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A Research of Drug Delivery System by Time-Varying Electric Field - Development of high performance electric infiltration anesthesia -

Research Project

Project/Area Number 08407066
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

UMINO Masahiro  Tokyo Medical and Dental University, School of Dentistry, Professor, 歯学部, 教授 (90014125)

Co-Investigator(Kenkyū-buntansha) FUKAYAMA Haruhisa  Tokyo Medical and Dental University, School of Dentistry, Assistant, 歯学部, 助手 (20189921)
ODA Nobuo  Tokyo Institute of Technology, 工学部, 名誉教授
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥34,500,000 (Direct Cost: ¥34,500,000)
Fiscal Year 1999: ¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1998: ¥9,600,000 (Direct Cost: ¥9,600,000)
Fiscal Year 1997: ¥10,700,000 (Direct Cost: ¥10,700,000)
Fiscal Year 1996: ¥6,500,000 (Direct Cost: ¥6,500,000)
Keywordsdrug delivery / iontophoresis / alternating current / in vitro / in vivo / lidocaine hydrochloride / microdialysis / impedance / A^C / 変動電界 / 電気浸透 / 電解質溶液 / インピーダンス / 周波数特性 / 局所麻酔薬 / 通電セル / イオン / ドラッグデリバリーシステム / 変動電磁場 / gradient force / イオン移動 / 電場勾配
Research Abstract

A Study for the basic mechanism of the high frequency AC iontophoresis (HFIP) has been pursued. First, we examined the efficiency of the by measuring the impedance of the solution in the receptor side of the diffusion cell. Several frequencies and a few voltages of external sinusoidal electric fields were used to evaluate the frequency dependency and the voltage dependency of the HFIP.
The permeable efficiency of the saline by HFIP increased with the increase of the external electric voltage up to 〜15 V and leveled off at the voltages larger than 15 V. A physical model was proposed to explain the mechanism of HFIP. The theory of physical model is as follows ; the ion-dipole interactions are broken by the vibrational energy of the ion supplied by the external electric field. The decrease of the effective Stokes radius causes the increase of the diffusion coefficient of the ion.
The permeable efficiency of the lidocaine by HFIP showed the maximum value at the frequency 〜300 Hz when the voltage was 30 V. A theoretical model that the rotational energy of the ion supplied by the external electric field break the 'ice burg' of the surrounding water molecules and that the decrease of the effective Stokes radius follows it.
It has been cleared that the shape of the external electric field affects the efficiency of the HFIP. A convergent shape electric field transport ions more effectively than the divergent or the parallel electric field.
We have developed a method of measuring the concentration of the lidocaine under the rat's skin with the microdialysis probe. This method will give us data of the drug distribution under the skin.
The HEIP of the 20 % lidocaine effectively anesthetized the forearm nerve without adverse events. It can be concluded that the HFIP is a new and safe technique for the transdermal drug delivery.

Report

(5 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 芝地貴夫ら: "変動電場による経皮的ドラッグデリバリー"日本DDS学会誌. 14(4). 296 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 芝地貴夫ら: "変動電場によるイオントフォレーシス効率の周波数依存性"日本歯科麻酔学会雑誌. 27(4). 495 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 木下樹ら: "マイクロダイアリンスを用いた局所麻酔薬のin vivo微量測定法の確立"日本歯科麻酔学会雑誌. 27(4). 496 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takao Shibaji, Yoshiaki Yasuhara, Nobuo Oda, Masahiro Umino: "A mechanism of the High Frequency AC iontophoresis"Journal of Controlled Release. (Submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 芝地 貴夫ら: "変動電場による経皮的ドラッグデリバリー"日本DDS学会誌. 14(4). 296 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 芝地 貴夫ら: "変動電場によるイオントフォレーシス効率の周波数依存性"日本歯科麻酔学会雑誌. 27(4). 495 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 木下 樹ら: "マイクロダイアリシスを用いた局所麻酔薬の in vivo 微量測定法の確立"日本歯科麻酔学会雑誌. 27(4). 496 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shibaji T.,Yasuhara Y.Oda N.,Umino M: "Drug transportation by alternating electric field." Medical & Biological Engineering & Computing. Vol.35・I. 40 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 芝地貴夫,安原愛明,海野雅浩: "変動電場による薬物浸透" 日本歯科麻酔学会雑誌. 25・4. 617 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 出口繁,芝地貴夫,安原愛明,海野雅浩: "HPLCおよびマイクロダイアリシスによる局所麻酔薬の微量測定法の確立-変動電場による薬物浸透への応用-" 日本歯科麻酔学会雑誌. 26・4. 613 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 芝地貴夫,出口繁,安原愛明,海野雅浩: "変動電場下の局所麻酔薬の電気化学的挙動" 日本歯科麻酔学会雑誌. 26・4. 614 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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