| Project/Area Number |
08457019
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nagoya University |
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Principal Investigator |
MANO Tadaaki Nagoya University, Research Institute of Environmental Medicine, Associate Professor, 環境医学研究所, 教授 (30023659)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIYAMA Yoshiki Nagoya University, Research Institute of Environmental Medicine, Assistant Profe, 環境医学研究所, 助手 (50240809)
MATSUKAWA Toshiyoshi Nagoya University, Research Institute of Environmental Medicine, Assistant Profe, 環境医学研究所, 助手 (60252293)
IWASE Satoshi Nagoya University, Research Institute of Environmental Medicine, Professor, 環境医学研究所, 助教授 (90184879)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥7,600,000 (Direct Cost: ¥7,600,000)
Fiscal Year 1997: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1996: ¥4,700,000 (Direct Cost: ¥4,700,000)
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| Keywords | Muscle sympathetic nerve activity / Parabolic flight / Gravitational Change / Microgravity / Hypergravity / Baroreflex / Microneurography / Cardiopulmonary reflex / ニューログラム |
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| Research Abstract |
Parabolic flight by a ject aircraft can produce approximately 20 seconds of microgravity, and hypergravity of 1.5 to 2.0 G before and after this microgravity period. Muscle sympathetic nerve activity (MSNA) recorded from the bitial nerve using microneurographic technique from healthy humans sitting in a passenger seat. We used MU-300 (Mitsubishi Heavy Industries) ject aircraft affiliated to Diamond Air Service next to Nagoya International Airport. MSNA innervating to the triceps surae was recorded using tungsten microelectrode, simultaneously with electrocardiography, respiration curve, blood pressure wave with Finapres, intrathoracic blood volume with impedance cardiography with natural and controlled (0.25Hz) respiration. MSNA was revealed to be activated (177%) under hypergravity and suppressed (52%) under microgravity, and these activation and suppression were quite transient and phasic under natural respiration. During later half of microgravity period, MSNA was then activated, which was induced through arterial baroreflex. This activation-suppression series was attenuated under controlled respiration, probably because controlling mechanism of MSNA might transfer from arterial baroreflexdominant to cardiopulmonary volume receptor dominant.
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