10101932)
笠原 正典  総合研究大学院大学, 先導科学研究科, 教授 (30241318)
福井 宣規  九州大学, 生体防御医学研究所, 助手 (60243961)
西村 泰治  熊本大学, 大学院・医学研究科, 教授 (10156119)
菊谷 仁  大阪大学, 微生物病研究所, 教授 (80161412)
Project Period (FY) 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥163,500,000 (Direct Cost: ¥163,500,000)
Fiscal Year 1999: ¥38,300,000 (Direct Cost: ¥38,300,000)
Fiscal Year 1998: ¥35,500,000 (Direct Cost: ¥35,500,000)
Fiscal Year 1997: ¥40,200,000 (Direct Cost: ¥40,200,000)
Fiscal Year 1996: ¥49,500,000 (Direct Cost: ¥49,500,000)
KeywordsMHC / T細胞抗原受容体 / 樹状細胞 / 抗原提示 / γδT細胞 / HLAゲノム解析 / プロテマソーム / Toll-like receptor / T細胞 / 抗原提示細胞 / 抗原ペプチド / T細胞活性化 / T細胞分化 / MHCの進化 / HLA / CD40 / 自己免疫疾患 / NK1.1 / プロテアソーム
Research Abstract

MHCの構造と機能を解析して、その成果を免疫病の病因・病態の解明に資することを目的として研究を実施し、以下のような成果を得た。
1)CLIP部分をランダム配列ペプチドに置換したインバリアント鎖ライブライーを作製し、HLA-DR遺伝子と共にCOS細胞に一過性発現させ、共培養したT細胞クローンの応答を検出することにより、T細胞クローンが認識するTCRリガンドを同定するシステムを構築した(西村)。
2)未熟な樹状細胞は抗原ペプチド・MHCクラスII複合体を形成しないが、成熟刺激により速やかにこれを形成して、CD80等の共刺激分子と共に細胞表面に発現し、特異的T細胞を活性化する(稲葉)。
3)Ly49C/I^+NK1.1^+γδT細胞細胞は胸腺内でMHCクラスI分子により分化の抑制を受ける。またinvariantVg6/Vd1鎖を発現するγδT細胞細胞は、Toll-like receptor-2を介して細菌成分に直接反応する(吉開)。
4)HLA領域のマイクロサテライト多型を解析し、尋常性乾癬ではHLA-C遺伝子のテロメア側にある新規遺伝子が、またベーチェット病ではHLA-B51遺伝子そのものが疾患感受性遺伝子であることを示した(猪子)。
5)HLA領域内の全遺伝子の1/3がHLAとパラロガスな3つの領域にパラロガスなコピーをもつ。Proteasome activatorγ遺伝子標的欠損マウスでは成長遅滞がおきるが、免疫系に異常は認められない(笠原)。
6)TCRα-/-classII-/-マウス(H-2^b)由来のCD8^+T細胞も、B6マウスのAPCに対してアロ刺激に対する応答と同レベルで強く反応することより、1種類のαβTCRがclassIとclassIIの両分子に反応できる(武田)。
以上の研究により、当初の目的をほぼ達成できた。

Report

(4 results)
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (145 results)

All Other

All Publications (145 results)

  • [Publications] Tanaka,Y.: "Identification of peptide superagonists for a self-K-ras-reactive CD4^+ T cell clone,using combinatorial peptide libraries and mass spectrometry"J.Immunol.. 162. 7155-7161 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamasaki,K.: "HLA-DPB1^*0501-associated optico-spinal multiple sclerosis:clinical,neuroimaging and immunogenetic studies"Brain. 122. 1689-1696 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yun,C.: "Augmentation of immune response by altered peptide ligands of the antigenic peptide in human CD4 T cell clone reacting to TEL/AML1 fusion protein"Tissue Antigens. 54. 153-161 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ito,K.: "Analysis of T-cell responses to the β2-glycoprotein I-derived peptide libraly in patients with anti-β2-glycoprotein I antibody-associated autoimmunity"Human Immunol.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fukuzawa,T.: "Both the HLA-DPB1 and-DRB1 alleles correlate with risk for multiple sclerosis in Japanese:Clinical phenotypes and gender as important factors"Tissue Antigens. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Inaba,K.: "The formation of immunogeneic MHC class II-peptide ligands in lysosomal compartments dendritic cells is regulated by inflammatory stimuli."J.Exp.Med.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Turley,S.: "Regulated transport pf MHC class II-peptide complexes and co-stimulatory molecules to the surface of developing dendritic cells"Science. (in revision). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y.Yamaguchi-Iwai.: "Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells"EMBO J.. 18. 6619-6629 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takata,M.: "Targeted disruption of the RAD51B,a member of RAD51-related gene family,impairs homoglogous recombination and repair of crosslink DNA damages"Mol.Cell.Biol.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Morrison,C.: "The controlling role of ATM in homologous recombinational repair of DNA damage."EMBO J.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nishimura,H.: "MHC class II-dependent NK1.1^+γδT cells are induced in mice by Salmonella infection"J.Immunol.. 162. 1573-1581 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kimura,K.: "Immunogene therapy for murine fibrosarcoma using IL-15 gene with high translation efficiency"Eur.J.Immunol.. 29. 1532-1542 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ishigami,M.: "The roles of intrahepatic Va14^+NK1.1^+T cells for liver injury induced by Salmonella infection"Hepatology. 29. 1799-1808 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ishigami,M.: "The roles of intrahepatic γδ-T cells for liver injury in mouse induced by Salmonella infection.Microbiol."Immunol.. 