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BIOLOGICAL ROLE OF CHROMOSOME TRANSLOCATION JUNCTION REGION GENES IN HEMATOPOIETIC CELL DIFFERENTIATION AND PROLIFERATION

Research Project

Project/Area Number 08457282
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionAICHI CANCER CENTER

Principal Investigator

SETO Masao  LABORATORY OF CHEMOTHERAPY, 化学療法部, 部長 (80154665)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Shigeo  AICHI CANCER CENTER,RESEARCH INSTITUTE, RESEARCHER, 研究所, 研究員 (80180363)
KAGAMI Yoshitoyo  AICHI CANCER CENTER,RESEARCH INSTITUTE, RESEARCHER, 研究所, 研究員 (30270721)
JOH Tatsuro  AICHI CANCER CENTER,LAB.OF CHEMOTHERAPY, RESEARCHER, 化学療法部, 研究員 (70280807)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 1998: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥3,400,000 (Direct Cost: ¥3,400,000)
KeywordsLYMPHOMA / Hematopoietic malignancy / cyclin D1 / BCL1 / BCL2 / BCL6 / MLL / MALT lymphoma / cyclin D2 / cyclin D3
Research Abstract

A specific chromosome translocation is recurrently found in a specific type of hematologic malignancy and the translocation junction region genes have been recognized to play and important role in hematopoietic cell differentiation and proliferation. Our research for three years produced following results.
1. MLL gene associated with infantile leukemia and therapy-related leukemia
We produced the specific antibody against N-terminal MLL recombinant protein and showed that the MLL product is localized in nuclei. We also showed that the MLL-partner chimeric products localize in nuclei irrespective of translocation partner genes. We succeeded in establishing leukemia cell lines which can express MLL-LTG9 chimeric product, the most common type of therapy-related leukemia, upon IPTG induction. Using this system, we demonstrated that Hox-a7, b7, c9 are the target for chimeric MLL products.
2. BCLl/cyclin Dl gene on 11q13 chromosome translocation junction region :
We established the specific mono … More clonal antibody, 5D4, which can immuno-stan formalin-fixed, paraffin-embedded tissues. Importantly, we have shown that the positive staining reflected overexpression of cyclin Dl. We have examined 151 cases of mantle cell lymphoma (MCL) and found that 85% showed positive staining. Furthermore, the negative group of MCL has been shown to be a group with good prognosis distinct from the positive group of MCL, indicating the immunostaining is very important in selecting therapy strategy.
3. Diffuse large B-cell lymphoma (DLBL) and mucosa-associated lymphoid tissue (MALI) lymphoma :
DLBL constitutes of heterogeneous subtypes of B-cell lymphoma. We could identify three groups based on immunophenotype. Major translocation junction genes in B-cell lymphoma development are BCLl, BCL2, and BCL6, but gene rearrangement of these genes failed to identify any unique subtypes. MALT lymphoma has similar immunophenotype with DLBL, and we are trying to disclose 18q2 1 translocation junction genes which also should be useful in dissecting DLBL. Less

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (102 results)

All Other

All Publications (102 results)

  • [Publications] Takahashi, N.et al: "Trnnsloeation (9) ; 11 ; 22)(p22 : q23 : q11) : A New Type of Complex Variant Translocation of t(9;11)(p22:q23) with MLL Rearrangement." Cancer Genet.Cytgenet.88. 26-29 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yatabe, Y.et al.: "Climicopahologic Study of PRAD1/cyclin D1 overoxpressing lymphoma with special reference to mantle cell lymphoma,a sistinct molecular pathologic enntity." Amer.J.Surg.Pathol. 20. 1110-1122 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taki, T.et al.: "Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia." 1303-1307 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Joh, T.et al.: "Identification of MLL and chimeric MLL gene products involved in Hq23 translocation and possible mechanisms of leukemogenesis by MLL truncation." Oncogene. 13. 1945-1953 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kakuda, H.et al.: "A novel human leukaemic cell line, CTS, has a t(6;11)chromosomal translocation and characteristics of pluripotent stem cells." Brit.J.Haematol.95. 306-318 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohshima, A.et al.: "Hq23 aberration is an additional chromosomal change in de nove acute leukemin after treatment with etoposide and mitoxantrone." Amer.J.Hematol.53. 264-266 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taki, T.et al.: "Fusion of the MLL gene with two different genes, AF-6 and AF-5a, by a coplex translocation involving chromosome 5, 6, 3, and 11 in infant leukemia." Oncogene. 13. 2121-2130 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura, S.et al.: "Clinicopathologie study of nasal T/NK-cell lymphoma among the Japanese." Pathol.Int.47. 38-53 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ida, K.et al.: "Detection of chimeric mRNAs by reverse transcriptase-polymerase chain reaction for diagnosis and monitoring of acute leukemias with 11q23 abnormalities." Medical and Pediat.Oncol.28. 325-332 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura, S. et al.: "Cyelin D1 overexpression in malignant lymphomas." Pathol.Int.47. 421-429 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kagami, Y.et al.: "A nodal γ/δ T-cell lymphoma with an association of Epstein-Barr virus." Amer.J.Surg.Pathol.21. 729-36 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Joh, T.et al.: "Expression of CD8β and a lteration of cell surface phenotype in adult T-cell leukaemia cells." Brit.J.Haematol. 98. 151-156 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kurokawa, T.et al.: "Complemerarity determining regions-III is a useful molecular marker for the evaluation of minimal residual disease in mantle cell lymphoma." Brit.J.Haematol.98. 408-412 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashima, T.et al.: "Detection of 14q32. 33 translocation and t(11;14) in interphase nuclei of chronic B cell lenkemia/lymphoma by in situ hybridization." Int.J.Cancer. 72. 31-38 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki, R.et al.: "CD7 and CD56 positive mycloid/natural killer cell precursor acute leukemia : A distinct hematolymphoid disease entity." Blood. 90. 2417-2428 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Joh, T.et al.: "Chimeric MLL products with a Ras binding cytoplasmic protein AF6 involved in t(6;11)(q27;q23)leukemia localize in the nucleus." Oncogene. 15. 1681-1687 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura, S.et al.: "Anaplastic large cell lymphoma - a distinet molecular pathologic entity : A reappraisal with special reference to p80NPM/ALK expression." Amer.J.Surg.Pathol.21. 1420-1432 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki, R.et al.: "Complete cytogenetic rosponse with host-derived hematopoiesis induced by cyclosporin discontinuation in a patient with relapsed chronic myelogenous leukemia after bone marrow" Bone Marrow Transplantation. 20. 615-617 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kume, M.et al.: "Somatic hypermutations in the V_Hsegment of immunoglobulin genes of CD5 positive diffuse large B-cell lymphomas." Jpn.J.Cancer Res.88. 1087-1093 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yatabe, Y.et al.: "Multiple polypoid lesions of premary mucosn-associated lymphoid tissue lymphoma of Colon." Histopathology. 32. 116-125 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miura, I.et al.: "BCL6 rearrangement in a patient with mantle cell lymphoma." Ann.Hematol.74. 247-250 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura, N.et al.: "Importance of T-Cell Receptor -Chain Gene Analysis on CD7+ and CD56+ Myeloid/Natural Killer Cell Precursor Acute Leukemia." Blood. 91. 2622-2624 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hosokawa, Y.et al.: "A small deletion at the 3'-untranslated region of cyclin D1/PRAD1/BCL1 oncogene in a patient with chronic lymphocytic leukemia." Int.J.Cancer. 76. 791-796 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harada, S.et al.: "Microsatellite instability is rare in the clinical course of myelodysplastic syndrome studied with DNA from fresh and paraffin-embedded tissues." J.Cancer Res.Clin.Oncol.124 :. 231-235 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kitazawa, J.et al: "Progression from myelodysplastic syndrome with monosomy 7 to acute monoblastic leukemta with MLL gene rearrangement." Int. J.Hematol.67. 23-26 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takizawa, J.et al.: "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-Cell leukemia." Jpn.J.Cancer Res.89. 712-718 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taji, H.et al.: "Growth inhibition of CD20 positive B lymphoma cell lines by IDEC-C2B8 anti-CD20 monoclonal antibody." Jpn.J.Cancer Res. 89. 748-756 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kubonishi, I.et al.: "Translocation (10;11)(p13;q13) and MLL gene rearrangement in a case of AML(M5a) with aggressive leukemia cutis." Cancer Genet.Cytogenet. 104. 28-31 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tomita, A.et al.: "Truncated e-Myb expression in the human leukemia cell line TK-6." Leukemia. 12. 1422-1429 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamura, A.et al.: "Molecular cytogenetic delineation of the breakpoint at 18q21.1 in a NHL cell line (Karpas 1106) derived from mediastinal B-cell lymphoma." Int.J.Cancer. 78. 100-105 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akao, Y.et al.: "Antisense oligodeoxyribonucleotide against the MLL-LTG19 chimeric transcript inhibits cell growth and induces apoptosis in cells of an infantile leukemia cell line carrying the t(11;19)" Cancer Res. 58. 3773-3776 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kagami, Y.et al.: "Establishment of an 1L-2 dependent cell line derived from“nasal-type"NK/T-cell lymphoma of CD2+, sCD3-, CD3□+, CD56+ phenotype and associated with the Epstein-Barr virus." Brit.J.Haematol.103. 669-677 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Joh, T.et al.: "Establishment of an inducible expression system of chimeric MLL-LTG9 protein and inhibition of Hox a7, Hox b7 and Hox c9 expression by MLL-LTG9 in 32Dcl3 cells." Oncogene,. 18. 1125-1130 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takizawa, J.and Seto, M: "The TCL1 oncogene is not overexpressed in patients with Adult T-cell leukemia." Leukemia,. 13. 314

