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Defense stragtegy of organisms against biological effects of active oxygen species

Research Project

Project/Area Number 08308032
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 環境影響評価(含放射線生物学)
Research InstitutionGraduate School of Science, Tohoku University

Principal Investigator

YAMAMOTO Kazuo  Graduate School of Science, Tohoku University, Professor, 大学院・理学研究科, 教授 (20093536)

Co-Investigator(Kenkyū-buntansha) IDE Hiroshi  Faculty of science, Hiroshima University, Professor, 理学部, 教授 (30223126)
ISHII Naoaki  Faculty of Medicine, Tokai University, Associate Professor, 医学部, 助教授 (60096196)
YUKAWA Osami  National Institute of Radiological Sciences, Division of Biology, Head, 生物影響研究部第2研究室, 室長 (80166850)
YONEI Shuji  Graduate School of Science, Kyoto University, Professor, 大学院理学研究科, 教授 (60093340)
KASAI Hiroshi  University of Occupational and Environmental Health, Professor, 産業生態科学研究所, 教授 (40152615)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥22,900,000 (Direct Cost: ¥22,900,000)
Fiscal Year 1998: ¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 1997: ¥9,500,000 (Direct Cost: ¥9,500,000)
Fiscal Year 1996: ¥8,100,000 (Direct Cost: ¥8,100,000)
Keywordsoxidative stress / active oxygen species / superoxide dismutase / OGG gene / Nth gene / GTP cyclohydrolaseII / cytochrome b / MutY protein / 5・formyl-dUTP / thymine glycol / アポトーシス誘導 / カタラーゼ欠損細胞 / 5-フォルミルウラシル / 酸化ストレス応答 / riboflavin光化学反応 / OxyR蛋白 / mutM遺伝子 / endonuclease III / endonuclease VIII / 過酸化水素細胞毒性 / Nicking assay / α-デオキシアデノシン / 生体膜脂質過酸化
Research Abstract

Oxidative stress is emerging as one of the most important causative agents of mutagenesis, carcinogenesis, aging and a number of diseases. DNA and deoxynucleotides are potential targets for attacking by active oxygen species, and virtually all aerobic organisms have developed complex defense and repair mechanisms to mitigate the deleterious effects of active oxygen species. The first line of defense seeks to neutralize the active oxygen species themselves. This line of defense includes various enzymatic and nonenzymatic defense mechanisms such as superoxide dismutase and catalase. Active oxygen species that escape the primary defense can damage nucleic acids. The second line of defense removes DNA damage caused by active oxygen species that escape the primary defense mechanisms. Several proteins have been demonstrated to be involved in the repair of DNA lesions.
In this research project, we have examined the defense mechanisms of cell against active oxygen species. During the periods, we cloned and characterized the genes coded for mammalian repair enzymes such as OGG gene (F.coli mutM homologue) and Nth gene (E.coli nth homologue). We demonstrated that E.coli GTP cyclohydrolase II can partially hydrolyze 8-oxodGTP, a mutagenic substrate for DNA synthesis. We found that E.coli MutY protein has a Guanine-DNA glycosylase that acts on 8-oxoG : G mispair to prevent spontaneous G : C->C : G transversions. We showed that a mutation in succinate dehydrogenase cytochrome b causes oxidative stress and aging in C.elegans. We suggested that the mutations can be induced by oxidative damaged nucleotides, 5-formyl-dUTP and 5-hydroxy-dCTP in F.coli. Including these results, we obtained more than 130 papers published in the prestigious international journals.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (316 results)

All Other

All Publications (316 results)

  • [Publications] H.Adachi: "Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans." J.Gerontology : Biol.Sci.53A. B240-B244 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Aoki: "Cytotoxicity induced by recombinant human tumor necrosis factor-a dependent on the types of its receptors on canine cells." J.Vet.Med.Sci.60. 889-895 (1998)

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      1998 Final Research Report Summary
  • [Publications] M.Aoki: "In vitro cytotoxicity of recombinant human-TNF-a and actinomycin D on canine normal and tumor cells." J.Vet.Med.Sci.60. 1087-1091 (1998)

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      1998 Final Research Report Summary
  • [Publications] K.Arashidani: "Genotoxicity of ribo-and deoxyribonucleosides of 8-hydroxyguanine 5-hydroxycytosine, and 2-hydroxyadenine : induction of SCE in human lymphocytes and mutagenicity in S. typhimurium TA 100." Mutation Res.403. 223-227 (1998)

    • Description
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      1998 Final Research Report Summary
  • [Publications] A.Asaeda: "Repair kinetics of abasic sites in mammalian cells selectively monitored by aldehde reactive probe (ARP)." Nucleosides and Nucleotides. 17. 503-513 (1998)

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    • Related Report
      1998 Final Research Report Summary
  • [Publications] A.Asaeda: "Highly sensitive assay of DNA abasic sites in mammalian cells--Optimization of the aldehyde reactive probe (ARP) method." Analytica Chimica Acta. 365. 35-41S (1998)

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      1998 Final Research Report Summary
  • [Publications] S.Asami: "Effects of forced and spontaneous exercise on 8-hydroxydeoxyguanosine levels in rat organs. Biochem." Biophys. Biochem. Res.Commun.243. 678-682 (1998)

    • Description
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    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Fujii: "A novel superoxide dismutase gene encoding membrane-bound and extracellular isoforms by alternative splicing in Caenorhabditis elegans." DNA Research. 5. 25-30 (1998)

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    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Fujikawa: "The mutation induced by oxidatively damaged nucleotides, 5-formyl-dUTP and 5-hydroxy-dCTP, in Escherichia coli." Nucleic Acids Res.26. 4582-4587 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] P.S.Hartman: "Isolating mutants of the nematode Caenorhabditis elegans that are hypersensitive to DNA-damaging agents." Methods in Molecular Biology, Vol.XX : DNA Repair Protocols : Eukaryotic Systems (ed.D.S.Henderson). 印刷中. p11-p16 (1999)

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      1998 Final Research Report Summary
  • [Publications] M.Inoue: "Lung cancer patients have increased 8-hydroxydeoxyguanosine leveles in peripheral lung tissue DNA." Jpn.J.Cancer Res.89. 691-695 (1998)

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      1998 Final Research Report Summary
  • [Publications] M.Inoue: "Induction of chromosomal gene mutations in Escherichia coli by direct incorporation of oxidatively damaged nucleotides." J.Biol.Chem.273. 11069-11074 (1998)

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    • Related Report
      1998 Final Research Report Summary
  • [Publications] O.Inanami: "Attenuation of caspase 3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells.Int." J.Radiat.Biol.印刷中. (1998)

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      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] O.Inanami: "Lipid peroxides and antioxidants in sera of neonatal calves." Am.J.Vet.Res.印刷中. (1998)

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      1998 Final Research Report Summary
  • [Publications] O.Inanami: "Oral administration of (-) catechin protects against ischemia-reperfusion-induced neuronal death in the gerbil." Free Rad.Res.29. 359-365 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] N.Ishii: "A mutation in succinate dehydrogenase b causes oxidative stress and ageing in nematodes." Nature. 394. 694-697 (1998)

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      1998 Final Research Report Summary
  • [Publications] H.Iyehara-Ogawa: "Cobaltous chloride-induced mutagenesis in the supF tRNA gene of Escherichia coli." Mutagenesis. 印刷中. (1999)

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    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Kasai: "Analysis of 8-hydroxydeoxyguanosine, an oxidative DNA damage product, in human samples." Journal of the International Federation of Clinical Chemistry and Laboratory Medicine. 10. 51-52 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] I.Kashiwakura: "Effects of carboxy-PTIO, a nitric oxide scavenger, on the proliferation of murine hematopoietic progenitor cells in vitro." Res.Comm.Molec. Pathol. and Pharmacol.99. 329-337 (1998)

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      1998 Final Research Report Summary
  • [Publications] M.Kobayashi: "Potential of GTP cyclohydrolase II of Escherichia coli for hydrolyzing 8-oxo-dGTP, a mutagenic substrate for DNA synthesis." J.Biol.Chem.273. 26394-26399 (1998)

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      1998 Final Research Report Summary
  • [Publications] T.Kohno: "Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA." Oncogene. 16. 3219-3225 (1998)

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      1998 Final Research Report Summary
  • [Publications] M.Krien: "A NIMA homologue promotes chromatin condensation in fission yeast." J.Cell Sci.111. 967-976 (1998)

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      1998 Final Research Report Summary
  • [Publications] K.Kubo: "Induction of fragile sites by fluorodeoxyuridine and caffeine accompanies with misincorpolation of endogenous uridine nucleotide into DNA of feline fibroblasts." J.Vet.Med.Sci.60. 1293-1297 (1998)

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      1998 Final Research Report Summary
  • [Publications] K.Kubo: "Novel putative fragile sites observed in feline fibroblasts treated with aphidicolin and fluorodeoxyuridine." J.Vet.Med.Sci.60. 809-813 (1998)

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      1998 Final Research Report Summary
  • [Publications] M.Kuwabara: "Radiation-and reactive oxygen-induced cell death and signal transduction in cultured mammalian cells." Biological Oxidants & Antioxidants : Molecular Mechanisms & Health Effects (Packer, L.and Ong, H.S.Eds.). 14-21 (1998)

