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QUANTITATIVE ANALYSIS OF MYOCARDIAL PERFUSION AND METABOLISM USING SPECT

Research Project

Project/Area Number 08407023
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

TAMAKI Nagara  School of Medicine, Hokkaido University, Pro., 医学部, 教授 (30171888)

Co-Investigator(Kenkyū-buntansha) KITABATAKE Akira  School of Medicine, Hokkaido University, Pro., 医学部, 教授 (00124769)
MIYASAKA Kazuo  School of Medicine, Hokkaido University, Pro., 医学部, 教授 (60001939)
TSUKAMOTO Eriko  School of Medicine, Hokkaido University, Asso.Pro., 医学部, 講師 (40201636)
伊藤 和夫  北海道大学, 医学部, 助教授 (40111166)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥32,700,000 (Direct Cost: ¥32,700,000)
Fiscal Year 1998: ¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 1997: ¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1996: ¥20,400,000 (Direct Cost: ¥20,400,000)
Keywordsemission tomography / myocardium / myocardial blood flow / metabolism / 1-123 BMIPP / Tc-99m sestamibi / Tc-99m sestsmibi / myocardial blood-flow / Emission Tomography / Tc-99m Sestamibi / Myocardium / Myocardial Blood Flow
Research Abstract

1.A new workstation with a recently developed algorithm was installed to perform three-dimensional image co-registration of SPECT images with other anatomical images using CT or MRI.This image co-registration was useful to differentiate actual hypoperfusion from the artifacts due to partial volume effect on the brain SPECT studies. Such image fusion analysis is considered to be valuable for precise evaluation of myocardial perfusion and function in various cardiac diseases.
2. ECG-gated myocardial perfusion SPECT has recently been applied for simultaneous evaluation of regional perfusion and function. This new technique was valuable for assessing pathophysiology in patients with complete left bundle branch block and risk stratification in patients suspected with coronary artery disease.
3. Assessment of regional myocardial metabolism in vivo has been performed with use of iodinated fatty acid compound, BMIPP.In the follow-up study of patients with acute myocardial infarction, the perfusion SPECT was applied to estimate the area at risk, infarcted myocardium, and salvaged myocardium. Since metabolic recovery was slower than the perfusion recovery after revascularization therapy, BMIPP-SPECT at one week after infarction was valuable for estimating the area at risk. Furthermore, BMIPP imaging was used for identifying metabolic abnormalities in hypertrophic myocardium in the spontaneous hypertensive rat model and patients with hypertrophic cardiomyopathy. Metabolic alterations preceded perfusion abnormalities in these myocardial disorders. Thus, the combined imaging of perfusion and metabolism with SPECT may provide insight in to pathophysiology in various myocardial disorders.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] E.Tadamura: "Myocardial Metabolic Changes in Hypertrophic Cardiomyopathy" The Journal of Nuclear Medicine. 37・4. 572-577 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Fujibayashi: "Metabolism and Kinetics of Iodine-123-BMIPP in Canine Myocardium" The Journal of Nuclear Medicine. 37・5. 757-761 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] R.Nohara: "Evaluation of Myocardial Viability with Iodine-123-BMIPP in a Canine Model" The Journal of Nuclear Medicine. 37・8. 1403-1407 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Mochizuki: "Sequential change of BMIPP uptake with age in spontaneously hypertensive rat model" Annals of Nuclear Medicine. 11・4. 299-306 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] R.Hosokawa: "Myocardial Kinetics of Iodine-123-BMIPP in Canine Myocardium After Regional Ischemia and Reperfusion : Implications for Clinical SPECT" The Journal of Nuclear Medicine. 38・12. 1857-1863 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Sugihara: "Septal Perfusion and Wall Thickening in Patients with Left Bundle Branch Block Assessed by Technetium-99m-Sestamibi Gated Tomography" The Journal of Nuclear Medicine. 38・4. 545-547 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Kawai: "Use of ^<123>I-BMIPP single-photon emission tomography to setimate areas at risk following successful revascularization in patients with axute myocardial infarction" European Journal of Nuclear Medicine. 25・10. 1390-1395 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] E.Tadamura: "Impairment of BMIPP Uptake Precedes Abnormalities in Oxygen and Glucose Metabolism in Hypertrophic Cardiomyopathy" The Journal of Nuclear Medicine. 39・3. 