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akagi, T.et al.: "Molecular Cytogenetic Delineation of the Breakpoint at 18q21.1 in Low-Grade B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue." Genes, Chrom.& Cancer,. 印刷中.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takahashi, N.et al.: "Translocation (9 ; 11 ; 22) (p22 ; q23 ; q11) : Anew type of complex variant translocation of t (9 ; 11) (p22 ; q23) with MLL rearrangement." Cancer Genet.Cytogenet.88. 26-29 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yatabe, Y.et al.: "Clinicopahologic study of PRAD1/cyclin D1 overexpressing lymphoma with special reference to mantle cell lymphoma, a distinct molecular pathologic entity." Amer.J.Surg.Pathol.20. 1110-1122 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kojima, M.et al.: "Centroblastic and centroblastic-centrocytic lymphomas associated with prominent epithelioid granulomatous response without plasma cell differentiation. A clinicopathologic study of twelve cases." Hum.Pathol.27. 660-667 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taki, T., et al.: "Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia." Leukemia. 10. 1303-1307 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Joh, T.et al.: "Indentification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation." Oncogene. 13. 1945-1953 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kakuda, H.et al.: "A novel human leukaemic cell line, CTS,has at (6 ; 11) chromosomal translocation and characteristics of pluripotent stem cells." Brit.J.Haematol.95. 306-318 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohshima, A.et al: "11q23 aberration is an additional chromosomal change in de nove acute leukemia after treatment with etoposide and mitoxantrone" Amer.J.Hematol.53. 264-266 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taki, T.et al: "Fusion of the MLL gene with two different genes, AF-6 and AF-5a, by a coplex translocation involving chromosome 5,6,8, and 11 in infant leukemia." Oncogene. 13. 2121-2130 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura, S.et al.: "Clinicopathologic study of nasal T/NK-cell lymphoma among the Japanese." Pathol.Int.47. 38-53 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ida, K et al.: "Detection of chimeric mRNAs by reverse transcriptase-polymerase chain reaction for diagnosis and monitoring of acute leukemias with 11q23 abnormalities." Medical and Pediat.Oncol.28. 325-332 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura, S.et al.: "Cyclin D1 overexpression in malignant lymphomas." Pathol.Int.47. 421-429 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kagami, Y.et al.: "A nodal g/d T-cell lymphoma with an association of Epstein-Barr virus." Amer.J.Surg.Pathol.21. 729-36 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Joh, T.et al.: "Expression of CD8b and alteration of cell surface phenotype in adult T-cell leukaemia cells." Brit.J.Haematol.98. 151-156 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kurokawa, T.et al.: "Complementarity determining regions-III is a useful molecular marker for the evaluation of minimal residual disease in mantle cell lymphoma." Brit.J.Haematol.98. 408-412 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashima, T.et al.: "Detection of 14q32.33 translocation and t (11 ; 14) in interphase nuclei of chronic B cell leukemia/lymphoma by in situ hybridization." Int.J.Cancer. 72. 31-38 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki, R.et al.: "CD7 and CD56 positive myeloid/natural killer cell precursor acute leukemia : A distinct hematolymphoid disease entity" Blood. 90. 2417-2428 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Joh, T.et al.: "Chimeric MLL products with a Ras binding cytoplasmic protein AF6 involved in t (6 ; 11) (q27 ; q23) leukemia localize in the nucleus." Oncogene. 15. 1681-1687 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura, S.et al.: "Anaplast c.large cell lymphoma-a distinct molecular pathologic entity : A reappraisal with special refernce to p80NPM/ALK expression." Amer.J.Surg.Pathol.21. 