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Research on xenotransplantation using genetic engineering

Research Project

Project/Area Number 08407030
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNagoya University

Principal Investigator

TAKAGI Hiroshi  Nagoya University School of Medicine Professor, 医学部, 教授 (70154755)

Co-Investigator(Kenkyū-buntansha) OKADA Hidechika  Medical School, Nagoya City University Professor, 医学部, 教授 (30160683)
YOKOYAMA Itsuo  Nagoya University School of Medicine M.D, 医学部, 講師 (60240206)
KITO Junzo  Nagoya University School of Medicine Professor, 医学部, 教授 (60022802)
MURAMATSU Takashi  Nagoya University School of Medicine Professor, 医学部, 教授 (00030891)
NAKASHIMA Izumi  Nagoya University School of Medicine Professor, 医学部, 教授 (40022826)
林 衆治  名古屋大学, 医学部, 助手 (30218573)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥30,700,000 (Direct Cost: ¥30,700,000)
Fiscal Year 1997: ¥11,500,000 (Direct Cost: ¥11,500,000)
Fiscal Year 1996: ¥19,200,000 (Direct Cost: ¥19,200,000)
KeywordsTransplantation, Heterologous / Animals, Transgenic / Complement Inactivators / Antigens, Heterophile / Galactosylransferases / Fucosyltransferases / 遺伝子制御 / トランスジェニックブタ / ノックアウト動物 / α1.3GT / α1.2FT
Research Abstract

The prospect of clinical xenotransplantation using pigs as donors holds out a potential solution to the shortage of human organs. The technical advance of genetic engineering has prompted the development of various strategies aimed at preventing xenograft rejection, including (i) expression of species-specific human complement regulatory proteins, (ii) modification of xenogeneic antigen expression and (iii) suppression of endothelial activation. The purpose of this study is to provide the useful information for clinical application of xenotransplantation.
As gene transfection of alpha1,2 fucosyl transferase (alpha1,2 FT), which was capable of competitive inhibition of alpha1,3 galactosyltransferase (alpha1,3 GT), caused the decreased expression of alphaGal antigens in pig cultured cells, we produced alpha1,2 FT transgenic pigs. However, this strain could not be established, since these pigs died of malignant tumor or incomplete development. We also showed the findings that such gene tra … More nsfer decreased not only alphaGal expression but also sialylation in cultured endothelial cells and inhibited the capacity for tube formation. We also demonstrated that alpha1,2 FT gene or alpha1,3 GT ribozyme transfer using adenoviral vectors decreased alphaGal expression in vitro. We are now exploring direct gene replacement of alpha1,3 GT gene with human alpha1,2 FTgene, namely knock-in method.
We analyzed the genomic structure of alpha1,3 GT in pigs and constructed a targeting vector with the aim of inducing alphaGal knockout pigs as soon as porcine embryonic stem cells or nuclear transplantation are available. Some alternative splicing variants without exon 8 or mutant cDNA (two mutations in the catalytic region ; exon 9) were also devoid of enzymatic activity. These observations provides a new strategy for reducing alphaGal antigen expression in a dominant-negative effect. With regard to non-alphaGal antigens, Hanganutziu-Deicher (HD) antigens were found to be expressed on the vascular endothelial cells of pig and baboon kidneys, but not in the human kidney, suggesting that HD antigens could elicit a strong humoral response in pig-to-human transplantation, even if HAR due to alphaGal epitopes is avoided. The pig-to-baboon transplantation model cannot demonstrate this possibility, because the baboon expresses HD antigens and does not appear to produce anti-HD antibodies.
We examined baboon sera to establish pig-to-baboon transplantation model. Some baboon sera showed the positivity for herpes B-virus using ELISA,however, this was ascribed to crossreactivity with human herpes simplex virus. Blood test revealed that all were within normal limits. All baboon sera contained anti-pig (anti-alphaGal) IgM antibodies as much as human sera, although anti-pig IgG and IgA in baboon sera were less than those in human sera. Usefulness and safety of pig-to-baboon transplantation model was demonstrated for clinical application. Less

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (283 results)

All Other

All Publications (283 results)

  • [Publications] 林 衆治, 高木 弘: "遺伝子制御による異種移植の研究" 日本消化器外科学会雑誌. 29-4. 907-910 (1996)

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  • [Publications] I Yokoyama, H Takagi: "Beneficial effect of donor pretreatment with thromboxane A2 synthase inhibitor on the graft survival in pig liver transplantation." Journal of Surgical Research. 60. 232-238 (1996)

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  • [Publications] S Hayashi, H Takagi: "Inhibitory effect of double transfection to xenoendothelial cells using both decay accelerating factor and homologous restriction factor 20 genes on complement dependent cytolysis." Journal of Surgical Research. 61. 165-169 (1996)

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  • [Publications] I Yokoyama, H Takagi: "Liberation of vasoactive substances and its prevention with thromboxane A2 synthase inhibitor in pig liver transplantation." Transplantation International. 9. 76-81 (1996)

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  • [Publications] 小林 孝彰, 高木 弘: "異種臓器移植におけるトランスジェニックブタ作製の重要性" 細胞工学. 15. 81-89 (1996)

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  • [Publications] Y Taminaga, H Takagi: "Molecular genetics of hyperparathyroid disease Currrent Opinion in Nephrology and Hypertention" Current Opin Nephrol Hypertiens. 5. 336-341 (1996)

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  • [Publications] S Hayashi, H Takagi: "Protection of guinea pig cell from rat complement-mediated lysis by the transfection of rat complement regulatory factor 512 gene Xenotransplantation" Xenotransplatation. 3. 217-221 (1996)

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  • [Publications] 高木 弘: "異種移植への展望" 臨床透析. 12-3. 269-270 (1996)

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  • [Publications] 横山 逸男、高木 弘: "異種移植" 日本科学会雑誌. 97-11. 1010-1017 (1996)

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  • [Publications] M Negita, H Takagi: "Human superoxide dismutase cDNA transfection and its in vitro effect on cold" Biomedical and biophysical resarch communication. 218. 653-657 (1996)

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  • [Publications] Kobayshi, Takagi H, and Cooper DKC: "Investigation of the anti-complement agents,FUT-175 and K76COOH,in discordant xenotransplantation" Xenotransplantation. 3. 237-245 (1996)

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  • [Publications] Hayashi S, Takagi H: "Protection of guinea pig cells transfected with the 512 gene for complement dependent cytolysis in rats." Transplantation Proceedings.28. 592- (1996)

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  • [Publications] Morozumi k, Takagi H: "A comparative study of morphological characteristics of renal injuries of tacrolimus (FK506) and cyclosporin(CyA) in renal and CyA nephrotoxicity similar?" Transplantation Proceedings. 28. 1076-1078 (1996)

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  • [Publications] Yokoyama I, Takagi H: "Liver transplantation and hepatocellular carcinoma." Sem Surg Oncol. 12. 212-216 (1996)

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  • [Publications] Yokoyama I, Takagi H: "Decreased Fas antigen expression of the cultured hepatocytes with tacrolimus (FK506)" Transplantation Proceedings. 28. 3191-3192 (1999)

