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Regulation and Analysis of Neurovascular Network and Circulatory Status by Site-Directed Superoxide Dismutase

Research Project

Project/Area Number 08457054
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionOSAKA CITY UNIVERSITY

Principal Investigator

INOUE Masayasu  Osaka City Univ. (Department of Biochemistry, ) Medical School Professor, 医学部, 教授 (80040278)

Co-Investigator(Kenkyū-buntansha) SATO Eisuke  Osaka City Univ. (Department of Biochemistry, ) Medical School Asistant Professo, 医学部, 助手 (60211942)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1997: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥5,400,000 (Direct Cost: ¥5,400,000)
KeywordsActive oxygen / superoxide / nitric oxide / oxygen stress / blood pressure / hypertension / brain / mannose-receptor / 酸化ストレス / 分子設計 / SOD / 酸素毒性 / フリーラジカル / NO / ショック
Research Abstract

Kinetic analysis using long acting and endothelially targeted superoxide dismutase (SOD) revealed that superoxide and related reactive oxygen species play important role in the pathogenesis of vasogenic tissue injury. Hence, selective dismutation of superoxide radicals is of critical importance in preventing and/or treating patients with circulatory disturbance. Targeting SOD to mannose-receptor-containing cells resulted inn rapid decrease in blood pressure, suggesting that the receprot-containing cells are responsible for the maintenance of blood pressure. Biochemical analysis using radiolabeled mannose-linked SOD revealed that more than 90% of SOD was localized in hepatic Kupffer cells and splenic macrophages. However, splenolectomy and 75% hepatectomy did not affect the depressor action of SOD,suggesting that other tissue (s) than liver and spleen might be responsible for the maintenance of the circulatory status. Kinetic analysis using various anesthetics, atropine and guanethidine suggested that the mannose receptor containing cells might localize in central nervous system. Specific antibody against mannose-linked SOD and mannose-linked xanthine oxidase might permit studies on the determination of the receptor-containing cells in the brain and on the mechanism by which circulatory status is regulated by cross-talk of reactive oxygen species.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (127 results)

All Other

All Publications (127 results)

  • [Publications] Minamiyama, Y.;Takemura, S.;Kawada, N.;Inoue, M.: "Role of nitric oxide in extracellular nucleotide-induced contractile status of assorted vessels including parts of portal vasculature" J.Hepatology. 28. 314-319 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nishikawa, M.;Sato, EF.;Kuroki, T.;Utsumi, K.;Inoue, M.: "Role of glutathione in energy metabolism of tumor cells" Hepatology. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakanishi, K.;Nishi, Y.;Sato, EF.;Ishii, M.;Hamada, T, ;Inoue, M.: "Termal injury induces thymoyte apoptosis in the rat" J.Trauma. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakahara, H.;Sato, EF.;Ishihara, R.;Yabuki, M, ;Inoue, M.;Utsumi, K.: "Biochemical properties of human neutrophils" Free Radic.Res.(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nishikawa, M.;Takeda, K.;Sato, EF.;Kuroki.T.;Inoue, M.: "Nitric oxide regulates energy metabolism and bcl-2 expression in rat interstional epithelial cells" Am.J.Physiol.(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Morishita, S.;Sato, EF.;Takahashi, YP.;Manabe, M., Inoue, M.: "Hypoglycemia-induced apoptosis in rat thymocytes in vivo" Dyabetes Res.Clin.Prac.(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nagata, K.;Yu, H.;Sato, EF.;Kasahiba, M.;Tamura, T.;Inoue, M.: "Irreversible inhibition of respiration of Helicobacter pylori by nitric oxide" J.Biol.Chem.(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawada, N.;Seki, S.;Inoue, M.;Kuroki, T.: "Effect of antioxidants,resveratol,quercetin and N-acetyl cysteine on the function of hepatic stellate cells and Kupffer cells" Hepatology. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Dunlap, WC.;Yamamoto, Y.;Inoue, M.;Kashiba, M.;Yamaguchi, M.;Tomita, K.: "Uric acid pjoto-oxidation assay : in vitro comparison of sunscreening agents" Int.I.Cosmetic Sci.20. 1-8 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I.Shiraishi.;E.F.Sato.;M.Nishikawa.;F.Sendo.;M.Inoue: "Mechanism of hypotensive shock induced by anti-neutrophil monocional antibody" Pathopysiology. 4. 197-204 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Yu.;E.F.Sato.;Arakawa.;K.Kobayashi, .;M.Inoue: "Protective action of lipopolysaccharide against stress-induced gastric mucosal injury" Digestion. 58. 311-318 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hirai, A.;Minamiyam, Y.;Hamada, T.;Ishii, M.;Inoue, M.: "Dynamic aspects of glutathione metabolism in mice with hapten-induced allergic and irritant contact" J.Invest.Dermatol.109. 314-318 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Minamiyam, Y.;Takemura, S.;Inoue, M.: "Effect of thiol status on nitric oxide metabolism in the circulation" Arch.Biochem.Biophys.341. 186-192 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yabuki, M.;Inai, Y.;Yoshioka, T.;Hamazaki, K.;Yasuda, T.;Inoue, M.;Utsumi, K.: "Oxygen-dependent fragmentation of cellular DNA by nitric oxide" Free Rad.Res.26. 245-255 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Uno, H.;Arakawa, T.;Fukuda, T.;Yu, H.;Fujiwara, Y.;Higuchi, K.;Inoue, M.;Kobavashi.K.: "Nitric oxide stimulates prostaglandin synthesis in cultured rabbit gastric cells" Prostaglandins. 53. 153-162 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yu, H.;Sato, EF.;Nagata, K.;Nishikawa, M.;Kashiba, M.;Arakawa, T.;Kobavashi.K.;Inoue.M.: "Oxygen-dependent regulation of the respiration and growth of Escherichia coli by nitric oxide" FEBS Letters. 409. 161-165 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamasu, S.;Sato, EF.;Ogita, S.;Inoue, M.: "Role of glutathione metabolism and apoptosis in the regression of liver hemopoiesis" Free Radical Biol.& Med.23. 100-109 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kashiba, M.;Miyamoto, M.;Inoue.M.: "Effect of nitric oxide on the ligand binding activity of albumin" Arch.Biochem.Biophys.345. 237-242 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Morishita, S.;Nishi, Y.;Sato, EF.;Yamaoka, K.;Manabe, M.;Inoue.M.: "Cold-stress induces thymocyte apoptosis in the rat" Pathophysiology. 4. 213-219 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hanada, H.;Kashiwagi, A.;Takehara, Y.;Kanno, T.;Yabuki, M.;Sasaki, J.;Inoue.M.;Utsumi.K.: "Do reactive oxygen species underlie the mechanism of apoptosis in the tadpole tail?" Free Radical Biol.& Med.23. 294-301 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nishikawa, M.;Sato, EF.;Kuroki, T.;Inoue.M.: "Role glutathione in the energy metabolism of mitochondria" FEBS Letters. 415. 