43. 461-470 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mitani,A.: "Interleukin-15 might be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in mice."Immunology.. 97. 92-99 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Naiki,Y.: "Regulatory role of peritoneal NK1.1^+αβT cells in IL-12 production during Salmonella infection"J.Immunol.. 163. 2057-2063 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hirose,K.: "Endogenous IL-15 might be responsible for early protection by natural killer cells against infection with avirulent stain of Salmonella choleraesuis in mice"J.Leukocyte Biol.. 66. 382-390 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mokuno,Y.: "Prostaglandin E1 protects against liver injury induced by Escherichia coli infection via a dominant Th2-like respose of liver T Cells in mice."Hepatology. 30. 1464-1472 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nishimura,H.: "Differencial roles of IL-15 mRNA isoforms Generated by alternative splicing in immune responses in vivo"J.Exp.Med.. 191. 157-170 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsuguchi,T.: "Gene expressions of lipopolysaccharide receptors,Toll-like receptors 2 and 4,are differently regulated in mouse T lymphocytes.of peptides by T cells"Blood.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mokuno,Y.: "γδT cells bearing invariant Vγ6/Vδ1 may respond to lipid A via Toll-like receptor 2"J.Immunol.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kasahara,M.: "The chromosomal duplication model of the major histocompatibility complex"Immunol.Rev.. 167. 17-32 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Flajnik,M.F.: "Two ancient allelic lineages at the single classical class I locus in the Xenopus MHC.osphorylation"J.Immunol.. 163. 3826-3833 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Murata,S.: "Growth retardation in mice lacking the proteasome activator PA28 γ"J.Biol.Chem. 274. 38211-38215 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kasahara,M.: "Genome dynamics of the major histocompatibility complex:insights from genome paralogy"Immunogenetics. 50. 134-145 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nishi,S.: "Existence of human DAZLA protein in the cytoplasm of human oocytes"Mol.Hum.Reprod.. 5. 495-497 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kasahara,M.: "Genome paralpgy:A new perspective on the organization and origin of the major histocompatibility complex"Curr.Top.Microbiol.Immunol.. 248. 53-66 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kasahara,M.: "Proteasomes and antigen presentation:biochemistry and genetics"Recent Res.Dev.Immunol.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kasahara,M.: "The MHC paralogous group:Listing of members and a brief overview"Major Histocompatibility Complex:Evolution,Structure,and Function. 27-44 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kirchhoff,C.: "Molecular biology of sperm maturation-New strategies for male contraception?"Male Contraception:Present and Future. 103-123 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yabuki K,: "Triplet repeat polymorphism in the MICA gene in HLA-B27 positive and negative Caucasian patients with anlkylosing spondylitis"Hum.Immunol.. 60. 83-86 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kimura,M.: "cDNA cloning,Northern hybridization and mapping of a putative GDS(guanine nucleotide dissociation stimulator of G proteins)-related protein gene at the centromeric ends of the human and mouse MHC regions"Immunogenetics. 49. 354-356 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ozawa,A.: "HLA-A-33 and -B44 and susceptibility to postherpetic neuralgia(PHN)"Tissue Antigens. 53. 263-268 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shiina,T.: "Genome sequencing analysis of the 1.8Mb entire human MHC class I region"Immunological Reviews. 167. 193-199 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamazaki,M.: "Genome organization around the centromeric end of the HLA class I region;large-scale sequencing analysis"J.Mol.Evol.. 48. 317-327 (1999)

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      1999 Annual Research Report
  • [Publications] Shiina,T.: "Multiple class I loci expressed by the quail Mhc"Immunogenetics. 49. 456-460 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shiina,T.: "Gene organization of the quail major histocompatibility complex(MhcCoja)class I gene region"Immunogenetics. 49. 384-394 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Naruse,KN.: "Limited polymorphism in the HLA-DOA gene"Tissue Antigens. 53. 359-365 (1999)

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      1999 Annual Research Report
  • [Publications] Ota,M.: "The critical region for Behcet's disease in the human major hitocompatibility complex is reduced to a46kb segment centromeric of HLA-B,by association analysis using refined microsattellite mapping"Am J Hum Genet. 64. 1406-1401 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kaneko,M.: "a1,3-Fucosyltransferase IX(Fuc-TIX) is very highly conserved between human and mouse:molecular cloning,characterization and tissue distribution of human Fuc-TIX"FEBS Lett. 452. 237-242 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Wallace,GR.: "Asociation of MICA alleles with Behcet's disease"Immunogenetics. 49. 613-617 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Komatsu-Wakui,M.: "Polymorphism of MICA in Japanese and a MICA-MICB null haplotype"Immunogenetics. 49. 620-628 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Moribe,T.: "Rapid HLA class I DNA typing using microtiter plate-reverse hybridization assay(MRHA) by simple thermoregulation:High resolution subtyping of HLA-A2 and B-40 alleles.unity"Hum Immunol.. 60. 539-549 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Adra,K.: "Chrormosome 11q13 and atopic ashma."Clinical Genetics. 55. 431-437 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Anzai,T.: "HLA genotyping of 5,000 and 6,000-year old ancient bones in Japan"Tissue Antigens. 54. 53-58 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Maeda,F.: "Bacterial expression of a human recombinant monoclonal antibody Fab fragment against hepatitis B surfaceantigen"J Medical Virology. 58. 338-345 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kulski,JK.: "Comaprison between two HERV-rich regions within the major histcompatibility complex"J.Mol.Evolutison. 48. 675-683 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Baba,T.: "Isolation and characterization of the swine MHC SLA-DNA cDNA clones"Immunogetics. 49. 915-917 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Katsuyama,Y.: "Sequencing based typing for genetic polymorphisms in exons 2,3 and 4 of the MICA gene"Tissue Antigens. 54. 178-184 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takashige,N.: "Genetic polymorphisms at the tumor necrosis factor loci(TNFA and TNFB)in cardiac sarcoidosis"Tissue Antigens. 54. 191-193 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yabuki,K.: "HLA class I and II typing of the patients with Behcet's disease in Saudi Arabia"Tissue Antigens. 54. 273-277 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tamiya,G.: "New microsatellite markers in the human MHC class I region"Tissue Antigens. 54. 221-228 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yabuki,K.: "Association of MICA gene and HLAB^*5101 with Behcet's disease in Greek.Investigtive Ophthalmology&Visual"Science. 40. 1921-1926 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mizuki,N.: "Association analysis between the MICA and HLA-B alleles in Japanese patients with Behcet'disease."Arthritis&Rheumatisms. 42. 1961-1966 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Miyagawa,S.: "HLA-DRB1 polymorphisms and autoimmune responsees to desmogleins in Japanese patients with pemphigus"Tissue Antigens. 54. 333-340 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakanishi,K.: "Human Leukocyte Antigen-A24 and-DQA1^*0301 in jJapanese insulin-dependent diabetes mellitus:Independent contributions to susceptibility to the disease amd addtive contributions to acceleration of β-cell destruction"J Clinical Endocrinology and Metabolism. 84. 3721-3725 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Aguado,B.: "Complete structure and gene map of a human major histocompatibility complex(MHC)"Nature. 401. 921-923 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shiina,T.: "Molecular dynamics of MHC genesis unraveled by sequencing analysis of the 1,796,938bp HLA class I region"Proc Natl Acad Sci USA. 96. 13282-13287 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Oka,A: "Association analysis using refined microsatellite markers localizes a susceptible locus for psoriasi vulgaris within a 111kb segment telomeric of the HLA-C gene"Hum.Mol.Genetics.. 