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  • [Publications] 横山 逸男、高木 弘: "肝細胞癌に対する肝移植" 肝胆膵. 33. 55-61 (1996)

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  • [Publications] S Hayashi H Takagi: "Genetic Enginnering targeted to donor organs using" Transplantation Proceeding. 28-28. 225 (1996)

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  • [Publications] T Kobayashi, H Takagi, D. K. C Cooner: "In vitro and in vivo investigation of anticomlement agents FUT-175 and K76COOH,in the prevention of hyperacute rejection following discordant xenotransplantation in a nonhuman primate model" Transplantation Proceeding. 28-2. 604- (1996)

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  • [Publications] S Hayashi, H Takagi: "Inhibition of human complement dependent cell lysis by bovine aortic endothelial cells transfected with membrane-bound complement regulatory factor (DAF and HRF20) gene a retroviral Vector" European Surgical Research. 28. 440-446 (1996)

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  • [Publications] I Yokoyma, H Takagi: "Decreased fas antigen expression of culutred hapatocytes with FK506" Transplantation Proceesings. 28-6. 3189-3190 (1996)

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  • [Publications] S Hiraga, H.Takagi, S Kitagawa: "Study of the status and certification of transplant coordinators in Japan." Transplantation Proceeding. 28-1. 260-263 (1996)

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  • [Publications] M Negita, H Takagi: "Retrovirus-mediated human superoxide dismutase cDNA transfer to prevent ischemia-reperfusion injury." Transplantation Proceedings. 28-1. 342- (1996)

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  • [Publications] S Hayashi, H Takagi: "Application of a vena cava allograft in split liver transplantation in pigs." Transplantation Proceedings. 28-1. 330- (1996)

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  • [Publications] M Negita, H Takagi: "Measurement of the ratio of superoxide-scavenging activity in the graft in swine liver transplantation." Transplantation Proceedings. 28-1. 329- (1996)

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  • [Publications] C Koike, H Takagi: "Introduction of α (1,2)-fucosyltransferase and its effect on α-Gal epitopes in transgenic pig." Xenotransplantation. 3. 81-86 (1996)

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  • [Publications] I Yokoyama, H Takagi: "Factors affecting graft function in cadaveric renal transplantation from non-heart-beating donors using a double balloon catheter." Transplantation Proceedings. 28-1. 116-117 (1996)

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  • [Publications] S Hayashi, H Takagi: "Genetic engineering targeted to donor organs using adenoviral vector." Transplantation Proceedings. 28-1. 215- (1996)

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  • [Publications] S Hayashi, H Takagi: "Tissue distribution of Gal α(1,3) Gal epitope in heart,kidney,and liver of pig and mouse." Transplantation Proceedings. 28-1. 216- (1996)

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  • [Publications] 横山 逸男, 高木 弘: "死体肝移植とシクロスポリンの臨床" シクロスポリンの実際 国際医学出版. 225-269 (1996)

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  • [Publications] 横山 逸男, 高木 弘: "免疫抑制剤と移植" 医系微生物学朝倉書店. 第二版. 159-161 (1996)

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  • [Publications] 高木 弘: "シクロスポリンの登場と移植の発展:シクロスポリンの実際" 国際医学出版. 3-13 (1996)

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  • [Publications] C Koike, H Takagi: "Establishment of a human DAF/HRF20 double transgenic mouse line is not sufficient to suppress hyperacute rejection" Surgery Today. 26. 993-998 (1996)

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  • [Publications] Y Namii, H Takagi: "Tetrahydropyranyladriamycin with FK506 combination therapy for hamster-to-rat concordant xenotransplantation" Transplantation Proceedings. 28-2. 709-710 (1996)

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  • [Publications] C Koike, H Takagi: "How can human DAF and HRF20 prevent HAR in transgenic mice?" Transplantation Proceedings. 28-2. 509-600 (1996)

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  • [Publications] C Koike, H Takagi: "Converting α-Gal epitope of pig into H antigen" Transplantation Proceedings. 28-2. 553- (1996)

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  • [Publications] S Hayashi, H Takagi: "Effect of antisense ribozyme to pig α(1,3) galactossyl transferase gene on the expression of Gal α(1,3) Gal epitope" Transplantation Proceedings. 28-2. 628- (1996)

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  • [Publications] 高木 弘: "異種移植" 医学のあゆみ. 177-3. 258-259 (1996)

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  • [Publications] 富永 芳博, 高木 弘: "腎性上皮小体機能亢進症の外科的治療" 腎と透析. 40. 92-96 (1996)

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  • [Publications] 禰宜田 政隆, 高木 弘: "肝移植における臓器保存の方向と将来" 国際医書出版. 43-58 (1996)

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  • [Publications] I Yokoyama, H Takagi: "Hyperamylasemia in kidney transplant recipients." Transplantation Proceedings. 28-3. 1476-1477 (1996)

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  • [Publications] S Hayashi, H Takagi: "Possibility of gene transfer to the xenogeneic liver of guinea pig and pig using adenoviral vector." Transplantation Proceedings. 28-3. 1440- (1996)

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  • [Publications] K Uchida, H Takagi: "OKT3 rescue therapy for 63 rafractory rejections in 405 renal allografts" Transplantation Proceedings. 28-3. 1358-1359 (1996)

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  • [Publications] S Hayashi, H Takagi: "Split liver transplantation in pigs with reconstruction of the inferior vena cava" Transplantation Proceedings. 28-3. 1798- (1996)

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  • [Publications] I Yokoyama, H Takagi: "Fas antigen expression and apoptosis inductioc of in vitro cultured hepatocytes with high concentrations of cycrosporine A" Transplantation Proceedings. 28-3. 1383-1384 (1996)

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  • [Publications] 高木 弘: "免疫抑制剤シクロスポリン" 〓日の移植. 9-4. 431-432 (1996)

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  • [Publications] H Takagi: "XENO-Xenotransplantation reserch in Japan" XENO. 4-4. 62-63 (1996)

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  • [Publications] 小林 孝彰, 高木 弘, 浅野 浩史: "免疫抑制剤投与時における真菌症" 臨床と微生物. 23-5. 511-516 (1996)

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  • [Publications] T Kobayashi, Takagi H: "TAP1,TAP2,LMP2,DMA,and DMB Genetic Polymorphisms in Renal Transplantation" Transplantation Proceedings. 30. 29-30 (1996)

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  • [Publications] T Tominaga, Takagi H: "Clonal Analysis of Nodular Parathyroid Hyperplasia in Renal Hyperparathroidism" World journal of Surgery. 20. 744-752 (1996)

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  • [Publications] T Kojima, Takagi H: "Role of FC Fragments in Inhibition of Xenogenic Hypeeracute Rejection by Intravenous Imunoglobulin" Transplantation. 62-5. 559-562 (1996)

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  • [Publications] T Taniguchi, Takagi H: "In vivo Immunoadsorption of Antipig Antibodies in Baboons Using a Specofic Gal-α 1-3Gal Column" Transplantation. 62-10. 1379-1384 (1996)

