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Analysis of the functional adaptation of biological tissues and its application to mechanical design

Research Project

Project/Area Number 08455062
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Materials/Mechanics of materials
Research InstitutionOsaka University

Principal Investigator

HAYASHI Kozaburo  Graduate School of Engineering Science, Osaka University, Professor, 基礎工学研究科, 教授 (90026196)

Co-Investigator(Kenkyū-buntansha) MIYAZAKI Hiroshi  Graduate School of Engineering Science, Osaka University, Research Associate, 基礎工学研究科, 助手 (00263228)
FUJIE Hiromichi  Graduate School of Engineering Science, Osaka University, Associate Professor, 基礎工学研究科, 助教授 (20199300)
TANAKA Masao  Graduate School of Engineering Science, Osaka University, Professor, 基礎工学研究科, 教授 (40163571)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1997: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1996: ¥6,100,000 (Direct Cost: ¥6,100,000)
KeywordsFunctional adaptation / Mechanical load / Mechanical property / Biological joint / Ligament / Structure / Optimal design / 膝蓋腱 / 動脈 / コラーゲン線維 / マクロファージ / 再構築
Research Abstract

We have been studying adaptation of tendons and ligaments to mechanical environments at various structure levels. In the present study, considering a locational dependence of applied stress to the anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL), a relationship between the load distribution in the ligaments under anterior-posterior drawer load and their mechanical properties was determined at different flexion angles. The following findings were obtained.
1) ACL
The load carried by the ACL depended on both the flexion angle and ligament bundle. In extension, the posterolateral (Pl) bundle carried more load than the anteromedial (AM) portion did. As the flexion angle increased, the load carried by the AM portion icreased while that carried the PL portion decreased. The mechanical property of the ACL was also dependent on both the flexion angle and ligament bundle. As the flexion angle increased, the stiffness of the PL bundle increased.
2) PCL
Both the load carried by the PCL and the mechanical property of the PCL were dependent on the ligament bundle. The anterolateral bundle always carried a considerable load, while the stiffness of the bundle was always great.
These findings indicate that the load distribution corresponds to the distribution of mechanical properties in the cruciate ligaments at different flexion angles. This suggests that the knee joint is optimally designed so that its ligaments function most effectively at specific flexion angles, and that the external and internal loading to the knee maintains the uniformity of the optimal structure and property. It is possible that this mechanism could be applied to the development of a novel mechanical design.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Sekito, T.Hayashi, K., et al.: "Development of a novel robotic simulator for the analysis of knee joint mechanical function" Proc.1997 ASME Summer Bioengineering Conference. BED-35. 393-394 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 山本 衛, 林 紘三郎, 他: "家兎膝蓋腱の横方向の引張特性に及ぼす除荷の影響" 日本機械学会第8回バイオエンジニアリング学術講演会夏季セミナー・ワークショップ講演論文集. 97-4. 102-103 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 西岡 史隆, 林 紘三郎, 他: "切断した家兎膝蓋腱の治癒に及ぼす成長の影響" 日本機械学会第8回バイオエンジニアリング学術講演会夏季セミナー・ワークショップ講演論文集. 97-4. 104-105 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 徳良 晋, 林 紘三郎, 他: "凍結処理後除荷した家兎膝蓋腱より摘出したコラーゲン線維束の力学的特性" 日本機械学会第8回バイオエンジニアリング学術講演会夏季セミナー・ワークショップ講演論文集. 97-4. 106-107 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 牧野 彰久, 林 紘三郎, 他: "局部的に切断した家兎膝蓋腱の治癒過程" 日本機械学会第8回バイオエンジニアリング学術講演会夏季セミナー・ワークショップ講演論文集. 97-4. 108-109 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sekito, T., Hayashi, K., et al.: "Development of a novel robotic simulator for the analysis of knee joint mechanical function" Proc.1997 ASME Summer Bioengineering Conference. BED-35. 393-394 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto, E., Hayashi, K., et al.: "Effects of stress shielding on the transverse tensile properties of rabbit patellar tendon" Proc.The 18th JSME Summer Bioengineering Conference Seminar & Workshop. 97-4. 102-103 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nishioka, F., Hayashi, K., et al.: "Effects of growth on the healing of transected patellar tendons in the rabbit" Proc.The 18th JSME Summer Bioengineering Conference Seminar & Workshop. 97-4. 104-105 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tokura, S., Hayashi, K., et al.: "Tensile properties of the collagen facicles from in-situ frozen and stress-shielded patellar tendons in the rabbit" Proc.The 18th JSME Summer Bioengineering Conference Seminar & Workshop. 97-4. 106-107 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Makino, A., Hayashi, K., et al: "Healing of locally incised patellar tendons in the rabbit" Proc.The 18th JSME Summer Bioengineering Conference Seminar & Workshop. 97-4. 108-109 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Sekito K.Hayashi, et al: "Development of a novel robotic simulator for the analysis of kneejoint mechanical function" Proc.1997 ASME Summer Bioengineering Conference. BED-35. 393-394 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Sekito,et al.: "Development of a novel robotic simulator for the analysis of kneejoint mechanical function" Abstract of Summer ASME Bioengineering Conference. (発表予定). (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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