| Project/Area Number |
08407036
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MAKUUCHI Masatoshi University of Tokyo Hospital Intemal Medicine, Professor, 医学部・附属病院, 教授 (60114641)
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| Co-Investigator(Kenkyū-buntansha) |
KAWARASAKI Hideo University of Tokyo Hospital Intemal Medicine, Lecturer, 医学部・附属病院, 講師 (60115475)
HARIHARA Yasushi University of Tokyo Hospital Intemal Medicine, Lecturer, 医学部・附属病院, 講師 (10189714)
KUBOTA Keiichi University of Tokyo Hospital Intemal Medicine, Lecturer, 医学部・附属病院, 講師 (70260388)
TAKAYAMA Tadatoshi University of Tokyo Hospital Intemal Medicine, Associate Professor, 医学部・附属病院, 助教授 (30280944)
岡 輝明 東京大学, 医学部・付属病院, 助手 (60177029)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥32,200,000 (Direct Cost: ¥32,200,000)
Fiscal Year 1998: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1997: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 1996: ¥24,100,000 (Direct Cost: ¥24,100,000)
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| Keywords | Liver Transplantation / Acute rejection / Cytokines / Eosinophilia / soluble II L-2 recepter / IL-6 / TNF |
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| Research Abstract |
At Tokyo University Hospital, 63 living-related liver transplantation have been performed since January, 1996. There were 27 males and 36 females (Average age : 14.9 years, range : 8 months-62 years). The diagnoses were biliary atresia in 40, primary biliary cirrhosis in 8, liver cirrhosis in 7, Alagille syndrome in 2 and others in the remaining 5. FK506 and steroid were employed as main immunosuppressive drugs. Acute rejection was diagnosed by the elevation of T-Bil, GOT, GPT, ALP and G-GTP, which was confirmed histologically. 15 of 52 patients showed acute rejection, whereas the remaining 37 had no rejection. Histology showed cellular infiltration in the Gulissonian triad, destruction of the bile duct and endothelialitis. Furthermore, liver dysfunction with eosinophilia in the peripheral blood highly suggested the presence of acute rejection. Whereas alteartions of cytokines in the peripheral blood were not specific to the acute rejection.
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