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      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] M.Kuwabara: "Biodefense against active oxygens and free radicals induced by oxidative stress." Biodefense Mechanisms against Environmental Stress, (Ozawa, T., Tatsumi, K.and Hori, T.eds.). 23-32 (1998)

    • Description
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      1998 Final Research Report Summary
  • [Publications] T.Mori: "Formation of 8-hydroxyguanine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine in DNA by riboflavin mediated photosensitization" Biochem.Biophys.Res.Commun.242. 98-10〓 (1998)

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      1998 Final Research Report Summary
  • [Publications] N.Murata-Kamiya: "Nucleotide excision repair proteins may be involved in the fixation of glyoxalinduced mutagenesis in Escherichia coli." Biochem. Biophys. Res.Commun.248. 412-417 (1998)

    • Description
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      1998 Final Research Report Summary
  • [Publications] S.Nakajima: "Cloning and characterization of a gene (UVR3) required for photorepair of 6-4 products in Arabidopsis thaliana." Nucleic Acids Res.26. 638-644 (1998)

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      1998 Final Research Report Summary
  • [Publications] F.Obata: "An improved system for selection of forward mutations in an Escherichia coli supF gene carried by plasmids." J.Radiat.Res.39. 263-270 (1998)

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      1998 Final Research Report Summary
  • [Publications] S.Oka: "B220 is expressed on apoptotic thymocytes induced by X-irradiation." J.Vet.Med.Sci.印刷中. (1998)

    • Description
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    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Oka: "Strain difference in the phenotype of radiation-induced thymic lymphoma in DBA1 and NFS mice." Cytologia. 印刷中. (1998)

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      1998 Final Research Report Summary
  • [Publications] T.Saito: "Mouse Cdc21 only 0.5 kb upstream from Dna-pkcs in a head-to-head organization : an implication of co-evolution of ATM family members and cell cycle regulating genes." Mammalian Genome. 9. 769-772 (1998)

    • Description
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      1998 Final Research Report Summary
  • [Publications] A.Sakamoto: "The genomic organization of the Arabidopsis 6-4 photolyase gene." Plant Physiol.印刷中. (1998)

    • Description
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      1998 Final Research Report Summary
  • [Publications] A.H.Sarker: "Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III." J.Mol.Biol.282. 761-774 (1998)

    • Description
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      1998 Final Research Report Summary
  • [Publications] K.Shinmura: "Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer." Jpn.J.Cancer.Res.89. 825-828 (1998)

    • Description
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      1998 Final Research Report Summary
  • [Publications] K.Sugaya: "Alteration of the largest subunit of RNA polymerase II and its effect on chromosome stability in Schizosaccharomyces pombe." Mol.Gen.Genet.258. 279-287 (1998)

    • Description
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      1998 Final Research Report Summary
  • [Publications] T.Suzuki: "Misincorporation of 2′-deoxyoxanosine 5′-triphosphate by DNA polymerases and its implication to mutagenesis." Biochemistry. 37. 11592-11598 (1998)

    • Description
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      1998 Final Research Report Summary
  • [Publications] T.Takemoto: "Different mechanisms of thioredoxin in its reduced and oxidized forms in defense against hydrogen peroxide in Escherichia coli." Free Rad.Biol.Med.24. 556-562 (1998)

    • Description
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      1998 Final Research Report Summary
  • [Publications] T.Takemoto: "3′-Blocking damage of DNA as a mutagenic lesion caused by hydrogen peroxide in Esherichia coli." J.Radiat.Res.39. 137-144 (1998)

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      1998 Final Research Report Summary
  • [Publications] M.Tani: "Genomic structure and chromosomal localization of the mouse Ogg gene that is involved in the repair of 8-hydroxyguanine in DNA damage." Mammalian Genome. 9. 32-37 (1998)

    • Description
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    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Tano: "Specificity of mutation induced in the supF gene by riboflavin mediated photosensitization in Escherichia coli." Mutation Res.420. 7-13 (1998)

    • Description
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      1998 Final Research Report Summary
  • [Publications] H.Terato: "Novel modification of 5-formyluracil by cysteine derivatives in aqueous solution." Nucleosides Nucleotides. 17. 131-141 (1998)

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      1998 Final Research Report Summary
  • [Publications] H.Terato: "Formation of highly fluorescent adducts between 2′-deoxyguanosine and amino acids by ionizing radiation." Anal.Chim.Acta. 365. 183-191 (1998)

    • Description
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      1998 Final Research Report Summary
  • [Publications] H.Terato: "Recognition of oxidative thymine damage by DNA repair enzymes." Nucleic Acids Symp.Ser.39. 237-238 (1998)

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      1998 Final Research Report Summary
  • [Publications] Y.Tsurudome: "2-Hydroxyadenine, a mutagenic form of oxidative DNA damage, is not repaired by a glycosylase type mechanism in rat organs." Mutation Res.408. 121-127 (1998)

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      1998 Final Research Report Summary
  • [Publications] N.Uematsu: "Asymmetric crossover for spontaneous formation of large deletions at the tonB-trp region of Escherichia coli K-12 cells." Mol.Gen.Genet.印刷中. (1999)

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      1998 Final Research Report Summary
  • [Publications] H.Utsumi: "Establishment and characterization of a hypocatalasemic mouse strain." J.Radiat.Res.39. 165-174 (1998)

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      1998 Final Research Report Summary
  • [Publications] K.Yasuda: "Protein carbonyl accumulation in aging dauer formation-defective (daf) mutants of Caenorhabditis elegans." J.Gerontology : Biol.Sci.54A. 印刷中 (1998)

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      1998 Final Research Report Summary
  • [Publications] O.Yukawa: "Induction of radical scavenging ability and protection against radiation-induced damage to microsomal membranes following low-dose irradiation." Int.J.Radiat.Biol.印刷中. (1998)

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      1998 Final Research Report Summary
  • [Publications] Q.-M.Zhang: "Replication in vitro and cleavage by restriction endonuclease of 5-formyluracil-and 5-hydroxymethyluracil-containing oligonucleotides." Int.J.Radiat.Biol.印刷中. (1998)

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      1998 Final Research Report Summary
  • [Publications] Q.-M.Zhang: "Escherichia coli MutY protein has a guanine-DNA glycosylase that acts on 7,8-dihydro-8-oxoguanine : guanine mispair to prevent spontaneous G : C-C : G transversions." Nucleic Acids Res.26. 4669-4675 (1998)

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      1998 Final Research Report Summary
  • [Publications] Q.-M.Zhang: "Oxygen stress model : E.coli, cultured cells." in : Experimental Protocols for reactive Oxygen species (ROS) and nitrogen species (RNS). (eds., N.Taniguchi and J.M.C.Gutteridge). 印刷中. (1999)

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  • [Publications] H.Sugiyama: "New synthetic method of 5-formyluracil-containing oligonucleotides and their melting betavior.." Tetrahedron Lett.37. 9067-9070 (1996)

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  • [Publications] N.Suzuki: "Cloning, sequencing and mapping of a manganese superoxide dismutase gene of the nematode Caenorhabditis elegans." DNA Res.3. 171-174 (1996)

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      1998 Final Research Report Summary
  • [Publications] T.Suzuki: "Isolation and characterization of a novel product, 2′-deoxyoxanosine, from 2′-deoxyguanosine, oligonucleotide, and calf thymus DNA treated by nitrous acid and nitric oxide." J.Am.Chem.Soc.118. 2515-2516 (1996)

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      1998 Final Research Report Summary
  • [Publications] M.Takao: "Characterization of a UV endonuclease gene from the fission yeast Schizosaccharomyces pombe and its bacterial homolog." Nucleic Acids Res.24. 1267-1271 (1996)

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      1998 Final Research Report Summary
  • [Publications] T.Todo: "Similarity among the Drosophila (6-4) photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family." Science. 272. 109-112 (1996)

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      1998 Final Research Report Summary
  • [Publications] H.Utsumi: "Thermal neutron capture therapy using 10B1-paraboronophenyl-alanine (BPA). Lethal effects on melanoma cells irrespective of x-ray sensitivity." J.Radiat.Res.37. 193-198 (1996)

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      1998 Final Research Report Summary
  • [Publications] X.Wang: "Mutagenic specificity of N-methyl-N′-nitro-N-nitrosoguanidine in the tonB gene on the chromosome of Escherichia coli recA+and recA-cells." Biochem.Biophys.Res.Commun.227. 334-339 (1996)

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      1998 Final Research Report Summary
  • [Publications] R.Yamaguchi: "Increased 8-hydroxyguanine levels in DNA and its repair activity in rat kidney after administraion of a renal carcinogen, ferric nitrilotriacetate." Carcinogenesis. 17. 2419-2422 (1996)

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      1998 Final Research Report Summary
  • [Publications] K.Yamamoto: "Properties of an oxygen-sensitive mutant mev-3 of the nematode Caenorhabditis elegans." Mutation Res.358. 1-6 (1996)

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      1998 Final Research Report Summary
  • [Publications] T.Yamashita: "The effects of α-phenyl--tert butyl nitrone (PBN) on copper-induced rat fulminant hepatitis with jaundice." Free Rad.Biol.Med.21. 755-761 (1996)