390-396 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Sugihara: "Prognostic Value of 1-Day Stress/Rest Electrocardiogram-Gated Single-Photon Emission Computed Tomography Using Tc-99m-Labeled Methoxy-Isobutyl Isonitrile" Japanese Circulation Journal. 62・6. 405-408 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tadamura, E., Tamaki, N., Matsumori, A., Magata, Y., Yonekura, Y., Nohara, R., Sasayama, S., Yoshibayashi, M., Kamiya, T., Konishi, J.: "Myocardial metabolic changes in hypertrophic cardiomyopathy." J Nucl Med. 37 (4). 572-577 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fujibayashi, Y., Nohara, R., Hosokawa, R., Okuda, K., Yonekura, Y., Tamaki, N., Konishi, J., Sasayama, S., Yokoyama, A.: "Metabolism and kinetics of iodine-123-BMIPP in canine myocardium." J Nucl Med. 37 (5). 757-761 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nohara, R., Okuda, K., Ogino, M., Hosokawa, R., Tamaki, N., Konishi, J., Fujibayashi, Y., Yonekura, Y., Fujita, M., Sasayama, S.: "Evaluation of myocardial viability with iodine-123-BMIPP in a canine model." J Nucl Med. 37 (8). 1403-1407 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hosokawa, R., Nohara, R., Fujibayashi, Y., Okuda, K., Ogino, M., Hata, T., Fujita, M., Tamaki, N., Konishi, J., Sasayama, S.: "Myocardial kinetics of iodine-123-BMIPP in canine myocardium after regional ischemia and reperfusion : Implications for clinical SPECT." J.Nucl.Med.38 (12). 1857-1863 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sugihara, H., Tamaki, N., Nozawa, M., Ohmura, T., Inamoto, Y., Taniguchi, T., Aoki, E., Mitsunami, K., Kinoshita, M.: "Septal perfusion and wall thickening in patients with left bundle branch block Assessed by technetium-99m-sestamibi gated tomography." J.Nucl.Med.38 (4). 545-547 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mochizuki, T., Tsukamoto, E., Ono, T., Kanegae, K., Katoh, C., Shiga, T., Nakada, K., Kohya, T., Tamaki, N.: "Sequential change of BMIPP uptake with age in spontaneously hypertensive rat model." Ann.Nucl.Med.11 (4). 299-306 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tadamura, E., Kudoh, T., Hattori, N., Inubushi, M., Magata, Y., Konishi, J., Matsumori, A., Nohara, R., Sasayama, S., Yoshibayashi, M., Tamaki, N.: "Impairment of BMIPP uptake precedes abnormalities in oxygen and glucose metabolism in hypertrophic cardiomyopathy." J.Nucl.Med.39 (3). 390-396 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kawai, Y., Tsukamoto, E., Nozaki, Y., Kishino, K., Kohya, T., Tamaki, N.: "Use of 123I-BMIPP single-photon emission tomography to estimate areas at risk following successful revascularization in patients with acute myocardial infarction." Eur.J.Nucl.Med.25 (10). 1390-1395 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sugihara, H., Tamaki, N., Mitsunami, K., Kinoshita, M.: "Prognostic value of 1-day stress/rest electrocardiogram-gated single-photon emission computed tomography using Tc-99m-labeled methoxy-isobutyl isonitrile." Jpn.Circulation J.62 (6). 405-408 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Kawai: "Use of ^<123>I-BMIPP single-photon emission tomography to estimate areas at risk following successful revascularization in patients with acute myocardial infarction" European Journal of Nuclear Medicine. 25・10. 1390-1395 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] E.Tadamura: "Impairment of Uptake BMIPP Precedes Abnormalities in Oxygen and Glucose Metabolism in Hypertrophic Cardiomyopathy" The Journal of Nuclear Medicine. 39・3. 390-396 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Sugihara: "Prognostic Value of 1-Day Stress/Rest Electrocardiogram-Gated Single-Photon Emission Computed Tomography Using Tc-99m-Labeled Methoxy-Isobutyl Isonitrile" Japanese Circulation Journal. 62・6. 405-408 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Mochizuki: "Sequential change of BMIPP uptake with age in spontaneously hypertensive rat model" Annals of Nuclear Medicine. 11・4. 299-306 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Sugihara: "Septal Perfusion and Wall Thickening in Patients with Left Bundle Branch Block Assessed by Technetium-99m-Sestamibi Gated Tomography" The Journal of Nuclear Medicine. 38・4. 545-547 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y. Fujibayashi: "Metabolism and Kinetics of Iodine-123-BMIPP in Canine Myocardium" The Journal of Nuclear Medicine. 37・5. 757-761 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ryuji Nohara: "Evaluation of Myocardial Viability with Iodine-123-BMIPP in a Canine Model" The Journal of Nuclear Medicine. 37.8. 1403-1407 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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