8. 2165-2170 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kaneko,M: "Assignment of the human a 1,3-fucosyltrandferase IX gene(FUT9)to chromosome band 6q16 by in situ hybridization"Cytogenet Cell Genet. 86. 329-330 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Chen,Y-Z.: "Modulation of calacium response by altered peptide ligands in a human T cell clone." Eur.J.Immunol.28. 3929-3939 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fujita,H.: "Evidence that HLA class II-restricted human CD4^+ T-cells specific to p53 self peptides respond to p53 proteins of both wild and mutant forms." Eur.J.Immunol.28. 305-316 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yasukawa,M.: "CD4^+ cytotoxic T-cell clones specific for bcr-abl b3a2 fusion peptide augment colony fomation by chronic myelogenous leukemia cells in a b3a2-specific and HLA-DR-restricted manner." Blood. 92. 3355-3361 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito,H.: "HLA-DP -associated susceptibility to optico spinal from of multiple sclerosis in the Japanese." Tissue Antigens. 52. 179-182 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ono,T.: "Molecular analysis of HLA class I(HLA-A and -B)and HLA class II(HLA-DRB1) genes in Japanese patients with multiple sclerosis(Western type and asian type)." Tissue Antigens. 52. 539-542 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Oiso,M.: "Differential binding of peptides substituted at a putative C-terminal anchor residue to I-A^<7b56His57Ser> and I-A^<g7b56Pro57Asp>" Immunogenetics. 47. 411-414 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fujii,S.: "The CLIP-substituted invariant chain efficiently targets an antigenic peptide to HLA class II pathway in L cell." Human Immunol.59. 607-614 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tabata,H.: "Characterization of self-glutamic acid decarboxylase 65-reactive CD4^+ T cell clones established from Japanese patients with insulin dependent diabetes mellitus." Human Immunol.59. 549-560 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tanaka,Y.: "Efficient induction CD4^+ T cell lines reactive with a self-K-ras-derived peptide in vitro,using a mAb to CD29." Human Immunol.52. 179-182 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohyama,H.: "Human T cell responses to 53-kDa outer membrane protein of Porphyromanas gingivalis in early-onset periodontitis patients." Human Immunol.59. 635-643 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Zeki,K.: "Inducation of expression of MHC-class-II antigen on human thyroid carcinoma by wild-type p53." Int.J.Cancer. 75. 391-395 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hashimoto,H.: "HLA-DRB1 alleles and b2 glycoprotein I-dependent anticardiolipin antibodies in Japanese patients with systemic Jupus erythematosus." Clin.Exp.Rheumatol.16. 423-427 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sadanaga,Y.: "HLA class II association with Type I a;;ergy to house dust mite and Japanese cedar pollen in Japanese subjects." Allergology International. 47. 285-291 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishimura,Y.: "(Review)Peptide-based molecular analyses of HLA class II -associated susceptibility to autoimmune dieases." Int.Rev.Immunol.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishimura,Y.: "(Review)Modification of human T cell responses by altered peptide ligands:a new approach to antigen-specific modification" Internal Medicine. 37. 804-817 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishimura,Y.: "(Review)Molecular analyses of HLA class II -associated susceptibility to subtypes of autoimmune diseases unique to Asians" Internatl.J.Cardiol.66(1). S93-S104 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Inaba,K.: "Efficient presentation of phagocytosed cellular fragments on the MHC class II products of dendritic cells." J.Exp.Med.188(11). 2163-2173 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] steinman,R.M.: "Myeloid dendritic cells." J.Leukocyte Biol.in press. (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kohda,K.: "characterization of the mouse PA28 activator complex gene family:Complete organizations of the three member genes and a physical map of the 〜150-kb region containing the α- and β-subunit genes." J.Immunol.160. 4923-4935 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tanaka,K.: "The MHC class I ligand generating system:Roles of immunoproteasomes and the interferon-g-inducible proteasome activator PA28." Immunol.Rev.163. 161-176 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Suto.Y.: "Gene arrangement of the killer cell inhibitory receptor family on human chromosome 19q13.4 detected by fiber-FISH." Immunogenetics. 48. 235-241 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kasahara.M.: "What do the paralogous regions in the genome tell us about the origin of the adaptive immune system?" Immunol.Rev.166. 159-175 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kasahara,M.: "the chromosomal duplication model of the major histocompatibility compex." Immunol.Rev.(in press). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kasahara,M.: "Genome paralogy:A new perspective on the organization and origin of the major histocompatibility complex." Curr.Top.Microbiol.Immuno;.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kimura,Y.: "The regulatory role of heat shock protein 70-reactive CD4+T cells during rat listeriosis." Int.Immunol.10. 117-130 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sakai,T.: "Interleukin 15 activity in the intestinal mucosa of inflammatory bowel disease." Gastroenterology. 114. 1237-1243 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takano,M.: "Dibutyryl cyclic adenosine monophosphate protects mice against tumor necrosis factor-a-induced hepatocyte apoptosis accompanied by increased heat shock protein 70 expression." Cell Stress & Chaperones. 3. 109-117 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Washizu,J.: "NF-kB binding site is essential for transcriptional activation of IL-15." Immunogenetics. 48. 1-7 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Murosaki,S.: "Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL-12 production in mice." J.Allergy Clin.Immunol.102. 57-64 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takano,M.: "A protective role of IL-15-dependent gd T cells in Escherichia coli infection in mice." Infect.Immun.66. 3270-3278 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takano,M.: "Prostaglandin E2 protects against liver injury after Escherichia coli infection but hampers the resolution of the infection in mice." J.Immunol.161. 3019-3025 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hirose,K.: "Interleukin-15 might be responsible early activation of intraepithelial lynphocytes after oral infection with Listeria monocytogenes in rats." Infect.Immun.66. 6577-5683 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamada,K.: "Characterization of CD4+ CD8aa+ and CD4- CD8aa- intestinal intraepithelial lymphocytes in rats." Int.Immunol.11. 21-28 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishimura,H.: "MHC class II-dependent NK1.1+gd T cells are induced in mice by Salmonella infection." J.Immunol.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mayumi,T.: "IL-15 is elevated in the patients of postoperative enterocllitis." Cytokine. (in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kimura,K.: "Immunogene therapy for murine fibrosarcoma using IL-15 gene with high translation efficiency." Eur.J.Immunol.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ishigami,M.: "The roles of intrahepatic Va 14+Nk1.1+T cells for liver injury induced by Salmonella infection." Hepatology. (in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ishigami,M.: "The roles of intrahepatic gd-Tcells for liver injury in mouse induced by Salmonella infection." Microbiol.Immunol.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hasegawa,T.: "Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice." Int.J.Immunopharmacol.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Murosaki,S.: "Immunopotentiating activity of nigerooligosaccharides for T helper 1-like immune response in mice." Biosci.Biotechnol.Biochem.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mitani,A.: "Interleukin-15 might be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in mice." Immunolgy. (in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hirose,K.: "IL-15 might be responsibel for early protection by natural killer cells against infection with avirulent strain of Salmonella cholerasuis mice." J.Leuco.Biol.