341-345 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kashiba, M.;Kitoh, K.;Yu, H.;Kasahara, E.;Nishikawa, M.;Matsuo, M.;Inoue.M.: "Ascorbic Acid and reducing agents regulates the fates and functions of S-nitrospthiols" J.Biochem.122. 1208-1214 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Minamiyama, Y.;Takemura, S.;Imaoka, S.;Funae, Y.;Tanimoto, Y.;Inoue.M.: "Irreversible inhibition of cytochrome P450 by nitric oxide" J.Phaemacol.Exp.Ther.283. 1479-1485 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamada, T.;Yukioka, H.;Asada, A.;Inoue.M.: "Effect of inhaled nitric oxide on platelet-activating factor induced pulmonary hypertension in dogs" Acta Anesthesiol.Scand.41. (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kashiba-Iwatsuki.M., Kitoh, K.Nishikawa, M., Sato, FE, Inoue, M: "Oxygen Homeostasis and its dynamics" Springer-Verlag,Tokyo(Ishimura,Y.,Suematsu.M.,Shimada,H), 7 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Utsumi, K., Takchara, Y., Inai.Y., Yabuki, M., Kanno, T., Nishikawa, M., Sato, FE., Inoue, M.: "Mitochondria,Oxidants,and Aging" Academic Press (L.Packer Cadenas)(in press), (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Fujino, Y. ; Ozaki, K. ; Yamamasu, S. ; Ito, F. ; Matsuoka, I. ; Hayashi, E. ; Nakamura, H. ; Ogita, S. ; Sato, E. ; Inoue, M.: "DNA fragmentation of oocytes in aged mice" Human Reproduction. 11(7). 1480-3 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iha, S. ; Orita, K. ; Manno, T. ; Utsumi, T. ; Sato, E.F. ; Inoue, M. ; Utsumi, K.: "Oxygen-dependent inhibition of neutrophil respiratory burst by nitric oxide" Free-Radic-Res. 25(6). 489-98 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Inai, Y. ; Takehara, Y. ; Yabuki, M. ; Sato, E.F. ; Akiyama, J. ; Yasuda, T. ; Inoue, M. ; Horton, A.A. ; Utsumi, K.: "Oxygen-dependent-regulation of Ehrlich ascites tumor cell respiration by nitric oxide" Cell Structure & Function. 21(2). 151-7 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Inoue, M. ; Minamiyama, Y. ; Takemura, S.: "Dynamic aspects of nitric oxide metabolism in the circulation and tissues" Methods in Enzymology. 269. 474-9 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Inoue, M. ; Inoue, K.: "Role of free radicals in and around vascular endothelial cells in the mechanism of aging" Annals of the New York Academy of Sciences. 786. 224-32 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kashiba Iwatsuki, M. ; Yamaguchi, M. ; Inoue, M.: "Role of ascorbic acid in the metabolism of S-nitroso-glutathione" FEBS-Lett. 389(2). 149-52 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawada, N. ; Kuroki, T. ; Uoya, M. ; Inoue, M. ; Kobayashi, K.: "Smooth muscle alpha-actin expression in rat hepatic stellate cell is regulated by nitric oxide and cGMP production" Biochemical & Biophysical Research Communication. 229(1). 238-42 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawada, N. ; Kuroki, T. ; Kobayashi, K. ; Inoue, M. ; Kaneda, K.: "Inhibition of myofibroblastic transformation of cultured rat hepatic stellate cells by methylxanthines and dibutyryl cAMP" Digestive Diseases & Sciences. 41(5). 1022-9 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawada, N. ; Kuroki, T. ; Kobayashi, K. ; Inoue, M. ; Nakatani, K. ; Kaneda, K. ; Nagata, K.: "Expression of heat-shock protein 47 in mouse liver" Cell & Tissue Research. 284(2). 341-6 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Minamiyama, Y. ; Takemura, S. ; Koyama, K. ; Yu, H. ; Miyamoto, M. ; Inoue, M.: "Dynamic aspects of glutathione and nitric oxide metabolism in endotoxemic rats" American Journal of Physiology. 271(4Pt1). G575-81 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Minamiyama, Y. ; Takemura, S. ; Inoue, M.: "Albumin is an important vascular tonus regulator as a reservoir of nitric oxide" Biochemical & Biophysical Research Communication. 225(1). 112-5 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nishikawa, M. ; Sato, E.F. ; Utsumi, K. ; Inoue, M.: "Oxygen-dependent regulation of energy metabolism in ascites tumor cells by nitric oxide" Cancer Research. 56(19). 4535-40 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nomura, T. ; Sasaki, J. ; Mori, H. ; Sato, E.F. ; Watanabe, S. ; Kanda, S. ; Matsuura, J. ; Watanabe, H. ; Inoue, M.: "Expression of manganese superoxide dismutase mRNA in reproductive organs during the ovulatory process and the estrous cycle of the rat" Histochemistry & Cell Biology. 105(1). 1-6 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Okada, S. ; Takehara, Y. ; Yabuki, M. ; Yashioka, T. ; Yasuda, T. ; Inoue, M. ; Utsumi, K.: "Nitric oxide, a physiological modulator of mitochondrial function" Physiological Chemistry & Physics & Medical NMR. 28(2). 