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  • [Publications] Yokoyama I, Takagi H: "Apoptosis in pig endothelial cells after reperfusion and its prevention by genetic induction of human Cu,Zn-SOD cDNA" Transplantation Proceedings. 29. 1364- (1997)

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  • [Publications] Morozumi K, Takagi H, Uchida K: "Electron-microscopic peritubular capillary lesion in a specific and uself diagnostic indicator for chronic rejection of renal allografts showing less specific morphologic lesion in the cyclosporin era." Transplantation Proceedings. 29. 89-92 (1997)

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  • [Publications] Takeda A, Takagi H: "Sevare cyclosporine arteriolopathy with focal segmental glomerulosclerosis is not a fatal finding in chronic renal allograft failure after year 5 of transplantation using cyclosporine." Transplantation Proceedings. 29. 96-99 (1997)

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  • [Publications] Hayashi S, Takagi H: "Effect of antisense ribozyme to alpha (1,3) galactosyl transferase gene on the expression of GAl alpha (1,3) GAL epitope." Transplantation Proceedings. 29. 893- (1997)

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  • [Publications] Koike C, Takagi H: "Reduction of α-gal epitopes in transgenic pig by introduction of human α 1,2 fucosvltransferase" Transplantation Proceedings. 29. 894- (1997)

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  • [Publications] Negita M, Takagi H: "Protective effect of human suoeroxide dismutase cDNA transfection in the prevention of cold nreservation iniury" Transplantation Proceedings. 29. 1363- (1997)

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  • [Publications] T Kojima, H Takagi: "Inhibition of complement-mediated immune hemolysis by the constant domain of immunoglobuin" Peptido Chemistry. (1997)

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  • [Publications] T Nagasaka, H Takagi: "α-garactosyl oligosaccharides conjugated with polyethylene glycol as notential inhihitors of hvneracute unon yenotransnlantation" BIOMEDICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 232. 731-736 (1997)

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  • [Publications] 小林 孝彰、高木 弘: "HLAのマッチングと臓器移植検査と技術-増刊号-輸血検査実践" マニュアル医学書院. 25-7. 120-121 (1997)

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  • [Publications] S Hayashi, H Takagi: "Adenovirus-mediated gene transfer to the xenogeneic liver in liver xenotransplantation : The transduction of complement regulatory factor genes (DAF and HRF20)" Transplantation Proceeding. 29. 2211- (1997)

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  • [Publications] S Hayashi, H Takagi: "Effect of CTLA4-Ig gene transfer using adenoviral vector in organ and cell transplantation" Transplantation Proceeding. 29. 2212- (1997)

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  • [Publications] S Hayashi, H Takagi: "Adenovirus-mediated gene transfer of antisense ribozyme for α (1,3) garactosyl transferase gene and (1,2) fucosyltransferase gene in xenotranplantation" Transplantation Proceeding. 29. 2213- (1997)

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  • [Publications] Y Namii, H Takagi: "Evidence that the adenoviral vector containing the CTLA-Ig gene improves transgene expression and graft survival" Transplantation Proceeding. 29. 1738-1739 (1997)

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  • [Publications] 林 衆治、高木 弘: "特集 寛容導入をめざす移植免疫学-ヒト遺伝子導入による異種拒絶反応制御" Molecular Medicine. 34-7. (1997)

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  • [Publications] Katayama A, Takagi H: "tudies of α-Gal Dependent Hyperacute Xenotransplant Rejection Using DOuble Knockout Embryonic Stem Cells" Transplantation Proceeding. 29. 2262- (1997)

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  • [Publications] Chihiro Koike, Hiroshi Takagi: "Direct gene replacement of the mouse α (1,3) garactsyltransgferase gene with human α (1,2)-fucosyltransgferase gene : Converting α galactsyl epitopes into Hantigens" Xenotransplantation. 4. 147-153 (1997)

