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Comparative embryological study on the molecular function of organizing centers in animal development

Research Project

Project/Area Number 08308039
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Developmental biology
Research InstitutionTOKYO METROPOLITAN UNIVERSITY

Principal Investigator

YASUGI Sadao  Graduate School of Science, Tokyo Metropolita University, Professor, 大学院・理学研究科, 教授 (70011591)

Co-Investigator(Kenkyū-buntansha) TAKEDA Hiroyuki  Fac.Sci., Nagoya Univ., Associate Prof., 理学部, 助教授 (80179647)
NISHIDA Hiroki  Fac.Life Sci., Tokyo Inst.Technol., Associate Prof., 生命理工学部, 助教授 (60192689)
ASASHIMA Makoto  Graduate Sch.Sci., Tokyo Univ., Prof, 大学院・総合文化研究科, 教授 (00090564)
SHIOKAWA Koichiro  Graduate Sch.Sci., Tokyo UNiv., Prof., 大学院・理学系研究科, 教授 (20037295)
SHIRAI Hiroko  Fac.Sci., Okayama Univ., Associate Prof., 理学部, 助教授 (50090478)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥26,400,000 (Direct Cost: ¥26,400,000)
Fiscal Year 1998: ¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1997: ¥9,300,000 (Direct Cost: ¥9,300,000)
Fiscal Year 1996: ¥10,600,000 (Direct Cost: ¥10,600,000)
KeywordsOrganizing center / organizer / comparative embryology / molecular embryology / germ layer formation / morphogenesis / chordates / echinoderms / オ-ガナイザー / 分子生物学
Research Abstract

The aim of this research group is to analyze from the view point of comparative embryology the molecular mechanims of the oraganizing center in deuterostome animals which plays important roles in determination of body axis and construction of body organization. Organizing center of each animal group has specific molecular action but, by the evolutionary constraints, ratains functionally and morphologically homologous domains. the main results obtained during 3 years can be summarized as follows :
1. The method to identify determinants in starfish was established. It will contribute much to the understanding of the molecular nature of organizing center in the echinoderms. Also genetic analysis of binding protein to exogastrulation- inducing peptide and of genes expressed spcifically in the micromeres which work as the organizing center was carried out.
2. As to the ascidinas, almost all aspects of mesoderm differentiation were elucidated. With using the antibody which recognizes the diffe … More rentiated state of the mesenchymal cells, the autonomy and determinants involved in the mesenchymal differentiation were analyzed. The analysis led to the conclusion that the differentiation of mesenchyme was reglutated both by determinants and cell-to-cell interactions. This study clearly demonstrated that there exists organizing center also in the ascidian embryos which develop with mosaic pattern.
3. The notion of organizing center in the fish and amphibians has been rather different so far. However, the study in this research group, especially on fish, showed that many genes are working in common between these two groups of vertebrates. Espcially, the organizing center of zebrafish was located to yolk syncythial cells, by elaborated experimental manipulations.
4. In the birds and mammals, the organizing center is the node. Cells differentiate into layers after going through this part of embryos. This process was precisely analyzed in the bird, while the formation and function of notochord in mammal was studied with T/t complex mutants. These studies made it possible to compare the organizing center of the higher vertebrates and that of other animal groups. Less

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (102 results)

All Other

All Publications (102 results)

