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Evaluation of significant dermal absorption on organic solvent vapor.

Research Project

Project/Area Number 08457119
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionNational Institute of Industrial Health (1997)
Keio University (1996)

Principal Investigator

SAKURAI Haruhiko  National Institute of Industrial Health, Director, 所長 (70051357)

Co-Investigator(Kenkyū-buntansha) OMAE Kazuyuki  Keio University, Dept.of Prev.Med.& Publ.Health, Associate Prof., 医学部・衛生学公衆衛生学, 助教授 (60118924)
武林 亨  慶應義塾大学, 医学部, 講師 (30265780)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥8,600,000 (Direct Cost: ¥8,600,000)
Fiscal Year 1997: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1996: ¥7,400,000 (Direct Cost: ¥7,400,000)
KeywordsDermal absorption / Organic solvents / Dimethylacetamide / Dimethylformamide / Human volunteers / ジメチルアセトアミド / ヒトボランティア / 皮膚吸収
Research Abstract

Aim We investigated the potential for dermal absorption of N,N-Dimethylacetamide (DMAC : CAS No. 127-19-5) or N,N-Dimethylformamide (DMF : CAS No.67-12-2) vapor, the biological half-life of N-Methylacetamide (NMAC) in urine or of N-Methylformamide (MNF) in urine which were major matabolites of DMAC or DMF respectively.
Method Twelve male Japanese healthy volunteers were exposed to DMAC or DMF vapor by inhalation and dermal exposures, exposed about 90% naked skin area without sweating, respectively for 4 hours at concentrations set below 10 ppm that was recommended as Occupational Exposure Limit by Japanese Society of Occupational Health and ACGIH.Dermal absorption was compared to absorption by inhalation exposure by the comparison with total excreted urinary metabolites' volume. All volunteers were checked their conditions before and during exposures and in 3 or 4 days after exposures by medical examinations and blld and urine examinations.
Results All exposures were conducted under 10 ppm. Exposure levels were 6.00 (]SY.+-。[) 1.00 ppm by inhalation and 6.00 (]SY.+-。[) 1.00 ppm by dermal exposures in DMAC experimental study and 6.00 (]SY.+-。[) 1.00 ppm by inhalation and 6.00 (]SY.+-。[) 1.00 ppm by dermal exposures in DMF experimental study on the conditions around 26゚C and 40% relative humidity. Absorption ratio determined were 40 : 60 or 42.5 : 57.5 in DMAC or DMF experimental studies respectively.
Conclusion Over 40% dermal absorption vs the absorption by inhalation of DMAC or DMF vapor were performed. It seems necessaty to care a concentration of workplace in order to protect dermal absorption as well as a care to DMAC or DMF liquid.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] 石塚 千鶴 ら: "ジメチルアセトアミド蒸気の生物学的モニタリング-彩尿時期及び尿中代謝物NMACの補正方法に関する検討-" 産業衛生学雑誌. 38. S528 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 野見山 哲生 ら: "ジメチルアセトアミド蒸気のヒトボランティアでの皮膚吸収に関する検討" 産業衛生学雑誌. 38. S529 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nomiyam et al.: "N,N-.Dimethylacetamide:Significance of vapor absorption from the skin on human volunteers." Book of abstracts of 25^<th> Intemational Congress on Occupational Health. Book II. 119

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 野見山 哲生 ら: "ジメチルホルムアミド蒸気の皮膚吸収寄与に関する検討" 産業衛生学雑誌. 40. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 陳 莉玲 ら: "ジメチルホルムアミド暴露者のCYP2E1遺伝子多型による尿中代謝物の生物学的半減期の検討" 産業衛生学雑誌. 40. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ishizuka C et al.: "Biological monitoring of N,N-Dimethylacetamide ; Timing of urinary sampling and adequate adijustment method of NMAC concentration in urine" San Ei Shi. 38. S528 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nomiyama T et al.: "N,N-Dimethylacetamide : Significance of vapor absorption from the skin on human volunteers." San Ei shi. 38. S529 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nomiyama T.et al.: "N,N-Dimethlacetamide : Significance of vapor absorption from the skin on human volunteers." Book of abstracts of 25^<th> International Congress on Occupational Health, Book II. 119 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nomiyama T.et al.: "Signifcant absorption of N,N--Dimethylformamide vapor from the skin on human volunteers." San Ei Shi. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Riley C et al: "Biological half-life of N-Methylformamide in urine by DYP2E1 genotype in N,N-Dimethylformamide exposed volunteers" San Ei Shi. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 石塚千鶴ら: "ジメチルアセトアミド蒸気の生物学的モニタリング-採尿時期及び尿中代謝物NMACの補正方法に関する検討-" 産業衛生学雑誌. 38. S528- (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 野見山哲生ら: "ジメチルアセトアミド蒸気のヒトボランティアでの皮膚吸収に関する検討" 産業衛生学雑誌. 38. S529- (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nomiyama et al.: "N,N-Dimethylacetamide:Significance of vapor absorption from the skin on human volunteers." Book of abstracts of 25^<th> International Congress on Occupational Health. Book II. 119-

    • Related Report
      1997 Annual Research Report
  • [Publications] 野見山哲生ら: "ジメチルホルムアミド蒸気の皮膚吸収寄与に関する検討" 産業衛生学雑誌. 40. (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 陳莉玲ら: "ジメチルホルムアミド曝露者のCYP2E1遺伝子多型による尿中代謝物の生物学的半減期の検討" 産業衛生学雑誌. 40. (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Namiyama T et al.: "N,N-Dimethylacetamide:Significance of vapor absorption from the skin on human volunteers" Book of abstracts II 25^<th> International Congress on Occupational Health. 119 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 野見山哲生 他: "ジメチルアセトアミド蒸気のヒトボランティアでの皮膚吸収に関する検討" 産業衛生学雑誌. 38. S528 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 石塚千鶴 他: "ジメチルアセトアミド蒸気の生物学的モニタリング-採尿時期及び尿中代謝物NMACの補正方法に関する検討-" 産業衛生学雑誌. 38. S529 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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