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      1998 Final Research Report Summary
  • [Publications] M.Yamauchi: "Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3′-untranslated region of human transcript." DNA Res.2. 269-275 (1996)

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      1998 Final Research Report Summary
  • [Publications] Q.-M.Zhang: "Induction of repair capacity for oxidatively damaged DNA as a component of peroxide stress in Escherichia coli." J.Radiat.Res.37. 171-175 (1996)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] T.Abe: "Inhibition of nucleolar function and morphological change by adriamycin associated with heat shock protein 70 accumulation." Jpn.J.Cancer Res.87. 945-951 (1996)

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      1998 Final Research Report Summary
  • [Publications] T.Hiroi: "The cDNA sequence encoding bovine SP-22, a new defence system against Oxygen species in mitochondria." DNA Sequence. 6. 239-242 (1996)

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      1998 Final Research Report Summary
  • [Publications] T.Hirano: "8-Hydroxyguanine levels in nuclear DNA and its repair activity in rat organs associated with age." J.Gerontology. 51A. B303-B307 (1996)

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      1998 Final Research Report Summary
  • [Publications] H.Kamiya: "Effects of sequence contexts on misincorporation of nucleotides opposite 2-hydroxyadenine." FEBS Letters. 391. 113-116 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Kamiya: "Oxidative DNA lesions and mutagenesis." Environ.Mutagen Res.18. 181-189 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Kitamura: "Mutagenic specificity of ultraviolet light in the tonB gene on the chromosome of Escherichia coli uvrA cells." Biochem. Biophys. Res.Commun.220. 496-501 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Kobayashi: "Bioprocessing in micrograbity : free flow electrophoresis of C. elegans DNA." J.Biotechnol.47. 367-376 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Kushibiki: "Molecular cloning of oxygen-inducible genes in Caenorhabditis elegans by RT-PCR differential display." Pathophysiol.3. 107-110 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.S.Lee: "Induction of oh8Gua glycosylase in rat kidneys by potassium bromate (KBrO3), a renal oxidative carcinogen." Mutation Res.364. 224-23〓 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Nakajima: "Radiation-induced translocation of protein kinase C through membrane lipid peroxidation in primary cultured rat hepatocytes." Int.J.Radiat.Biol.70. 473-480 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Ohshima: "Damage induced by hydroxyl radicals generated in the hydration layer of γ-irradiated frozen aqueous solution of DNA." J.Radiat.Res.37. 199-207 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] I.Sakonju: "Cryopreservation of isolated rat islets of Lnagerhans in the presence of ethylene glycol or dimethyl sulfoxide : Evaluation of toxicity and the dynamic pattern of subsequent insulin release in vitro." Cryobiology. 33. 354-362 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Takimoto: "Spectrum of spontaneous mutations in the cyclic AMP receptor protein gene on chromosomal DNA of Escherichia coli." J.Radiat. Res.38. 27-36 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Tano: "Amplification of the DNA repair gene O6-methylguanine-DNA methyltransferase associated with resistant to alkylating agents drugs in mammalian cell line." J.Biol. Chem.272. 13250-13254 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Tao: "oxyR-dependent induction of Escherichia coli grx gene expression by peroxide stress." J.Bacteriol.179. 5967-5970 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Uematsu: "Mutational specificity of topB deletion mutator in Escherichia coli." Mutation Res.383. 223-230 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Yamamoto: "Enzymatic repair mechanisms for base modifications induced by oxygen radicals." J.Radiat. Res.38. 1-4 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Yamashita: "Progressive effect of α-phenyl-N-tert-butylnitrone (PBN) on rat embryo development in vitro." Free Rad.Biol.Med.23. 1073-1077 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] R.Yonemasuo: "Chracterization of the alternative excision repair pathway of UV-damaged DNA in Schizosaccharomyces pombe." Nucleic Acids Res.25. 1553-1559 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Yoshida: "Substrate and misparing properties of 5-formyl-2′-deoxyuridine 5′-triphosphate assessed by in vitro DNA polmerase reactions." Nucleic Acids Res.25. 1570-1577 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] D.Zhang: "Vitamin E inhibits apoptosis, DNA modfication, and Cancer incidence induced by iron-mediated peroxidation in Wister rat kidney." Cancer Res.57. 2410-2414 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Q.-M.Zhang: "Replication of DNA templates containing 5-formyluracil, a major oxidative lesion of thymine in DNA." Nucleic Acids Res.25. 3969-3973 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Nagashima: "Presence of human cellular protein (s) that specifically binds and cleaves 8-hydroxyguanine containing DNA." Mutation Res.383. 49-59 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Ohshima: "Reactions between hydroxyl-radical-induced 7 8-dihydro-8-oxo-2′-deoxyguanosine precursor and the spin trap α-phenyl-N-tert-butylnitrone." J.Radiat. Res.38. 15-25 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Ono: "X-ray-and ultraviolet-radiation-induced mutations in Muta^<TM> Mouse." Radiat. Res.148. 123-128 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Saito: "Characterization of endonuclease III (nth) and endonuclease VIII (nei) mutants of Escherichia coli K12." J.Bacteriol.179. 3783-3785 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Shimamura: "Mutational specificity of the ferrous ion in a supF gene of endonuclease III/VIII deficient Escherichia coli." J.Radiat. Res.38. 165-171 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Shimizu: "Replication bypass and mutagenic effect of alpha-deoxyadenosine site-specifically incorporated into single-stranded vector." Nucleic Acid Res.25. 597-603 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Shinmura: "8-Hydroxyguanine (7, 8-dihydro-8-oxoguanine) DNA glycosylase and AP lyase activities of hOGG1 protein and their substrate specificity." Mutation Res.385. 75-82 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Sugaya: "Cloning and sequencing for the largest subunit of chinese hamster RNA polymerase II gene : identification of a mutation related to abnormal induction of sister chromatid excahnges." Gene. 194. 267-272 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Suzuki: "A comparison of the genotoxicity of ethylnitrosourea and ethyl methanesulfonate in lacZ transgenic mice." Mutation Res.395. 75-82 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Suzuki: "Deglycosylation susceptibility and base-pairing stability of 2′-deoxyoxanosine in oligodeoxynucleotide." Biochemistry. 36. 8013-8019 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Suzuki: "Construction of mutants of Salmonella typhymurium deficient in 8-hydroxyguanine DNA glycosylase and their sensitivities to oxidative mutagens and nitro compounds." Mutation Res.393. 233-246 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Takahashi: "Relationship between asbestos exposures and 8-hydroxydeoxyguanosine levels in leukocytic DNA of workers at a chinese asbestos-material plant." Int.J.Occup. Environ. Health.3. 111-119 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Abe, T., Fukamachi, Y., Kanazawa, Y., Furukawa, H., Shimizu, K., Hirano, T., Kasai, H., Kashimura, M.and Higashi, K.: "Inhibition of nucleolar function and morphological change by adriamycin associated with heat shock protein 70 accumulation" Jpn.J.Cancer Res.87. 945-951 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiroi, T., Watabe, S., Takimoto, K., Yago, N., Yamamoto, Y.and Takahashi, S.: "The cDNA sequence encoding bovine SP-22, a new defense system against oxygen species in mitochondria" DNA Sequence. 6. 239-242 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hirano, T., Yamaguchi R., Asami, S., Iwamoto, N.and Kasai, H.: "8-Hydroxyguanine levels in nuclear DNA and its repair activity in rat organs associated with age." J.Gerontology. 51A. B303-B307 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kamiya, H.and Kasai, H.: "Effects of sequence contexts on misincorporation of nucleotides opposite 2-hydroxyadenine." FEBS Letters. 391. 113-116 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kamiya, H.and Kasai, H.: "Oxidative DNA lesions and mutagenesis" Environ.Mutagen Res.18. 181-189 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kitamura, K.and Yamamoto, K.: "Mutagenic specificity of ultraviolet light in the tonB gene on the chromosome of Escherichia coli uvrA cells" Biochem.Biophys.Res.Commun.220. 496-501 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kobayashi, H., Ishii, N.and Nagaoka, S.: "Bioprocessing in micrograbity : free flow electrophoresis of C.elegans DNA." J.Biotechnol. 47. 367-376 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kushibiki, Y., Ishii, N., Yanase, S.and Nakazawa, H.: "Molecular cloning of oxygen-inducible genes in Caenorhabditis elegans by RT-PCR differential display" Pathophysiol. 3. 107-110 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Lee, Y.S., Choi, J.Y., Park, M.K., Choi, E.M., Kasai, H.and Chung, M.H.: "Induction of oh8Gua glycosylase in rat kidneys by potassium bromate (KBrO3), a renal oxidative carcinogen" Mutation Res.364. 227-233 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakajima, T.and Yukawa, O.: "Radiation-induced translocation of protein kinase C through membrane lipid peroxidation in primary cultured rat hepatocytes" Int.J.Radiat.Biol.70. 473-480 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohshima, H., Iida, Y., Matsuda, A.and Kuwabara, M.: "Damage induced by hydroxyl radicals generated in the hydration layer of v-irradiated frozen aqueous solution of DNA" J.Radiat.Res.37. 199-207 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sakonju, I., Taura, Y., Inayoshi, Y., Suzuki, T., Takimoto, K., Nakaichi, M.and Nakama, S.: "Cryopreservation of isolated rat islets of Lnagerhans in the presence of ethylene glycol or dimethyl sulfoxide : Evaluation of toxicity and the dynamic pattern of subsequent insulin release in vitro." Cryobiology. 33. 354-362 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sugiyama, H., Matsuda, S., Zhang, Q.-M., Yonei, S.and Saito, I.: "New synthetic method of 5-formyluracil-containing oligonucleotides and their melting behavior" Tetrahedron Lett.37. 