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Helicobacter pylori and its association with gastric cancer

Research Project

Project/Area Number 08457158
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

ASAKA Masahiro  Hokkaido University, School of Medicine, Professor, 医学部, 教授 (10113507)

Co-Investigator(Kenkyū-buntansha) KATO Mototsugu  Hokkaido University, Medical Hospital, Instructor, 医学部附属病院, 助手 (60271673)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥3,700,000 (Direct Cost: ¥3,700,000)
KeywordsH.pylori / Intestinal metaplasia / gastritis / gastric cancer / Cag A gene / Cag A gene / H. pylori
Research Abstract

Several lines of evidence support an association between H.pylori infection and gastric cancer. The natural history of H.pylori associated gastritis is inexorable progression involving more and more of the stomach, ultimately leading to gastric atrophy. In general, this process is slow requiring between 20 and 40 years to complete. Atrophic gastritis is widely considered to be a precursor lesion of the intestinal type of gastric cancer. Moreover, areas with a high prevalence of H.pylori infection also have a high prevalence of gastric cancer. The strong evidence comes from three prospective studies which have shown the risk of gastric cancer to be increased by about fourfold in H.pylori positive persons. After exhaustively reviewing the published literature, the Working Group Meeting of the International Agency for Research on Cancer (IARC) held in Lyon in 1994, in affiliation with the WHO,concluded that there was sufficient evidence from human studies to establish the carcinogenicity … More of infection with H.pylori and that H.pylori infection is carcinogenic to humans (Group 1).
It appears unlikely that H.pylori alone is responsible for gastric cancer. Rather, it may provide a suitable environment, including chronic gastritis and intestinal metaplasia for neoplastic change. The recognition that there is an association between H.pylori infection and gastric cancer has led to a major shift in emphasis when considering the etiology of the disease. Research into H.pylori has focused attention on the importance of chronic inflammation and impaired host defense mechanisms as factors in the development of gastric cancer. H.pylori infection leads to changes in many factors which are important to the pathogenesis of gastric cancer, including the vitamin C content of gastric juice, reactive oxygen metabolites and epithelial cell proliferation. Eradication of the organism can reverse these changes. Therefore, eradication of H.pylori in infected persons might be a route to preventing gastric cancer, although many questions still remain as to the effectiveness of this strategy. Less

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Masahiro Asaka: "Atrophic changes of gastric mucosa are caused by Helicobacter pylori infection rather than aging:Studies in asymptomatic Japanese adults." Helicobacter. 1. 52-56 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mototsugu Kato: "Effects of lansoprazole plus amoxycillin on the cure of Helicobacter pylori nfection in Japanese peptic ulcer patients." Alinet Pharmacol.Ther. 10. 821-827 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sakiko Mitani: "Studies on gastric mucosal cell injury induced by Helicobacter pylori." J.Clini.Gastroeterol.25. S164-168 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masaki Katagiri: "Increased cytokine production by gastric mucosa in patients with Helicobacter pylori infection." J.Clin.GAstroenterol.25. S211-214 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masahiro Asaka: "What role does Helicobacter pylori play in gastric cancer?" Gastroenterology. 113. S56-60 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masahiro Asaka: "Review artircle:Long-term Helicoabcter pylori infection-from gastritis to gastric cancer." Aliment Pharmacol.Ther.12. 9-15 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Asaka, et al.: "Atrophic changes of gastric mucosa are caused by Helicobacter pylori infection rather than aging : Studies in asymptomatic Japanese adults." Helicobacter. 1 (1). 52-56 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Kato, et al.: "Effects of lansoprazole plus amoxycillin on the cure of Helicobacter pylori infection in Japanese peptic ulcer patients." Aliment Pharmacol.Ther.l0. 821-827 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Mitani, et al.: "Studies on gastric mucosal cell injury induced by Helicobacter pylori." J.Clin.Gastroenterol.25 (Suppl.1). S164-168 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Katagiri, et al.: "Increased cytokine production by gastric mucosa in patients with Helicobacter pylori infection." J.Clin.Gastroenterol.25 (Suppl.l). S211-214 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Asaka, et al.: "What role does Helicobacter pylori play in gastric cancer?" Gastroenterology. 113 (Suppl). S56-60 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Asaka, et al.: "Review article : Long-term Helicobacter pylori infection-from gastritis to gastric cancer." Aliment Pharmacol.Ther.12 (Suppl.1). 9-15 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 加藤元嗣: "Helicobacter pylori除菌療法の現状" 医学のあゆみ. 183. 418-419 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 加藤元嗣: "耐菌性の出現とその対策" Helicobacter Research. 1. 459-465 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sakiko Mitani: "Studies on gastric mucosal cell injury induced by Helicobacter pylori." J.Clin Gastroenterol.25. S164-168 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masaki Katagiri: "Increased cytokine production by gastric mucosal in patients with Helicobacter pylori." J.Clin.Gastroenterol.25. S211-214 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Msahiro Asaka: "What role dose Helicobacter pylori play in gastric cancer?" Gastroenterology. 113. S56-60 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masahiro Asaka: "Review article:Long-term Helicobacter pylori infection-from gastritis to gastric cancer." Alment Pharmacol.Ther.12. 9-15 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masahiro Asaka: "Epidemiology of Helicobacter pylori infection" Asian Med. J.39. 171-177 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Masahiro Asaka: "Atrophic chages of gastric mucosa are caused by Helicobacter pylori infection rather than aging : Studies in asymptomatic Japanese adults." Helicobacter. 1. 52-56 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mototsugu Kato: "Effects of lansoprazole plus amoxycillin on the cure of Helicobacter pylori infection in Japanese peptic ulcer patients." Aliment. Parmacol. Ther.10. 821-827 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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