  • [Publications] H.Nishida: "Vegetal egg cytoplasm promotes gastrulation and is responsible for specification of vegetal Hastomeres in embryos of the ascidian Halognthia roretzi" Development. 122. 1271-1279 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Sakuma: "The protein tyrosine kinases of sea archin Anthecidaris crassipina" Zoological Science. 14. 307-312 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ariizumi,T.: "Activin treated urodele ectoderm:amodel experimental system of cardiogenesis" Int.J.Develop.Biol.40. 715-718 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yokota,C.: "Pattern of gene expression in the core of Spemann's organizer and activin-treated ectoderm in Cyropus pyrrhogaster" Develop.Growth & Differ. 40. 335-341 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Uochi,T.: "XCIRP(Xenopus homolag of cold-inducible RNA binding Protein)is expressed transiently in developing pronephros and neural tissue" Gene. 211. 245-250 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mizuno,T.: "Mesoderm induction in zebrafish" Nature. 383. 131-132 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nikaido,M.: "In vivo analysis using variants of zebrafish BMPR-IA:range of action and involvement of BMP in ectoderm patterning" Development. 126. 181-190 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki,M.: "Specific arreit of spermatogenesis caused by apopotic cell death in transgenic mice" Genes to Cells. 1. 1077-1086 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Abe,K.: "Endoderm-specific gene expression in embryonic stem cells differentiated to embryoide bodies" Exptl.Cell.Res.229. 27-34 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Abe,K.: "A systematic molecular genetic approach to atudy mammalian germ line development" Int.J.Dev.Biol.42. 1051-1065 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shinga,J.: "Maternal and zygotic expression of mRNA for S-adenosyl methionine decarboxylase and its relevance to the unique polyamine composition in xenopus oocyte and enbryos" Biochim,Biophys.Acta. 1308. 31-40 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Urase,K.: "Analysis of mesenchymal influence on the pepsinogen gene expression in the epitheliun of chicken embryonic digestive tract" Roux's Arch.Dev.Biol.205. 382-390 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishii,Y.: "Eonly specification of infestinal epitheliun in the chicken embryo:A study on the localization and regulation of Cdx A expression" Dev.Growth & Differ.39. 643-653 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Narita T.: "Sonic hedgeliog expression in the developing chicken digeatire orgams is regulated by epithelial-mesenchymal interacitons" Dev.Growth & Differ. 40. 67-74 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsmoto,K.: "Differential expression of the fos and jun family members in the developing gastrointestinal tract" Oncogene. 16. 1611-1616 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukuda,K.: "CFKBP/SMAP; a novel molecule involved in the regulation of smooth muscle differentiation" Development. 125. 3535-3542 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sakamoto,N.: "Analysis of temporal expression pattern and cis-regulatory sequences of chicken pepsinogen A and C" Biochem.Biophys.Res.Commun.250. 420-424 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishii,Y.: "Region-specific expression of chicken sox2 in the developing gut and lung epithelium;regulation by epithelial-mesenchymal interactions" Dev.Dyn.213. 464-475 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Nishida: "Vegetal egg cytoplasm promotes gastrulation and is responsible for specification of vegetal blastomers in embryos of the ascidian Halocynthia roretzi" Development. 122. 1271-1279 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Sakuma, H.Onodera, T.Suyemitsu and K.Yamasu: "The protein tyrosine kinases of the sea urchin Anthocidaris crassispina" Zool.Sci.14. 307-312 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ariizumi, T.Komazaki, S., Asashima, M., and G.M.Malacinski.: "Activin treated urodele ectoderm : a model experimental system for cardiogenesis." Int.J.Dev.Biol.40. 715-718 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yokota, C., Ariizumi, T.and Asashima, M.: "Pattern of gene expression in the core of Spemann's organizer and activin-treated ectoderm in Cynops pyrrhegaster." Dev.Growth Differ.40. 335-341 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Uochi, T.and Asashima, M.: "XCIRP (Xenopus homolog of cold-inducible RNA binding protein) is expressed transiently in developing pronephros and neural tissue." Gene. 211. 245-250 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mizuno, T., Yamaha, E., Wakahara, M., Kuroiwa, A.& Takeda, H.: "Mesoderm induction in zebrafish." Nature. 