| Project/Area Number |
08457245
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
KANAZAWA-KAMEI Yoko Kyushu University, Faculty of Pharmaceutical Sciences, Assosiate professor, 薬学部, 助教授 (20037584)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOKAWA Kazuhiro DAIKIN Industries, Chemical Industrial Department, Head investigator, 化学事業部, 主任研究員
山下 恒雄 ダイキン工業(株), 化学事業部, 研究員
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1997: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1996: ¥4,800,000 (Direct Cost: ¥4,800,000)
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| Keywords | Non invasive cancer diagnosis / chemical shift imaging / Multinuclear NMR / ^<19>FNMR / 2-deoxy-2fluoro-D-glucose / 2-deoxy-2fluoro-D-mannose / Animal experiments / 2-デオキシ-2-フルオロ-D-ガラクトース / NMR画像 / ^<19>F NMR / マウス / 2-デオキシ-2-フルオロ-D-マンノース |
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| Research Abstract |
(1) The objective of this project is to developa new method of qualitative cancer diagnosis using the dynamics of fluorinated hexoses. We have found that MRS gives the good metabolic information on the famous PET pharmaceutical2-deoxy-2-fluoro-D-glucose (FDG) : the trapping of NDP-FDM in cancer. The proposalis the differential cancer diagnosis by the 19F-MRI of FDG.
(2) The imaging sequence for the simultaneous chamical shift selective observation was developed during the first year. This enabled us to image the FDG and its metabolites separetely and sfficiently. The diagnosis of transplanted tumor in mice was successful. (Reported at the 5th ISMRM,Vancouver, 1997)
(3) The fast spin echo sequence has been modified for the chemical shift observation. The diagnosis of transplanted and spontaneous tumors were performed with success.
(4) The preliminary results using 2-deoxy-2-fluoro-D-galactose (FDGal) gave us the better results : The comparison of FDG and FDGal gave us the much clearer basis of tumor differentiation. (To be reported at the 18th ICMRBS,Tokyo, 1998)
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