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      1997 Final Research Report Summary
  • [Publications] H Asano, H Takagi: "Significance of tumor necrosis factor microsatellite polymorphism in renal transplantation" TISSUE ANTIGENS. 50. 484-488 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shuji Hayashi, Hiroshi Takagi: "Inhibition of establishment of hepatic metastasis in mice by combination gene therapy using both herpes simplex virusthymidine kinase and granulocyte macrophage-colony stimulating factor gene in mune colon cancer" Cancer Genen Therapy. 4-6. 339-344 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 小林 孝彰、高木 弘: "ABO血液型不適合腎移植と異種移植の接点" 今日の移植. 10-6. 947-951 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M Negita, Takagi H: "Protective Effect of Human Superoxide Dismutase cDNA Transfection in the Prevebtion of Cold Preservation Injury" Transplantation Proceedings. 29. 1363- (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takagi H: "Organ Transplants Still Too in Japan and Asian Countries" Transplantation Proceedings. 29. 1580-1583 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I Yokoyama, Takagi H: "Measurement of portal venous flow velocity with an implantable miniature Doppler probe in pig liver transplantation" Transplantation international. 10. 116-120 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takagi H: "Evalution of Tetrahydropyranyladriamycin as an Immunosuppressant in Concordant Xenotransplantation" World jounal of Surgey. 16. 283-289 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S hayashi, Takagi H: "Effevt of Gene with the Herpes Simplex Virus-Thymidine Kinase Gene on Hepatic Metastasis in Murine Colon Canser" Surgery Today. 27. 40-43 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K Uchida, Takagi H: "Renal Transplantation and Secondary Hyperparathyroidism" Seminars in Surgical Oncology. 13. 97-103 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y Tominaga, Takagi H: "Histopathology,Pathophysiology,and Indications for Surgical Treatment of Renal Hyperparathyroidism" Seminars in Surgical Oncology. 13. 78-86 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takagi H: "PARATHYROID HYPERPLASIA AND TU MOR" Seminars in Surgical Oncology. 13. 71-72 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y Tominaga, Takagi H: "Surgical Treatment of Renal Hyperparathroidism" Seminars in Surgical Oncology. 13. 87-96 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y Tachi, Takagi H: "Variability of Cytotoxicity to Pig Cultured Cells and Its Determinant Factor in Human Sera" Transplantation Proceedings. 30. 71-73 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoyama I, Takagi H: "Transplant Portal venbous flow velocity measured by the implantable miniature Doppler probe in pig liver transplantation." International. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoyama I, Takagi H: "Prevention of endothelial cell apoptosis with genetic induction of human Cu,Zn-SOD cDNA." Transplantation. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoyama I, Takagi H: "Portal venous flow velocity measured by the implantable miniature Doppler probe in pig liver transplantation" International. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoyama I, H.Takagi: "Fas antigen expression and its modification by immunosuppressants." Dig Dis Sci. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, Takagi H: "Protection of guinea pig cell from rat complement-mediated lysis by the transfection of rat complement regulatory factor512 gene Xenotrasplaentattoom" Xenotransplantation. 3. 217-221 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 高木 弘: "異種移植への展望" 臨床透析. 12-3. 269-270 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 横山 逸男, 高木 弘: "異種移植" 日本外科学会雑誌. 97-11. 1010-1017 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M Negita, H Takagi: "Human superoxide dismutase cDNA transfection and its in vitro effect on cold preservation." Biomedical and biophysical resarch communication. 218. 653-657 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kobayashi, Takagi H, and Cooper DKC: "Investigation of the anti-complement agents,FUT-175 and K76COOH,in discordant xenotransplantation" Xenotransplantation. 3. 237-245 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hayashi S, Takagi H: "Protection of guinea pig cells transfected with the 512 gene for complement dependent cytolysis in rats." Transplantation Proceedings. 28. 592- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Morozumi k, Takagi H: "A comparative study of morphological characteristics of renal injuries of tacrolimus (FK506) and cyclosporin (CyA) in renal and CyA nephrotoxicity similar?" Transplantation Proceedings. 28. 1076-1078 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoyama I, Takagi H: "Liver transplantation and hepatocellular carcinoma." Sem Surg Oncol. 12. 212-216 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoyama I, Takagi H: "Decreased Fas antigen expression of the cultured hepatocyted with tacrolimus (FK506)" Transplantation Proceedings. 28. 3191-3192 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 横山 逸男、高木 弘: "肝細胞癌に対する肝移植" 肝胆膵. 33. 55-61 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, H Takagi: "genetic Enginnering targeted to donor organs using" Transplantation Proceedings. 28-28. 225- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T Kobayashi, H Takagi, D, K.C Cooner: "In vitro and in vivo investigation of anticomplement agents FUT-175 and K76COOH,in the prevebtion of hyperacute rejection follwing discordant xenotrasnsplantation in a nonhuman primate model" Transplantation Proceeding. 28-2. 604- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I Yokoyama, H Takagi.: "Beneficial effect of donor pretreatment with thromboxane A2 synthase inhibitor on the graft survival in pig liver transplantation ." Journal of Surgical Research. 60. 232-238 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, H Takagi: "Inhibitory effect of double transfection to xenoendothelial cells using both decay accelerating factor and homologous restriction factor 20 genes on complement dependent cytolysis." Journal of Surgical Research. 61. 165-169 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I Yokoyama, H Takagi: "Liberation of vasoactive substances and its prevention with thromboxane A2 synthase inhibitor in pig liver transplantation." Transplantation International. 9. 76-81 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y Taminaga, H Takagi: "Molecular genetics of hyperparathyroid disease." Currrent Opinion in Nephrology and Hypertention. 5-4. 336-341 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Hayashi, H Takagi: "Protection of guinea pig cell from rat complement-mediated lysis by the transfection of rat complement regulatory factor 512 gene" Xenotransplantation. 3. 217-221 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M Negita, H Takagi: "Human superoxide dismutase cDNA transfection and its in vitro effect on cold preservation." Biomedical and biophysical resarch communication. 218. 653-657 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kobayashi, Takagi H,and Cooper DKC: "Investigation of the anti-complement agents, FUT-175 and K76COOH,in discordant xenotransplantation" Xenotransplantation. 3. 237-245 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hayashi S,Takagi H: "Protection of guinea pig cells transfected with the 512 gene for complement dependent cytolysis in rats. Morozumi K,Takagi H ; A comparative study of morphological characteristics of renal injuries of tacrolimus (FK506) and cyclosporin (CyA) in renal and CyA nephrotoxicity similar ?" Transplantation Proceedings. 28. 592 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoyama I,Takagi H: "Liver transplantation and hepatocellular carcinoma." Sem Surg Oncol. 12-3. 212-216 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoyama I,Takagi H: "Decreased Fas antigen expression of the cultured hepatocytes with tacrolimus (FK506)" Transplantation Proceedings. 28-6. 3189-3190 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, H Takagi: "Genetic Enginnering targeted to donor organs using" Transplantation Proceeding. 28-28. 225 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T Kobayashi, H Takagi, D.K.C Cooper: "In vitro and in vivo investigation of anticomplement agents FUT-175 and K76COOH,in the prevention of hyperacute rejection following discordant xenotransplantation in a nonhuman primate model" Xenotransplantation. Vol.3. P237-P245 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, H Takagi: "Inhibition of human complement dependent cell lysis by bovine aortic endothelial cells transfected with membrane-bound complement regulatory factor (DAF and HRF20) gene using a retroviral vector" Transplant Proc. 28. 330 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I Yokoyma, H Takagi: "Decreased fas antigen expression of culutred hapatocytes with FK506" Transplantation Proceesings. 28-6. 3189-3190 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hiraga, H Takagi, S Kitagawa: "Study of the status and certification of transplant coordinators in Japan." Transplantation Proceeding. 28-1. 260-263 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M Negita, H Takagi: "Retrovirus-mediated human superoxide dismutase cDNA transfer to prevent ischemia-reperfusion injury." Transplantation Proceedings. 28-1. 342 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, H Takagi: "Application of a vena cava allograft in split liver transplantation in pigs." Transplantation Proceedings. 28-1. 