69-82 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Radak, Z. ; Asano, K. ; Inoue, M. ; Kizaki, T. ; Oh-Ishi, S. ; Suzuki, K. ; Taniguchi, N. ; Ohno, H.: "Superoxide dismutase derivative prevents oxidative damage in liver and kidney of rats induced by exhausting exercise" European Journal of Applied Physiology & Occupatio Physiology. 72(3). 189-94 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato, E.F. ; Utsumi, K. ; Inoue, M.: "Human oral neutrophils : isolation and characterization" Methods in Enzymology. 268. 503-9 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato, E.F. ; Yamaoka, K. ; Yu, H. ; Morishita, S. ; Inoue, M.: "Low dose X-ray irradiation induces stress proteins but does not prevent gastric mucosal lesion" Physiological Chemistry & Physics & Medical NMR. 28(2). 103-9 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I.Shiraishi. ; E.F.Sato. ; M.Nishikawa. ; F.Sedo. ; M.Inoue.: "Mechanism of hypotensive shock induced by anti-neutrophil monoclonal antibody" Pathopysiology. 4. 197-204 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Yu. ; E.F.Sato. ; T.Arakawa. ; K.Kobayashi, . ; M.Inoue.: "Protective action of lipopolysaccharide against stress-induced gastric mucosal injury" Digestion. 58. 311-318 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hirai, A. ; Minamiyama, Y. ; Hamada, T. ; Ishii, M. ; Inoue, M.: "Dynamic aspects of glutathione metabolism in mice with hapten-induced allergic and irritant contact" J.Invest.Dermatol. 109. 314-318 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Minamiyama, Y. ; Takemura, S. ; Inoue, M.: "Effect of thiol status on nitric oxide metabolism in the circulation" Arch.Biochem.Biophys.341. 186-192 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yabuki, M. ; Inai, Y. ; Yoshioka, T. ; Hamazaki, K. ; Yasuda, T. ; Inoue, M. ; Utsumi, K.: "Oxygen-dependent fragmentation of cellular DNA by nitric oxide" Free Rad.Res.26. 245-255 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Uno, H. ; Arakawa, T. ; Fukuda, T. ; Yu, H. ; Fujiwara, Y. ; Higuchi, K. ; Inoue, M. ; Kobayashi, K.: "Nitric oxide stimulates prostaglandin synthesis in cultured rabbit gastric cells" Prostaglandins. 53. 153-162 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yu, H. ; Sato, EF. ; Nagata, K. ; Nishikawa, M. ; Kashiba, M. ; Arakawa, T. ; Kobayashi, K. ; Inoue, M.: "Oxygen-dependent regulation of the respirarion and growth of Escherichia coli by nitric oxide" FEBS Letters. 409. 161-165 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamasu, S. ; Sato, EF. ; Ogita, S. ; Inoue, M.: "Role of glutathione metabolism and apoptosis in the regression of liver hemopoiesis" Free Radical Biol. & Med.23. 100-109 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kashiba, M. ; Miyamoto, M. ; Inoue, M.: "Effect of nitric oxide on the ligand binding activity of albumin" Arch.Biochem.Biophys.345. 237-242 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Morishita, S. ; Nishi, Y. ; Sato, EF. ; Yamaoka, K. ; Manabe, M. ; Inoue, M.: "Cold-stress induces thymocyte apoptosis in the rat" Pathophysiology. 4. 213-219 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hanada, H. ; Kashiwagi, A. ; Takehara, Y. ; Kanno, T. ; Yabuki, M. ; Sasaki, J. ; Inoue, M. ; Utsumi, K.: "Do reactive oxygen species underlie the mechanism of apoptosis in the tadpole tail?" Free Radical Biol.& Med.23. 294-301 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nishikawa, M. ; Sato, EF. ; Kuroki, T. ; Inoue, M.: "Role glutathione in the energy metabolism of mitochondria" FEBS Letters. 415. 341-345 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kashiba, M. ; Kitoh, K. ; Yu, H. ; Kasahara, E. ; Nishikawa, M. ; Matsuo, M. ; inoue, M.: "Ascorbic Acid and reducing agents regulates the fates and functions of S-nitrospthiols" J.Biochem.122. 1208-1214 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Minamiyama, Y. ; Yakemura, S. ; Imaoka, S. ; Funae, Y. ; Tanimoto, Y. ; Inoue, M.: "Irreversible inhibition of cytochrome P450 by nitric oxide" J.Phaemacol.Exp.Ther.283. 1479-1485 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamada, T. ; Yukioka, H. ; Asada, A. ; Inoue, M.: "Effect of inhaled nitric oxide on platelet-activating factor induced pulmonary hypertension in dogs" Acta Anesthesiol.Scand.41. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Minamiyama, Y. ; Takemura, S. ; Kawada, N. ; Inoue, M.: "Role of nitric oxide in extracellular nucleotide-induced contractile status of assorted vessels including parts of portal vasculature" J.Hepatology. 28. 