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Research on simultaneous measurement of refractive index and thickness of bilogical tissue by low coherence interferometry

Research Project

Project/Area Number 08455039
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied optics/Quantum optical engineering
Research InstitutionOsaka University

Principal Investigator

HARUNA Masamitsu  Fac.Med., Dept.Allied Health Sci., Professor, 医学部, 教授 (20029333)

Co-Investigator(Kenkyū-buntansha) OHMI Masato  Fac.Med., Dept.Allied Health Sci., Research Associate, 医学部, 助手 (60273645)
ITO Kazuyoshi  Fac.Eng., Dept.Applied Phys., Professor, 工学部, 教授 (80113520)
NIDSHIHARA Hiroshi  Fac.Eng., Dept.Electron.Eng., Professor, 工学部, 教授 (00029018)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥7,100,000 (Direct Cost: ¥7,100,000)
Fiscal Year 1997: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥4,800,000 (Direct Cost: ¥4,800,000)
KeywordsLow coherence interferometry / Refractive index and thickness measurement / in vitro measurement / Confocal microscopy / レーザ蒸着 / 電気光学結晶膜 / ニオブ酸リチウム / 光相互接続
Research Abstract

The research has been made to demonstrated a novel low coherence interferometer which can provide simultaneous measurement of the refractive index and thickness of biological tissue. Major research results are described in the following.
1. We proposed and demonstrated a novel technique for simultaneous measurement of refractive index n and thickness t of a measured object. The technique is based on the low coherence interferometry combined with precise translation stages. It is applicable for accurate measurement of refractive index of biological tissue. The measurement accuracy of <0.1% is expected for a thickness of more than 1mm. In the experiment using the object scanning method, the accuracy of 0.2% or less was attained for nearly 1-mm thick transparent plates.
2. On the basis of our proposed method, refractive index and thickness measurement were successfully achieved for a human nail, tooth, chicken tissue and a crustacean which has multiple layrs.
3. We suggest that this method is applicable for birefringence measurement without any polarization control. The ordinary and extraordinary indices, n_o and n_e of a X-cut LiNbO_3 plate were measured.
4. Moreover, we propose and demonstrate a novel technique for simultaneous measurement of plase and group lidices n_p and n_g of a transparent plate, as well as the thickness t, using the low coherence interferometer where a single superluminescent diode is used as the light source.
5. To realize a stable and compact measurement system, the low coherence interferometer consisted of micro-optic components on a breadboard of 50 x 50cm^2.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Yusaku Shimaoka: "Nanosecond stroboscopic microscope for laser ablation of biological tissue" Conf.Laser & Electro-Optics/Pacific Rim(CLEO/PR´97). FF3. 261-262 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 春名 正光: "光CTへのアプローチ-低コヒーレンス光干渉法を中心として-" 医用画像情報学会雑誌. 11. 74-82 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masato Ohmi: "Simultaneous measurement of refractive index and thickness of transparent plates by low coherence interferometry" Optical Review. 4. 507-515 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 春名 正光: "光干渉による生体内部構造の検出" 日本ME学会雑誌BME. 11. 34-40 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 春名 正光: "生体光計測の現状と将来" 光学. 26. 457-460 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Simultaneous measurement of phase and group indices of transparent plates using the low coherence interferometry" Proc.Int´l Conf.Optical Fiber Sensors(OFS´97). OThC23. 496-499 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 満山 照樹: "低コヒーレンス光干渉による屈折率と厚さ同時精密測定-位相・群屈折率の導入-" 応用物理学会 光波センシング技術研究会. LST20-12. 41-48 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 丸山 英樹: "低コヒーレンス光干渉による屈折率と厚さ同時測定-屈折率波長分散を考慮した精密測定と樹脂硬化度の評価-" 電子情報通信学会 光エレクトロニクス研究会. OPE97-539. 25-30 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 春名 正光(共著): "飯沼武他編「医用物理学」第6章 医用光学" 医歯薬出版株式会社, 45 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yusaku Shimaoka: "Nanosecond stroboscopic microscope for laser ablation of biological tissue" Conf.Laser & Electro-Optics /Pacific Rim (CLEO/PR'97). FF3. 261-262 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "An approach to Optical CT-Low coherence interferometry-" Medical Imaging and Information Sciences. Vol.14. 74-82 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masato Ohmi: "Simultaneous measurement of refractive index and thickness of transparent plates by low coherence interferometry" Optical Review. Vol.4. 507-515 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Detection/imaging of inner structure of biological tissue by optical interferometry" Bio Medical Engineering. Vol.11. 34-40 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Future and recent progress of biomedical optics" Japanese Journal of Optics. Vol.26. 456-460 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Simultaneous measurement of phase and group indices of transparent plates using the low coherence interferometry" Tech.Dig.11th Int'l Conf.Optical Fiber Sensors (OFS'97). OThC23. 496-499 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yusaku Shimaoka: "Nanosecond stroboscopic microscope for laser ablation of biological tissue" Conf.Laser & Electro-Optics/Pacific Rim(CLEO/PR'97). FF3. 261-262 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 春名正光: "光CTへのアプローチ-低コヒーレンス光干渉法を中心として-" 医用画像情報学会雑誌. 11. 74-82 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masato Ohmi: "Simultaneous measurement of refractive index and thickness of transparent plates by low coherence interferometry" Optical Review. 4. 507-515 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 春名正光: "光干渉による生体内部構造の検出" 日本ME学会雑誌BME. 11. 34-40 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 春名正光: "生体光計測の現状と将来" 光学. 26. 457-460 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masamitsu Haruna: "Simultaneous measurement of phase and group indices of transparent plates using the low coherence interferometry" Proc.Int'l Conf.Optical Fiber Sensors(OFS'97). OThC23. 496-499 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 満山照樹: "低コヒーレンス光干渉による屈折率と厚さ同時精密測定ー位相・群屈折率の導入ー" 応用物理学会 光波センシング技術研究会. LST20-12. 41-48 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 丸山英樹: "低コヒーレンス光干渉による屈折率と厚さ同時測定-屈折率波長分散を考慮した精密測定と樹脂硬化度の評価-" 電子情報通信学会 光エレクトロニクス研究会. OPE97-539. 25-30 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 春名正光(共著): "飯沼武他編「医用物理学」第6章 医用光学" 医歯薬出版株式会社, 45 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masato Ohmi: "Simulataneous measurement of refractive index and thickness of transparent plates by low coherence interferometry" Proc.Int′1 Conf.Optical Fiber Sensors (OFS′96). We3-40. 332-335 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Masatoshi Fujimura: "Thermally Nd-diffused Z-propagation of Ti : LiNbO3 waveguide laser pumped by laser diode" Electronics Letters. 32. 2003-2004 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 島岡優策: "生体レーザアブレーションのナノ秒ストロボ顕微観測" 電子情報通信学会 MEとバイオサイバネティクス研究会. MBE96-93. 9-16 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 田尻秀幸: "低コヒーレンス光干渉による屈折率と厚さ同時精密測定ー複屈折の測定と群屈折率ー" 電子情報通信学会 光エレクトロニクス研究会. OPE95-116. 37-42 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 春名正光: "光CTへのアプローチ-低コヒーレンス光干渉法を中心として-" 医用画像情報学会雑誌. 14(No.3掲載予定). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 春名正光: "光干渉による生体内構造検出" 日本ME学会雑誌. 11(NO.5掲載予定). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yusaku Shimaoka: "Nanosecond stroboscopic microscope for laser ablation of biological tissue" Conf.Laser & Electro-Optics/Pacific Rim (CLEO/PR′97). (accepted). (July) (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 春名正光(共著): "立入弘他編「診療放射線技術(改訂第9版)」10章 医用光学機器.電子機器" 南江堂, 10ページ (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 春名正光(共著): "田中俊一他編「オプトエレクトロニクス用語辞典」" オーム社, 15ページ (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 春名正光(共著): "飯沼武他編「医用物理学」第6章 医用光学" 医歯薬出版, 45ページ (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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