9067-9070 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki, N., InokumaK., Yasuda, K.and Ishii, N.: "Cloning, sequencing and mapping of a manganese superoxide dismutase gene of the nematode Caenorhabditis elegans." DNA Res.3. 171-174 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki, T., Yamaoka, R., Nishi, M., Ide, H.and Makino, K.: "Isolation and characterization of a novel product, 2'-deoxyoxanosine, from 2'-deoxyguanosine, oligonucleotide, and calf thymus DNA treated by nitrous acid and nitric oxide." J.Am.Chem.Soc.118. 2515-2516 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takao, M., Yonemasu, R., Yamamoto, K.and Yasui, A.: "Characterization of a UV endonuclease gene from the fission yeast Schizosaccharomyces pombe and its bacterial homolog" Nucleic Acids Res.24. 1267-1271 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Todo, T., Ryo, H., Yamamoto, K., Toh, H., Inui, T., Ayaki, H., Nomura, T.and Ikenaga, M.: "Similarity among the Drosophila (6-4) photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family" Science. 272. 109-112 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Utsumi, H., Tano, K., Mizuma, N., Kobayashi, T.and Ichihasi, M.: "Thermal neutron capture therapy using 10B1-paraboronophenyl-alanine (BPA). Lethal effects on melanoma cells irrespective of x-ray sensitivity" J.Radiat.Res.37. 193-198 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wang, X., Kitamura, K.and Yamamoto, K.: "Mutagenic specificity of N-methyl-N'-nitro-N-nitrosoguanidine in the tonB gene on the chromosome of Escherichia coli recA+ and recA-cells." Biochem.Biophys.Res.Commun.227. 334-339 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamaguchi, R., Hirano, T., Asami, S., Chung, M.H., Sugita, A.and Kasai, H.: "Increased 8-hydroxyguanine levels in DNA and its repair activity in rat kidney after administration of a renal carcinogen, ferric nitrilotriacetate" Carcinogenesis. 17. 2419-2422 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamamoto, K., Honda, H.and Ishii, N.: "Properties of an oxygen-sensitive mutant mev-3 of the nematode Caenorhabditis elegans" Mutation Res.358. 1-6 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamashita, T., Ohshima, H., Asanuma, T., Inukai, N., Miyoshi, I., Kasai, N., Kon, Y., Watanabe, T., Sato, F.and Kuwabara, M.: "The effects of alpha-phenyl-tert butyl nitrone (PBN) on copper-induced rat fulminant hepatitis with jaundice" Free Rad.Biol.Med.21. 755-761 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamauchi, M., Seki, N., Mita, K., Saito, T., Tsuji, S., Hongo, E., Morimyo, M., Shiomi, T., Koyama, H., Ayusawa, D., Hori, T.: "Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript." DNA Res. 2. 269-275 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zhang, Q.-M., Mito, S., Takemoto, T.and Yonei, S.: "Induction of repair capacity for oxidatively damaged DNA as a component of peroxide stress in Escherichia coli" J.Radiat.Res.37. 171-175 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Abe, H., Ikebuchi, K., Wagner, S.J., Kuwabara, M., Kamo, N.and Sekiguchi, S.: "Involvement of both type I and type II mechanisms in M13 virus inactivation by methylene blue photosensitization" Photochem.Photobiol.66. 204-208 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Abe, H., Wagner, S.J., Kuwabara, M., Kamo, N., Ikebuchi, K.and Sekiguchi, S.: "Factors affecting M13 bacteriophage inactivation by methylene blue photosensitization" Photochem.Photobiol. 65. 873-876 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Aburatani, H., Hippo, Y., Ishida, T., Takashima, R., Matsuba, C., Kodama, T., Takao, M., Yasui, A., Yamamoto, K., Asano, M., Fukasawa, K., Yoshinari, T., Inoue, H., Ohtsuka, E.and Nishimura, S.: "Cloning and characterization of mammalian 8-hydroxyguaninespecific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue" Cancer Res.57. 2151-2156 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Araki, R., Fujimura, A., Hamatani, K., Mita, K., Saito, T., Mori, M., Fukumura, R., Morimyo, M., Muto, M., Itoh, M., Tatsumi, K., Abe, M.: "Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice" Proc.Natl.Acad.Sci.USA. 94. 2438-2443 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Asami, S., Manabe, H., Miyake, J., Tsurudome, Y., Hirano, T., Yamaguci, R., Itoh, H.and Kasai, H.: "Cigarette smoking induces an increase in oxidative DNA damage, 8-hydroxydeoxyguanosine, in a central site of the human lung" Carcinogenesis. 18. 1763-1766 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hirano, T., Yamaguchi, Y.and Kasai, H.: "Inhibition of 8-hydroxyguanine repair in testes after administration of cadmium chloride to GSH-depleted rats" Toxicology and Applied Pharmacology. 147. 9-14 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiraoka, W., Fuma, K.and Kuwabara, M.: "Concentration-dependent modes of cell death in Chinese hamster V79 cells after treatments with H_2O_2" J.Radiat.Res.38. 95-102 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ide, H., Kow, Y.W., Chen, B., Erlanger B.F.and Wallace S.S.: "Antibodies to oxidative DNA damage : Characterization of antibodies to 8-oxopurines" Cell Biol.Toxicol. 13. 405-417 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ide, H., Terato, H., Masaoka, A., Nagasawa, N.and Ohyama, Y.: "Mechanisms of the genotoxic effects associated with 5-formyluracil-Effect of exogenous 5-formyl-2'-deoxyuridine." Nucleic Acids Symp.Ser.37. 165-166 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Izumi, T., Tatsuka, M., Tano, K,Asano, M.and Mitra, S.: "Molecular cloning and characterization of the promoter of the human N methylpurin-DNA glycosylase (MPG) gene" Carcinogenesis. 18. 1837-1839 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kamath-Loeb, A.S., Hizi, A., Kasai, H.and Loeb, L.A.: "Incorporation of the guanosine triphosphate analogs 8-oxo-dGTP and 8-NH2-dGTP by reverse transcriptases and mammalian DNA polymerases" J.Biol.Chem.272. 5892-5898 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kamiya, H.and Kasai, H.: "Substitution and deletion mutations induced by 2-hydroxyadenine in Escherichia coli : Effects of sequence contexts in leading and lagging strands" Nucleic Acids Res.25. 304-310 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kamiya, H.and Kasai, H.: "Mutations induced by 2-hydroxyadenine on a shuttle vector during leading and lagging strand syntheses in mammalian cells" Biochemistry. 36. 11125-11130 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kanbashi, K., Wang, X., Komura, J.-I., Ono, T.and Yamamoto, K.: "Frameshifts, base substitutions and minute deletions constitute X-ray-induced mutations in the endogenous tonB gene of Escherichia coli K12" Mutation Res.385. 259-267 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Saito, Y., Uraki, F., Nakajima, N., Asaeda, A., Ono, K., Kubo, K.and Yamamoto, K.: "Characterization of endonuclease III (nth) and endonuclease VIII (nei) mutants of Escherichia coli K12" J.Bacteriol. 179. 3783-3785 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimamura, H., Akasaka, S., Kubo, K., Saito, Y., Nakajima, S., Tano, K., Utsumi, H.and Yamamoto, K.: "Mutational specificity of the ferrous ion in a supF gene of endonuclease III/VIII deficient Escherichia coli" J.Radiat.Res.38. 165-171 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu, H., Yagi, R., Kimura, Y., Makino, K.and Ide, H.: "Replication bypass and mutagenic effect of alpha-deoxyadenosine site-specifically incorporated into single-stranded vector" Nucleic Acids Res. 25. 597-603 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shinmura, K., Kasai, H., Sasaki, A., Sugimura, H.and Yokota, J.: "8-Hydroxyguanine (7,8-dihydro-8-oxoguanine) DNA glycosylase and AP lyase activities of hOGG1 protein and their substrate specificity" Mutation Res.385. 75-82 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sugaya, K., Sasanuma, S., Nohata, J., Kimura, T., Hongo, E., Higashi, T.Morimyo, M., Tsuji, H., Mita, K.: "Cloning and sequencing for the largest subunit of chinese hamster RNA polymerase II gene : identification of a mutation related to abnormal induction of sister chromatid excahnges" Gene. 194. 267-272 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki, T., Hayashi, M., Wang, X., Yamamoto, K., Ono, T., Myhr, B.C.and Sofuni, T.: "A comparison of the genotoxicity of ethylnitrosourea and ethyl methanesulfonate in lacZ transgenic mice" Mutation Res.395. 75-82 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki, T., Matsumura, Y., Ide, H., Kanaori, K., Tajima, K.and Makino, K.: "Deglycosylation susceptibility and base-pairing stability of 2'-deoxyoxanosine in oligodeoxynucleotide" Biochemistry. 36. 8013-8019 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki, M., Matsui, K., Yamada, M., Kasai, H., Sofuni, T.and Nohmi, T.: "Construction of mutants of Salmonella typhymurium deficient in 8-hydroxyguanine DNA glycosylase and their sensitivities to oxidative mutagens and nitro compounds" Mutation Res.393. 233-246 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takahashi, K., Pan, G., Kasai, H., Hanaoka, T., Feng, Y., Liu, N., Zhang, S., Xu, Z., Tsuda, T., Yamoto, H., Higashi, T.and Okubo, T.: "Relationship between asbestos exposures and 8-hydroxydeoxyguanosine levels in leukocytic DNA of workers at a Chinese asbestos-material plant" Int.J.Occup.Environ.Health. 3. 111-119 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takimoto, K., Tachibana, A., Ayaki, H.and Yamamoto, K.: "Spectrum of spontaneous mutations in the cyclic AMP receptor protein gene on chromosomal DNA of Escherichia coli" J.Radiat.Res. 38. 27-36 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tano, K., Dunn, W.C., Darroudi, F., Shiota, S., Preston, R.J.Natarajan, A.T.and Mitra, S.: "Amplification of the DNA repair gene 06-methylguanine-DNA methyltransferase associated with resistant to alkylating agents drugs in mammalian cell line" J.Biol.Chem. 272. 13250-13254 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tao, K.: "oxyR-dependent induction of Escherichia coli grx gene expression by peroxide stress" J.Bacteriol. 179. 5967-5970 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kasai, H., Asami, S., Yamaguchi, R.and Hirano, T.: "Increased 8-hydroxyguanine repair activity in animal livers and human leukocytes induced by oxidative stress : Effects of diet, physical exercise, and cigarette smoking" In "Food Factors for Cancer Prevention", Springer-Verlag Tokyo. 58-62 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kasai, H.: "Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis" Mutation Res.387. 147-163 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kashiwakura, I., Kuwabara, M., Murakami, M., Hayase, Y.and Takagi, Y.: "Effects of alpha-phenyl-N-tert-butylnitrone, a spin trap reagent, on the proliferation of murine hematopoietic progenitor cells in vitro" Res.Comm.Molec.Path.Pharm.98. 67-76 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kuwabara, M., Ohshima, H., Iida, Y.and Inanami, O.: "The increased formation of alkali-labile sites by a spin-trapping agent alpha-phenyl-N-tert-butylnitrone in gamma-irradiated frozen aqueous solution of DNA" J.Radiat.Res.38. 153-155 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuyama, S., Kubo, K., Ohashi, F.and Takamori, Y.: "Partial cloning of prohibitin cDNA from canine, feline, bovine, equine, and rabbit liver mRNA by RT-PCR" J.Vet.Med.Sci. 59. 201-203 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mita, K., Morimyo, M., Ito, K., Sugaya, K., Ebihara, K., Hongo, E., Higashi, T., Hirayama, Y., Nakamura, Y.: "Comprehensive cloning of Schizosaccharomyces pombe genes encoding translation elongation factors" Gene. 187. 259-266 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Murata-Kamiya, N., Kamiya, H., Muraoka, M., Kaji, H.and Kasai, H.: "Comparision of oxidation products from DNA components by v-irradiation and Fenton-type reactions" J.Radiat.Res.38. 121-131 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Murata-Kamiya, N., Kaji, H.and Kasai, H.: "Types of mutations induced by glyoxal, a major oxidative DNA-damage product, in Salmonella typhimurium" Mutation Res.377. 13-16 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Murata-Kamiya, N., Kamiya, H., Kaji, H.and Kasai, H.: "Mutational specificity of glyoxal, a product of DNA oxidation, in the lacI gene of wild-type Escherichia coli W3110" Mutation Res.377. 225-262 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Murata-Kamiya, N., Kamiya, H., Kaji, H.and Kasai, H.: "Glyoxal, a major product of DNA oxidation, induces mutations at G : C sites on a shuttle vector plasmid replicated in mammalian cells" Nucleic Acid Res. 25. 1897-1902 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Nagashima, M., Sasaki, A., Morishita, K., Takenoshita, S., Nagamachi, Y., Kasai, H.and Yokota, J.: "Presence of human cellular protein (s) that specifically binds and cleaves 8-hydroxyguanine containing DNA" Mutation Res.383. 49-59 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohshima, H., Ono, A., Matsuda, A., Sawamura, S.and Kuwabara, M.: "Reactions between hydroxyl-radical-induced 7,8-dihydro-8-oxo-2'-deoxyguanosine precursor and the spin trap alpha-phenyl-N-tert-butylnitrone" J.Radiat.Res.38. 15-25 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ono, T., Ikehata, H., Hosoi, Y., Shung, B.S., Kurishita, A., Wang, X., Yamamoto, K., Suzuki, T.and Sofuni, T.: "X-ray-and ultraviolet-radiation-induced mutations in MutaTM Mouse" Radiat.Res. 148. 123-128 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Uematsu, N., Eda, S.and Yamamoto, K.: "Mutational specificity of topB deletion mutator in Escherichia coli." Mutation Res.383. 223-230 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamamoto, K., Uraki, F., Yonei, S.and Yukawa, O.: "Enzymatic repair mechanisms for base modifications induced by oxygen radicals" J.Radiat.Res.38. 1-4 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Yamashita, T.Yamazaki, H., Kon, Y., Watanabe, T., Arikawa, J., Miyoshi, I., Kasai, N.and Kuwabara, M.: "Progressive effect of alpha-phenyl-N-tert-butylnitrone (PBN) on rat embryo development in vitro" Free Rad.Biol.Med.23. 1073-1077 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yonemasu, R., McCready, S., Murray, J.M., Osman, F., Takao, M., Yamamoto, K., Lehmann, A.R.and Yasui, A.: "Chracterization of the alternative excision repair pathway of UV-damaged DNA in Schizosaccharomyces pombe" Nucleic Acids Res. 25. 1553-1559 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshida, M., Makino, K., Morita, H., Terato, H., Ohyama, Y.and Ide, H.: "Substrate and misparing properties of 5-formyl-2'-deoxyuridine 5'-triphosphate assessed by in vitro DNA polymerase reactions." Nucleic Acids Res.25. 1570-1577 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zhang, D., Okada, S., Yu, Y., Zheng, P., Yamaguchi, R.and Kasai, H.: "Vitamin E inhibits apoptosis, DNA modfication, and cancer incidence induced by iron-mediated peroxidation in Wister rat kidney" Cancer Res. 57. 2410-2414 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zhang, Q.-M., Sugiyama, H., Miyabe, I., Matsuda, S., Saito, I.and Yonei, S.: "Replication of DNA templates containing 5-formyluracil, a major oxidative lesion of thymine in DNA" Nucleic Acids Res. 25. 3969-3973 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Adachi, H., Fujiwara, Y.and Ishii, N.: "Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans" J.Gerontol. : Biol.Sci.53A. B240-B244 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Aoki, M., Sasaki, N., Nomura, K., Katamoto, H., Kubo, K., Kodama, H., Mukamoto, M., Shimada, T.and Ohashi, F.: "Cytotoxicity induced by recombinant human tumor necrosis factor-a dependent on the types of its receptors on canine cells" J.Vet.Med.Sci. 60. 889-895 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Aoki, M., Kuwamura, M., Kotani, T., Katamoto, H., Kubo, K., Nomura, K., Sasaki, N.and Ohashi, F.: "In vitro cytotoxicity of recombinant human-TNF-a and actinomycin D on canine normal and tumor cells" J.Vet.Med.Sci. 60. 1087-1091 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Arashidani, K., Iwamoto-Tanaka, N., Muraoka, M.and Kasai, H.: "Genotoxicity of ribo-and deoxyribonucleosides of 8-hydroxyguanine 5-hydroxycytosine, and 2-hydroxyadenine : induction of SCE in human lymphocytes and mutagenicity in Salmonella typhimurium TA 100" Mutation Res.403. 223-227 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Asaeda, A., Ide, H., Tano, K., Takmori, Y.and Kubo, K.: "Repair kinetics of abasic sites in mammalian cells selectively monitored by aldehyde reactive probe (ARP)" Nucleosides and Nucleotides. 17. 503-513 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Asaeda, A., Ide, H., Terato, H.Takmori, Y.and Kubo, K.: "Highly sensitive assay of DNA abasic sites in mammalian cells-Optimization of the aldehyde reactive probe (ARP) method" Analytica Chimica Acta. 365. 35-41S (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Asaeda, A., Ide, H., Tano, K,Takamori, Y.and Kubo, K.: "Repair kinetics of abasic sites in mammalian cells selectively monitored by the aldehyde reactive prove (ARP)" Nucleosides Nucleotides. 17. 503-513 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Asami, S., Hirano, T., Yamaguchi, R., Tsurudome, Y., Itoh, H.and Kasai, H.: "Effects of forced and spontaneous exercise on 8-hydroxydeosyguanosine levels in rat organs" Biochem.Biophys.Res.Commun.243. 678-682 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fujii, M., Ishii, N., Joguchi, A., Yasuda, K.and Ayusawa, D.: "A novel superoxide dismutase gene encoding membrane-bound and extracellular isoforms by alternative splicing in Caenorhabditis elegans" DNA Res. 5. 25-30 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fujikawa, K., Kamiya, H.and Kasai, H.: "The mutation induced by oxidatively damaged nucleotides, 5-formyl-dUTP and 5-hydroxy-dCTP,in Escherichia coli" Nucleic Acids Res. 26. 4582-4587 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hartman, P.S.and Ishii, N.: "Isolating mutants of the nematode Caenorhabditis elegans that are hypersensitive to DNA-damaging agents, Methods" in Molecular Biology, Vol.XX : DNA Repair Protocols : Eukaryotic Systems (ed.D.S.Henderson), p11-16, Humana Press Inc., Totowa, NJ. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Inanami, O., Watanabe, Y., Syuto, B., Nakano, M., Tsuji, M.and Kuwabara, M.: "Oral administration of (-) catechin protects against ischemia-reperfusion-induced neuronal death in the gerbil" Free Rad.Res. 29. 359-365 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Inanami, O., Takahashi, K.and Kuwabara, M.: "Attenuation of caspase 3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells" Int.J.Radiat.Biol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Inoue, M., Osaki, T., Noguchi, M., Hirohashi, S., Yasumoto, K.and Kasai, H.: "Lung cancer patients have increased 8-hydoxydeoxyguanosine leveles in peripheral lung tissue DNA" Jpn.J.Cancer Res. 89. 691-695 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Inoue, M., Kamiya, H., Fujikawa, K., Ootsuyama, Y., Murata-Kamiya, N., Osaki, T., Yasumoto, K., Kasai, H.: "Induction of chromosomal gene mutations in Escherichia coli by direct incorporation of oxidatively damaged nucleotides" J.Biol.Chem.273. 11069-11074 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishii, N., Fujii, M., Hartman, P.S., Tsuda, M., Yasuda, K., Senoo-Matsuda, N., Yanase, S., Ayusawa, D.and Suzuki, K.: "A mutation in succinate dehydrogenase b causes oxidative stress and ageing in nematodes" Nature. 394. 694-697 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Iyehara-Ogawa, H., Ohyama, Y., Kakimoto, K., Kato, Y., Shirai, Y., Nunoshiba, T.and Yamamoto, K: "Cobaltous chloride-induced mutagenesis in the supF tRNA gene of Escherichia coli" Mutagenesis. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kamiya, H., Iwai, S.and Kasai, H.: "The (6-4) photoproduct of thymine-thymine induces targeted substitution mutations in mammalian cells" Journal of the Nucleic Acids Res. 26. 2611-2617 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kasai, H.and Lunec, J.: "Analysis of 8-hydroxydeoxyguanosine, an oxidative DNA damage product, in human samples." International Federation of Clinical Chemistry and Laboratory Medicine. 10. 51-52 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kasai, H., Iwamoto-Tanaka, N.and Fukada, S.: "DNA modifications by the mutagen glyoxal : adduction to G and C,demination of C and GC and GA cross-linking" Carcinogenesis. 19. 1459-1465 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kashiwakura, I., Kuwabara, M., Murakami, M., Hayase, Y.and Takagi, Y.: "Effects of carboxy-PTIO,a nitric oxide scavenger, on the proliferation of murine hematopoietic progenitor cells in vitro" Res.Comm.Molec.Path.Pharm. 99. 329-337 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kubo, K., Matsuyama, S., Sato, K., Shiomi, A., Ono, K., Ito, Y., Ohashi, F.and Takamori, Y.: "Novel putative fragile sites observed in feline fibroblasts treated with aphidicolin and fluorodeoxyuridine" J.Vet.Med.Sci. 60. 809-813 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kuwabara, M., Inanami, O., Takahashi, K.and Hiraoka, W.: "Radiation-and reactive oxygen-induced cell death and signal transduction in cultured mammalian cells" In : Biological Oxidants & Antioxidants : Molecular Mechanisms & Health Effects, pp.14-21, Packer, L.& Ong, H.S.Eds., AOCS Press, Illinois. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kuwabara, M.and Inanami, O.: "Biodefense against active oxygens and free radicals induced by oxidative stress" In : Biodefense Mechanisms against Environmental Stress, pp.23-32, Ozawa, T., Tatsumi, K.and Hori, T.eds., Kodansha and Springer, Tokyo. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mori, T., Tano, K,Takimoto, K.and Utsumi, H.: "Formation of 8-hydroxyguanine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine in DNA by riboflavin mediated photosensitization" Biochem.Biopys.Res.Commun.242. 98-101 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Morimyo, M., Mita, K., Hongo, E., Higashi, T., Sugaya, K., Ajimura, M., Yamauchi, M., Tsuji, S., Park, W-Y., Sasanuma, S., Nohata, J., Kimura, T., Inoue, H., Ishihara, Y.: "cDNA catalog of fission yeast (Schizosaccharomyces pombe) and its application for cloning of mammalian DNA repair gene" in "Biodefence mechanisms against environmental stress" eds.by Ozawa, T., Hori, T., Tatsumi, K.Kodansha and Springer-Verlag. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Murata-Kamiya, N., Kamiya, H., Kaji, H.and Kasai, H.: "Nucleotide excision repair proteins may be involved in the fixation of glyoxal-induced mutagenesis in Escherichia coli.Biochem." Biophys.Res.Commun.248. 412-417 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakajima, S., Sugiyama, M., Iwai, S., Hitomi, K., Otoshi, E., Kim, S.-T., Jiang, C.-Z., Todo, T., Britt, A.B.and Yamamoto, K.: "Cloning and characterization of a gene (UVR3) required for photorepair of 6-4 products in Arabidopsis thaliana" Nucleic Acids Res.26. 638-644 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Obata, F., Nunoshiba, T.and Yamamoto, K: "An improved system for selection of forward mutations in an Escherichia coli supF gene carried by plasmids" J.Radiat.Res.39. 263-270 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Asami: "Effects of forced and spontaneous exercise on 8-hydroxydeoxyguanosine levels in rat organs.Biochem." Biophys.Biochem.Res.Commun.243. 678-682 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Fujii: "A novel superoxide dismutase gene encoding membrane-bound and extracellular isoforms by alternative splicing in Caenorhabditis elegans." DNA Research. 5. 25-30 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Fujikawa: "The mutation induced by oxidatively damaged nucleotides,5-formyl-dUTP and 5-hydroxy-dCTP,in Escherichia coli." Nucleic Acids Res.26. 4582-4587 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] P.S.Hartman: "Isolating mutants of the nematode Caenorhabditis elegans that are hypersensitive to DNA-damaging agents." Methods in Molecular Biology,Vol.XX:DNA Repair Protocols:Eukaryotic Systems(ed.D.S.Henderson). 印刷中. p11-p16 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Inoue: "Lung cancer patients have increased 8-hydroxydeoxyguanosine leveles in peripheral lung tissue DNA." Jpn.J.Cancer Res.89. 691-695 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Inoue: "Induction of chromosomal gene mutations in Escherichia coli coli by direct incorporation of oxidatively damaged nucleotides." J.Biol.Chem.273. 11069-11074 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Adachi: "Effects of oxygen on protein carbonyl and aging in Caenorhabditis eiegans mutants with long(age-1)and short(mev-1)life spans." J.Gerontology:Biol.Sci.53A. B240-B244 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Aoki: "Cytotoxicity induced by recombinant human tumor necrosis factor-a dependent on the types of its receptors on canine cells." J.Vet.Med.Sci.60. 889-895 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Aoki: "In vitro cytotoxicity of recombinant human-TNF-a and actinomycin D on canine normal and tumor cells." J.Vet.Med.Sci.60. 1087-1091 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Arashidani: "Genotoxicity of ribo- and deoxyribonucleosides of 8-hydroxyguanine 5-hydroxycytosine,and 2- hydroxyadenine:induction of SCE in human lymphocytes and mutagenicity in S.typhimurium TA 100." Mutation Res.403. 223-227 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.Asaeda: "Repair kinetics of abasic sites in mammalian cells selectively monitored by aldehyde reactive probe(ARP)." Nucleosides and Nucleotides. 17. 503-513 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.Asaeda: "Highly sensitive assay of DNA abasic sites in mammalian cells‥Optimization of the aldehyde reactive probe(ARP)method." Analytica Chimica Acta. 365. 35-41S (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] O.Inanami: "Attenuation of caspase 3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells.Int." J.Radiat.Biol.(印刷中). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] O.Inanami: "Lipid peroxides and antioxidants in sera of neonatal calves." Am.J.Vet.Res.(印刷中). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] O.Inanami: "Oral administration of (-)catechin protects against ischemia-reperfucion-induced neuronal death in the gerbil." Free Rad.Res.29. 359-365 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] N.Ishii: "A mutation in succinate dehydrogenase b causes oxidative stress and ageing in nematodes." Nature. 394. 694-697 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Iyehara-Ogawa: "Cobaltous chloride-induced mutagenesis in the supF tRNA gene of Escherichia coli." Mutagenesis. (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Kasai: "Analysis of 8-hydroxydeoxyguanousine,an oxidative DNA damage product,in human samples." Journal of the International Federation of Clinical Chemistry and Laboratory Medicine. 10. 51-52 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] I.Kashiwakura: "Effects of carboxy-PTIO,a nitric oxide scavenger,on the proliferation of murine hematopoietic progenitor cells in vitro." Rec.Comm.Molec.Pathol.and Pharmacol.99. 329-337 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Kobayashi: "Potential of GTP cyclohydrolase II of Escherichia coli for hydrolyzing 8-oxo-dGTP,a mutagenic substrate for DNA synthesis." J.Biol.Chem.273. 26394-26399 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Kohno: "Genetic polymorphisms and alternative splicing of the hOGG1 gene,that is involved in the repair of 8-hydroxyguanine in damaged DNA." Oncogene. 16. 3219-3225 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Krien: "A NIMA homologue promotes chromatin condensation in fission yeast." J.Cell Sci.111. 967-976 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Kubo: "Induction of fragile sites by fluorodeoxyuridine and caffeine accompanies with misincorpolation of endogenous uridine nucleotide into DNA of feline fibroblasts." J.Vet.Med.Sci.60. 1293-1297 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Kubo: "Novel putative fragile sites observed in feline fibroblasts treated with aphidicolin and fluorodeoxyuridine." J.Vet.Med.Sci.60. 809-813 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Kuwabara: "Radiation-and reactive oxygen-induced cell death and signal transduction in cultured mammalian cells." Biological Oxidants & Antioxidants:Molecular Mechanisms & Health Effects(packer,L.and Ong,H.S.Eds.). 14-21 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Kuwabara: "Biodefense against active oxygens and free radicals induced by oxidative stress." Biodefense Mechanisms against Environmental Stress,(Ozawa,T.,Tatsumi,K.and Hori,T.eds.). 23-32 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Mori: "Formation of 8-hydroxyguanine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine in DNA by riboflavin mediated photosensitization" Biochem.Biophys.Res.Commun.242. 98-101 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] N.Murata-Kamiya: "Nucleotide excision repair proteins may be involved in the fixation of glyoxal-induced mutagenesis in Escherichia coli." Biochem.Biophys.Res.Commun.248. 412-417 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] S.Nakajima: "Cloning and characterization of a gene(UVR3) required for photorepair of 6-4 products in Arabidopsis thaliana." Nucleic Acids Res.26. 638-644 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] F.Obata: "An improved system for selectioin of forward mutations in an Escherichia coli supF gene carried by plasmids." J.Radiat.Res.39. 263-270 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] S.Oka: "B220 is expressed on apoptotic thymocytes induced by X-irradiation." J.Vet.Med.Sci.(印刷中). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] S.Oka: "Strain difference in the phenotype of radiation-induced thymic lymphoma in DBA1 and NFS mice." Cytologia. (印刷中). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Saito: "Mouse Cdc21 only 0.5kb upstream from Dna-pkcs in a head-to-head organization:an implication of co-evolution of ATM family members and cell cycle regulating genes." Mammalian Genome. 9. 769-772 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.Sakamoto: "The genomic organization of the Arabidopsis 6-4 photolyase gene." Plant Physiol.(印刷中). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.H.Sarker: "Cloning and characterization of a mouse homologue(mNthl1)of Escherichia coli endonuclease III." J.Mol.Biol.282. 761-774 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Shinmura: "Infrequent mutations of the hOGG1 gene,that is involved in the excision of 8-hydroxyguanine in damaged DNA,in human gastric cancer." Jpn.J.Cancer Res.89. 825-828 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Sugaya: "Alteration of the largest subunit of RNA polymerase II and its effect on chromosome stability in Schizosaccharomyces pombe." Mol.Gen.Genet.258. 279-287 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Suzuki: "Misincorporation of 2′-deoxyoxanosine 5′-triphosphate by DNA polymerases and its implication to mutagenesis." Biochemistry. 37. 11592-11598 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Takemoto: "Different mechanisms of thioredoxin in its reduced and oxidized forms in defense against hydrogen peroxide in Escherichia coli." Free Rad.Biol.Med.24. 556-562 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Takemoto: "3′-Blocking damage of DNA as a mutagenic lesion caused by hydrogen peroxide in Escherichia coli." J.Radiat.Res.39. 137-144 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Tani: "Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage." Mammalian Genome. 9. 32-37 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Tano: "Specificity of mutation induced in the supF gene by riboflavin mediated photosensitization in Escherichia coli." Mutation Res.420. 7-13 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Terato: "Novel modification of 5-formyluracil by cysteine derivatives in aqueous solution." Nucleosides Nucleotides. 17. 131-141 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Terato: "Formation of highly fluorescent adducts between 2′-deoxyguanosine and amino acids by ionizing radiation." Anal.Chim.Acta. 365. 183-191 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Terato: "Recognition of oxidative thymine damage by DNA repair enzymes." Nucleic Acids Symp.Ser.39. 237-238 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Tsurudome: "2-Hydroxyadenine,a mutagenic form of oxidative DNA damage,is not repaired by a glycosylase type mechanism in rat organs." Mutation Res.408. 