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Scanning Tunneling Microscopy on Complex Formation of Cyclodextrins and on Their Catalytic Mechanism for Selective Organic Synthesis

Research Project

Project/Area Number 08455412
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 有機工業化学
Research InstitutionGraduate School of Engineering, The University of Tokyo

Principal Investigator

KOMIYAMA Makoto  The University of Tokyo, Graduate School of Engineering, Department of Chemistry and Biotechnology, Professor, 大学院・工学系研究科, 教授 (50133096)

Co-Investigator(Kenkyū-buntansha) SHIGEKAWA Hidemi  University of Tsukuba, Institute of Materials Science, Assosiate Professor, 物質工学研究科, 助教授 (20134489)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 1997: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1996: ¥5,300,000 (Direct Cost: ¥5,300,000)
KeywordsCyclodextrin / Scanning tunneling microscopy / Intramolecular interaction / Ethylene glycol / Phenol / Chloroform / エチレングレコール / 走査型トンネル顕微鏡 / 芳香族置換反応 / 触媒
Research Abstract

Scanning tunneling microscopy (STM) on cyclodextrins and their complexes with various guests has been achieved to obtain molecular-level information on these attractive cyclic oligosaccharides. By choosing appropriate conditions for the STM measurements, clear images of molecular structures of cyclodextrins were for the first time obtained. Typical examples are the images of (1) parent cyclodextrins, (2) the complexes with ethylene glycol, (3) complexes with adamantanecarboxylate, (4) cyclodextrin derivatives having a glucose branch, (5) the complexes with phenol, and (6) the complexes with chloroform. The complexes in the items (5) and (6) are directly associated with the selective organic synthesis which was previously found by the authors. The present results should greatly facilitate the molecular design of cyclodextrin complexes which have desired physicochemical and catalytic properties. It was also found that cyclodextrins have specific activities for self-aggregation. The structures of the aggregates are highly dependent on the kind of guest compounds, cyclodextrin derivatives, and substrates, indicating the possibility of artificial control of the aggregation (and thus the preparation of nano-structures assemblies of cyclodextrins).

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] M.Shigekawa et al: "Scanning Tunneling Microscopy on Ordered Self-assemblies of CyD Inclusion Complexes formed by Substrate-induced Two-dimensional Crystal" Jpn.J.Appl.Phys.印刷中. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Asanuma et al: "Imprinting polymer of cyclodextrin forefficient binding of cholesterol" Chem.Comman.1971-1972 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Komiyama et al: "Synthesis of molecularly imprinted of cyclodextrin for the efficient recongition of cholesterol" Supramol.Sci.印刷中. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Komiyama et al: "Cyclodextrins as Enzyme Models" Comprehensive Supramolecular Chemsitry,Vol 3,Cycloextrins. 401-422 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Yoshida, K.Miyake, Y.Goto, M.Ishida, K.Hata, M.Fujita, M.Yoshida, J.Sumaoka, M.Komiyama, and H.Shigekawa: "Scanning Tunneling Microscopy on Ordered Self-assemblies of CyD Inclusion Complex formed by Substrate-induced Two-dimensional Crystal" Jpn.J.Appl.Phys.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Asanuma, M.Kakazu, M.Shibata, T.Hishiya, and M.Komiyama: "Imprinting polymer of cyclodextrin for efficient binding of cholesterol" J.Chem.Soc., Chem.Commun.1971-1972 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Asanuma, M.Kakazu, M.Shibata, T.Hishiya, and M.Komiyama: "Synthesis of molecularly imprinted polymer of cyclodextrin for the efficient recognition of cholesterol" Supramol.Sci.(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Komiyama and H.Shigekawa: "Cyclodextrins as Enzyme Models" Comprehensive Supramolecular Chemsitry, Vol 3, Cycloextrins, Ed by J.Szejtli and T.Osa, Chap.11, Elsevier Science. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Asanuma and M.Komiyama: "Prepareation of artificial enzymes and their applications" Iden. 51. 51-56 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Asanuma and M.Komiyama: "Isolating a future for manmade antibodies" Look Japan. 43. 24-25 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Shigekawa: "Self-assembled cyclodextrin inclusion complexes studied by STM" Jpn.J.Appl.Phys.(印刷中).

    • Related Report
      1997 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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