383. 131-132 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nikaido, M., Tada, M., Takeda, H., Kuroiwa, A.& Ueno, N.: "in vivo analysis using variants of zebrafish BMPR-IA : range of action and involvement of BMP inectoderm patterning." Development. 126. 181-190 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki, M., Abe, K., Yoshinaga, K., Obinata, M., Furusawa, M.and abe, K.: "Specific arrest of spermatogenesis caused by apoptotic cell death in transgenic mice." Genes to Cells. 1. 1077-1086 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Abe, K., Niwa, H., Iwase, K., Takiguchi, M., Mori, M., Abe, S.-l., Abe, K.and Yamamura, K.: "Endoderm-specific gene expression in embryonic stem cells differentiated to embryoid bodies." Exptl. Cell Res.229. 27-34 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Abe, K., Ko, M.S.H.and MacGregor, G.R.: "A Systematic Molecular Genetic Approach to Study Mammalian Germ Line Development." Int.J.Dev.Biol.42. 1051-1065 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shinga, J., Kashiwagi, K., Tashiro, K., Igarashi, K., Shiokawa, K.: "Maternal and zygotic expression of mRNA for S-adenosylmethionine decarboxylase and its relevance to the unique polyamine composition in Xenopus oocytes and embryos" Biochim. Biophy. Acta.1308. 31-40 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Urase, K.Fukuda, Y., Ishii, N.Sakamoto and S.Yasugi: "Analysis of mesenchymal influence on the pepsinogen gene expression in the epithelium of chicken embryonic digestive tract. Roux's Arch." Dev.Biol.205. 382-390 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Ishii, K.Fukuda, H.Saiga, S.Matsushita and S.Yasugi: "Early specification of intestinal epithelium in the chicken embryo : A study on the localization and regultion of CdxA expression" Dev.Growth and Differ.39. 643-653 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Narita, Y.Ishii, T.Nohno, S.Noji and S.Yasugi: "Sonic hedgehog expression in the developing chicken digestive organs is regulated by epithelial-mesenchymal interactions." Dev.Growth and Differ. 40. 67-74 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Matsumoto, K.Saitoh, C.Koike, T.Narita, S.Yasugi H.and Iba: "Differential expression of the fos and jun family members in the developing chicken gastrointestinal tract." Oncogene. 16. 1611-1616 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Fukuda, Y.Tanigawa, G.Fujii, S.Yasugi and S.Hirohashi: "cFKBP/SMAP ; a novel molecule involved in the regulation of smooth muscle differentiation." Development. 125. 3535-3542 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Sakamoto, H.Saiga and S.Yasugi: "Analysis of temporal expression pattern and cisregulatory sequences of chicken pepsinogen a and C.Biochem. Biopys" Res. Commun.250. 420-424 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Ishii, M.Rex, P.J.Scotting and S.Yasugi, S.: "Region-spcific expression of chicken Sox2 in the developing gut and lung epithelium : regulation by epithelial-mesenchymal interactions" Dev.Dyn.213. 464-475 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukuda,K.: "CFKBP/SMAP;A novel molecule involved in the regulation of smooth muscle differentiation" Development. 125. 3535-3542 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ishii,Y.: "Region-specific expression of chicken Sox2 in the developing gut and lung epithelium:Regulation by epithelial-mesenchymal interactions" Dev. Dynamics. 213. 464-475 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Saito,M: "Induction of metamorphosis in the sand dollar peronelia japonica by thyrcid hormones" Dev.Growth & Differ.40. 307-312 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hibino,T.: "CAB(Centrosome-attracting body):A novel structure closely related to unequal cleavages in the ascidian embryo" Dev.Growth & Differ.40. 85-95 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kumano,G.: "Maternal and zygotic expression of the endoderm-specific alkaline phosphatase gene in embryos of the ascidian Halocynthia roretzi" Dev. Biol.198. 245-252 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Bates,W.R.: "Developmental roles of nuclear complex factors released during oocyle maturation in the ascidians Halocynthia roretzi and Bortenia villosa" Zool.Sci.15. 69-76 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kobayashi,M.: "overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish" Development. 125. 2973-2982 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamanaka,T.: "A novel homeobox gene,dharma,can induce the organaizer in a non-cell autonomous manner" Genes & Dev.12. 2345-2353 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Makita,R: "Zebrafish wnt 11 : pattern and regulation of the expression by the yolk cell and No tail activity" Mech. Dev.71. 165-176

