| Project/Area Number |
08457252
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | YAMANASHI MEDICAL UNIVERSITY |
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Principal Investigator |
KANBA Shigenobu YAMANASHI MEDICAL UNIVERSITY,NEUROPSYCHIATRY,PROFESSOR, 医学部, 教授 (50195187)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | manic depressive illness / stress / cytokine / vasopressin / TNF / interleukin / inteferon / インターロイキン-1 / インターロイキン-1受容体アンタゴニスト / 視床下部 / HPA系 |
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| Research Abstract |
Interleukin-1 (IL-1) and IL-1, receptor antagonist mRNA levels peaked at approximately 0.5 and 2-4 hr, respectively. The maximum mRNA levels of IL-1b were 15-fold higher than pre-immobilization levels, whereas those of IL-1 receptor antagonists were 250-fold higher in the hypothalamus. After the biosynthesis of IL-1b has peaked, IL-1 receptor antagonist may contribute to attenuation of the IL-1 activity which has been enhanced by immobilization.
Chronic treatments of psychotropics for 28 days raised the levels of both mRNAs. The increase in IL-1 receptor antagonist mRNA was 6-112 times larger than that of IL-1b mRNA in most brain regions examined. These results suggest that chronic treatment with psychotropics causes greater amplifying effects on IL-1 receptor antagonist than IL-1b mRNA in the brain.
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