• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Interaction between environmental and genetic factors in the development of esophageal cancer

Research Project

Project/Area Number 08457128
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionShinshu University

Principal Investigator

NASU Tamie  Department of Hygiene, Shinshu University School of Medicine, Lecturer, 医学部, 講師 (10020794)

Co-Investigator(Kenkyū-buntansha) OHTA Setsuko  Department of Public Health Shinshu University School of Medicine, Researcher, 医学部, 助手 (90143974)
FUKUSHIMA Yoshimitsu  Department of Hygiene, Shinshu University School of Medicine, Professor, 医学部, 教授 (70273084)
SATO Akio  Medical University of Yamaanashi Professor, 教授 (40020747)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥7,600,000 (Direct Cost: ¥7,600,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1996: ¥3,500,000 (Direct Cost: ¥3,500,000)
Keywordsesophageal cancer / China / Nutritional status / Life style / p53 / smoking / alcohol intake / molecular epidemiology / P53 / 食道癌 / ビタミンA / βカロテン / ビタミンE / セレン / ビタミンC / カロテン / シトクロムP450
Research Abstract

The purpose of this study is to find out environmental risks for the development of esophageal cancer in Ci-Xian, where is one of the highest incidence area of esophageal cancer in China.
Subjects were 404, 352 and 400 inhabitants living in high, medium and low incidence areas of esophageal cancer, as well as 301 esophageal patients. A food intake-frequency survey using the 7-day weighted inventory questionnaire was conducted for these subjects. Occupation, working condition, income per year, family history of diseases, complaints, and demographic features were also included in the questionnaire. The levels of nitrogen compound in selected well water were measured in each three area. Clear-cut differences in the intake of foods were seen among inhabitants living in the three different areas, suggesting that the regional differences in the nutritional style exist. In both males and females, the intakes of potatoes, fruit, vegetables and meat were significantly lower in inhabitants living … More in the high-incidence area than the other inhabitants, much the same as those of cancer patients. The lowered intakes of carotene, vitamin A and C were also seen in populations living in the high-incidence area of esophageal cancer. The polluted well water with nitrogen compounds was significantly related to the high incidence of esophageal cancer. In contrast, tobacco, alcohol consumption, and intake of pickled vegetable and moldy foods did not relate to the different incidence. These results suggest that the lowered intakes of fruit, vegetables, potatoes and meat, and quality of well water may be important risks for 'the development of esophageal cancer in Ci-Xian.
Carcinomas of upper digestive tract (squamous-cell carcinoma of the esophagus) from 65 patients residing in Ci-Xian (China) and near-by high-incidence areas were analyzed for mutations in exons 5-8 of the p53 tumor-repressor gene. Mutations were identified by polymerase chain reaction amplification. Of 65 specimens, 40% had mutations mainly in exon 5 and 8. In general, patients without p53 mutations had lowered intake of several kinds of foods. Especially, the intake of meat was significantly lower in patients without p53 mutations than in those with p53 mutations. Less

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Nakajima T.et al: "Expression of cytochrone p450s and gbstathione S-traneferases in human esophagus with squamous-cell careinonos." Corcinogenesis. 17・9. 1477-1481 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nimura Y et al: "Genotyping of the CYPIAI and GSTMI genes in esophageal carcinoma patients with special reference to smoking" Cancer. 80・8. 852-857 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakajima, T., Wang, R.S., Nimura, Y., Pin.Y.M., He, M., Vainio, H., Murayama, N., Aoyama, T., and Iida F.: "Expression of cytochrome P450s and glutathione S-transferases in human esophagus with squamous-cell carcinomas." Carcinogenesis. 17 (9). 1477-1481 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nimura, Y., Yokoyama, S., Fujimori, M., Aoki, T., Adachi, W., Nasu, T., He, M., Ping, Y.M.and Iida, F.: "Genotyping of the CYP1A1 and GSTM1 genes in esophageal carcinoma patients with special reference to smoking." Cancer. 80 (8). 852-857 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakajima T et al.: "Expressron of cytochrone P450s and glutathione S-transterases in humax with sqvamous-sell carcinonas" Carcinogenesis. 17・9. 1477-1481 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nimura Y et al.: "Genotyping of the CYPIAL ovol GS TMI genes in esophageal carcinoma patiente with special reterence to moking" Carcer. 80・8. 852-857 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nimura Y et al: "Genotyping of the CYPIAI and GSTMI genes in esophageal carcinoma patients with special reference to smoking" Cancer. 80・5. 852-857 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakajima T et al: "Expression of cytochrome P450s and glutathione S-transfereses in human esophagus with squamous-cell carcinomas" Carcino genesis. 17・7. 1472-1481 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tamie Nakazima,et al: "Expression of cyto chrome P450s and glutorthione S-tramsferases in human esopldgus with squamous-cell carcinomas" Carcino genesis. 17・7. 1477-1481 (1996)

    • Related Report
      1996 Annual Research Report

URL: 

Published: 1996-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi