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On the skin as an immunological organ

Research Project

Project/Area Number 08307009
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionThe University of Tokyo

Principal Investigator

TAMAKI Kunihiko  Dept of Derma Univ. of Tokyo. Professor, 医学部・附属病院, 教授 (30010432)

Co-Investigator(Kenkyū-buntansha) AIBA Setsuya  Dept of Derma Tohoku Univ. Associate Professor, 医学部, 助教授 (80159269)
SHIOHARA Tetsuo  Dept of Derma Kyorin Univ. school of Medicine. Professor, 医学部, 教授 (10118953)
TAKIGAWA Masahiro  Dept of Derma Hamamatsu Univ. school of Medicine Professor, 医学部, 教授 (80115873)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥27,000,000 (Direct Cost: ¥27,000,000)
Fiscal Year 1998: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 1997: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1996: ¥8,000,000 (Direct Cost: ¥8,000,000)
Keywordsskin / immunological organ / T cells / Langerhans cells / keratinocytes / fibroblasts / hair / cytokine / 皮膚 / ケロチノサイト / 繊維芽細胞 / 共刺激分子 / ハプテン / ヘルパーT細胞亜群 / 樹状細胞 / 情報伝達 / 角層バリヤ- / 皮膚器官 / αβTCR / γδTCR
Research Abstract