314-319 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nishikawa, M. ; Sato, EF. ; Kuroki, T. ; Utsumi, K. ; Inoue, M.: "Role of glutathione in energy metabolism of tumor cells" Hepatology. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakanishi, K. ; Nishi, Y. ; Sato, EF. ; Ishii, M. ; Hamada, T, ; Inoue, M.: "Termal injury induces thymoyte apoptosis in the rat" J.Trauma. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakahara, H. ; Sato, EF. ; Ishihara, R. ; Yabuki, M. ; Inoue, M. ; Utsumi, K.: "Biochemical properties of human neutrophils" Free Radic.Res.(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nishikawa, M. ; Takeda, K. ; Sato, EF. ; Kuroki.T. ; Inoue, M.: "Nitric oxide regulates energy metabolism and bcl-2 expression in rat intestional epithelial cells" Am.J.Physiol.(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Morishita, S. ; Sato, EF. ; Takahashi, YP. ; Manabe, M. ; Inoue, M.: "Hypoglycemia-induced apoptosis in rat thymocytes in vivo" Dyabetes Res.Clin.Prac.(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nagata, K. ; Yu, H. ; Sato, EF. ; Kasahiba, M. ; Tamura, T. ; Inoue, M.: "Trreversible inhibition of respiration of Helicobacter phlori by nitric oxide" J.Biol.Chem.(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawada, N. ; Seki, S. ; Inoue, M. ; Kuroki, T.: "Effect of antioxidants, resveratol, quercetin and N-acetyl cysteine on the function of hepatic stellate cells and Kupffer cells" Hepatology. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Dunlap, WC. ; Yamamoto, Y. ; Inoue, M. ; Kashiba, M. ; Yamaguchi, M. ; Tomita, K.: "Uric acid photo-oxidation assay : in vitro comparison of sunscreening agents" Int.I.Cosmetic Sci.20. 1-8 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Minamiyama,Y.;Takemura,S.;Kawada,N.;Inoue,M.: "Role of nitric oxide Tn extracellular nucleotide-induced contractile status of assorted vessels including parts of portal vasculature" J.Hepatology. 28:314-319. 314-319 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nishikawa,M.;Sato,EF.;Kuroki,T.;Utsumi,K.;Inoue,M.: "Role of glutathione in energy metabolism of tumor cells" Hepatology. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakanishi,K.;Nishi,Y.;Sato,EF,;Ishii,M.;Hamada,T.;Inoue,M.: "Termal injury induces thymoyte apoptosis in the rat" J.Trauma. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakahara,H.;Sato,EF.;Ishihara,R.;Yabuki,M.;Inoue,M.;Utsumi,K.: "Biochemical properties of human neutrophils" Free Radic.Res.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nishikawa,M.;Takeda,K.;Sato,EF.;Kuroki,T.;Inoue,M.: "Nitric oxide regulates energy metabolism and bc1-2 expression in rat intestional epithelial cells" Am.J.Physiol.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Morishita,S.;Sato,EF.;Takahashi,YP.;Manabe,M.;Inoue,M.: "Hypoglycemia-induced apoptosis in rat thymocytes in vivo" Dyabetes Res.Clin.Prac.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nagata,K.;Yu,H.;Sato,EF;Kasahiba,M.;Tamura,T.;Inoue,M.: "Irreversible inhibition of respiration of Helicobacter pylori by nitric oxide" J.Biol.Chem.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kawada,N.;Seki,S.;Inoue,M.;Kuroki,T.: "Effect of antioxidants,resveratol,quercetin and N-acetyl cysteine on the function of hepatic stellate cells and Kupffer cells" Hepatology. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Dunlap,WC.;Yamamoto,Y.;Inoue,M.;Kashiba,M.;Yamaguchi,M.;Tomita,K.: "Uric acid photo-oxidation assay:in vitro comparison of sunscreening agents" Int.I.Cosmetic Sci.20:1-8. 1-8 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] I.Shiraishi,;E.F.Sato.;M.Nishikawa.;F.Sendo.;M.Inoue: "Mechanism of hypotensive shock induced by anti-neutrophil monoclonal antibody" Pathopysiology. 4:197-204. 197-204 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Yu.;E.F.Sato.;T.Arakawa.;K.Kobayashi,.;M.Inoue: "Protective action of lipopolysaccharide against stress-induced gastric mucosal injury" Digestion. 58:311-318. 311-318 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hirai,A.;Minamiyama,Y.;Hamada,T.;Ishii,M.;Inoue,M.: "Dynamic aspects of glutathione metabolism in mice with hapten-induced allergic and irritant contact" J.Invest.Dermatol.109:314-318. 314-318 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Minamiyama,Y.;Takemura,S.;Inoue,M.: "Effect of thiol status on nitric oxide metabolism in the circulation" Arch. Biochem.Biophys.341:186-192. 186-192 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yabuki,M.;Inai,Y.;Yoshioka,T.;Hamazaki,K.;Yasuda,T.;Inoue,M.;Utsumi.K.: "Oxygen-dependent fragmentation of cellular DNA by nitric oxide" Free Rad.Res.26:245-255. 245-255 (1997)

