| Project/Area Number |
08308042
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | University of Tokushima |
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Principal Investigator |
NIKI Noboru Univ.of Tokushima, Faculty of Engineering, Professor, 工学部, 教授 (80116847)
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| Co-Investigator(Kenkyū-buntansha) |
KAWATA Yoshiki Univ.of Tokushima, Faculty of Engineering, Lecturer, 工学部, 講師 (70274264)
BABA Norio Osaka-Kyoiku University, Professor, 教授 (30035654)
OHMASTU Hironobu National Cancer Center Hospital East, Staff, 呼吸器科, 医員(臨床)
EGUCHI Kenji National Shikoku Cancer Center, Vice Director, 内科, 副院長(研究職)
MORINAGA Noriyuki National Cancer Center Hospital, Chief, 放射線科, 部長(研究職)
佐藤 均 東芝医用機器技術所, 主査(研究職)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥10,100,000 (Direct Cost: ¥10,100,000)
Fiscal Year 1998: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1997: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1996: ¥5,000,000 (Direct Cost: ¥5,000,000)
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| Keywords | CT screeing / lung cancer / Computer assisted diagnosis / Double reading / 存在診断 / 質的診断 / コンピュータ支援診断 / 臨床テスト / 比較読影 / 自動読影 / CAD / 臨床試験 / らせんCT / 経過観察診断 / 集団検診システム |
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| Research Abstract |
In Japan more than 45,000 people died of lung cancer in 1997 and the lung cancer was the highest cause among males. Recently, several studies have been reporting feasibility and efficacy of helical CT imaging that it may be an effective screening modality for lung cancer. In order to improve the chance of detecting pulmonary nodules which may be early lung cancers, we have been developping a computer-assisted diagnostic (CAD) system. This CAD system has an automatic detection of candidate nodules based on low dose helical CT images. Double reading of the CT screening is one potential solution to decreasing the number of the missed nodules. However, in practice, that is not feasible. Another potential solution is the use of the CAD system as the second reader. Two thousand consecutive CT images, which are obtained as part of lung cancer screeing, were tested to the thoracic radiologists and the CAD system. As a result, many candidate nodules were detected by the CAD system which were not seen initially by the radiologist. The double reading between the radiologist and the CAD system was effectively certified. The CAD system also has a benign or malignant diagnosis for each nodule candidate based on high dose helical CT images. A hundred of consecutive CT images, which are measured for the detection of candidate nodules on the CT screening, were comparatively evaluated between the radiologists and the CAD system. The CAD system showed an 80 % performance superior to the radiologist interpretation. The CAD software may detect pulmonary nodules which may have otherwise been overlooked by the radiologists at the initial interpretation. This may provide substantial benefit to the patient if the detected nodules are found to be at an early stage of lung cancer.
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