| Project/Area Number |
08455442
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
高分子合成
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| Research Institution | Osaka University |
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Principal Investigator |
MIYATA Mikiji Osaka Univ., Fac.of Engineering, Prof., 工学部, 教授 (90029322)
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| Co-Investigator(Kenkyū-buntansha) |
SADA Kazuki Osaka Univ., Fac.of Engineering, Assis.Prof., 工学部, 助手 (80225911)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 1997: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1996: ¥5,900,000 (Direct Cost: ¥5,900,000)
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| Keywords | Sequence / Carbon-chain Polymers / Chiral Recognition / Molecular Information / Steric Control / Expression of Information / X-ray Analysis / Molecular Graphics |
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| Research Abstract |
We aimed to control steric structures of inclusion compounds of chiral and sequential polymers, enabling us to establish the concept of molecular information and expression by carbon-chain compounds. The results are summarized as follows ;
1. We synthesized many steroidal compounds, starting from commercially availabe bile acids and their derivatives. We confirmed that most of the steroids form the inclusion compounds with a variety of organic substances. The inclusion behaviors varied from one case to another. We evaluated a relation between the original host molecules and the inclusion behaviors.
2. We determined a scope of the guest components included. The scope varied from one case to another. We accumulated basic experimental data necessary for considering possible mechanism of the molecular recognition from a viewpoint in size, shape, chirality and polarity.
3. We analyzed powder X-ray diffraction patterns of the resulting inclusion compounds. The comparative study led to a classification of the molecular assemblies. Many single crystals were analyzed by X-ray crystallography, resulting in acquiring over hundred crystal structures of the inclusion compounds.
4. We confirmed that multiple combinations among the hydrogen-bonding groups may play an important role in determining the host-guest relationship. Four or three discrete hydrogen bonding groups associate together in various ways. This diversity is responsible for variable inclusion phenomena which is dependent on the host structures.
5. We condtructed molecular assemblies suitable for studying on various aspects of the host-guest interactions by using personal computers. Tomographic study enabled us to understand spaces at a molecular level to accommodate the guest components.
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