330 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M Negita, H Takagi: "Measurement of the ratio of superoxide-scavenging activity in the graft in swine liver transplantation." Transplantation Proceesings. 28-1. 329 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] C Koike, H Takagi: "Introduction of alpha(1,2)-fucosyltransferase and its effect on alpha-Gal epitopes in transgenic pig." Xenotransplantation. 3. 81-86 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I Yokoyama, H Takagi: "Factors affecting graft function in cadaveric renal transplantation from non-heart-beating donors using a double balloon catheter." Transplantation Proceedings. 28-1. 116-117 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, H Takagi: "Genetic engineering targeted to donor organs using adenoviral vector." Transplantation Proceedings. 28-1. 215 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, H Takagi: "Tissue distribution of Gal alpha(1,3) Gal epitope in heart, kidney, and liver of pig and mouse." Transplantation Proceedings. 28-1. 216 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] C Koike, H Takagi: "Establishment of a human DAF/HRF20 double transgenic mouse line is not sufficient to suppress hyperacute rejection" Surgery Today. 26. 993-998 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y Namii, H Takagi: "Tetrahydropyranyladriamycin with FK506 combination therapy for hamster-to-rat concordant xenotransplantation" Transplantation Proceedings. 28-2. 709-710 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] C Koike, H Takagi: "How can human DAF and HRF20 prevent HAR in transgenic mice ?" Transplantation Proceedings. 28-2. 509-600 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] C Koike, H Takagi: "Converting alpha-Gal epitope of pig into H antigen" Transplantation Proceedings. 28-2. 553 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, H Takagi: "Effect of antisense ribozyme to pig alpha(1,3) galactossyl transferase gene on the expression of Gal alpha(1,3)Gal epitope" Transplantation Proceedings. 28-2. 628 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I Yokoyama, H Takagi: "Hyperamylasemia in kidney transplant recipients." Transplantation Proceedings. 28-3. 1476-1477 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, H Takagi: "Possibility of gene transfer to the xenogeneic liver of guinea pig and pig using adenoviral vector." Transplantation Proceedings. 28-3. 1440 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K Uchida, H Takagi: "OKT3 rescue therapy for 63 rafractory rejections in 405 renal allografts" Transplantation Proceedings. 28-3. 1358-1369 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, H Takagi: "Split liver transplantation in pigs with reconstruction of the inferior vena cava" Transplantation Proceedings. 28-3. 1798 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I Yokoyama, H Takagi: "Fas antigen expression and apoptosis inductioc of in vitro cultured hepatocytes with high concentrations of cycrosporine A" Transplantation Proceedings. 28-3. 1383-1384 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H Takagi: "XENO-Xenotransplantation reserch in Japan" XENO. 4-4. 62-63 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T Kobayashi, Takagi H: "TAP1, TAP2, LMP2, DMA,and DMB Genetic Polymorphisms in Renal Transplantation" Transplantation Proceedings. 30. 29-30 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y Tominaga, Takagi H: "Clonal Analysis of Nodular Parathyroid Hyperplasia in Renal Hyperparathroidism" Eorld journal of Surgery. 20. 744-752 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T Kojima, Takagi H: "Role of Fc Fragments in Inhibition of Xenogenic Hypeeracute Rejection by Intravenous Imunoglobulin" Transplantation. 62-5. 559-562 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Taniguchi, Takagi H: "In vivo Immunoadsorption of Antipig Antibodies in Baboons Using a Specofic Gal-alpha1-3Gal Column" Transplantation. 62-10. 1379-1384 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoyama I,Takagi H: "Apoptosis in pig endothelial cells after reperfusion and its prevention by genetic induction of human Cu, Zn-SOD cDNA." Transplantation Proceedings. 29-1/2. 1364 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Morozumi K,Takagi H,Uchida K: "Electron-microscopic peritubular capillary lesion in a specific and uself diagnostic indicator for chronic rejection of renal allografts showing less specific morphologic lesion in the cyclosporin era." Transplantation Proceedings. 29-1/2. 89-92 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takeda A,Takagi H: "Sevare cyclosporine arteriolopathy with focal segmental glomerulosclerosis is not a fatal finding in chronic renal allograft failure after year 5 of transplantation using cyclosporine." Transplantation Proceedings. 29 1/2. 96-99 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hayashi S,Takagi H: "Effect of antisense ribozyme to alpha (1,3) galactosyl transferase gene on the expression of GAl alpha (1,3) GAL epitope" Transplantation Proceedings. 29 1/2. 893 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Koike C,Takagi H: "Reduction of alpha-gal epitopes in transgenic pig by introduction of human alpha1-2 fucosyltransferase." Transplantation Proceedings. 29-1/2. 894 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Negita M,Takagi H: "Protective effect of human suoeroxide dismutase cDNA transfection in the prevention of cold preservation injury." Transplantation Proceedings. 29-1/2. 1363 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T Kojima, H Takagi: "Inhibition of completment-mediated immune hemolysis by the constsnt domain of immunoglobuin" Peptido Chemistry. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T Nagasaka, H Takagi: "alpha-garactosyl oligosaccharides conjugated with polyethylene glycol as potential inhibitors of hyperacute upon xenotransplantation" BIOMEDICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 232-3. 731-736 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, H Takagi: "Adenovirus-mediated gene transfer to the xenogeneic liver in liver xenotransplantation : The transduction of complement regulatory factor genes (DAF and HRF20)" Transplantation Proceeding. 29. 2211 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, H Takagi: "Effect of CTLA4-lg gene transfer using adenoviral vector in organ and cell transplantation" Transplantation Proceeding. 29. 2212 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y Namii, H Takagi: "Evidence that the adenoviral vector containing the CTLA-lg gene improves transgene expression and graft survival" Transplantation Proceeding. 29. 2213 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, H Takagi: "Adenovirus-mediated gene transfer of antisense ribozyme for alpha(1,3) garactosyl transferase gene and (1,2)fucosyltransferase gene in xenotransplantation" Transplantation Proceeding. 29. 1738-1739 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Katayama A,Takagi H: "tudies of alpha-Gal Dependent Hyperacute Xenotransplant Rejection Using Double Knockout Embryonic Stem cells" Transplantation Proceeding. 29. 2262 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Chihiro Koike, Hiroshi Takagi: "Direct gene replacement of the mouse alpha(1,3)-galactsyltransgferase gene with human alpha(1,2)-fucosyltransgferase gene : Converting alphagalactsyl epitopes into H antigens" Xenotransplantation. 4. 147-153 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H Asano, H Takagi: "Significance of tumor necrosis factor microsatellite polymorphism in renal transplantation" TISSUE ANTIGENS. 50. 484-488 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shuji Hayashi, Hiroshi Takagi: "Inhibition of establishment of Hepatic metastasis in mice by combination gene therapy using both herpes simplex virusthymidine kinase and granulocyte macrophage-colony stimulating factor gene in mune colon cancer" Cancer Genen Therapy. 4-6339-344. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M Negita, Takagi H: "Protective Effect of Human Superoxide Dismutate cDNA Transfection in the Prevention of Cold Preservation Injury" Transplantation Proceedings. 29. 1363 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takagi H: "Organ Transplants Still Too in Japan and Asian Countries" Transplantation Proceedings. 29. 1580-1583 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I Yokoyama, Takagi H: "Measurement of portal venous flow velocity with an implantable miniature Doppler probe in pig liver transplantation" Transplantation International. 10. 116-120 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takagi H: "Evalution of Tetrahydropyranyladriamycin as an Immunosuppressant in Concordant Xenotransplantation" World journal of Surgery. 16. 283-289 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Hayashi, Takagi H: "Effect of Gene with the Herpes Simplex Virus-Thymidine Kinase Gene on Hepatic Metastasis in Murine Colon Cancer" Surgery Today. 27. 40-43 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K Uchida, Takagi H: "Renal Transplantation and Secondary Hyperparathyroidism" Seminars in Surgical Oncology. 13. 97-103 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y Tominaga, Takagi H: "Histopathology, Pathophysiology, and Indications for Surgical Treatment of Renal Hyperparathyroidism" Seminars in Surgical Oncology. 13. 78-86 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takagi H: "PARATHYROID HYPERPLASIA AND TUMOR" Seminars in Surgical Oncology. 13. 71-72 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y Tominaga, Takagi H: "Surgical Treatment of Renal Hyperparathroidism" Seminars in Surgical Oncology. 13. 