1420-1432 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki, R.et al.: "Complete cytogenetic response with host-derived hematopoiesis induced by cyclosporin discontinuation in a patient with relapsed chronic myelogenous leukemia after bone marrow transplantation." Bone Marrow Transplantation. 20. 615-617 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kume, M.et al.: "Somatic hypermutations in the V_H segment of immunoglobulin genes of CD5 positive diffuse large B-cell lymphomas" J.Cancer Res.88. 1087-1093 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yatabe, Y.et al.: "Multiple polypoid lesions of primary mucosa-associated lymphoid tissue lymphoma of Colon." Histopathology. 32. 116-125 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miura, I et al.: "BCL6 rearrangement in a patient with mantle cell lymphoma." Ann.Hematol.74. 247-250 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura, N.et al.: "Importance of T-Cell Receptor-Chain Gene Analysis on CD7+ and CD56+ Myeloid/Natural Killer Cell Precursor Acute Leukemia" Blood. 91. 2622-2624 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hosokawa, Y.et al: "A small deletion at the 3'-untranslated region of cyclin D1/PRAD1/BCL1 oncogene in a patient with chronic lymphocytic leukemia." Int.J.Cancer. 76. 791-796 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harada, S.et al.: "Microsatellite instability is rare in the clinical course of myelodysplastic syndrome studied with DNA from fresh and paraffin-embedded tissues." J.Cancer Res.Clin.Oncol.124. 231-235 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kitazawa, J.et al.: "Progression from myelodysplastic syndrome with monosomy 7 to acute monoblastic leukemia with MLL gene rearrangement." Int.J.Hematol.67. 23-26 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takizawa, J.et al.: "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-Cell leukemia." Jpn.J.Cancer Res.89. 712-718 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taji.H.et al.: "Growth inhibition of CD20 positive B lymphoma cell lines by IDEC-C2B8 anti-CD20 monoclonal antibody." Jpn.J.Cancer Res.89. 748-756 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kubonishi, I.et al.: "Translocation (10 ; 11) (p13 ; q13)and MLL gene rearrangement in a case of AML(M5a) with aggressive leukemia cutis." Cancer Genet.Cytogenet.104. 28-31 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tomita, A.et al.: "Truncated c-Myb expression in the human leukemia cell line TK-6." Leukemia. 12. 1422-1429 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamura, A.et al.: "Molecular cytogenetic delineation of nhe breakpoint at 18q21.1 in a NHL cell line (Karpas 1106) derived from mediastinal B-cell lymphoma." Int.J.Cancer. 78. 100-105 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akao, Y.et al.: "Antisense oligodeoxyribonucleotide against the MLL-LTG19 chimeric transcript inhibits cell growth and induces apoptosis in cells of an infantile leukemia cell line carrying the t (11 ; 19) chromosomal translocation." Cancer Res.58. 3773-3776 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kagami, Y.et al.: "Establishment of an IL-2 dependent cell line derived from "nasal-type" NK/T-cell lymphoma of CD2+.sCD3-, CD3e+, CD56+ phenotype and associated with the Epstein-Barr virus." Brit.J.Haematol.103. 669-677 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Joh, T.et al.: "Establishment of an inducible expression system of chimeric MLL-LTG9 protein and inhibition of Hox a7, Hox b7 and Hox c9 expression by MLL-LTG9 in 32Dcl3 cells." Oncogene. 18. 1125-1130 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takizawa, J.and Seto, M.: "The TCL1 oncogene is not overexpressed in patients with Adult T-cell leukemia." Leukemia. 13. 314 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akagi, T.et al.: "Molecular Cytogenetic Delineation of the Breakpoint at 18q21.1 in Low-Grade B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue." Genes, Chrom.& Cancer. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura,N.et al.: "Importance of T-Cell Receptor γ/δ-Chain Gene Analysis on CD7+ and CD56+ Myeloid/Natural Killer Cell Precursor Acute Leukemia." Blood. 91. 2622-2624 (1998)

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      1998 Annual Research Report
  • [Publications] Hosokawa,Y.et al.: "A small deletion at the 3'-untranslated region of cyclin D1/PRAD1/BCL1 oncogene in a patient with chronic lymphocytic leukemia." Int.J.Cancer. 76. 791-796 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Harada,S.et al.: "Microsatellite instability is rare in the clinical course of myelodysplastic syndrome studied with DNA from fresh and paraffin-embedded tissues." J.Cancer Res.Clin.Oncol.124. 231-235 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kitazawa,J.et al.: "Progression from myelodysplastic syndrome with monosomy 7 to acute monoblastic leukemia with MLL gene rearrangement." Int.J.Hematol.67. 23-26 (1998)

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      1998 Annual Research Report
  • [Publications] Takizawa,J.et al.: "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-Cell leukemia" Jpn.J.Cancer Res.89. 712-718 (1998)

    • Related Report
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  • [Publications] Taji,H.et al.: "Growth inhibition of CD20 positive B lymphoma cell lines by IDEC-C2B8 anti-CD20 monoclonal antibody." Jpn.J.Cancer Res.89. 748-756 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kubonishi,I.et al.: "Translocation(10;11)(p13;q13)and MLL gene rearrangement in a case of AML(M5a) with aggressive leukemia cutis." Cancer Genet.Cytogenet.104. 28-31 (1998)

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      1998 Annual Research Report
  • [Publications] Tamura,A.et al.: "Molecular cytogenetic delineation of the breakpoint at 18q21.1 in a NHL cell line(Karpas 1106) derived from mediastinal B-cell lymphoma." Int.J.Cancer. 78. 100-105 (1998)

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  • [Publications] Akao,Y.et al.: "Antisense oligodeoxyribonucleotide against the MLL-LTG19 chimeric transcript inhibits cell growth and induces apoptosis in cells of an infantile leukemia cell line carrying the t(11;19)chromosomal" Cancer Res.58. 3773-3776 (1998)

    • Related Report
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  • [Publications] Kagami,Y.et al.: "Establishment of an IL-2 dependent cell line derived from “nasal-type" NK/T-cell lymphoma of CD2+,sCD3-,CD3_+,CD56+ phenotype and associated with the Epstein-Barr virus." Brit.J.Haematol.103. 669-677 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Joh,T.et al.: "Establishment of an inducible expression system of chimeric MLL-LTG9 protein and inhibition of Hox a7,Hox b7 and Hox c9 expression by MLL-LTG9 in 32Dc13 cells." Oncogene. 18. 1125-1130 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Akagi,T.et al.: "Molecular Cytogenetic Delineation of the Breakpoint at 18q21.1 in Low-Grade B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue." Genes,Chrom.& Cancer. (印刷中).

