• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Clinical Application of Magnetophysiology : Spatiotemporal Integration of Magnetoencephalography and Functional Magnetic Resonance Imaging

Research Project

Project/Area Number 08407042
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionTohoku University School of Medicine

Principal Investigator

SHIRANE Reizo (1997)  Department of Neurosurgery, Tohoku University School of Medicine, Associate Professor, 医学部, 助教授 (30206297)

溝井 和夫 (1996)  東北大学, 医学部, 助教授 (70157519)

Co-Investigator(Kenkyū-buntansha) NAKASATO Nobukazu  Department of Neurosurgery, Tohoku University School of Medicine, Research Assoc, 医学部, 助手 (80207753)
YOSHIMOTO Takashi  Department of Neurosurgery, Tohoku University School of Medicine, Professor, 医学部, 教授 (50091765)
高安 秀樹  東北大学, 大学院・情報科学研究科, 教授 (00183062)
白根 礼造  東北大学, 医学部, 講師 (30206297)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥33,500,000 (Direct Cost: ¥33,500,000)
Fiscal Year 1997: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1996: ¥28,400,000 (Direct Cost: ¥28,400,000)
KeywordsMagnetoencephalograpy / Functional MRI / Magnetophysiology / Functional Brain Map / Presurgical Evaluation / Evoked Potentials / Evoked Magnetic Fields / Cortical Stimulation / 脳機能マッピング / 誘発脳磁界 / 感覚刺激 / 逆問題
Research Abstract

In this study, magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) have been applied to basic and clinical brain mapping. Both techniques have been recently developed as non-invasive magnetophysiological tools.
Results are summarized as follows.
Somatosensory evoked field for tongue, digit, hand, low extremities, and urogenital organs indicated somatotopic organization of the primary somatosensory cortex of the brain. fMRI for hand, tongue and lip movement as well as hand sensory stimuli also indicated a certain area responsible for each activity. These data were integrated on MRI-based anatomical images, venography and surface anatomical scan. In cases of glioma, we verified these functional localization of sensori-motor cortices by intraoperative cortical stimulation under the awake condition.
Auditory and visually evoked magnetic fields were applied for patients with various types of intracranial structural lesions. In a certain abnormal conditions, we found delay of peak latency of major components in evoked responses. In some patients, latency of the responses normalized after removal of lesions.
Spatial and temporal resolution of MEG are millimeter and millisecond order respectively. MEG is especially useful to localize pin-point sources spatially and temporally. On the other hand, fMRI is suitable to localize brain activity of spatially extended area and within a certain length of time, of usually a few ten seconds order. For understanding human brain function, both techniques are complementary ; integration of the two techniques will be important especially for clinical application.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Nakasato N, et al: "Neuromagnetic evaluation of cortical auditory function in patients with temporal lobe tumors." J Neurosurg. 86. 610-618 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hatanaka K, et al: "Striate cortical genelators of the N75,P100 and N145 components localized by pattern reversal visual evoked magnetic fields." Tohoku J Exp Med. 182. 9-14 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohtomo S, et al: "Hemispheric asymmetry of the auditory evoked N100m response in relation to the crossing point between the central sulcus and sylvian fissure." Electroencephalogr Clin Neurophysiol. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimizu H, et al: "Localizing the central sulcus by functional MRI and MEG" Clin Neurol Neurosurg. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 中里 信和, 他: "多チャンネルSQUIDによる脳磁図計測の臨床応用" 応用物理. 66. 1229-1232 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakasato N,Seki K,Fujita S,Hatanaka K,Kawamura T,Ohtomo S,Kanno A,Ikeda H,Yoshimoto T: "Clinical application of visual evoked fields using an MRI-linked whole head MEG system." Frontiers Med Biol Engineering. 7. 275-283 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakasato N,Seki K,Kawamura T,Fujita S,Kanno A,Fujiwara S,Yoshimoto T: "Functional brain mapping using an MRI-linked whole head magnetoencephalography (MEG) system. Electroencephalogr Clin" Neurophysiol Suppl. 46. 119-126 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakasato N,Seki K,Kawamura T,Ohtomo S,Kanno A,Fujita S,Hatanaka K,Fujiwara S,Kayama T,Takahashi A,Jokura H,Kumabe T,Ikeda H,Mizoi K,Yoshimoto T: "Cortical mapping using an MRI-linked whole head MEG system and presurgial decision making." Electroencephalogr Clin Neurophysiol Suppl. 47. 333-341 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawamura T,Nakasato N,Seki K,Kanno A,Fujita S,Fujiwara S,Yoshimoto T: "Neuromagnetic evidence of pre-and post-central cortical sources of somatosensory evoked responses." Electroencephalogr Clin Neurophysiol. 100. 44-50 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Murayama N,Nakasato N,Hatanaka K,Fujita S,Igasaki T,Kanno A,Yoshimoto T: "Gustatory evoked magnetic fields in human." Neurosci Lett. 210. 121-123 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Seki K,Nakasato N,Fujita S,Hatanaka K,Kawamura T,Kanno A,Yoshimoto T: "Neuromagnetic evidence that the P100 component of pattern reversal visual evoked response originates in the bottom of calcarine fissure." Electroencephalogr Clin Neurophysiol. 100. 436-442 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kanno A,Nakasato N,Fujita S,Seki K,Kawamura T,Ohtomo S,Fujiwara S,Yoshimoto T: "Right hemispheric dominance in the auditory evoked magnetic fields for pure-tone stimuli." Electroencephalogr Clin Neurophysiol Suppl. 47. 129-132 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohtomo S,Nakasato N,Kawamura T,Kanno A,Seki K,Fujiwara S,Shimizu H,Fujita S,Yoshimoto T: "Correspondence of anatomy and function in the human digit sensory cortex revealed by an MRI-linked whole head MEG system." Electroencephalogr Clin Neurophysiol Suppl. 47. 91-95 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakasato N,Kumabe T,Kanno A,Ohtomo S,Mizoi K,Yoshimoto T: "Neuromagnetic evaluation of cortical auditory function in patients with temporal lobe tumors." J Neurosurg. 86. 610-618 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mino K,Niki N,Nakasato N,Yoshimoto T: "An estimation algorithm for neuromagnetic source distribution using MRI information." IEEE Trans Nucl Sci. 44. 230-234 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hatanaka K,Nakasato N,Seki K,Mizoi K,Yoshimoto T: "Striate cortical generators of the N75, P100 and N145 components localized by pattern reversal visual evoked magnetic fields." Tohoku J Exp Med. 182. 9-14 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Suzuki K,Okuda J,Nakasato N,Kanno A,Hatanaka K,Yamadori A,Fujii T,Yoshimoto T: "Auditory evoked magnetic fields in patients with right hemisphere language dominance." NeuroReport. 8. 3363-3366 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimizu H,Nakasato N,Mizoi K,Yoshimoto T: "Localizing the central sulcus by functional MRI and MEG" Clin Neurol Neurosurg. 99. 235-238 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimizu H,Shirane R,Fujiwara S,Takahahi A,Yoshimoto T: "Proton magnetic resonance spectroscopy in chidren with moyamoya disease." Clin Neurol Neurosurg. Suppl 2. S64-S67 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakasato N,Yoshimoto T: "Magnetoencephalography (MEG) and functional brain mapping." J Jpn Assoc Radiol Technologist English Issue. 1996. 12-21 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakagawa H,Namima T,Aizawa M,Uchi K,Kaiho Y,Yoshikawa K,Orikasa S,Nakasato N: "Somatosensory evoked magnetic fields elicited by dorsal penile, posterior tibial and median nerve stimulation." Electroencephalogr Clin Neurophysiol. 108. 57-61 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohtomo S,Nakasato N,Kanno A,Hatanaka K,Shirane R,Mizoi K,Yoshimoto T: "Hemispheric asymmetry of the auditory evoked N100m response in relation to the crossing point between the central sulcus and sylvian fissure." Electroencephalogr Clin Neurophysiol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakasato N, et al: "Neuromagnetic evaluation of cortical auditory function in patients with temporal lobe tumors." J Neurosurg. 86. 610-618 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hatanaka K, et al: "Striate cortical generators of the N75,P100 and N145 components localized by pattern reversal visual evoked magnetic fields." Tohoku J Exp Med. 182. 9-14 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohtomo S, et al: "Hemispheric asymmetry of the auditory evoked N100m response in relation to the crossing point between the central sulcus and sylvian fissure." Electroencephalogr Clin Neurophysiol. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Shimizu H, et al: "Localizing the central sulcus by functional MRI and MEG" Clin Neurol Neurosurg. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] 中里信和, 他: "多チャンネルSQUIDによる脳磁図計測の臨床応用" 応用物理. 66. 1229-1232 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakasato N, et al.: "Clinical application of visual evoked fields using an MRI-linked whole head MEG system." Frontiers Med Biol Engineering. 7. 275-283 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Murayama N, et al.: "Gustatory evoked magnetic fields in human." Neurosci Lett. 210. 121-123 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Seki K, et al.: "Neuromagnetic evidence that the P100 component of pattern reversal visual evoked response originates in the bottom of calcarine fissure." Electroencephalogr Clin Neurophysiol. 100. 436-442 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nakasato N, et al.: "Neuromagnetic evaluation of cortical auditory function in patients with temporal love tumors." J Neurosurg. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Nakagawa H, et al.: "Somatosensory evoked magnetic fields elicited by dorsal penile nerve stimulation." Electroencephalogr Clin Neurophysiol, in press.

    • Related Report
      1996 Annual Research Report
  • [Publications] Hatanaka K, et al.: "Striate cortical generators of the N75, P100 and N145 components localized by pattern reversal visual evoked magnetic fields." Tohoku J. Exp Med, in press.

    • Related Report
      1996 Annual Research Report

URL: 

Published: 1996-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi