| Project/Area Number |
08404044
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Inorganic chemistry
|
|---|
| Research Institution | NARA WOMEN'S UNIVERSITY |
|---|
Principal Investigator |
YANO Shigenobu NARA WOMEN'S UNIV., PROF., 大学院・人間文化研究科, 教授 (60011186)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Takahito NARA WOMEN'S UNIV., PROF., 理学部, 教授 (60144135)
MIKATA Yuji NARA WOMEN'S UNIV., RESEARCH ASSISTANT, 理学部, 助手 (10252826)
KATO Masako NARA WOMEN'S UNIV., ASSOCIATED. PROF., 大学院・人間文化研究科, 助教授 (80214401)
OKURA Ichiro TOKYO INSTITUTE OF TECHNOLOGY, PROF., 生命理工学部, 教授 (90089821)
|
|---|
| Project Period (FY) |
1996 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥40,000,000 (Direct Cost: ¥40,000,000)
Fiscal Year 1999: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1998: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1997: ¥17,400,000 (Direct Cost: ¥17,400,000)
Fiscal Year 1996: ¥17,400,000 (Direct Cost: ¥17,400,000)
|
|---|
| Keywords | BIOACTIVITY / INTERCALETER / HYBRID COMPLEX / GLYCOSIDE COMPLEX / ANTIFUNGAL ACTIVITY / PHOTOTOXITY / ANTITUMOR ACTIVITY / PORPHYRIN / 糖 / 錯体化学 / 白金錯体 / ジアジド / 抗がん活性 / 抗癌性 / シスプラチン / ニッケル錯体 / 配糖ジアミン / ハイブリッド / 抗ガン活性 / 結晶解析 |
|---|
| Research Abstract |
[Ni(aldose3-tren)]ィイD12+ィエD1(aldoseィイD23ィエD2-tren = tris(N-aldosyl-2-aminoethyl)amine) were successfully isolated and characterized including x-ray crystallography. Antitumor cis-dichloroplatinum(II) complexes linked to an intercalator via one methylene chain were prepared and characterized, and their intercalation with DNA was examined. Trimanganese complexes with a linear MnィイD1IIィエD1MnィイD1IIIィエD1MnィイD1IIィエD1assemblage bridged by carbohydrates were prepared and their magnetic properties were analyzed. Peroxo-bridged dinuclear cobalt(III) complex containing N-glycoside ligands from tris(2-aminoethyl)amine and D-Glucose were prepared and its reversible dioxygen binding property has been observed. Unprecedented chiral Inversion around the seven-coordinated cobalt center induced by an Interaction between sugars and sulfate anions has been discovered. Antifungal nickel(II) complexes derived from amino sugars against pathogenic yeast, Candida Albicans were newly developed. First zinc(II) complexes containing N-glycosides derived from ethylenediamine and D-glucosamine were prepared and characterized. General Synthetic method of useful chelating reagents having a sugar unit via o-glycoside linkage was developed and effective antitumor cisplatin type complexes were developed. Sugar-dependent photocytotoxic property of tetra- and octa-glycoconjugated tetraphenylporphyrins has been examined. Effective phototoxic property of newly prepared tetra- and octa-glycoconjugated tetraphenylchlorins was observed.
|