121-127 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] N.Uematsu: "Asymmetric crossover for spontaneous formation of large deletions at the tonB-trp region of Escherichia coli K-12 cells." Mol.Gen.Genet.(印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Utsumi: "Establishment and characterization of a hypocatalasemic mouse strain." J.Radiat.Res.39. 165-174 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Yasuda: "Protein carbonyl accumulation in aging dauer formation-defective (daf)mutants of Caenorhabditis elegans." J.Gerontology:Biol.Sci.54A(印刷中). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] O.Yukawa: "Induction of radical scavenging ability and protection against radiation-induced damage to microsomal membranes following low-dose irradiation." Int.J.Radiat.Biol.(印刷中). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Q.-M.Zhang: "Replication in vitro and cleavage by restriction endonuclease of 5-formyluracil- and 5-hydroxymethyluracil-containing oligonucleotides." Int.J.Radiat.Biol.(印刷中). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Q.-M.Zhang: "Escherichia coli MutY protein has a guanine-DNA glycosylase that acts on 7,8-dihydro-8-oxoguanine: guanine mispair to prevent spontaneous G:C-C:G transversions." Nucleic Acids Res.26. 4669-4675 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Q.-M.Zhang: "Oxygen stress model:E.Coli,cultured cells." in:Experimental Protocols for reactive oxygen species(ROS) and nitrogen species (RNS).(eds.,N.Taniguchi and J.M.C.Gutteridge). (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Abe,H.: "Involvement of both type I and type II mechanisms in M13 virus inactivation by methylene blue photosensitization." Photochemistry and Photobiology. 66. 204-208 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Abe,H.: "Factors affecting M13 bacteriophage inactivation by methylene blue photosensitization." Photochemistry and Photobiology. 65. 873-876 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Aburatani,H: "Cloning and characterization of mammalian 8-hydroxyguaninespecific DNA glycosylase/apurinic,apyrimidinic lyase,a functional mutM homologue." Cancer Res.57. 2151-2156 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Asaeda,A: "Repair kinetics of abasic sites in mammalian cells selectively monitored by aldehyde reactive probe (ARP)" Nucleosides and Nucleotides. 16(印刷中). (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Asaeda,A: "Highly sensitive assay of DNA abasic sites in mammalian cells-optimization of the aldehyde reactive probe (ARP)" Anal.Chim.Acta. (印刷中). (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Asaeda,A: "Repair kinetics of abasic sites in mammalian cells selectively monitored by the aldehyde reactive prove (ARP)." Nucleosides and Nucleotides. (印刷中). (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Asami,S.: "Cigarette smoking induces an increase in oxidative DNA damage,8-hydroxydeoxyguanosine,in a central site of the human lung." Carcinogenesis. 18. 1763-1766 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hirano,T: "Inhibition of 8-hydroxyguanine repair in testes after administration of cadmium chloride to GSH-depleted rats." Toxicology and applied pharmacology. 147. 9-14 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiraoka,W.: "Concentration-dependent modes of cell death in Chinese hamster V79 cells after treaments with H_2O_2." J.Radiat.Res.38. 95-102 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ide,H.: "Antibodies to oxidative DNA damage : Characterization of antibodies to 8-oxopurines." Cell Biol.Toxicol.13. 405-417 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ide,H.: "Mechanisms of the genotoxic effects associated with 5-formyluracil-Effect of exogenous 5-formyl-2′-deoxyuridine." Nucleic Acids Res.Symp.Ser.37. 165-166 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Izumi,T.: "Molecular cloning and characterization of the promoter of the human N-methylpurin DNA glycosylase (MPG) gene." Carcinogenesis. 18. 1837-1839 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kamath-Loeb,A.S.: "Incorporation of the guanosine triphosphate analogs 8-oxo-dGTP and 8-NH2-dGTP by reverse transcriptases and mammalian DNA polymerases." J.Biol.Chem.272. 5892-5898 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kamiya,H.: "Mutations induced by 2-hydroxyadenine on a shuttle vector during leading and lagging strand syntheses in mammalian cells." Biochemistry. 36. 11125-11130 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kamiya,H.: "Substitution and deletion mutations induced by 2-hydroxyadenine in Escherichia coli・Effects of sequence contexts in leading and lagging strands." Nucleic Acide Res.25. 304-310 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kanbashi,K: "Frameshifts,base substitutions and minute deletions constitute X-ray-induced mutations in the endogenous tonB gene of Escherichia coli K12." Mutation Res.(印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kuwabara,M: "The increased formation of alkali labile sites by a spin-trapping agent alpha-phenyl-N-tert-butylnitrone in gamma-irradiated frozen aqueous solution of DNA." J.Radiat.Res.38. 153-155 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mita,K.: "Comprehensive cloning of Schizosacharomyces pombe genes encoding translation elongation factors." Gene. 187. 259-266 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mori,T.: "Formation of 8-hydroxyguanine and 2,6-diamino4-hydroxy-formamidopyrimidine in DNA by riboflavin mediated photosensitization." Biochem.Biophys.Res.Comun.(印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Murata-Kamiya,N.: "Comparision of oxidation products from DNA components by γ-irradiation and Fenton-type reactions." J.Radiat.Res.38. 121-131 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Murata-Kamiya,N.: "Glyoxal,a major product of DNA oxidation,induces mutations at G : C sites on a shuttle vector plasmid replicated in mammalian cells." Nucleic Acid Res.25. 1897-1902 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Murata-Kamiya,N.: "Types of mutations induced by glyoxal,a major oxidative DNA-damage product,in Salmonella typhimurium." Mutation Res.377. 13-16 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Murata-Kamiya,N.: "Mutational specificity of glyoxal,a product of DNA oxidation,in the lacI gene of wild-type Escherichia coli W3110." Mutation Res.377. 255-262 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakajima,S.: "Cloning and characterization of a gene (UVR3) required for photorepair of 6-4 products in Arabidopsis thaliana." Nucleic Acid Res.26. 638-644 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nagashima,M.: "Presence of human cellular protein(s) that specifically binds and cleaves 8-hydroxyguanine containing DNA." Mutation Res.383. 49-59 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohshima,H.: "Reactions between hydroxyl-radical-induced 7,8-dihydro-8-oxo-2′-deoxyguanosine precursor and the spin trap alpha-phenyl-N-tert-butylnitrone." J.Radiat.Res.38. 15-25 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ono,T.: "X-ray-and ultraviolet-radiation-induced mutations in Muta^<TM> Mouse." Radiation Res.148. 123-128 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Saito,Y.: "Characterization of endonuclease III (nth) and endonuclease VIII (nei) mutants of Escherichia coli K-12." J.Bacteriol.179. 3783-3785 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shimamura,H.: "Mutational Specificity of the ferrous ion a sup F gene of endonuclease III/VIII deficient Escherichia coli." J.Radiat・Res.38. 165-171 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shimuzu,H.: "Replication bypass and mutagenic effect of alpha-deoxyadenosine site-specifically incorporated into single-stranded vector." Nucleic Acids Res.25. 597-603 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shinmura,K.: "8-hydroxyguanine (7,8-dihydro-8-oxoguanine) DNA glycosylase and AP lyase activities of hOGG1 protein and their substrate specificity." Mutation Res.385. 75-82 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Suzuki,T.: "Deglycosylation susceptibility and base-pairing stability of 2′-deoxyoxanosine in oligodeoxynucleotide." Biochemistry. 36. 8013-8019 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takahashi,K.: "Relationship between asbestos exposures and 8-hydroxydeoxyguanosine levels in leukocytic DNA of workers at a Chinese asbestos-material plant." Int.J.Occup.Environ.Health. 3. 111-119 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takemoto,T.: "Different mechanisms of thioredoxin in its reduced and oxidized forms in defense against hydrogen peroxide in Escherichia coli." Free Rad.Biol.Med.(印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takimoto,K: "Spectrum of spontaneous mutations in the cyclic AMP receptor protein gene on chromosomal DNA of Escherichia coli." J.Radiat.Res.38. 27-36 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tano,K.: "Amplification of the DNA repair gene O6-methylguanine-DNA methyltransferase associated with resistant to alkylating agents drugs in mammalian cell line." J.Biol.Chem.272. 13250-13254 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tao,K.: "OxyR-dependent induction of Escherichia coli grx gene expression by peroxide stress." J.Bacteriol.179. 5967-5970 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Terato,H.: "Novel modification of 5-formyluracil by cysteine derivatives in aqueous solution." Nucleosides Nucleotides. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Terato,H.: "Formation of highly fluorescent adducts between 2′-deoxyguanosine and amino acids by ionizing radiation." Anal.Chim.Acta. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamamoto,K.: "Enzymatic repair mechanisms for base modifications induced by oxygen radicals." J.Radiat.Res.38. 1-4 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamashita,T.: "Progressive effect of alpha-phenyl-N-tert-butylnitrone (PBN) rat embryo development in vitro." Free Radical Biol.Med.23. 1073-1077 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yonemasu,R.: "Chracterization of the alternative excision repair pathway of UV-damaged DNA in Schizosaccharomyces pombe." Nucleic Acids Res.25. 1553-1559 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yoshida,M.: "Substrate and misparing properties of 5-formyl-2′-deoxyuridine 5′-triphosphate assessed by in vitro DNA polymerase reactions." Nucleic Acids Res.25. 1570-1577 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Zhang,Q.M.: "Replication of DNA templates containing 5-formyluracil,a major oxidative lesion of thymine in DNA." Nucleic Acids Res.25. 3969-3973 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Zhang,D.: "Vitamin E inhibits apoptosis,DNA modfication,and cancer incidence induced by iron-mediated peroxidation in Wister rat kidney." Cancer Res.57. 2410-2414 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山本和生: "活性酸素によるDNAの傷とその修復。" 「健康と環境II」、池永満生、野村大成、森本兼襄 編集、株式会社へるす出版, 310(183-197) (1998)

