| Project/Area Number |
08307018
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
FUTAI Masamitsu Institute of Scientific and Industrial Research, Osaka University, Professor, 産業科学研究所, 教授 (50012646)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Hiroyuki Pharmaceutical Science, Tokyo University, Associate Professor, 薬学部, 助教授 (40167987)
MORIYAMA Yoshinori Institute of Scientific and Industrial Research, Assistant Professor, 産業科学研究所, 助教授 (10150658)
KAKINUMA Yoshimi Pharmaceutical Science, Tiba University, Associate Professor, 薬学部, 助教授 (80134394)
TOMIOKA Kiyoshi Pharmaceutical Science, Kyoto University, Professor, 薬学部, 教授 (50114575)
MAEDA Masatomo Pharmaceutical Science, Professor, 薬学部, 教授 (80190297)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥20,600,000 (Direct Cost: ¥20,600,000)
Fiscal Year 1997: ¥11,500,000 (Direct Cost: ¥11,500,000)
Fiscal Year 1996: ¥9,100,000 (Direct Cost: ¥9,100,000)
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| Keywords | organelles / vacuoles / ATPase / microvesicles / pinealocyte / 液胞ATPase / ベータ-ラクタム / bafilomycin / concanamycinA / 酸性オルガネラ / H^+-PPiase / ホスファチジルセリン |
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| Research Abstract |
Plant or animal cells have endomembrane organelles such as endosome, lysosome, synaptic vesicles and Golgi apparatus. They participate in the process of endocytosis or exocytosis. Scientists with different back ground and discipline carried out this project exchanging techniques and ideas. Major results obtained are : (1) new organelle (microvesicles) were identified in pinealocytes and its properties were extensively studied. (2) New vesicle type ATPase transporting Na^+ was found in bacteria. (3) We found isoforms of proton pathway subunits (proteolipid). (4) Transport of lipids between organelles was studied in detail. (5) We studied inhibitors for vacuolar tyoe ATPase from different origins. These results contribute greatly to the understanding on the role of vacuolar type ATPase in different cells and will contribute to find possible pharmaceutically valuable chemicals.
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