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Selection mechanism for ovulatory follicles in the rat ovary

Research Project

Project/Area Number 08454264
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 生物形態・構造
Research InstitutionUniversity of Tokyo

Principal Investigator

MORI Takao  University of Tokyo, Graduate School of Science, Professor, 大学院・理学系研究科, 教授 (80011659)

Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 1997: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1996: ¥4,200,000 (Direct Cost: ¥4,200,000)
Keywordsovulation number / atresia / apoptosis / GnRH / rat / 哺乳類 / 卵巣 / 排卵 / 濾胞閉鎖
Research Abstract

To clarify the effect of GnRH on ovarian function, the expression of GnRH receptor in adult rat ovary was examined by in situ hybridization. GnRH receptor mRNA was detected mainly in the granulosa cells of most follicles and luteal cells. The granulosa cells of atretic follicles showed a very high level of the mRNA expression throughout their degenerating process. Strong hybridization signals were also detected in the mural granulosa cells of mature follicles. Newly formed corpora lutea exhibited signals with moderate intensity in the luteal cells, and the older ones showed weaker signals. In neonatal rat ovaries, no significant GnRH receptor mRNA signals were detected until 5 days of age. The expression was first observed at 10 days of age in the interstitial cells. At 15 days of age, the recptor mRNA was expressed in the granulosa cells of most preantral and early antral follicles, while no hybridization signals were detected in oocyte and and theca cells. The present findings that GnRH receptor mRNA was expressed in atretic and mature follicles support the putative roles of GnRH in the induction of follicular atresia and ovulation in rat ovaries.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] M.Matsuda: "Effect of estrogen on hyperprolactinenia-induced glucose into lerarce in SHN mice" Proc.Soc.Exp.Biol.Med.212. 243-247 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Iizuka: "Effects of unilateral cyptorchidism on the expression of gonadotropin receptor mRNA" Biochem.Biophys.Res.Comm.221. 290-294 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Akazone: "Highly heterologous region in the N-terminal extracelblor domain of reptition folliteopin recepter" Gen.Com.Endocrinal. 104. 374-381 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Yamashita: "Increased expression of prolactin receptor mRNA in alenopyctic uterus in mices" Life Science. 60. 1437-1446 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Matsuda: "Effect of hormones on expression of prolactin reception mRNA in paxacba atic isltes of adult femole mice in vitro" Zoological Science. 14. 159-165 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Shinohara: "Gnanulosa cell kinectics exanined by bromocleaxyuidine in combinction with colchicine in move onasisur fallicles" In vivo. 11. 248-252 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Matsuda et al.: "Effect of estrogen on hyperprolactinemia-induced glucose intolerance in SHN mice." Proc. Soc. Exp. Biol. Med.212. 243-247 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Iizuka et al.: "Effects of unilateral cryptorchidism on the expression on gonadotropin receptor mRNA." Biochem. Biophys. Res. Commun.221. 290-294 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Akazome et al.: "Highly heterologous region in the N-terminal extracellular domain of reptilian follitropin receptor" Gen.Comp.Endocrinol.104. 374-381 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Yamashita et al.: "Increased expressoin of prolactin receptor mRNA in adenomyotic uterus in mice." Life Sci.60. 1437-1446 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Matsuda et al.: "Effect of hormones on expression of prolactin receptor mRNA in pancreatic islets of adult female mice in vitro." Zool.Sci.14. 159-165 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Shimohara et al.: "Granulosa cell kinetics examined by bromodeoxyuridine in combination with colchicine in mouse ovarian follicles." In vivo. 11. 248-252 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Mori: "Animal model of uterine adenonyosis : lndnction of the loein in rats by ectopic pstuitary isograhts." Lab.Anim.Science. 48. 64-69 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y.Yamashita: "In creaeed expression of prolactin receptor mRNA in adenomyotic uterun in mice" Life Sciences. 60. 1437-1446 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y.Shinohara: "Granrlosa cell kinetics examined by bromoleoxy wridine in combination with colcbicene in the mouse ovaiam follicle" In vivo. 11. 248-252 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y.Akazome: "Ontogeny of the expresdion of messenger ribonucleic acid encoding lutrapin recopton in chicker enbryo" Zoological Suence. 14. 363-367 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y.Yamashita: "Disturbed cell aranzemut ; increased all menbrve permeab・lity and apoptotic cell death occur in adenenyatic utiu ticaes in mice" Zoological Science. 14. 659-664 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Matsuda: "Ethect of hormones on expression of pnlrctin recepton messenger ribondcleic rcids in panorlatic islets of adult mice" Zoological Science. 14. 159-165 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Matsuda: "Modification of PRL receptor expression by PRL in the mouse liver Estimation of the ratio of two forms of PRL-KmRNA by"ore-sided c PCR"" Zoological Science. 13. 435-441 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] A.Iizuka: "Effect of unilateral cryptorchiclisan on the exprussion of gonadotiopin reccptor mRNA" Biochem.Biophy.Res.Comm.221. 290-294 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Akazome: "Highly heterologous region in the N-terminal extracellular domain of Reptilian follitrspin receptor" Gen.Comp.Endocrinal. 104. 374-381 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Matsuda: "Chronic effect of hyparprolactine mia on blood glucose and lipid levels in mice." Life Sciences. 58. 1171-1177 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] A.Iizuka: "Changes in citrate concentration in the mouse utoms with experimentally-induced adenomyosis" Life Sciences. 58. 397-403 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Matsuda: "Effect of estrogen on hyperorala ctinemia-induced glucose" Proc.Soc Exp.Biol.Med.212. 243-247 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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