87-96 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y Tachi, Takagi H: "Variability of Cytotoxicity to pig Cultured Cells and Its Determinant Factor in Human Sera" Transplantation Proceedings. 30. 71-73 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoyama I,Takagi H: "Transplant Portal venous flow velocity measured by the implantable miniature Doppler probe in pig liver transplantation" International. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoyama I,Takagi H: "Prevention of endothelial cell apoptosis with genetic induction of human Cu, Zn- SOD cDNA." Transplantation. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoyama I,Takagi H: "Portal venous flow velocity measured by the implantable miniature Doppler probe in pig liver transplantation" International. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoyama I,Takagi H: "Fas antigen expression and its modification by immunosuppressants." Dig Dis Sci. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 林 衆治, 高木 弘: "遺伝子制御による異種移植の研究" 日本消化器外科学会雑誌. 29-4. 907-910 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] I Yokoyama, H Takagi: "Beneficlal effect of donor pretreatment with thromboxane A2 synthase inhibitor on the graft survival in pig liver transplantation." Journal of Surgical Research. 60. 232-238 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, H Takagi: "Inhibitory effcct of double transfection to xenoendothelial cells using both decay accelerating factor and homologous restriction factor 20 genes on complement dependent" Journal of Surgical Research. 61. 165-169 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] I Yokoyama, H Takagi: "Liberation of vasoactivc substances and its prevention with thromboxane A2 synthase inhibitor in pig liver transplantation." Transplantation International. 9. 76-81 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小林孝彰, 高木弘: "異種臓器移植におけるトランスジェニックブタ作製の重要性" 細胞工学. 15. 81-89 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y Taminaga, H Takagi: "Molecuitar genetics of hyperparathyroid disease Current Opinion in Nephrology and Hypertention" Current Opin Nephrol Hypertiens. 5. 336-341 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, H Takagi: "Inhibition of human complement dependent cell lysis by bovine aortic endothelial cells transfected with membrane-bound complement regulatory factor (DAF and HRF20) gene using a retroviral vector" Enropean Surgical Research. 28. 440-446 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] I Yokoyma, H.Takagi: "Decreased fas antigen expression of culutred hapatocytes with FK506" Transplantation Proceesings. 28-6. 3189-3190 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hiraga, H Takagi, S kitagawa: "Study of the status and Certification of transplant coordinators in Japan." Transplantation Proceeding. 28-1. 260-263 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M Negita, H Takagi: "Retrovirus-mediated human superoxide dismutase cDNA transfer to prevent ischemia-reperfusion injury." Transplantation Proceedings. 28-1. 342 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, H Takagi: "Application of a vena cava allograft in split liver transplantation in pigs." Transplantation Proceedings. 28-1. 330 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M Negita, H Takagi: "Measurement of the ratio of superoxide-scavenging activity in the graft in swine liver transplantation." Transplantation Proccedings. 28-1. 329 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] C Koike, H Takagi: "Introduction of α(1,2)-fucosyltransferace and its effect on α-Gal epitopes in transgenic pig." Xenotransplantation. 3. 81-86 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] I Yokoyama, H Takagi: "Factors affecting graft function in cadaveric renal transplantation from non-heart-beating donors using a double balloon catheter." Transplantation Proceedings. 28-1. 116-117 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, H Takagi: "Genetic engineering targeted to donor organs using adenoviral vector." Transplantation Proccedings. 28-1. 215 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, H Takagi: "Tissue distribution of Gal α(1,3) Gal epitope in heart,kidney,and liverk of pig and mouse." Transplantation Proccedings. 28-1. 216 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 横山逸男, 高木 弘: "死体肝移植とシクロスポリンの臨床" シクロスポリンの実際 国際医学出版. 225-269 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 横山逸男, 高木 弘: "免疫抑制剤と移植" 医系微生物学朝倉書店. 第二版. 159-161 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 高木 弘: "シクロスポリンの登場と移植の発展:シクロスポリンの実際" 国際医学出版. 3-13 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] C Koike, H Takagi: "Establishment of a human DAF/HRF20 double transgenic mouse line is not sufficient to suppress hyperacute rejection" Surgery Today. 26. 993-998 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y Namii, H Takagi: "Tetrahydropyranyladriamycin with FK 506 combination therapy for hamster-to-rat concordant xenotransplantation" Transplantation Proceedings. 28-2. 709-710 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] C Koike, H Takagi: "How can human DAF and HRF20 prevent HAR in transgenic mice?" Transplantation Proceedings. 28-2. 509-600 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] C Koike, H Takagi: "Converting α-Gal epitope of pig into H antigen" Transplantation Proceedings. 28-2. 553 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, H Takagi: "Effect of antisense ribozyme to pig α(1,3) galactossyl transferase gene on the expression of Gal α(1,3)Gal epitope" Transplantation Proceedings. 28-2. 628 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 高木 弘: "異種移植" 医学のあゆみ. 177-3. 258-259 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 冨永芳博, 高木 弘: "腎性上皮小体機能亢進症の外科的治療" 腎と透析. 40. 92-96 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 福宜田正隆, 高木 弘: "肝移植における臓器保存の方向と将来" 国際医書出版. 45-58 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] I Yokoyama, H Takagi: "Hyperamylasemia in kidney transplant recipients." Transplantation Proceedings. 28-3. 1476-147 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, H Takagi: "Possibility of gene transfer to the xenogeneic liver of guinea pig and pig using adenoviral vector." Transplantation Proceedings. 28-3. 1440 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] K Uchida, H Takagi: "OKT3 rescue therapy for 63 rafractory rejections in 405 renal allografts" Transplantation Proceedings. 28-3. 1358-1359 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, H Takagi: "Split liver transplantation in pigs with reconstruction of the inferior vena cava" Transplantation Proceedings. 28-3. 1798 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] I Yokoyama, H Takagi: "Fas antigen expression and apoptosis inductioc of in vitro cultured hepatocytes with high concentrations of cycrosporine A" Transplantation Proceedings. 28-3. 1383-138 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 高木 弘: "免疫抑制剤シクロスポリン" 今日の移植. 9-4. 431-432 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] H Takagi: "XENO-Xenotransplantation reserch in Japan" XENO. 4-4. 62-63 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小林孝彰, 高木 弘, 浅野浩史: "免疫抑制剤投与時における真菌症" 臨床と微生物. 23-5. 511-516 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] T Kobayashi, Takagi H: "TAP1,TAP2,LMP2,DMA,and DMB Genetic Polymorphisms in Renal Transplantation" Transplantation Proceedings. 30. 29-30 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y Tominaga, Takagi H: "Clonal Analysis of Nodular Parathyroid Hyperplasia in Renal Hyperparathroidism" World journal of Surgery. 20. 744-752 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] T Kojima, Takagi H: "Role of Fc Fragments in Inhibition of Xenogenic Hypeeracute Rejection by Intravenous Imunoglobulin" Transplantation. 62-5. 559-562 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Taniguchi, Takagi H: "In vivo Immunoadsorption of Antipig Antibodies in Baboons Using a Specofic GaL-α 1-3Gal Column" Transplantation. 62-10. 1379-138 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yokoyama I, Takagi H: "Apoptosis in pig endothelial cells after reperfusion and its prevention by genetic induction of human Cu,Zn-SOD cDNA." Transplantation Proceedings. 29. 1364 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Morozumi K, Takagi H, Uchida K: "Electron-microscopic peritubular capillary lesion in a specific and uself diagnostic indicator for chronic rejection of renal allografts showing less specific morphologic lesion in the cyclosporin era." Transplantation Proceedings. 29. 1389-92 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takeda A, Takagi H: "Sevare cyclosporine arteriolopathy with focal segmental glomerulosclerosis is not a fatal finding in chronic renal allograft failure after year 5 of transplantation using cyciosporine." Transplantation Proceedings. 29. 96-99 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hayashi S, Takagi H: "Effect of antisense ribozyme to alpha (1,3) galactosyl transferase gene on the expression of GAl alpha (1,3) GAL epitope." Transplantation Proceedings. 29. 893 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Koike C, Takagi H: "Reduction of α-gal epitopes in transgenic pig by introduction of fuman α 1-2 fucosyltransterase." Transplantation Proceedings. 29. 894 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Negita M, Takagi H: "Protective effect of human suoeroxide dismutase cDNA transfection in the prevention of cold preservation injury." Transplantation Proceedings. 29. 