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shimokata,T.: "Bystander suppression of natirally fed antigen-specific IgE response by systemic asministration of unrelated antigen." J.Immunol.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sonoda,E.: "Rad51 deficient vertebrate cells accumulate chromosomal breaks prior to cell death." EMBOJ.17. 598-608 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takata,M.: "Homologous recombination and nonhomologous end joining pathways of DNA double-strand break repair have oberlapping roles in the maintenance of chromosomal integrity in vertebrate cells." EMBOJ.17. 5497-5508 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishimura,H.: "MHC class II-dependent NK1.1= = cells are induced in mice by Salmonella infection." J.Immunol.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sano,t.: "Spontaneous clusterin of Thy-1 antigens on CD4+CD8+ thymocytes lacking TCR engagement by MHC/peptide complexes." Eur.J.Immunol.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Gyotoku,T.: "An endogeneously processed self peptide and the corresponding exogenous peptide bound to the same MHC class II molecule could be distinct ligands for TCR with different kinetic stability." Eur.J.Immunol.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fukui,Y.: "Highly restricted T cell repertoire shaped by a sible MHC/peptide ligand in the presence of signal rearranged T cell receptor beta chain." J.Exp.Med.188. 897-907 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Gapin,L.: "Quantitative analysis of the T-cell reperotire by a signal peptide/MHC complex." J.Exp.Med.187. 1871-1883 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takahashi,A.: "Development of peptide vaccines inducing production of neurtralizing antibodies against HIV-I viruses in HLA-DQ6 mice." Vaccine. 16. 1537-1543 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 西村泰治: "「免疫遺伝学」医科遺伝学" 南山堂(印刷中),

    • Related Report
      1998 Annual Research Report
  • [Publications] 西村泰治: "「MHCの構造と機能:抗原のプロセッシングとT細胞への抗原提示の機構」分子予防医学" 医学書院(印刷中),

    • Related Report
      1998 Annual Research Report
  • [Publications] 西村泰治: "「抗原ペプチドのアナログを用いたヒトT細胞の抗原認識と活性化機構の解析」第21回阿蘇シンポジウム" 南山堂(印刷中),

    • Related Report
      1998 Annual Research Report
  • [Publications] 入江厚: "「T細胞とMHCの相互作用」免疫 しくみと疾患のすべて" 羊土社, 13 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Wang XJ.: "gp130,The cytokine common signal-transducer of interleukin-6 cytokine family,is down-regulated in T cells in vivo by interleukin-6." Blood. (in.press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Tana T.: "A HLA binding motif-aided peptide epitope library:A novel library design for the screening of HLA-DR4-restricted antigenic peptides recognized by CD4_+ T cells." J.Human Genet.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Nishimura H.: "Translational efficiency is upregulated by alternative exon in murine interleukin-15 mRNA." J.Immunol.vol.160. 936-942 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fujita H.: "Evidence that HLA class II-restricted human CD4_+ T-cells specific to p53 self peptides respond to p53 proteins of both wild and mutant forms." Eur.J.Immunol.vol.28. 305-316 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fukui Y.: "Positive and negative CD4_+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus." Immunity. vol.6. 401-410 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ishimoto T.: "In Vitro and In Vivo evidence for high frequency of I-Ab-reactive CD4_+ T cells in HLA-DQ or HLA-DRA transgenic mice lacking endogenous MHC class I and/or class II expression." J.Immunol.vol.159. 3717-3722 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Higashi Y.: "Impairment of T cell development in gEF1 mutant mice." J.Exp.Med.vol.185. 1467-1479 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Enomoto A.: "Predominant appearance of NK1.1_+ T cells producing IL-4 in the peritoneal cavity of mice with beige mutation during Salmonella infection." J.Immunol.vol.158. 2268-2277 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Pierre P.: "Development regulation of MHC class II transport and compartmentalization in mouse dendritic cells." Nature. vol.388. 787-792 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Inaba K.: "High levels of an MHC class II-self peptide complex on dendritic cells from the T cell areas of lymph nodes." J.Exp.Med.vol.186. 