    • Related Report
      1998 Annual Research Report
  • [Publications] Yokota,C: "Pattern of gene expression in the core of Spemann's organizer and activin-treated ectoderm in Cynopus pyrrhogaster" Dev. Growth & Differ. 40. 335-341 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Uochi,T: "XCIP(Xenopus homolog of cold-inducible RNA binding protein) is expressed transiently in developing pronephros and neural tissue" Gene. 211. 245-250 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shibata,M.: "Overexpression of S-adenosylmethionine docarboxylase (SAMDC) in early Xenopus embryos induces cell dissociation and inhibits transition from the blastula to gostrula" Int. J. Dev. Biol.42. 675-686 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Abe,K.: "A systematic molecular genetics approach to study mammalian germ line development" Int. J. Dev. Biol.42. 1051-1065 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kawakami,S.: "Tctex 3, related to Drosophila polycomblike,is expressed in male germ cells and mapped to the mouse t-complex" Mammalian Genome. 9. 874-880 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Vemet,C.: "Genetic mapping of 10 macrosatellites in the t complex region of mouse chromosome 17" Mammalian Genome. 9. 412 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mitsumoto,K.: "Differential expression of fos and jun family members in the developing chicken gastrointestinal tract" Oncogene. 16. 1611-1616 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Narita,T.: "Sonic hedgehog expression in developing chicken digestive organs is regulated by epithelia-mesencluymal interactions" Dev.Growth & Differ.40. 67-74 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 西田宏記: "ホヤの生物学" 東京大学出版会, (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 浅島誠: "発生のしくみが見えてきた" 岩波書店, 149 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 駒崎伸二: "分子生物学イラストレイテッド" 羊土社, 334 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Akazome,Y.: "Ontogeny of the expression of messenger ribonucleic acid encoding lutropin receptor in chiken embryo" Zoological Science. 14. 363-367 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ishii,Y.: "Early specification of intestinal epithelium in the chicken embyro:A study on the localization and regulation of CdxA expression" Development,Growth and Differentiation. 39. 643-653 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sato,K.: "Chicken keratin-19:cloning of cDNA and analysis of expression in the chicken embryonic gut" Development,Growth and Differentiation. 39. 751-761 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 八杉 貞雄: "総合化の可能性に関する生物教育学会の対応と意見" 地学教育. 50. 261-264 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Narita,T.: "Sonic hedgenog expression in the developing chicken digestive organs is regulated by epithelial-mesenchymal interactions" Development,Growth and Differentiation. 40(印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumoto,K.: "Differential expression of fos and jun family members in the developing chicken gastrointestinal tract" Oncogene. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Adachi,N.: "Isolation and expression study of a maternally expressed novel Xenopus gene Xeml encoding a putative evolutionarily coxserved membrane protein" Biochem.Biophys.Res.Commun.238. 899-904 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hikasa,H.: "Structure of muscle-type(type-A)aldolasecDNA and its regulated expression in oocyles,embryos and adult tissues of Xenopus laevis" Biochim.Biophys.Acta. 1354. 189-203 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takabayashi,K.: "Conversion of ectoderm into a neural fate by ATH-3,a verterate helix-loop-helix gene homologous to Drosophila proneceral gene atonal" EMBOJ.16. 384-395 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hatada,S.: "A novelgene encoding a fernedoxin reducfase-related protein expressed in the ectoderm of Xenopus neurula" Gene. 194. 297-299 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Abe,K.: "A DEAD-box family protein gene,Dax4,encoding amurine holnolog of Drosophila vasa,mops to the distal end of mouse chromosome 13" Mammalian Genome. 8. 622-623 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sakuma,M.: "The protein tyrosine kinases of the sea urchin Anthocidaris crassipina" Zool.Sci.14. 941-946 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nishida,H.: "Cell-fate specification by localized determinants and cell interactions in asodian embryos" International Review of Cytology. 176. 245-306 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hirano,T.: "Developmental fates of larval tissues ofter metamorphosis in ascidian,Holocynthia roretzi.I.Origin of mesodermal tissues of the juveniles" Develop.Biol.19L. 199-210 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nishikawa,T.: "First find of Epigonichthys malokedemis(Looper)and rediscovery of E.lucayaniss(Andrews)from Nanwan Bay,Southern Taiwan" Benthos Res.52. 103-109 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Jin,D.-Y: "Localization of DNA-synthesizing cells and cell prolifcration pattern in developing proventricular (glandular stomach)epithelium of embryonic and hatched chickens" Development,Growth and Differentiation. 38. 1-8 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takiguchi-Hayashi,K.: "Cytokeratin expression in the stomach epithelia of the chicken embryois regulated by epithelial-mesenchymal interactions" Eoological Science. 13. 263-270 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoshida,N: "Mucus-associated antigen in epithelial cells of the chicken digestive tract : Developmental changes in expression and implications for morphogenesis-function relationships" Development,Growth and Differentiation. 38. 185-192 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 福田公子: "消化器官、特に胃の形態形成と分化における成長因子および形態形成因子の役割" 実験医学. 14(8). 1192-1198 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Urase,K.: "Analysis of mesenchymal influence on the pepsinogen gene expression in the epithelium of chicken embryonic digestive tract" Roux's Archives of Developmental Biology. 205. 382-390 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 福田公子: "消化管の形態形成と成長因子・転写因子" Molecular Medicine. 33. 796-804 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Urase,K.: "Spatial expression of sonic hedge hog in the lung epithelium during branching morphogeresis" Biochemical and Biophysical Research Communications. 225. 161-166 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tabata,H.: "Cultivation of chicken proventricular epithelial cells and their potential for differentiation" Development,Growth and Differentiation. 38. 499-507 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nakamura,H.: "Isolation of Xeropus HGF gene promoter and its functional analysis in embryos and animol caps" Roux's Archives of Developmental Biology. 205. 300-310 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kondo,M.: "Molecular cloning of Xenopus activin type I receptor and the analysis of its expression during embryogenesis" Biochemistry and Biophysics Research Communications. 218. 549-555 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kugawa,F.: "Cloning of Xenopus TEIIS and its expression in oocytes and early embryos" Biochemistry and Biophysics Research Communications. 222. 541-546 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mizuno,T.: "Mesoderm induction in zebrafish" Nature. 383. 131-132 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kumano,G.: "Biochemical evidence for membrane-bound endoderm-specific alkaline phosphatase in larvae of the asudiars,Halocynthia roretzi" European Journal of Biochemistry. 240. 485-489 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamada,A.: "Distribution of cytoplasmic determinants in unfertilized eggs of the ascidian Halocyntha roretzi" Development,Genes and Evolution. 206. 297-304 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kawaminami,S.: "Induction of trunk lateral cells,the blood cell precursors,during ascidian embryogenesis" Developmental Biology. 181. 14-20 (1997)