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      1997 Annual Research Report
  • [Publications] Uno,H.;Arakawa,T.;Fukuda,T.;Yu,H.;Fujiwara,Y.;Higuchi,K.;Inoue,M.;Kobayashi.K.: "Nitric oxide stimulates prostaglandin synthesis in cultured rabbit gastric cells" Prostaglandins. 53:153-162. 153-162 (1997)

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      1997 Annual Research Report
  • [Publications] Yu,H.;Sato,EF.;Nagata,K.;Nishikawa,M.;Kashiba,M.;Arakawa,T.;Kobayashi.K.;Inoue.M.: "Oxygen-dependent regulation of the respiration and growth of Escherichia coli by nitric oxide" FEBS Letters. 409:161-165. 161-165 (1997)

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      1997 Annual Research Report
  • [Publications] Yamamasu,S.;Sato,EF.;Ogita,S.;Inoue,M.: "Role of glutathione metabolism and apoptosis in the regression of liver hemopoiesis" Free Radical Biol. & Med.23:100-109. 100-109 (1997)

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      1997 Annual Research Report
  • [Publications] Kashiba,M.;Miyamoto,M.;Inoue,M.: "Effect of nitric oxide on the ligand binding activity of albumin" Arch.Biochem.Biopjys.345:237-242. 237-242 (1997)

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      1997 Annual Research Report
  • [Publications] Morishita,S.;Nishi,Y.;Sato,EF.;Yamaoka,K.Manabe,M.;Inoue,M.: "Cold-stress induces thymocyte apoptosis in the rat" Pathophysiology. 4:213-219. 213-219 (1997)

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      1997 Annual Research Report
  • [Publications] Hanada,H.;Kashiwagi,A.Takehara,Y.;Kanno,T.;Yabuki,M.;Sasaki,J.;Inoue.M.;Utsumi.K.: "Do reactive oxygen species underlie the mechanism of apoptosis in the tadpole tail?" Free Radical Biol. & Med. 23:294-301. 294-301 (1997)

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      1997 Annual Research Report
  • [Publications] Nishikawa,M.;Sato,EF.;Kuroki,T.;Inoue,M.: "Role glutathione in the energy metabolism of mitochondria" FEBS Letters. 415:341-345. 341-345 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kashiba,M.;Kitoh,K.;Yu,H.;Kasahara,E.;Nishikawa,M.;Matsuo,M.;Inoue,M.: "Ascorbic Acid and reducing agents regulates the fates and functions of S-nitrospthiols" J.Biochem.122:1208-1214. 1208-1214 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Minamiyama,Y.;Takemura,S.;Imaoka,S.;Funae,Y.;Tanimoto,Y.;Inoue,M.: "Irreversible inhibition of cytochrome P450 by nitric oxide" J.Phaemacol.Exp.Ther.283:1479-1485. 1479-1485 (1997)

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      1997 Annual Research Report
  • [Publications] Yamada,T.;Yukioka,H.;Asada,A.;Inoue,M.: "Effect of inhaled nitric oxide on platelet-activating factor induced pulmonary hypertension in dogs" Acta Anesthesiol. Scand.41. (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kashiba-Iwatsuki.M.,Kitoh.K.,Nishikawa.M.,Sato.E.F.Inoue.M.: "Oxygen Homeostasis and its dynamics" Springer-Verlag.Tokyo(Ishimura,Y.,Suematsu,M.,Shimada,H), 7 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Utsumi.K.,Takehara.Y.,Inai.Y.Yabuki.M.,Kanno,T.,Nishikawa,M.Sato,EF.,Inoue.M.: "Mitochondria,Oxidants,and Aging" Academic Press (L.Packer Cadenas)(in press), (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] M. Yabuki, Y. Inai, T. Yoshioka et, al: "Oxygen-dependent fragmentation of cellular DNA by nitric oxide" Free Rad. Res.(in press). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S. Iha, K. Orita, T. Kanno et, al.: "Oxygen-dependent inhibition of neutrophil respiratory burst by nitric oxide." Free Radical Res.(1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kawada, N., Inoue, M. and Decker et, al.: "Effect of endothelins on hepatic stellate cells" Hepatology. (in press). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S. Okada, Y. Takehara, M. Yabuki et, al.: "Nitric oxide, a physiological modulator of mitochondrial function" Physiol Chem. Physics. 28. 69-82 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N. Kawada, T. Kuroki, M. Uoya et, al.: "Smooth muscle alpha-actin expression in rat hepatic stellate cells is regulated by nitric oxide and cGMP production" Biochem. Biophys. Res. Commun. (in press). (1996)

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      1996 Annual Research Report
  • [Publications] N. Kawada, T. Kuroki, K. Kobayashi et, al.: "Expression of heat shock protein 47 in mouse liver" Cell Tissue Res. 284. 341-346 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N. Kawada, T. Kuroki, K. Kobayashi et, al.: "Inhibition of myofibroblastic transformation of rat hepatic stellete cells by methylxanthine and cAMP" Dig. Dis. Sci.41. 1022-1029 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sato, EF., Yamaoka, K. Morishita, S et al: "Low dose X-ray irradiation induce stress proteins but not prevent gastric mucosal lesion" Physiol. Chem. Phys. & Med.28. 103-109 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ikeda, K., Kubo, S., Sato, EF et al: "Mechanism that regulates nitric oxide production by lipopolysaccharide-stimulated rat kupffer cells" Physiol. Chem.Phys. & Med. 2(in press). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M. Yabuki, Y. Inai, T. Yoshioka et, al.: "Oxygen-dependent fragmentation of cellular DNA by nitric oxide" Free Rad. Res.(in press). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S. Iha, K. Orita, T. Kanno et, al.: "Oxygen-dependent inhibition of neutrophil respiratory burst by nitric oxide." Free Radical Res.(1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kawada, N., Inoue, M. and Decker et. al.: "Effect of endothelins on hepatic stellate cells" Hepatology. (in press). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S. Okada, Y. Takehara, M. Yabuki et, al.: "Nitric oxide, a physiological modulator of mitochondrial function" Physiol. Chem. Physics. 28. 69-82 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N. Kawada, T. Kuroki, M. Uoya et, al.: "Smooth muscle alpha-actin expression in rat hepatic stellate cells is regulated by nitric oxide and cGMP production" Biochem. Biophys. Res. Commun. (in press). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N. Kawada, T. Kuroki, K. Kobayashi et, al.: "Expression of heat shock protein 47 in mouse liver" Cell Tissue Res. 284. 341-346 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N. Kawada, T. Kuroki, K. Kobayashi et, al.: "Inhibition of myofibroblastic transformation of rat hepatic stellete cells by methylxanthine and cAMP" Dig. Dis. Sci.41. 1022-1029 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sato, EF., Yamaoka, K. Morishita, S et al: "Low dose X-ray irradiation induce stress proteins but not prevent gastric mucosal lesion" Physiol. Chem. Phys. & Med.28. 103-109 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ikeda, K., Kubo, S., Sato, EF. et al: "Mechanism that regulates nitric oside production by lipopolysaccharide-stimulated rat kupffer cells" Physiol. Chem. Phys. & Med. 28 (in press). (1996)