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      1997 Annual Research Report
  • [Publications] 石井直明: "老化と死" 「生物学のすすめ」黒田洋一郎、馬淵一誠編 編集、筑摩書房, 205(55-84) (1997)

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      1997 Annual Research Report
  • [Publications] Kouki Kitamura: "Mutagenic specificity of ultraviolet light in the tonB gene on the chromosome of Fscherichia coli uvrA cells" Biochem.Biophys.Res.Commun.220. 496-501 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Masashi Takao: "Characterization of a UV endonuclease gene from the fission yeast Schizosaccharomyces pombe and its bacterial homolog" Nucleic Acids Res.24. 1267-1271 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Oshima: "Damage induced by hydroxyl radicals generated in the hydration layer of g-irradiated frozen aqueous solution of DNA" J.Radiatoin Res.37. 199-207 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Asami: "Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking" Cancer Res.56. 2546-2549 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Kamiya: "Substitution and deletion mutations induced by 2-hydroxyadenine in Escherichia coli : Effects of sequence contexts in leading and lagging strands" Nucleic Acids Res.25. 304-311 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kengo Yamamoto: "Properties of an oxygen-sensitive mutant mev-3 of the nematode Caenorhabditis elegans" Mutation Res.358. 1-6 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Utsumi: "Thermal neuron capture therapy using 10B1-paraboronophenyl-alanine (BPA). Lethal effects on melanoma cells irrespective of x-ray sensitivity" J.Radiation Res.37. 193-198 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Q.M.Zhang: "Inductoin of repair capacity for oxidatively damaged DNA as a component of peroxide stress in Escherichia coli" J.Radiation Res.37. 171-175 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tomoko Hiroi: "The cDNA sequence encoding bovine SP-22, a new defence system against oxygen species in mitochondria" DNA Sequence. 6. 239-242 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hironori Shimizu: "Replicatoin bypass and mutagenic effect of alpha-deoxyadenosine site-specifically incorporated into single-stranded vector" Nucleic Acids Res.(印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kazuo Yamamoto: "Enzymatic repair mechanisms for base modifications induced oxygen radicals" J.Radiation Res.(印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Nakajima: "Radiation-induced translocation of proteinkinase C through membrane lipid peroxidation in primary cultured rat hepatocytes" Int.J.Radiat.Biol.70. 473-480 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.S.Kim: "Induction of E.coli oh8Gua endonuclease by oxidative stress : its significance in aerobic life" Mutation Res.363. 115-125 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Norio Suzuki: "Cloning, sequencing and mapping of a manganese superoxide dismutase gene of the nematode Caenorhabditis elegans" DNA Research. 3. 171-174 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Toshinori Suzuki: "Isolation and Characterization of a novel product, 2'-deoxyoxanosine, from 2'-deoxyguanosine, oligonucleotide, and calf thymus DNA treated by nitrous acid nitric acid" J.Am.Chem.Soc.118. 2515-2516 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] R.Yamaguchi: "Increased 8-hydroxyguanine levels in DNA and its repair activity in rat kidney after administraion of a renal carcinogen, ferric nitrilotriacetate" Carcinogenesis. 17. 2419-2422 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takeshi Todo: "Similarity among the Drosophila (6-4) photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family" Science. 272. 109-112 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Xue Wang: "Mutagenic specificity of N-methyl-N'-nitro-N-nitrosoguanidine in the tonB gene on the chromosome of Escherichia coli recA+ and recA- cells" Biochem.Biophys.Res.Commun.227. 334-339 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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