| Project/Area Number |
08457112
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Saitama Medical School |
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Principal Investigator |
WADA Osamu Professor, Department of Hygiene and PreventiveMedicine, Saitama medical School, 医学部, 教授 (60009933)
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| Co-Investigator(Kenkyū-buntansha) |
YANAGISAWA Hiroyuki Associate Professor, Department of Hygiene and Preventive Medicine, Saitama Medi, 医学部, 助教授 (10200536)
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| Project Period (FY) |
1996 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥7,300,000 (Direct Cost: ¥7,300,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥4,300,000 (Direct Cost: ¥4,300,000)
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| Keywords | Chemical Substance / Pharmacokinetic model / Risk assessment / CAT assay |
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| Research Abstract |
The present study was designed to develop the new risk assessment system of the chemical substances in the environment by means of the CAT assay and the pharmacokinetic model consisting og six components such as blood-rich organs(brain, adrenal gland and bone marrow), blood-poor organs(hone and adipose tissue), kidney, liver and intestine. The CAT assay was available because of utilizing human cells and providing the valuable information on the mechanisms responsible for cell toxicity and carcinogenesis. The pharmacokinetic model was also considered to be an useful method to presume the concentration of drugs in the target organ and to evaluate the toxicity of unknown chemical substances.
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