| Co-Investigator(Kenkyū-buntansha) |
OHARA Kazuyuki Hyogo College of Medicine, Medicine, Assistant, 医学部, 助手 (00268541)
MARUI Norihiro KYOTO UNIVERSITY,Graduate School of Medicine, Assistant, 医学研究科, 助手 (90199919)
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| Budget Amount *help |
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1998: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1997: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1996: ¥7,100,000 (Direct Cost: ¥7,100,000)
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| Research Abstract |
Morphometric investigations revealed that temporal and occipital lobe were most severely degenerated in the cerebral cortex of Alzheimer's disease.
The brains from 5 AD patients and 5 age-matched brains from the case with normal aging were studied morphometrically with computer image analyzing system. Serial paraffin sections of 10 microns were prepared from the tissues of the cerebral cortex, and stained with Nissl for counting neurons, Bodian for neurofibrillary tangles, and beta-protein for senile plaques.
The diminution rates of total neurons in the examined areas were as follows : orbital gyrus (32.0%), precentral gyrus (18.0%), inferior temporal gyrus (43.0%), medial temporal gyrus (44.0%), superior temporal gyrus (58.0%), parietal cortex (45.0%), calcarine area of the occipital lobe (52.0%), and hippocampus (48.0%). Large sized neurons diminished remarkably in the cerebral cortex. The severity of neuronal loss of neruons was different in each cortical layer. For example, in the inferior temporal cortex, the neuronal diminution rates of the cortical layers were 18.6%, 17.8%, 9.3% in the 3rd, 4th, and 5-6th layers, respectively. The diminution rates of the neurons in the cortical layers were had direct correlation with the number of neurofibrillary tangles, but did not have positive correlation with the number of senile plaques. Most distinguished neuronal losses were observed in the 5-6th layer of the superior temporal gyrus, and in 3rd layer of the inferior temporal gyrus.
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