    • Related Report
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  • [Publications] Suzuki,R.: "CD7 and CD56 positive myeloid/naturel killer cell precursor acute leukemia:A dustinct hematolymphoid disease entity." Blood. 90. 2417-2428 (1997)

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  • [Publications] Jho,T.: "Chimeric MLL products with a Ras binding cytoplasmic protein AF6 involved in t(6;11)(q27;q23) leukemia localize in the nucleus." Oncogene. 15. 1681-1687 (1997)

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  • [Publications] Suzuki,R.: "Complete cytogenetic response with host-derived hematopoiesis induced by cyclosporin discontinuation in a patient with relapsed chronic myelogenous leukemia after bone marrow" Bone Marrow Transplantation. 20. 615-617 (1997)

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  • [Publications] Kume,M.: "Somatic hypermutations in the V_H segment of immunoglobulin genes of CD5 positive diffuse large B-cell lymphomas." Jpn.J.Cancer Res.88. 1087-1093 (1997)

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  • [Publications] Yatabe,Y.: "Multiple polypoid lesions of primary mucosa-associated lymphoid tissue lymphoma of Colon." Histopathology. (in press).

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  • [Publications] Nakamura,S.: "Anaplastic large cell lymphoma- a distinct molecular pathologic entity: A reappraisal with special reference to p80NPM/ALK expression." Amer,J.Surg.Pathol.(in press).

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  • [Publications] Takahashi,N.: "Translocation (9;11;22) (p22;q23;q11) : A New Type of Coplex Variant Translocation of t (9;11) (p22;q23) with MLL Rearrangement." Cancer Genet.Cytogenet.88. 26-29 (1996)

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  • [Publications] Yatabe,Y.: "Clinicopahologic Study of PRAD1/cyclin D1 overexpressing lymphoma with special reference to mantle cell lymphoma,a distinct molecular pathologic entity." Amer,J.Surg.Pathol.20. 1110-1122 (1996)

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  • [Publications] Kojima,M.: "Centroblastic and centroblastic-centrocytic lymphomas associated with prominent epithelioid granulomatous response without plasma cell differentiation. A clinicopathologic study of twelve cases." Hum.Pathol.27. 660-667 (1996)

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  • [Publications] Taki,T.: "Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia." Leukemia. 10. 1303-1307 (1996)

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  • [Publications] Joh,T.: "High establishment efficiency of lymph node stroma cells which spontaneously produce multiple cytokines derived from adult T-cell leukemia/lymphoma patients." Int.J.Oncology. 9. 619-624 (1996)

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  • [Publications] Joh,T.: "Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation." Oncogene. 13. 1945-1953 (1996)

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  • [Publications] Hata,M.: "Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) andits chromosomal localization to 19p13.2." Genomics. 38. 446-449 (1996)

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  • [Publications] Kakuda,H.: "A novel human leukaemic cell line,CTS,has a t (6;11) chromosomal translocation and characteristics of pluripotent stem cells." Brit.J.Haematol.95. 306-318 (1996)

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  • [Publications] Ohshima,A.: "11q23 aberration is an additional chromosomal change in de nove acute leukemia after treatment with etoposide and mitoxantrone." American J.Hematol.53. 264-266 (1996)

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      1996 Annual Research Report
  • [Publications] Taki,T.: "Fusion of the MLL gene with two different genes,AF-6 and AF-5a,by a coplex translocation involving chromosome 5,6,8,and 11 in infant leukemia." Oncogene. 13. 2121-2130 (1996)

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  • [Publications] Kagami,Y.: "A nodal g/d T-cell lymphoma with an association of Epstein-Barr virus." Amer.J.Surg.Pathol.(印刷中). (1997)

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      1996 Annual Research Report
  • [Publications] Nakamura,S.: "Cyclin D1 overexpression in malignant lymphomas." Pathol.Int.(印刷中). (1997)

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      1996 Annual Research Report
  • [Publications] Takashima,T.: "Detection of 14q32.33 translocation and t (11;14) in interphase nuclei of chronic B cell leukemia/lymphoma by in situ hybridization." Int.J.Cancer. 印刷中 (1997)

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      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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