| Project/Area Number |
08457144
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Osaka Prefectural Institute of Public Health |
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Principal Investigator |
OKUNO Yoshinobu Osaka Prefectural Insititute of Public Health, Department of Public Health, Head of Division of Virology, 公衆衛生部, 課長 (30112064)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Naoko Osaka Prefectural Institute of Public Health ; Department of Public Health, Seni, 公衆衛生部, 主任研究員 (10280835)
YAMAZAKI Kenji Osaka Prefectural Institute of Public Health ; Department of Public Health, Seni, 公衆衛生部, 主任研究員 (60159209)
MAEDA Akiko Osaka Prefectural Institute of Public Health ; Department of Public Health, Seni, 公衆衛生部, 主任研究員 (40250279)
木本 達雄 大阪府立公衆衛生研究所, 公衆衛生部, 主任研究員 (90192020)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1997: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1996: ¥3,900,000 (Direct Cost: ¥3,900,000)
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| Keywords | Vaccination / Vaccine / Side effects / Virus / Allergy / ゼラチン / チメロサール |
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| Research Abstract |
We examined the side effects occured after vaccination. They were divided into two categories, (1) side effects due to chief components of vaccine and accidental infections with field pathogens and (2) allergic reactions caused by additional compornents in the vaccine.
(1) Side effects due to chief components of vaccine and accidental infections with field pathogens.
Clinical samples from 25 cases who showed clinical symptoms after vaccination were brought into the Division of Virology, Osaka Prefectural Institute of Public Health during May 1994 and March 1998. They were 17 cases of mumps vaccine, 3 cases of Japanese encephalitis vaccine, 2 cases of measeles vaccine, 2 cases of rubella vaccine and one case of polio vaccine. Nine mumps virus strains were isolated from 17 cases who showed meningitis, and we could identified that all of them were vaccine strains. A measles virus strain was isolated from a child who was vaccinated with measles vaccine and developed measles-like symptoms. When nucleotide sequence of the virus strain was analyzed, it was clearly identified taht the strain was a field strain. this study demonstrated that virus examination is important to know whether clinical symptoms are caused by vaccine or not.
(2) Examination of allergic reactions after vaccination.
A total of 151 children with allergic diseases were investigated by the intradermal testing and prick test using each component in the vaccine and vaccine solution itself before vaccination. Positive rates of intradermal testing for live vaccine and DPT were 13.3/25.5%. Although gelatin is the main substance for allergic reaction, some individuals showed positive reaction to another components such as thimerosal. This observation urges us to develop vaccines free of allergic materials such as gelatin.
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