| Project/Area Number |
08457130
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Public health/Health science
|
|---|
| Research Institution | Tottori University |
|---|
Principal Investigator |
NOSE Takayuki Department of Public Health, Faculty of Medicine, Tottori University, Professor, 医学部, 教授 (10032195)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IWAI Nobuo Department of Public Health, Faculty of Medicine, Tottori University Assistant, 医学部, 助手 (80191906)
KUROZAWA Youichi Department of Public Health, Faculty of Medicine, Tottori University, Instructor, 医学部, 助手 (50161790)
|
|---|
| Project Period (FY) |
1996 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1996: ¥2,500,000 (Direct Cost: ¥2,500,000)
|
|---|
| Keywords | cytokine / adhesion molecules / vibration syndrome / 接着因子 / VCAM-1 / ICAM-1 / E-selectin |
|---|
| Research Abstract |
1) Eleven healthy subjects were exposed to vibration (100Hz 10min).We investigated levels of TNF, IL-1, sE-selectin, sICAM-1 and sVCAM-1 in serum before and after exposure of vibration. No significant increases of them were found.
2) We investigated whether a relationship existed between soluble adhesion molecules and vascular damage from vibration-induced white finger (VWF). Twenty-five vibration exposed men and 23 normal healthy men as controls were examined. Concentrations of sE-selectin, sICAM- 1 and sVCAM-1 in serum were measured by the sandwich ELAISA method. Soluble VCAM-1, neither sE-selectin nor sICAM-1, was elevated in vibration-exposed men with VWF compared with those in vibration-exposed men without VWF and controls.
|
