| Project/Area Number |
08307014
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
小児外科
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| Research Institution | University of Tsukuba |
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Principal Investigator |
OHKAWA Haruo University of Tsukuba, Institute of Clinical medicine, Professor, 臨床医学系, 教授 (30009667)
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| Co-Investigator(Kenkyū-buntansha) |
TSUNEMATU Yukiko National Children's Hospital, Department of Hematology and Oncology, Head, 医長
KANEKO Yasuhiko Saitama Cancer Center, Section of Clinical Research, Head, 部長
HATA Junnichi Keio University, School of Medicine, Professor, 医学部, 教授 (90051614)
OHASHI Yasuo Tokyo University, School of Medicine, Professor, 医学部, 教授 (00134461)
IWAKAWA Mayumi University of Tsukuba, Institute of Clinical medicine, Assistant Professor, 臨床医学系, 講師 (30231723)
土田 嘉昭 群馬県立小児医療センター, 院長
山田 正夫 国立小児病院小児医療センター, 先天異常研究部, 部長
横森 欣司 東京大学, 医学部・小児外科, 助教授 (20251291)
三杉 和章 横浜市立大学, 医学部・第2病理, 教授 (50106332)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥10,800,000 (Direct Cost: ¥10,800,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1997: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1996: ¥6,100,000 (Direct Cost: ¥6,100,000)
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| Keywords | Wilms tumor / network / ウイルス腫瘍 / WT-1 / WT-2 / 病理セントラルレビュー / 化学療法 / 治療スタディーグループ / インフォームドコンセント / グループスタディ / central review system / 病理診断 / WT-1遺伝子 / 治療プロトコール |
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| Research Abstract |
Japanese Wilms Group Study was started in 1996 to improve the survival rate of Wilms tumor patients. New patients as followings were registered to this project since 1996 until 1998. In 1996, 12 patients, in 1997, 17 patients, in 1998, 28 patients were newly diagnosed. Sex distribution was 26 male, and 27 female. Clinical staging distribution was as followings, stage 1 : 17 cases, stage 2 : 14 cases, stage 3 : 10 cases, stage 4 : 5 cases, stage 5 : 6 cases. Treatment protocol was decided by prescheduled regimens : regimen EE-4A ; 25 cases, DD-4A ; 9 cases, RTK ; 2 cases, CCSK ; 1 case. Pathological diagnosis was done owing to Japanese classification by Japanese association of Pathologists : nephroblastoma, 38 cases, MRTK ; 4 cases, CCSK 1 case. Molecular biological investigation found point mutation of WT 1 gene in 5 cases. The other main aim of our group study is to establish the network system covering all over Japan, and furthermore China and Korea. Trial use of intranet among three main institution was working smoothly.
10. Key Words
(1) Wilms tumor (2) network
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