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Morphometric Studies of the Brains of Alzheimer's Disease by Computer Image Analyzer.

Research Project

Project/Area Number 08457249
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

MIYOSHI Koho  KYOTO UNIVERSITY,Graduate School of Medicine, Professor, 医学研究科, 教授 (10068447)

Co-Investigator(Kenkyū-buntansha) OHARA Kazuyuki  Hyogo College of Medicine, Medicine, Assistant, 医学部, 助手 (00268541)
MARUI Norihiro  KYOTO UNIVERSITY,Graduate School of Medicine, Assistant, 医学研究科, 助手 (90199919)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1998: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1997: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1996: ¥7,100,000 (Direct Cost: ¥7,100,000)
KeywordsImage Analyzer / Morphometry / Neuronal Death / Neurofibrillary Tangles / Senile Plaque / アルツハイマー病 / アミロイド沈着
Research Abstract

Morphometric investigations revealed that temporal and occipital lobe were most severely degenerated in the cerebral cortex of Alzheimer's disease.
The brains from 5 AD patients and 5 age-matched brains from the case with normal aging were studied morphometrically with computer image analyzing system. Serial paraffin sections of 10 microns were prepared from the tissues of the cerebral cortex, and stained with Nissl for counting neurons, Bodian for neurofibrillary tangles, and beta-protein for senile plaques.
The diminution rates of total neurons in the examined areas were as follows : orbital gyrus (32.0%), precentral gyrus (18.0%), inferior temporal gyrus (43.0%), medial temporal gyrus (44.0%), superior temporal gyrus (58.0%), parietal cortex (45.0%), calcarine area of the occipital lobe (52.0%), and hippocampus (48.0%). Large sized neurons diminished remarkably in the cerebral cortex. The severity of neuronal loss of neruons was different in each cortical layer. For example, in the inferior temporal cortex, the neuronal diminution rates of the cortical layers were 18.6%, 17.8%, 9.3% in the 3rd, 4th, and 5-6th layers, respectively. The diminution rates of the neurons in the cortical layers were had direct correlation with the number of neurofibrillary tangles, but did not have positive correlation with the number of senile plaques. Most distinguished neuronal losses were observed in the 5-6th layer of the superior temporal gyrus, and in 3rd layer of the inferior temporal gyrus.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (50 results)

All Other

All Publications (50 results)