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      1996 Annual Research Report
  • [Publications] Binette,J.P.: "The content and distribution of glycosaminogly cans in the ejaculates of normal and vasectomized men" Andrologia. 28. 145-149 (1996)

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      1996 Annual Research Report
  • [Publications] 西田宏記: "ホヤの胚発生の普遍性と特殊性" 遺伝. 50(12). 12-17 (1996)

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      1996 Annual Research Report
  • [Publications] 西方敬人: "初期発生における不等分裂のしくみ" 細胞工学. 15. 1687-1697 (1996)

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      1996 Annual Research Report
  • [Publications] Miyagawa,T.: "Specification of posterior midbrain region in zebrafish neuroepithelium" Genes to Cells. 1. 369-377 (1996)

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      1996 Annual Research Report
  • [Publications] Niwa,H.: "Cell-cycle-dependent expression of the STK-1 gene encoding a novel murine putative protein kinase" Gene. 169. 197-201 (1996)

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      1996 Annual Research Report
  • [Publications] Ando,A.: "cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at he centromeric end of the human MHC region" Genomics. 35. 600-602 (1996)

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      1996 Annual Research Report
  • [Publications] Abe,K.: "Endoderm-specific gene expression in embryoricstem cells differentiated to embryoid bodies" Experimental Cell Research. 229. 27-34 (1996)

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      1996 Annual Research Report
  • [Publications] Abe,K.: "Purification of primordial germ cells from TNAPb-geo mouse embyos using FACS-gal" Developmental Biology. 180. 468-472 (1996)

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      1996 Annual Research Report
  • [Publications] Uochi,T.: "Sequential gene expresion during pronephric tubule formation in vitroin Xenopus ectoderm" Development Growth and Differentiation. 38. 625-634 (1996)

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      1996 Annual Research Report
  • [Publications] Uchiyama,H.: "Occurrence of immunoreactive activin/inhibin β B in gonadotrophs,thyrotrophs and somatotrophs of the Xenopus pituitary" General and Comparative Endocrinology. 102. 1-10 (1996)

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      1996 Annual Research Report
  • [Publications] Ariizumi,T.: "Activin treated urodele ectoderm i a model experimental System for cardiogenesis" International Journal of Developmental Biology. 40. 715-718 (1996)

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      1996 Annual Research Report
  • [Publications] Okabayashi,K.: "cDNA Cloning and expression of the Xenopus laevis" Biochemical and Diophysical Research Communications. 224. 406-413 (1996)

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      1996 Annual Research Report
  • [Publications] Tiedemann,H.: "Determination,induction and pattern formation in early amphibian embryos" Development,Growth and Differentiation. 38. 233-246 (1996)

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      1996 Annual Research Report
  • [Publications] Nishida,H.: "Vegetal egg cytoplam promotes gastrulation and is responsible for specification of vegetal blastoneres in embryos of the ascidian Holocynthia roretzi" Development. 122. 1271-1279 (1996)

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      1996 Annual Research Report
  • [Publications] Nakatani,Y.: "Basic fibroblast growth factors induces notodiord formation and the expression of AS-T,a brachyury homologue,during ascidian embyogenesis" Development. 122. 2023-2031 (1996)

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      1996 Annual Research Report
  • [Publications] Shirai,H.: "Recent Advance in Marine Biotechnology" Oxford and IBH Publishing Co., 367 (1996)

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      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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