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The study on the molecular basis for neurovirulence of influenza virus.

Research Project

Project/Area Number 08457099
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionNagoya City University

Principal Investigator

NAKAJIMA Katsuhisa  Nagoya city university, Medical school, professor, 医学部, 教授 (40012778)

Co-Investigator(Kenkyū-buntansha) NAKAJIMA Setsuko  The Institute of Public Health, Microbiology, Section Chief, 微生物学部, 室長 (80124402)
NOBUSAWA Eri  Nagoya city university, Medical school, Assistant professor, 医学部, 講師 (90183904)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 1997: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1996: ¥4,600,000 (Direct Cost: ¥4,600,000)
KeywordsInfluenza virus / neurovirulence / intranasal inoculation / neuron / immunohistochemical / substantia nigra / レセプター / ラット / 脳細胞 / シアル酸
Research Abstract

we previously reported that the neurovirulent influenza A virus strain, A/WSN/33 has strong affinity for the substantia nigra in mouse brain. In this project we tried two study. (1)we observed the cellular response to viral infection in vitro with using a neuron-glia co-culture system. Viral antigens were strictly confined to the neuronal cell bodies and their neurites. We can conclude that the virus preferentially infects neurons, mainly TH-positive neurons in the SN as reported in vivo infection.. Therefore In vitro culture system is useful for the study of neurovirulence of influenza Virus. (2)We examined the immunohistochemical localization of neurovirulent influenza A virus in the brain after intranasal inoculation. We observed in the early phase of infection, influenza A virus invades, probably through hematogenous spread, and particularly affects catecholaminergic neurons.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] T.Yamada: "Invasion of Brain by Neurovirulent Influenza A virus after Intranasal Inoculation" Parkinsonism & Related Disorder. 2・4. 187-193 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Yamada: "Immunohistochemistry of a cytoplasmic dynein-likemolecule in rodent and human brain tissue" Acta Neuropathol.92. 306-311 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Morishita: "Studies on the molecule basis for loss of the ability of recent influenza A virus to agglutinate chichen eruthrocyte" J.Gen.Virol.77. 2499-2506 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Takahashi: "Influenza A virus infection of primary cultured cells from rat brain" Parkinsonism & Related Disorder. 3・2. 97-102 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Morishita: "Analysis of the host-specific haemagglutination of influenza A Viruses isolated in 1995/6 season" Epidemial Infect.119. 327-334 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 中島 捷久: "神経病原性を支配するインフルエンザウイルスの遺伝子" 2693-2698

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 中島 捷久: "インフルエンザ" PHP新書, 221 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Yamada, I.Yamanaka, M.Takahashi & S.Nakajima: "Invasion of brain by neurovirulent influenza A virus after intranasal inoculation" Parkinsonism & Related Disorder. 2. 187-193 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Yamada, I.Yamanaka & S.Nakajima: "Immunohistochemistry of a cytoplasmic dynein (MAP-P)-like molecule in rodent and human brain tissue." Acta Neuropathol. 92. 306-311 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Morishita, E.Nobusawa, K.Nakajima & S.Nakajima: "Studies on the molecular basis for the loss of the ability of recent influenza A (H1N1) virus strain to agglutinate chicken erythrocytes." J.Gen.Virol.77. 2499-2506 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Takahashi, T.Yamada, K.Nakanishi, K.Fujita, K.Nakajima, E.Nobusawa, T.Yamamoto, T.Kato & H.Okada: "Influenza A Virus infection of primary cultured cells from rat fetal brain." Parkinsonism & Related Disorder. 3. 97-102 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Morishita, E.Nobusawa, S.Luo, K.Sato, S.Nakajima & K.Nakajima: "Analysis of the host-specific haemagglutination of influenza A (H1N1) viruses isolated in the 1995/6 season" Epidem.Infect.119. 327-334 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 中島捷久: "神経病原性を支配するインフルエンザウイルスの遺伝子" 日本臨床. 55・10. 2693-2698 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mitsuo Takahashi: "Influenza A virus infection of primary cultured cells from rat fetal brain" Parkinsonism & Related Disorders. 3・2. 97-102 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Morishita: "Analysis of the host-specific haemagglutiration of influenza A(H1N1)Viruses isolated in the 1995/96 season" Epidemiology Infection. 119. 327-334 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 中島捷久: "インフルエンザ(PHP新書)" PHP研究所, 221 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takayuki Morishita: "Studies on the molecular basis for loss of the ability of recent influenza A (HINI) virus strains to agglutinate chicken erythrocytes" Journal of General Virology. 72. 2499-2506 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T. Yamada: "Invasion of brain by nearovirulent influenza A virus after intranasrl inoculation" Parkinsonism & Related Disorders. 2. 187-193 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T. Yamada: "Immunohistochemistry of a cytoplasmic dynein (MAPIC)-like molecult in rodent and human brain tissue" Acta Neuropathol. 92. 306-311 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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