665-672 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsushita S.: "Evidence for self- and non-self-peptide partial agonists that prolong clonal survival of mature T cells in vitro." J.Immunol.vol.158. 5685-5691 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kasahara M.: "Chromosomal duplication and the emergence of the adaptive immune system." Trends Genet.vol.13. 90-92 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hayashi M.: "The mouse genes encoding the third pair of β-type proteasome subunits regulated reciprocally by IFN-γ:Structural comparison,localization,and analysis of the promotor." J.Immunol.vol.159. 2760-2770 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fukui Y.: "Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand in vivo affected by its expression level in the thymus." Immunity. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamaguchi Y.: "Contrasting effect of TGFβ1 and TNFα on the development of dendritic cells from progenitors in mouse bone marrow." Stem Cells. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Enomoto A.: "Predominant appearance of NK1.1+ T cells producing IL-4 in the peritoneal cavity of mice with beige mutation curing Salmonella infection." J.Immunol.158. 2268-2277 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mineta M.: "Contribution of HLA class I and class II alleles to the regulation of antibody Productionto hepatitis B surface antigen in humans." Int.Immunol.8. 525-531 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hori T.: "Japanese cedar pollinosis and HLA-DP5." Tissue Antigens. 47. 485-491 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kamanaka M.: "Protective role of CD40 in Leishmania major infection at two distinc phases of cell-mediated immunity." Immunity. 4. 275-281 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Moritani M.: "Prevention of adoptively transferred diabetes in non-obese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes:Gene therapy model for autoimmune Labetes." J.Clinc.Invest.98. 1851-1859 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nagasawa T.: "Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1." Nature. 382. 635-638 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kira J-I.: "Western vs. Asian types of multiple sclerosis: immunogenetically and clinically distinct disorders." Ann. Neurol.40. 569-574 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Chen Y-Z.: "Response of a human T cell clone to a large panel of altered peptide ligands carrying single residue substitutions in an antigenic peptide;characterization and frequencles of TCR agonism and TCR antagonism with or without partial activation." J.Immunol.157. 3783-3790 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsuoka T.: "Altered TCR ligands affect antigen-presenting cell responses:Uprerulation of IL-12 by an analogue peptide." J.Immunol.157. 4837-4843 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nishimura H.: "IL-5 is novel growth factor for murineγδ T cells induced by Salmonella infection." J.Immunol.156. 663-669 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ortner U.: "An improved method to obtain murine migratory cutaneous dendritic cells." J.Immunol.Methods. 193. 71-79 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Fazle Akbar S.M.: "Upregulation of MHC class II antigen on dendritic cells from hepatitis B virus transgenic mice by γ-interferon:abrogation of immune response defect to a T cell-dependent antigens." Immunology. 87. 519-527 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kasahara M.: "Chromosomal localization of the mouse proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex." Proc.Natl.Acad.Sci.U.S.A.93. 9096-9101 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kandil E.: "Isolation of low molecular mass polypeptide complementary DNA clones from primitive vertebrates:Implications for the origin of MHC class I-restricted antigen presentation." J.Immunol.156. 4245-4253 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kasahara M.: "Origine and evolution of the class I gene family:Why are some of the mammalian class I genes encoded outside the major histocompatibility complex?" Res.Immunol.147. 278-284 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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