  • [Publications] Ohara, Kazuyuki: "A morphological study of subcortical changes in Alzheimer′s disease." Neuropahology. 19 in press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohara, Kazuyuki: "A morphological study of subcortical neurofibrillary tangles in Alzheimer′s disease." Neuropathology. 16. 231-238 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsumura, Y.: "Japanese siblings with missense mutation (717 VAl-Ile) in amyloid precursor protein of early-onset Alzhimer′s disease." Neurology. 46. 1721-1723 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ueki, A.: "Histological evidence for cholinergic alteration in the hippocampus following entorhinal cortex lesion." J.Neurol.Sci.142. 14-21 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三好功峰: "アルツハイマー病の臨床症状と診断基準" Modern Physician. 18. 379-381 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三好功峰: "21世紀の"痴呆診療"はどうなるか" 治療. 80. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三好功峰: "アルツハイマー型痴呆の仮説" こころの臨床. 17増刊号. 351-353 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三好功峰: "前頭葉型痴呆とアルツハイマー型痴呆" Jpn.J.Geriat.33. 154-157 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三好功峰: "日本人の病気・病態 -老年性痴呆-" 最新医学. 52. 1176-1187 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三好功峰: "老年期痴呆の諸病態" Dementia Japan. 11. 207-215 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三好功峰: "痴呆とは" 現代医療. 28. 1099-1102 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三好功峰: "痴呆とうつ" 総合臨床. 45. 895-898 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三好功峰: "老年期の痴呆性疾患" 医学書院, 250 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三好功峰: "Alzheimer病『臨床精神医学講座10巻、器質・症状性精神障害』(三好功峰、黒田重利編)" 中山書店, 520(87-105) (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三好功峰: "痴呆のモデル動物 『Key Word, 1997-′98,精神』 (松下正明ほか編)" 先端医学社, 268 (174-175) (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohara, Kazuyuki: "A morphological study of subcortical changes in Alzheimer's disease." Neuropathology. 19 (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohara, Kazuyuki: "A morphological study of subcortical neurofibrillary tangles in Alzheimer's disease." Neuropathology. 16. 231-238 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsumura, Y.: "Japanese siblings with missense mutation (717VA1-Ile) in amyloid precursor pretein of early-onset Alzhimer's disease." Neurology. 46. 1721-1723 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ueki, A.: "Histological evidence for cholinergic alteration in the hippocampus following entorhinal cortex lesion." J.Neurol.Sci.142. 14-21 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyoshi, Koho: "Frontal lobe dementia and Alzheimer type dementia." Jpn.J.Geriat.33. 154-157 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyoshi, Koho: "Clinico-pathology of dementia in the elderly." Dementia Japan. 11. 207-215 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyoshi, Koho: Dementiry disorders in the elderly.Igaku shoin, 250 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyoshi, Koho: Alzheimer's disease, "Encyclopedia of clinical psychiatry.Vol.10.". Nakayama shoten, 520(87-105) (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohara, Kazuyuki: "A morphological study of subcortical changes in Alzheimer's disease." Neuropathology(in press). 19. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohara, Kazuyuki: "A morphometric study of subcortical neurofibrillary tangles in Alzheimer's disease." Neuropathology. 16. 231-238 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsumura, Y.: "Japanese siblings with missense mutation(717 VA1-Ile)in amyloid precursor protein of early-onset Alzheimer's disease." Neurology. 46. 1721-1723 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ueki, A.: "Histological evidence for cholinergic alteration in the hippocampus following entorhinal cortex lesion." J.Neurol.Sci.142. 14-21 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三好功峰: "アルツハイマー病の臨床症状と診断基準." Modern Physician. 18. 379-381 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三好功峰: "21世紀の“痴呆診療"はどうなるか." 治療. 80. 1686-1690 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三好功峰: "アルツハイマー型痴呆の仮説." こころの臨床.17増刊号. 351-353 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三好功峰: "アルツハイマー病における神経組織の変化の在り方を探る." 文部時報.1453. 74-75 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三好功峰: "日本人の病気・病態-老年性痴呆-." 最新医学. 52. 1176-1187 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三好功峰: "老年期痴呆の諸病態." Dementia Japan. 11. 207-215 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三好功峰: "痴呆とは." 現代医療. 28. 1099-1102 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三好功峰: "痴呆とうつ" 綜合臨床. 45. 895-898 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三好功峰: "老年期の痴呆性疾患" 医学書院, 250 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三好功峰: "Alzheimer病『臨床精神医学講座10巻、器質・症状性精神障害』(三好功峰、黒田重利編)" 中山書店, 520(87-105) (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三好功峰: "痴呆のモデル動物『Key Word, 1997-'98.精神』(松下正明ほか編)" 先端医学社, 268(174-175) (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takauchi S, Ohara K, Miyoshi K, et al.: "Synaptic degeneration in rat brain induced by intraventricular infusion of a protease inhibitor,leupeptin." Brain pathology. 7. 1346-1347 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大原一幸, 三好功峰 他: "プロテアーゼ阻害ラットにおけるシナプス変性の組織計測的検討" Neuropathology. 17,suppl.227-228 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohara K, Miyoshi K: "A morphometric study of subcortical neurofibrillary tangles in Alzheimer's disease." Neuropathology. 16-2. 231-238 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ueki A, Miyoshi K: "Hitological evidence for cholinergic alteration in the hippocampus following entorhinal cortex lesion." J.Neurol.Sci.142-1. 14-21 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumura Y, Miyoshi K: "Japanese siblings with missense mutation (717 VAl-Ile) in amyloid precursor protein of early-onset Alzheimer's disease." Neurology. 46-11. 1721-1723 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大原一幸, 三好功峰: "アルツハイマー病の皮質下灰白質における老人斑の出現率について" Neuropathology. 16. 23-25 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 三好功峰: "老年期の痴呆性疾患" 医学書院, 250 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 三好功峰: "Alzheimer病,臨床精神医学講座10巻,器質・症状性精神障害(三好功峰、黒田重利 編)" 中山書店, 87-105 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohara K,Miyoshi K: "A morphometric study of subcprtical neurofibrillary tangles in Alzheimer's disease." Neuropathology. 16-2. 231-238 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ueki A,Miyoshi K: "Hitological evidence for cholinergic alteration in the hippocampus following entorhinal cortex lesion." J.Neurol.Sci.142-1. 14-21 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsumura Y,Miyoshi K: "Japanese siblings with missense mutation (717 VAl-Ile) in amyloid precrusor protein of early-onset Alzheimer's disease." Neurology. 46-11. 1721-1723 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 大原一幸,三好功峰: "アルツハイマー病の皮質下灰白質における老人斑の出現率について." Neuropathology. 16. 23-25 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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