1363 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T Kojima, H Takagi: "Inhibition of completment-mediated immune hemolysis by the constant domain of immunoglobuin" Peptido Chemistry. (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T Nagasaka, H Takagi: "α-garactosyl oligosaccharides conjugated with polyethylene glycol as potential inhibitors of hyperacute upon xenotransplantation" BIOMEDICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 232. 731-736 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小林孝彰, 高木 弘: "HLAのマッチングと臓器移植検査と技術-増刊号-輸血検査実践" マニュアル医学書院. 25-7. 120-121 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, H Takagi: "Adenovirus-mediated gene transfer to the xenogeneic liver in liver xenotransplantation : The transductio of complement regulatory factor genes (DAF and HRF20)" Transplantation Proceeding. 29. 2211 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, H Takagi: "Effect of CTLA4-Ig gene transfer using adenoviral vector in organ and cell transplantation" Transplantation Proceeding. 29. 2212 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, H Takagi: "Adenovirus-mediated gene transfer of antisense ribozyme for α(1,3) garactosyl transferase gene and (1,2) fucosyltransferase gene in xenotranplantation" Transplantation Proceeding. 29. 2213 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y Namii, H Takagi: "Evidence that the adenoviral vector containing the CTLA-Ig gene improves transgene expression and graft survival" Transplantation Proceeding. 29. 1738-1739 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 林 衆治、高木 弘: "特集 寛容導入をめざす移植免疫学-ヒト遺伝子導入による異種拒絶反応制御" Molecular Medicine. 34-7. (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Katayama A, Takagi H: "tudies of α-Gal Dependent Hyperacute Xenotransplant Rejection Using DOuble Knockout Embryonic Stem Cells" Transplantation Proceeding. 29. 2262 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Chihiro Koike, Hiroshi Takagi: "Direct gene replacement of the mouse α(1,3)-galactsyltransgferase gene with human α(1,2)-fucosyltransgferase gene : Converting α galactsyl epitopes into H antigens" Xenotransplantation. 4. 147-153 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H Asano, H Takagi: "Significance of tumor necrosis factor microsatellite polymorphism in renal transplantation" TISSUE ANTIGENS. 50. 484-488 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shuji Hayashi, Hiroshi Takagi: "Inhibition of establishment of Hepatic metastasis in mice by combination gene therapy using both herpes simplex virusthymidine kinase and granulocyte macrophage-colony stimulating factor gene in mune colon cancer" Cancer Genen Therapy. 4-6. 339-344 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小林孝彰、高木 弘: "ABO血液型不適合腎移植と異種移植の接点" 今日の移植. 10-6. 947-951 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M Negita, Takagi H: "Protective Effect of Human Superoxide Dismutase cDNA Transfection in the Prevention of Cold Preservation Injury" Transplantation Proceedings. 29. 1363 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takagi H: "Organ Transplants Still Too in Japan and Asian Countries" Transplantation Proceedings. 29. 1580-158 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] I Yokoyama, Takagi H: "Measurement of portal venous flow velocity with an implantable miniature Doppler probe in pig liver transplantation" Transplantation international. 10. 116-120 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takagi H: "Evalution of Tetrahydropyranyladriamycin as an Immunosuppressant in Concordant Xenotransplantation" World journal of Surgery. 16. 283-289 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, Takagi H: "Effect of Gene with the Herpes Simplex Virus-Thymidine Kinase Gene on Hepatic Metastasis in Murine Colon Cancer" Surgery Today. 27. 40-43 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] K Uchida, Takagi H: "Renal Transplantatio and Secondary Hyperparathyroidism" Seminars in Surgical Oncology. 13. 97-103 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y Tominaga, Takagi H: "Histopathology,Pathophysiology,and Indications for Surgical Treatment of Renal Hyperparathyroidism" Seminars in Surgical Oncology. 13. 78-86 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takagi H: "PARATHYROID HYPERPLSIA AND TUMOR" Seminars in Surgical Oncology. 13. 71-72 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y Tominaga, Takagi H: "Surgical Treatment of Renal Hyperparathroidism" Seminars in Surgical Oncology. 13. 87-96 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y Tachi, Takagi H: "Variability of Cytotoxicity to Pig Cultured Cells and Its Determinant Factor in Human Sera" Transplantation Proceedings. 30. 71-73 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yokoyama I, Takagi H: "Transplant Portal venous flow velocity measured by the implantable miniature Doppler probe in pig liver transplantation." International. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Yokoyama I, Takagi H: "Prevention of endothelial cell apoptosis with genetic induction of human Cu,Zn-SOD cDNA." Transplantation. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Yokoyama I, Takagi H: "Portal venous flow velocity measured by the implantable miniature Doppler probe in pig liver transplantation." International. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Yokoyama I, Takagi H: "Fas antigen expression and its modification by immunosuppressants." Dig Dis Sci. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, H Takagi: "Protection of guinea pig cell from rat complement-mediated lysis by the transfection of rat complement regulatory factor512 gene Xenotransplantation" Xenotransplantation. 3. 217-221 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 高木 弘: "異種移植への展望" 臨床透析. 12-3. 269-270 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 横山逸男, 高木 弘: "異種移植" 日本外科学会雑誌. 97-11. 1010-101 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M Negita, H Takagi: "Human superoxide dismutase cDNA transfection and its in vitro effect on cold preservation." Biomedical and biophysical resarch communication. 218. 653-657 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kobayashi, Takagi H, and Cooper DKC: "Investigation of the anti-complement agents,FUT-175 and K76COOH,in discordant xenotransplantation" Xenotransplantation. 3. 237-245 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hayashi S, Takagi H: "Protection of guinea pig cells transfected with the 512 gene for complement dependent cytolysis in rats." Transplantation Proceedings. 28. 592 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Morozumi k, Takagi H: "A comparative study of morphological characteristics of renal injuries of tacrolimus (FK506) and cyclosporin (CyA) in renal and CyA nephrotoxicity similar?" Transplantation Proceedings. 28. 1076-1078 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yokoyama I, Takagi H: "Liver transplantation and hepatocellular carcinoma." Sem Surg Oncol. 12. 212-216 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yokoyama I, Takagi H: "Decresed Fas antigen expression of the cultured hepatocytes with tacrolimus (FK506)" Transplantation Proceedings. 28. 3191-3193 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 横山逸男、高木 弘: "肝細胞癌に対する肝移植" 肝胆膵. 33. 55-61 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] S Hayashi, H Takagi: "Genetic Enginnering targeted to donor organs using" Transplantation Proceeding. 28-28. 225- (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] T Kobayashi, H Takagi, D.K.C.Cooper: "In vitro and vivo investigation of anticomplement agents FUT-175 and K76COOH,in the prevention of hyperacute rejection following discordant xenotransplantation in a nonhuman primate model" Transplantation Proceeding. 28-2. 604 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hayashi S: "Evidence that Double Transfection to Xenoendothelial Cells Using GPI-Anchoring Complement Regulatory Factor 8Decay" Proceedings. 27(1). 330 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hayashi S: "How can human DAF and HFR20 prevent hyperacute rejection in transgenic mice?" Transplant Troc. 28(2). 599-600 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takagi H: "In vitro and in vivo investigation of the anti-complement agents,FUT-175 and K76COOH,in the prevention of hyperacure rejection following discordant" Xenotransplantation. 3(3). 237-245 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hayashi S: "Protection of guinea pig cells transfected with 5I2 gene from complement dependent cytolysis of rat." Tranplant Proc. 3. 217-221 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takagi H: "Introduction of α(1,2)fucosyltransferase and its effect on α-Gal epitopes in transgenic pig." Xenotransplantation. 3. 81-86 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yokoyama I: "Liberation of vasoactive substances and its prevention with thromboxane A2 synthase inhibitor in pig liver transplantation." Transplant International. 9. 76-81 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takagi H: "Elucidation of rejection mechanisms using the splenocyte injection model in concordant xenotransplantation." Transplantation Proceedings. 27. 1883-1884 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takagi H: "Effect of tetrahydropyranyladriamycin on concordant xenotransplantation in the splenocyte injection and heart transplantation model." Transplantation Proceedings. 27. 1628-1629 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 高木弘: "遺伝子制御による異種移植" 臨床科学. 31. 862-867 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takagi H: "Evidence that double transfection to xenoendothelial cells using GPI-anchoring complement regulatory factor(DAF and HRF20)genes is useful for the inhibition" Xenotransplantation. 2. 259-294 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 高木弘: "異種移植の展望" 今日の移植. 7(3). 193-198 (1995)

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      1996 Annual Research Report
  • [Publications] 高木弘: "異種移植の展望" 平成7年度名古屋大学公開講座「生命を考える」. 66-70 (1995)

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      1996 Annual Research Report
  • [Publications] Takagi H: "臓器移植と遺伝子操作-異種移植の免疫抑制" BIO Clinica. 10(10). 735-737 (1995)

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  • [Publications] 高木弘: "異種移植臨床への研究" BIO Clinica. 10(14). 1064-1066 (1995)

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      1996 Annual Research Report
  • [Publications] Okada H: "Antagonistic peptides against human anaphylatoxin C5a." Immunology. 86. 149-154 (1995)

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      1996 Annual Research Report
  • [Publications] Okada H: "Tubulointerstitial injury induced in rats by a monolonal antibody which inhibits function of a membrane inhibitor of complement." J.Clin.Inv.96. 2348-2356 (1995)

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      1996 Annual Research Report
  • [Publications] 高木弘: "遺伝子制御による異種移植" 臨床科学. 1. 862-867 (1995)

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      1996 Annual Research Report
  • [Publications] 林衆治: "治療用遺伝子導入種血管内皮細胞を用いたハイブリット型人工血管作成に関する研究" 人工臓器. 24(3). 834-837 (1995)

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      1996 Annual Research Report
  • [Publications] Takagi H: "Beneficial effect of donor pretreatment with thromboxane A2 synthase inhibitor on the graft survival in pig liver transplantation." Journal of Surgical Research. 60. 238-239 (1996)

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      1996 Annual Research Report
  • [Publications] Takagi H: "Human superoxide dismutase cDNA transfection and its in vitro effect on cold preservation" Biochemical and biophysical research commumunications. 218. 653-657 (1996)

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      1996 Annual Research Report
  • [Publications] Takagi H: "Inhibition of human complement-dependent cell lysis by bovine aortic endothelial cells transfected with menbrane-bound complement-regulatory" European Surgical Research. 28. 440-446 (1996)

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      1996 Annual Research Report
  • [Publications] Takagi H: "Retrovirus-mediated human superoxide dismutase cDNA transfer to prevent Ischemia-reperfusion injuly" Transplantation Proceedings. 28(1). 342 (1996)

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      1996 Annual Research Report
  • [Publications] Takagi H: "Measurement of the ratio of superoxide-scavenging activity in the graft in swine liver transplantation" Transplantation Proceedings. 28(1). 329 (1996)

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      1996 Annual Research Report
  • [Publications] Takagi H: "Tissue distribution of GALα(1,3)GAL epitope in heart,kidney,and liver of pig and mouse" Transplantation Proceedings. 28(1). 216 (1996)

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      1996 Annual Research Report
  • [Publications] Takagi H: "Decreased Fas antigen expression of the cultured hepatocytes with FK506" Transplantation Proceedings. 28(6). 3189-3190 (1996)

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  • [Publications] Takagi H: "Establishment of a Human DAF/HRF20 Double Transgenic Mouse Line in not Sufficient to Suppress Hyperacute Rejection" Surg Today. 26. 993-998 (1996)

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      1996 Annual Research Report
  • [Publications] Takagi H: "Tetrahydropyranyladriamycin with FK506 combination therapy for hamster-to-rat-concordant xenotransplantation." Transplant Proc. 28. 709-710 (1996)

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      1996 Annual Research Report
  • [Publications] Takagi H: "Effect of antisense ribozyme to pitα(1,3)galactosyl transferase gene on the expression of Galα(1,3)Gal epitope." Transplant Proc. 28. 628 (1996)

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      1996 Annual Research Report
  • [Publications] 高木弘: "異種移植" 医学のあゆみ. 177(3). 258-259 (1996)

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      1996 Annual Research Report
  • [Publications] 高木弘: "異種臓器移植におけるトランスジェニックブタ作製の重要性" 細胞工学. 15(1). 81-89 (1996)

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      1996 Annual Research Report
  • [Publications] 高木弘: "異種移植への展望" 臨床透析. 12(3). 269-270 (1996)

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      1996 Annual Research Report
  • [Publications] 林衆治: "遺伝子制御による異種移植の研究" 日本消化器外科学会雑誌. 29(4). 907-910 (1996)

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      1996 Annual Research Report
  • [Publications] 高木弘: "免疫抑制剤シクロスポリン" 今日の移植. 9(4). 431-432 (1996)

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      1996 Annual Research Report
  • [Publications] 高木弘: "異種移植" 日本外科学会雑誌. 97(11). 1010-1017 (1996)

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      1996 Annual Research Report
  • [Publications] Okada H: "Local inflammation caused by a monoclonal antibody which blocks the function of the rat membrane inhibitor of C3 convertase." J.Immunol.156. 1182-1188 (1996)

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      1996 Annual Research Report
  • [Publications] Okada H: "Molecular cloning of murine decay accelerating factor(DAF)by immunoscreening." Int.Immunol.8. 379-385 (1996)

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      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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