In this research project, immunological aspect of the skin was studied from different viewpoints such as 1) T cells in the skin, 2) Langerhans cells (LC), 3) Keratinocytes (KC), 4) Fibroblasts (Fb) and 5)Hair. In this study the existence of T cells unique to the skin was proposed from clinical as well as basic mouse study. This would be very important in terms of the development of T cell mediated skin lesions such as cutaneous T cell lymphoma. LC was investigated as for their migration as well as maturation and/on activation by cytokines and haptens. The immunological regulation of KC was also studied with the relationship to the external stimuli such as bacteria, physical barrier destination. The participation of Fb and hair cycle in skin immunology was studied. Overall, this project revealed the importance of skin as an immunological organ and suggest more studies are necessary to reveal this.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Kokura Y.Takigawa et al.: "Cross-Reactivity in murine Fluoloquinollene Photoaloorgy:Exclusive Usage of TCRDβ13 by immune T cells that recognize Fluorog*inolo*c Cell"J Immunol. 160. 3719-3728 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Aiba S: "Maturation of Dendutic Cells Induced by Cytokines and Haptens"Tohoku J Exp Med. 159-72 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Aiba S et al.: "Phorbol 12-myriate 13 acetate can transform monoccyte-derived dendritic cells to different cell types similar to those found in dermatofibroma"J Cutan Pathol. 25. 65-71 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shiohara T et al.: "Resistance to cutanous graft-vs-* disease is not induced in T cell receptor δ-gene-mutant mice"J Exp Med. 183. 1483-1489 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Komatsu,T.Shiohara et al.: "T cell receptor repertoire and function of human epidemal T cells neotri*del TCR Vα-Vβ genes are utilized by T cells residiy in the l***"Clin Exp Immun*l. 104. 343-350 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fume M,Tamaki K et al.: "Interlenkic 1 but not tumol nei**is*factorα synergistically apregulates the gramlocyte-macrophage induced B7-1 expression of murine Layer** cells"Brit J Dernatol. 135. 194-198 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tokura Y, Takigawa et.al.: "Cross-reactivity in marine Fluoroquinoline Photo allity Exclusive Usage of TCR Vβ13 by immune T cells that recognize Fluoroquinoline-Photomodified cells"J Immunol. 160. 3719-28 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Aiba S: "Maturation of Dendritic Cells Induced by Cytokines and Haptens"Tohoku J Exp Med. 184. 159-172 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Aiba S et.al.: "Phorbol 12-myuste 13 acetrle can transform monocyte-derived dendritic cells to different cell typessimilar to those found in dermatofilrona"J Cutan Pathrl. 25. 65-71 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shiohara T et.al.: "Resistance to cutaneono graft-vs-hat disease is not induced in T cell receptor δ-gene mutant mice"J Exp Med. 183. 1483-1489 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Komats T. Shiohara T at.al.: "T cell receptor repertoire and function of human epidermal T cells : restricted TCR Vα-Vβ genes are utilized by T cells residing in the lesion of fixed dry eruption"Clin Exp Juornal. 104. 343-50 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fume M. Tamaki K et al: "Interlenhir-1 bust not tumor nacronis factorα synegistically upregntalas the granuloife-macrophage induced β7-1 expressed on mime Layerhons cells"Brit J Demtol. 135. 194-8 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tokura Y,Takigawa et al: "Cross-Reactivity in nucrive Flueroquinolose Photoallergy : Exclusive Usage (7)TCR VβB by immuse Tceulls the T recgnize Flueroquinolose Photomadified Cells" J Immunol. 160. 3719-3728 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Aiba S: "Maturation of Dendritic Cells Induced by Cytokines and Hapteno" Tohoku J Exp Med. 184. 159-172 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Aiba S et al: "Phorbol 12-myriate 18 acetate can transform monocite-derived dendritic cells to different cell types similar to those found in dervatibilroma" J Cutan Pathol. 25. 65-71 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] WakitaH,Takigawa,M et al: "Sphingosiyl phosphonyl choline stimilated proliferation and spregulates cell surface associated plasuring on schvater adirty in human haratayls" J Invest Dermapl. 110. 253-258 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kitagaki K,Shiohara F et al: "Repeated elicitation of contact hypreioniting inducts a shift in ontagiuos sytokine from TH1 to TH2 profile" J Immunol. 159. 2484-2491 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Funce,Tamaki K et al: "Dysregulated expression of transforming growth frotal β and its type I and type II isecoptors in basal cell carcimyosites" Int.J Cancer. 71. 505-509 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kitagaki H,Ono N,Hagakiwa K,Kitazawa T,Watanabe K,Shiohara T: "Repeated ulicutation of contact hypersensitroy inducis a shift in untancons on tokive nulieu from Thelipe cell type 1 to a T cell type 2 profile" J Immunol. 159. 2484-2491 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shiohara T., Moriya N: "Epdermal Tulls : Their functional role and disese relevancl for dermatologists" J Invest Dermatol. 109. 271-275 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fusie M,Kato M,Tcovaki K: "Dysreyulated expression of transforming growth factor β and its type I and type II receptars in basal-cell carcinoma" Int J Cancer. 71. 505-509 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tokura Y,Furukasa F,Takigawa M: "T-cell proliferation to superantigen-releasing Staphylococeus aureus by MHCclass in bearing keratinocytes under profection from bacteral cytolysin" J Invest Dermatol. 108. 488-494 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nishijima T,Tokura Y,Takigawa M: "Altered permeability and disordered cutaneous immunorejnlatary functids in mice with auk barried disruption" J Invest Dermatol. 109. 175-182 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Aiba S,Terunuma A,Maema H,H.Tagami: "Dendutic cells differently respond to haptens and initants their pronduction of eytohins and exlnessuin of co-stinulatory milecnles" Ear J Immunol. 27. 3031-3038 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Tamaki et al: "Identification and characterization of novel derwal Thy-1-antigen-bearing clendrihc cells in murine skin" J Invest Dermatol.106. 571-576 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Yagi,M.Takigawa et al: "TCR V_β7^+Th_2 cells mediate UVB-induced suppresion of contact photosencitrity by relcasiy IL-10" J Immunol. 156. 1824-1831 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Tokura,M.Takigawa et al.: "Th_2 suppressor cells are more susceptible to sphingosine than Th_1 cells in murice contact photo sensitivity" J Inoest Dumatol. 107. 34-40 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Shiohara et al: "Resistance to cutaneens graft-uersus-host diseace is not induced in TCRδ gene mutant mice" J Exp Med. 183. 1483-1489 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] J.Hayakawa,T.Shiohara et al: "Adult thymus contains dendritic epidecwal T cell precursors hat home to the epiderwis in irradiated but not in normal mice" Cell Immunol. 174. 190-198 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Ozawa,S.Aiba et al.: "Interferon-gamna and inteleukin-10 inhit antigen presentation by trangerlems cells for T helper tepre 1 cells liy suppussing ther CD80(B7-1)" Eur.J Immunol.26. 648-652 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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