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      1996 Annual Research Report
  • [Publications] Yamamasu, S., Sato, E. F., Ogita, S., and Inoue, M.: "Role of glutathione metabolism and apoptosis in the regression of liver hemopoiesis" Free Radic. Biol. Med.23 (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yu, H., Sato, E. F., Arakawa, T. Kobayashi, K., and Inoue, M.: "Protective action of lipopolysaccaride on stress-induced gastric mucosal injury." Digestion.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] M. Inoue, K. Inoue, K. Utsumi: "Brain Physiology and Disorder" Academic Press, 474 (1996)

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      1996 Annual Research Report
  • [Publications] M. Inoue, M. Nishikawa, E Sato, K. Utsumi: "Biology of nitric oxide" Portland Press, 353 (1996)

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      1996 Annual Research Report
  • [Publications] Y. Minamiyama, Takemura, M. Inoue: "Biology of nitric oxide" Portland Press, 353 (1996)

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      1996 Annual Research Report
  • [Publications] S.Takemura, Y. Minamiyama, M. Inoue: "Biology of nitric oxide" Portland Press, 353 (1996)

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      1996 Annual Research Report
  • [Publications] M. Inoue: "Food and Free Radicals (in press)" Prenum Press (in press), (1996)

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      1996 Annual Research Report
  • [Publications] M. Inoue, Y. Minamiyama, S. Takemura: "Meth. Enzymol." Academic Press, 528 (1996)

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      1996 Annual Research Report
  • [Publications] E. Sato, M. Inoue, K. Utsumi: "Meth. Enzymol." Academic Press, 522 (1996)

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      1996 Annual Research Report
  • [Publications] N. Kawada, S. Takemura, Y. Minamiyama, M. Inoue: "J. Hep. Bil. Pancr. Surg." 550 (1996)

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      1996 Annual Research Report
  • [Publications] N. Kawada, T. Kuroki, M. Uoya, K. Kobayashi, M. Inoue: "Cells of the Hepatic Sinusoid" Kuppfer Cells foundations, 650 (1997)

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      1996 Annual Research Report
  • [Publications] M. Uoya, N. Kawada, H. Tsutui, T. Kuroki, et al: "Cells of the Hepatic Sinusoid" Kuppfer Cells foundations, 650 (1996)

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      1996 Annual Research Report
  • [Publications] K. Ikeda, N. Kawada, F. Sato K. Kaneda, M. Inoue: "Cells of the Hepatic Sinusoid" Kuppfer Cells foundations, 650 (1996)

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  • [Publications] 井上正康: "活性酸素と医食同源" 共立出版, 356 (1996)

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      1996 Annual Research Report
  • [Publications] 井上正康: "活性酸素とシグナル伝達" 講談社, 220 (1996)

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  • [Publications] 井上正康: "アポトーシスの分子機構と病態" メディカルトリビューン社, 126 (1996)

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Published: 1996-04-01   Modified: 2016-04-21  

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